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Malaria Journal
Published in: Malaria Journal 2/2010

Open Access 01-12-2010 | Poster presentation

kdr-like mutations in the voltage gated sodium channel of a malaria vector Anopheles stephensi and development of PCR-based assays for their detection

Authors: OP Singh, CL Dykes, T Adak

Published in: Malaria Journal | Special Issue 2/2010

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Excerpt

Knockdown resistance (kdr) in insects resulting from mutation(s) in the voltage gated sodium channel (VGSC) gene is one of the mechanisms of resistance against DDT and pyrethroid group of insecticides. The most common mutation(s) associated with knock down resistance has been reported to be present at residue Leu1014 in the IIS6 transmembrane segment of the VGSC gene. The present study reports presence of two alternative kdr-like mutations in An. stephensi— L1014S and L1014S, and development of PCR-based assays for their detection. …
Metadata
Title
kdr-like mutations in the voltage gated sodium channel of a malaria vector Anopheles stephensi and development of PCR-based assays for their detection
Authors
OP Singh
CL Dykes
T Adak
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Malaria Journal / Issue Special Issue 2/2010
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-9-S2-P67

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Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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