Top

Health and Quality of Life Outcomes

Published in:

Open Access 01-12-2013 | Research

Relationship of treatment satisfaction to medication adherence: findings from a cross-sectional survey among hypertensive patients in Palestine

Authors: Sa’ed H Zyoud, Samah W Al-Jabi, Waleed M Sweileh, Donald E Morisky

Published in: Health and Quality of Life Outcomes | Issue 1/2013

Abstract

Background

The concepts of medication adherence and Treatment satisfactions are commonly used in clinical research for assessing pharmaceutical care and improving treatment outcomes. Generally, one would expect a positive relationship between the two concepts. The objectives of this study were to investigate the factors associated with adherence to antihypertensive therapy among hypertensive patients and to assess the relationship between antihypertensive medication adherence and treatment satisfaction.

Methods

A cross-sectional study was conducted, adopting the Morisky eight-item Medication Adherence Scale (MMAS) for the assessment of medication adherence and using the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4) for the assessment of treatment satisfaction. Descriptive and comparative statistics were used to describe socio-demographic and disease-related characteristics of the patients. All analyses were performed using SPSS v 15.0.

Results

Four hundred and ten hypertensive patients were enrolled in the study. The mean age of participants was 58.38 ± 10.65 years; 52% were female and 36.8% had low antihypertensive medication adherence. There was a significant difference in the mean scores in the Effectiveness (p < 0.001), Convenience (p < 0.001), and Global Satisfaction (p < 0.001) domains, but not in the Side Effects (p = 0.466) domain among patients with different levels of adherence. After adjustment for covariates using multiple linear regression, global treatment satisfaction was still statistically significantly (p = 0.001) associated with medication adherence.

Conclusions

Low treatment satisfaction may be an important barrier for achieving high rates of adherence to treatment. These study findings could be helpful in clinical practice, mainly in the early treatment of hypertensive patients, at a point where improving treatment satisfaction is still possible.

Stein AD, Stoyanovsky V, Mincheva V, Dimitrov E, Hodjeva D, Petkov A, Tsanova V: Prevalence, awareness, treatment and control of hypertension in a working Bulgarian population. Eur J Epidemiol 2000, 16: 265–270. 10.1023/A:1007601107752PubMedCrossRef

Trevisol DJ, Moreira LB, Kerkhoff A, Fuchs SC, Fuchs FD: Health-related quality of life and hypertension: a systematic review and meta-analysis of observational studies. J Hypertens 2011, 29: 179–188. 10.1097/HJH.0b013e328340d76fPubMedCrossRef

Morisky DE, Ang A, Krousel-Wood M, Ward HJ: Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich) 2008, 10: 348–354. 10.1111/j.1751-7176.2008.07572.xCrossRef

Trevisol DJ, Moreira LB, Fuchs FD, Fuchs SC: Health-related quality of life is worse in individuals with hypertension under drug treatment: results of population-based study. J Hum Hypertens 2012, 26: 374–380. 10.1038/jhh.2011.48PubMedCrossRef

DiMatteo MR, Giordani PJ, Lepper HS, Croghan TW: Patient adherence and medical treatment outcomes: a meta-analysis. Med Care 2002, 40: 794–811. 10.1097/00005650-200209000-00009PubMedCrossRef

Bharmal M, Payne K, Atkinson MJ, Desrosiers MP, Morisky DE, Gemmen E: Validation of an abbreviated Treatment Satisfaction Questionnaire for Medication (TSQM-9) among patients on antihypertensive medications. Health Qual Life Outcomes 2009, 7: 36. 10.1186/1477-7525-7-36PubMedCentralPubMedCrossRef

Zyoud SH, Al-Jabi SW, Sweileh WM, Wildali AH, Saleem HM, Aysa HA, Badwan MA, Awang R, Morisky D: Health-related quality of life associated with treatment adherence in patients with hypertension: a cross-sectional study. Int J Cardiol 2013, 168: 2981–2983. 10.1016/j.ijcard.2013.04.105PubMedCrossRef

Sweileh WM, Ihbesheh MS, Jarar IS, Taha AS, Sawalha AF, Zyoud SH, Jamous RM, Morisky DE: Self-reported medication adherence and treatment satisfaction in patients with epilepsy. Epilepsy Behav 2011, 21: 301–305. 10.1016/j.yebeh.2011.04.011PubMedCrossRef

Atkinson MJ, Kumar R, Cappelleri JC, Hass SL: Hierarchical construct validity of the treatment satisfaction questionnaire for medication (TSQM version II) among outpatient pharmacy consumers. Value Health 2005,8(Suppl 1):S9-S24.PubMedCrossRef

10.

Barbosa CD, Balp MM, Kulich K, Germain N, Rofail D: A literature review to explore the link between treatment satisfaction and adherence, compliance, and persistence. Patient Prefer Adherence 2012, 6: 39–48.PubMedCentralPubMedCrossRef

11.

AlGhurair SA, Hughes CA, Simpson SH, Guirguis LM: A systematic review of patient self-reported barriers of adherence to antihypertensive medications using the world health organization multidimensional adherence model. J Clin Hypertens (Greenwich) 2012, 14: 877–886. 10.1111/j.1751-7176.2012.00699.xCrossRef

12.

Giacaman R, Khatib R, Shabaneh L, Ramlawi A, Sabri B, Sabatinelli G, Khawaja M, Laurance T: Health status and health services in the occupied Palestinian territory. Lancet 2009, 373: 837–849. 10.1016/S0140-6736(09)60107-0CrossRef

13.

Husseini A, Abu-Rmeileh NM, Mikki N, Ramahi TM, Ghosh HA, Barghuthi N, Khalili M, Bjertness E, Holmboe-Ottesen G, Jervell J: Cardiovascular diseases, diabetes mellitus, and cancer in the occupied Palestinian territory. Lancet 2009, 373: 1041–1049. 10.1016/S0140-6736(09)60109-4PubMedCrossRef

14.

Daniel WW: Biostatistics: basic concepts and methodology for the health sciences. New York: John Wiley & Sons; 2010.

15.

Morisky DE, Green LW, Levine DM: Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care 1986, 67–74.

16.

Jamous RM, Sweileh WM, Abu-Taha AS, Sawalha AF, Zyoud SH, Morisky DE: Adherence and satisfaction with oral hypoglycemic medications: a pilot study in Palestine. Int J Clin Pharm 2011, 33: 942–948. 10.1007/s11096-011-9561-7PubMedCrossRef

17.

Krousel-Wood M, Islam T, Webber LS, Re R, Morisky DE, Muntner P: New medication adherence scale versus pharmacy fill rates in hypertensive seniors. Am J Manag Care 2009, 15: 59–66.PubMedCentralPubMed

18.

Atkinson MJ, Sinha A, Hass SL, Colman SS, Kumar RN, Brod M, Rowland CR: Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease. Health Qual Life Outcomes 2004, 2: 12. 10.1186/1477-7525-2-12PubMedCentralPubMedCrossRef

19.

Tabachnick BG, Fidell LS: Using multivariate statistics. Boston: Pearson/Allyn & Bacon; 2007.

20.

Krousel-Wood MA, Muntner P, Islam T, Morisky DE, Webber LS: Barriers to and determinants of medication adherence in hypertension management: perspective of the cohort study of medication adherence among older adults. Med Clin North Am 2009, 93: 753–769. 10.1016/j.mcna.2009.02.007PubMedCentralPubMedCrossRef

21.

Krousel-Wood M, Hyre A, Muntner P, Morisky D: Methods to improve medication adherence in patients with hypertension: current status and future directions. Curr Opin Cardiol 2005, 20: 296–300. 10.1097/01.hco.0000166597.52335.23PubMedCrossRef

22.

Svensson S, Kjellgren KI: Adverse events and patients’ perceptions of antihypertensive drug effectiveness. J Hum Hypertens 2003, 17: 671–675. 10.1038/sj.jhh.1001596PubMedCrossRef

23.

Norman SA, Marconi KM, Schezel GW, Schechter CF, Stolley PD: Beliefs, social normative influences, and compliance with antihypertensive medication. Am J Prev Med 1985, 1: 10–17.PubMed

24.

Holt E, Joyce C, Dornelles A, Morisky D, Webber LS, Muntner P, Krousel-Wood M: Sex differences in barriers to antihypertensive medication adherence: findings from the cohort study of medication adherence among older adults. J Am Geriatr Soc 2013, 61: 558–564. 10.1111/jgs.12171PubMedCentralPubMedCrossRef

25.

Monane M, Bohn RL, Gurwitz JH, Glynn RJ, Levin R, Avorn J: The effects of initial drug choice and comorbidity on antihypertensive therapy compliance: results from a population-based study in the elderly. Am J Hypertens 1997, 10: 697–704. 10.1016/S0895-7061(97)00056-3PubMedCrossRef

26.

Monane M, Bohn RL, Gurwitz JH, Glynn RJ, Levin R, Avorn J: Compliance with antihypertensive therapy among elderly Medicaid enrollees: the roles of age, gender, and race. Am J Public Health 1996, 86: 1805–1808. 10.2105/AJPH.86.12.1805PubMedCentralPubMedCrossRef

27.

Wang PS, Bohn RL, Knight E, Glynn RJ, Mogun H, Avorn J: Noncompliance with antihypertensive medications: the impact of depressive symptoms and psychosocial factors. J Gen Intern Med 2002, 17: 504–511. 10.1046/j.1525-1497.2002.00406.xPubMedCentralPubMedCrossRef

28.

Egan BM, Lackland DT, Cutler NE: Awareness, knowledge, and attitudes of older americans about high blood pressure: implications for health care policy, education, and research. Arch Intern Med 2003, 163: 681–687. 10.1001/archinte.163.6.681PubMedCrossRef

29.

Iskedjian M, Einarson TR, MacKeigan LD, Shear N, Addis A, Mittmann N, Ilersich AL: Relationship between daily dose frequency and adherence to antihypertensive pharmacotherapy: evidence from a meta-analysis. Clin Ther 2002, 24: 302–316. 10.1016/S0149-2918(02)85026-3PubMedCrossRef

30.

Gregoire JP, Moisan J, Guibert R, Ciampi A, Milot A, Cote I, Gaudet M: Tolerability of antihypertensive drugs in a community-based setting. Clin Ther 2001, 23: 715–726. 10.1016/S0149-2918(01)80021-7PubMedCrossRef

31.

Krousel-Wood M, Thomas S, Muntner P, Morisky D: Medication adherence: a key factor in achieving blood pressure control and good clinical outcomes in hypertensive patients. Curr Opin Cardiol 2004, 19: 357–362. 10.1097/01.hco.0000126978.03828.9ePubMedCrossRef

Title: Relationship of treatment satisfaction to medication adherence: findings from a cross-sectional survey among hypertensive patients in Palestine
Authors: Sa’ed H Zyoud
Samah W Al-Jabi
Waleed M Sweileh
Donald E Morisky
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Health and Quality of Life Outcomes / Issue 1/2013
Electronic ISSN: 1477-7525
DOI: https://doi.org/10.1186/1477-7525-11-191

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Relationship of treatment satisfaction to medication adherence: findings from a cross-sectional survey among hypertensive patients in Palestine

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2013

‘Peace’ and ‘life worthwhile’ as measures of spiritual well-being in African palliative care: a mixed-methods study

Quality of life among patients living with epilepsy attending the neurology clinic at kenyatta national hospital, Nairobi, Kenya: a comparative study

Patient-reported outcomes among patients using exenatide twice daily or insulin in clinical practice in six European countries: the CHOICE prospective observational study

Course of COPD assessment test (CAT) and clinical COPD questionnaire (CCQ) scores during recovery from exacerbations of chronic obstructive pulmonary disease

Potential of patient-reported outcomes as nonprimary endpoints in clinical trials

Cross cultural evaluation of the Warwick-Edinburgh mental well-being scale (WEMWBS) -a mixed methods study