Published in:
Open Access
01-12-2014 | Research
The ears of the African elephant: unexpected high seroprevalence of Plasmodium ovale and Plasmodium malariae in healthy populations in Western Africa
Authors:
Cécile Doderer-Lang, Pascal S Atchade, Lydia Meckert, Elodie Haar, Sylvie Perrotey, Denis Filisetti, Ahmed Aboubacar, Alexander W Pfaff, Julie Brunet, Nicodème W Chabi, Casimir D Akpovi, Ludovic Anani, André Bigot, Ambaliou Sanni, Ermanno Candolfi
Published in:
Malaria Journal
|
Issue 1/2014
Login to get access
Abstract
Background
Malaria Is A Life-Threatening Pathology In Africa. Plasmodium Falciparum And Plasmodium Vivax Attract The Most Focus Because Of Their High Prevalence And Mortality. Knowledge About The Prevalence Of The Cryptic Pathogens Plasmodium Ovale And Plasmodium Malariae Is Limited. Thanks To Recombinant Tools, Their Seroprevalence Was Measured For The First Time, As Well As The Prevalence Of Mixed Infections In A Malaria-Asymptomatic Population In Benin, A Malaria-Endemic Country.
Methods
A Panel Of 1,235 Blood Donations Collected Over Ten Months In Benin Was Used For Validation Of The Recombinant Tools. Recombinant P. Falciparum, P. Malariae, P. Ovale MSP1, And P. Falciparum AMA1 Were Engineered And Validated On A Biobank With Malaria-Infected Patients (N = 144) Using A Species-Speific ELISA Test (Recelisa). Results Were Compared To An ELISA Using A Native P. Falciparum Antigen (NatELISA).
Results
Among Microscopically Negative African Blood Donors, 85% (1,050/1,235) Present Antibodies Directed To Native P. Falciparum, 94.4% (1,166/1,235) To rPf MSP1 And rPf AMA1, 56.8% (702/1,235) To rPo MSP1, 67.5% (834/1235) To rPm MSP1 And 45.3% Of The Malaria Seropositive Population Had Antibodies Recognizing The Three Species.
Conclusion
A High Rate Of Antibodies Against P. Ovale And P. Malariae Was Found In Asymptomatic Blood Donors. The Proportion Of Mixed Infections Involving Three Species Was Also Unexpected. These Data Suggest That Determining Seroprevalence For These Cryptic Species Is An Appropriate Tool To Estimate Their Incidence, At The Eve Of Upcoming Anti-P. Falciparum Vaccination Campaigns.