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Open Access 01-12-2012 | Research

Magnetic nanoparticles sensitize MCF-7 breast cancer cells to doxorubicin-induced apoptosis

Authors: Khaled Aljarrah, Nizar M Mhaidat, M-Ali H Al-Akhras, Ahmad N Aldaher, BA Albiss, Khaled Aledealat, Fawzi M Alsheyab

Published in: World Journal of Surgical Oncology | Issue 1/2012

Abstract

Background

Resistance of breast cancer cells to the available chemotherapeutics is a major obstacle to successful treatment. Recent studies have shown that magnetic nanoparticles might have significant application in different medical fields including cancer treatment. The goal of this study is to verify the ability of magnetic nanoparticles to sensitize cancer cells to the clinically available chemotherapy.

Methods

The role of iron oxide nanoparticles, static magnetic field, or a combination in the enhancement of the apoptotic potential of doxorubicin against the resistant breast cancer cells, MCF-7 was evaluated using the MTT assay and the propidium iodide method.

Results

In the present study, results revealed that pre-incubation of MCF-7 cells with iron oxide nanoparticles before the addition of doxorubicin did not enhance doxorubicin-induced growth inhibition. Pre-incubation of MCF-7 cells with iron oxide nanoparticles followed by a static magnetic field exposure significantly (P < 0.05) increased doxorubicin-induced cytotoxicity. Sensitization with pre-exposure to the magnetic field was dose-dependent where the highest cytotoxicity was seen at 1 tesla. Further experiments revealed that the anti-proliferative effect of this treatment procedure is due to induction of apoptotic cell death.

Conclusions

These results might point to the importance of combining magnetic nanoparticles with a static magnetic field in treatment of doxorubicin-refractory breast cancer cells.

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Title: Magnetic nanoparticles sensitize MCF-7 breast cancer cells to doxorubicin-induced apoptosis
Authors: Khaled Aljarrah
Nizar M Mhaidat
M-Ali H Al-Akhras
Ahmad N Aldaher
BA Albiss
Khaled Aledealat
Fawzi M Alsheyab
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2012
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-10-62

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Magnetic nanoparticles sensitize MCF-7 breast cancer cells to doxorubicin-induced apoptosis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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