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Open Access 01-12-2011 | Case report

Is there any advantage to combined trastuzumab and chemotherapy in perioperative setting her 2neu positive localized gastric adenocarcinoma?

Authors: Yassir Sbitti, Ismail Essaidi l, Adil Debbagh, Habiba Kadiri, Mohamed Oukabli, Yassine Moussaid, Khaoula Slimani, Mohamed Fetohi, Hakim Elkaoui, Abderrahmane Albouzidi, Mohamed Mahi, Abdelmounaim Ait Ali, Mohamed Ichou, Hassan Errihani

Published in: World Journal of Surgical Oncology | Issue 1/2011

Abstract

We report here a 44-year-old Moroccan man with resectable gastric adenocarcinoma with overexpression of human epidermal growth factor receptor 2 (HER2) by immunohistochemistry who was treated with trastuzumab in combination with chemotherapy in perioperative setting. He received 3 cycles of neoadjuvant chemotherapy consisting of trastuzumab, oxaliplatin, and capecitabine. Afterwards, he received total gastrectomy with extended D2 lymphadenectomy without spleno-pancreatectomy. A pathologic complete response was obtained with a combination of trastuzumab and oxaliplatin and capecitabine. He received 3 more cycles of trastuzumab containing regimen postoperatively.

We conclude that resectable gastric carcinoma with overexpression of the c-erbB-2 protein should ideally be managed with perioperative combination of trastuzumab with chemotherapy. Further research to evaluate trastuzumab in combination with chemotherapy regimens in the perioperative and adjuvant setting is urgently needed.

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Title: Is there any advantage to combined trastuzumab and chemotherapy in perioperative setting her 2neu positive localized gastric adenocarcinoma?
Authors: Yassir Sbitti
Ismail Essaidi l
Adil Debbagh
Habiba Kadiri
Mohamed Oukabli
Yassine Moussaid
Khaoula Slimani
Mohamed Fetohi
Hakim Elkaoui
Abderrahmane Albouzidi
Mohamed Mahi
Abdelmounaim Ait Ali
Mohamed Ichou
Hassan Errihani
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2011
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-9-112

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Is there any advantage to combined trastuzumab and chemotherapy in perioperative setting her 2neu positive localized gastric adenocarcinoma?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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