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Molecular Cancer
Published in: Molecular Cancer 1/2007

Open Access 01-12-2007 | Research

Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses

Authors: Kristine Kleivi, Guro E Lind, Chieu B Diep, Gunn I Meling, Lin T Brandal, Jahn M Nesland, Ola Myklebost, Torleiv O Rognum, Karl-Erik Giercksky, Rolf I Skotheim, Ragnhild A Lothe

Published in: Molecular Cancer | Issue 1/2007

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Abstract

Background

Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studied the overall gene expression levels in metastases from colorectal carcinomas, and so far, none has investigated the peritoneal carcinomatoses by use of DNA microarrays. Therefore, the aim of the present study is to investigate and compare the gene expression patterns of primary carcinomas (n = 18), liver metastases (n = 4), and carcinomatoses (n = 4), relative to normal samples from the large bowel.

Results

Transcriptome profiles of colorectal cancer metastases independent of tumor site, as well as separate profiles associated with primary carcinomas, liver metastases, or peritoneal carcinomatoses, were assessed by use of Bayesian statistics. Gains of chromosome arm 5p are common in peritoneal carcinomatoses and several candidate genes (including PTGER4, SKP2, and ZNF622) mapping to this region were overexpressed in the tumors. Expression signatures stratified on TP53 mutation status were identified across all tumors regardless of stage. Furthermore, the gene expression levels for the in vivo tumors were compared with an in vitro model consisting of cell lines representing all three tumor stages established from one patient.

Conclusion

By statistical analysis of gene expression data from primary colorectal carcinomas, liver metastases, and carcinomatoses, we are able to identify genetic patterns associated with the different stages of tumorigenesis.
Appendix
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Metadata
Title
Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses
Authors
Kristine Kleivi
Guro E Lind
Chieu B Diep
Gunn I Meling
Lin T Brandal
Jahn M Nesland
Ola Myklebost
Torleiv O Rognum
Karl-Erik Giercksky
Rolf I Skotheim
Ragnhild A Lothe
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2007
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-6-2

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