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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2007

Open Access 01-12-2007 | Review

Castleman's disease in the head of the pancreas: report of a rare clinical entity and current perspective on diagnosis, treatment, and outcome

Authors: Hongbei Wang, Rosemary L Wieczorek, Michael E Zenilman, Fidelina Desoto-Lapaix, Bimal C Ghosh, Wilbur B Bowne

Published in: World Journal of Surgical Oncology | Issue 1/2007

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Abstract

Background

Castleman's disease of the pancreas is a very rare condition that may resemble more common disease entities as well as pancreatic cancer.

Case presentation

Here we report the case of a 58-year-old African American male with an incidentally discovered lesion in the head of the pancreas. The specimen from his pancreaticoduodectomy contained a protuberant, encapsulated mass, exhibiting microscopic features most consistent with localized/unicentric Castleman's disease. These included florid follicular hyperplasia with mantle/marginal zone hyperplasia along with focal progressive transformation of germinal centers admixed with involuted germinal centers.

Conclusion

To date, eight cases of Castleman's disease associated with the pancreas have been described in the world literature. We report the first case of unicentric disease situated within the head of the pancreas. In addition, we discuss the diagnostic dilemma Castleman's disease may present to the pancreatic surgeon and review current data on pathogenesis, treatment, and outcome.
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Metadata
Title
Castleman's disease in the head of the pancreas: report of a rare clinical entity and current perspective on diagnosis, treatment, and outcome
Authors
Hongbei Wang
Rosemary L Wieczorek
Michael E Zenilman
Fidelina Desoto-Lapaix
Bimal C Ghosh
Wilbur B Bowne
Publication date
01-12-2007
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2007
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-5-133

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