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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2014

Open Access 01-12-2014 | Research

Overexpression of IL-17RC associated with ocular sarcoidosis

Authors: Wenting Wu, Ming Jin, Yujuan Wang, Baoying Liu, Defen Shen, Ping Chen, Susan Hannes, Zhiyu Li, Sima Hirani, Shayma Jawad, H Nida Sen, Chi-Chao Chan, Robert B Nussenblatt, Lai Wei, UNITE Human Ocular Inflammation Consortium

Published in: Journal of Translational Medicine | Issue 1/2014

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Abstract

Background

Sarcoidosis is a chronic inflammatory disease with a systemic granulomatous disorder affecting multiple organs including the eye. Both CD4+ T cell and macrophage have been linked to the pathogenesis of the disease.

Methods

The expression of IL-17RC was measured using FACS,immunohistochemistry and real-time PCR. Serum level of IL-17 was detected using ELISA.

Results

An elevated expression of IL-17RC on CD8+ T cells in peripheral blood was found in patients with ocular sarcoidosis as compared to healthy controls. Interestingly, we found a significant increase in the serum level of IL-17 in patients with ocular sarcoidosis as compared to healthy controls, which may be responsible for the induction of IL-17RC on CD8+ cells. In addition, IL-17RC appeared only in the retinal tissue of the patient with clinically active sarcoidosis.

Conclusions

Our results suggested a potential involvement of IL-17RC+CD8+ T cells in pathogenesis of ocular sarcoidosis.
Appendix
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Metadata
Title
Overexpression of IL-17RC associated with ocular sarcoidosis
Authors
Wenting Wu
Ming Jin
Yujuan Wang
Baoying Liu
Defen Shen
Ping Chen
Susan Hannes
Zhiyu Li
Sima Hirani
Shayma Jawad
H Nida Sen
Chi-Chao Chan
Robert B Nussenblatt
Lai Wei
UNITE Human Ocular Inflammation Consortium
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2014
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-12-152

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