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Published in: Malaria Journal 1/2013

Open Access 01-12-2013 | Research

Prevalence of clinically captured and confirmed malaria among HIV seropositve clinic attendants in five hospitals in Ghana

Authors: Dennis Adu-Gyasi, Caterina I Fanello, Frank Baiden, John DH Porter, Dan Korbel, George Adjei, Emmanuel Mahama, Alexander Manu, Kwaku Poku Asante, Sam Newton, Seth Owusu-Agyei

Published in: Malaria Journal | Issue 1/2013

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Abstract

Background

Malaria is associated with an increase in HIV viral load and a fall in CD4-cell count. Conversely, HIV infection disrupts the acquired immune responses to malaria and the efficacy of antimalarial drugs. This study was carried out in five Ghanaian hospitals to estimate the prevalence of clinically confirmed malaria among HIV patients by evaluating their hospital records.

Methods

This retrospective descriptive cross sectional study reviewed and collected data on malaria, using Case Record Forms from HIV patients’ folders in five hospitals in Ghana.

Results

There were 933 patients records made up of 272 (29.2%) males and 661 (70.8%) females. Majority of the patients were aged between 21–40 (63.6%) years and the rest were between the ages 1–20 (2.8%) years, 41–60 (31.6%) years and 61–80 (2.1%) years of age.
A total of 38.1% (355/933) of the patients were clinically suspected of having clinical malaria. Of these 339 (95.5%) were referred to the laboratory for confirmation of the diagnosis of malaria. Only 4.4% (15/339) of patients tested were confirmed as cases of malaria among the patients that were clinically suspected of having malaria and subsequently confirmed. Fever, was not significantly associated with a confirmed diagnosis of malaria [OR = 3.11, 95% CI: (0.63, 15.37), P = 0.142].

Conclusions

There was a 4.4% prevalence of confirmed malaria and 38.1% of presumptively diagnosed malaria from the case records of HIV patients from the selected hospitals in Ghana.
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Literature
1.
go back to reference Murray CJ, Rosenfeld LC, Lim SS, Andrews KG, Foreman KJ, Haring D, Fullman N, Naghavi M, Lozano R, Lopez AD: Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet. 2012, 379: 413-431. 10.1016/S0140-6736(12)60034-8.CrossRefPubMed Murray CJ, Rosenfeld LC, Lim SS, Andrews KG, Foreman KJ, Haring D, Fullman N, Naghavi M, Lozano R, Lopez AD: Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet. 2012, 379: 413-431. 10.1016/S0140-6736(12)60034-8.CrossRefPubMed
2.
go back to reference WHO: World malaria report 2011. 2011, Geneva: World Health Organization WHO: World malaria report 2011. 2011, Geneva: World Health Organization
3.
go back to reference Keiser J, Utzinger J, de Castro MC, Smith TA, Tanner M, Singer BH: Urbanization in sub-saharan Africa and implication for malaria control. Am J Trop Med Hyg. 2004, 71: 118-127.PubMed Keiser J, Utzinger J, de Castro MC, Smith TA, Tanner M, Singer BH: Urbanization in sub-saharan Africa and implication for malaria control. Am J Trop Med Hyg. 2004, 71: 118-127.PubMed
4.
go back to reference WHO/Roll Back Malaria: World malaria report 2008. 2008, Geneva: World Health Organization WHO/Roll Back Malaria: World malaria report 2008. 2008, Geneva: World Health Organization
5.
go back to reference Bryce J, Boschi-Pinto C, Shibuya K, Black RE: WHO estimates of the causes of death in children. Lancet. 2005, 365: 1147-1152. 10.1016/S0140-6736(05)71877-8.CrossRefPubMed Bryce J, Boschi-Pinto C, Shibuya K, Black RE: WHO estimates of the causes of death in children. Lancet. 2005, 365: 1147-1152. 10.1016/S0140-6736(05)71877-8.CrossRefPubMed
6.
go back to reference Modjarrad K, Vermund SH: Effect of treating co-infections on HIV-1 viral load: a systematic review. Lancet Infect Dis. 2010, 10: 455-463. 10.1016/S1473-3099(10)70093-1.PubMedCentralCrossRefPubMed Modjarrad K, Vermund SH: Effect of treating co-infections on HIV-1 viral load: a systematic review. Lancet Infect Dis. 2010, 10: 455-463. 10.1016/S1473-3099(10)70093-1.PubMedCentralCrossRefPubMed
7.
go back to reference Chalwe V, Van geertruyden JP, Mukwamataba D, Menten J, Kamalamba J, Mulenga M, D’Alessandro U: Increased risk for severe malaria in HIV-1–infected adults, Zambia. Emerg Infect Dis. 2009, 15: 749-755. 10.3201/eid1505.081009.PubMedCentralCrossRefPubMed Chalwe V, Van geertruyden JP, Mukwamataba D, Menten J, Kamalamba J, Mulenga M, D’Alessandro U: Increased risk for severe malaria in HIV-1–infected adults, Zambia. Emerg Infect Dis. 2009, 15: 749-755. 10.3201/eid1505.081009.PubMedCentralCrossRefPubMed
8.
go back to reference Collaboration TATC: Prognosis of patients treated with cART from 36 months after initiation, according to current and previous CD4 cell count and plasma HIV-1 RNA measurements. AIDS. 2009, 23: 2199-2208.CrossRef Collaboration TATC: Prognosis of patients treated with cART from 36 months after initiation, according to current and previous CD4 cell count and plasma HIV-1 RNA measurements. AIDS. 2009, 23: 2199-2208.CrossRef
9.
go back to reference Kamya MR, Gasasira AF, Achan J, Mebrahtu T, Ruel T, Kekitiinwa A, Charlebois ED, Rosenthal PJ, Havlir D, Dorsey G: Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children. AIDS. 2007, 21: 2059-2066. 10.1097/QAD.0b013e3282ef6da1.CrossRefPubMed Kamya MR, Gasasira AF, Achan J, Mebrahtu T, Ruel T, Kekitiinwa A, Charlebois ED, Rosenthal PJ, Havlir D, Dorsey G: Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children. AIDS. 2007, 21: 2059-2066. 10.1097/QAD.0b013e3282ef6da1.CrossRefPubMed
10.
go back to reference Mermin J, Ekwaru JP, Liechty CA, Were W, Downing R, Ransom R, Weidle P, Lule J, Coutinho A, Solberg P: Effect of co-trimoxazole prophylaxis, antiretroviral therapy, and insecticide-treated bednets on the frequency of malaria in HIV-1-infected adults in Uganda: a prospective cohort study. Lancet. 2006, 367: 1256-1261. 10.1016/S0140-6736(06)68541-3.CrossRefPubMed Mermin J, Ekwaru JP, Liechty CA, Were W, Downing R, Ransom R, Weidle P, Lule J, Coutinho A, Solberg P: Effect of co-trimoxazole prophylaxis, antiretroviral therapy, and insecticide-treated bednets on the frequency of malaria in HIV-1-infected adults in Uganda: a prospective cohort study. Lancet. 2006, 367: 1256-1261. 10.1016/S0140-6736(06)68541-3.CrossRefPubMed
11.
go back to reference Birku Y, Mekonnen E, Bjorkman A, Wolday D: Delayed clearance of Plasmodium falciparum in patients with human immunodeficiency virus co-infection treated with artemisinin. Ethiop Med J. 2002, 40 Suppl: 17-26. Birku Y, Mekonnen E, Bjorkman A, Wolday D: Delayed clearance of Plasmodium falciparum in patients with human immunodeficiency virus co-infection treated with artemisinin. Ethiop Med J. 2002, 40 Suppl: 17-26.
12.
go back to reference Whitworth J, Morgan D, Quigley M, Smith A, Mayanja B, Eotu H, Omoding N, Okongo M, Malamba S, Ojwiya A: Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study. Lancet. 2000, 356: 1051-1056. 10.1016/S0140-6736(00)02727-6.CrossRefPubMed Whitworth J, Morgan D, Quigley M, Smith A, Mayanja B, Eotu H, Omoding N, Okongo M, Malamba S, Ojwiya A: Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study. Lancet. 2000, 356: 1051-1056. 10.1016/S0140-6736(00)02727-6.CrossRefPubMed
13.
go back to reference French N, Nakiyingi J, Lugada E, Watera C, Whitworth JA, Gilks CF: Increasing rates of malarial fever with deteriorating immune status in HIV-1-infected Ugandan adults. AIDS. 2001, 15: 899-906. 10.1097/00002030-200105040-00010.CrossRefPubMed French N, Nakiyingi J, Lugada E, Watera C, Whitworth JA, Gilks CF: Increasing rates of malarial fever with deteriorating immune status in HIV-1-infected Ugandan adults. AIDS. 2001, 15: 899-906. 10.1097/00002030-200105040-00010.CrossRefPubMed
14.
go back to reference Van geertruyden J-P, Mulenga M, Mwananyanda L, Chalwe V, Moerman F, Chilengi R, Kasongo W, van Overmeir C, Dujardin J-C, Colebunders R, Kestens L, D’Alessandro U: HIV-1 immune suppression and antimalarial treatment outcome in Zambian adults with uncomplicated malaria. J Infect Dis. 2006, 194: 917-925. 10.1086/507310.CrossRefPubMed Van geertruyden J-P, Mulenga M, Mwananyanda L, Chalwe V, Moerman F, Chilengi R, Kasongo W, van Overmeir C, Dujardin J-C, Colebunders R, Kestens L, D’Alessandro U: HIV-1 immune suppression and antimalarial treatment outcome in Zambian adults with uncomplicated malaria. J Infect Dis. 2006, 194: 917-925. 10.1086/507310.CrossRefPubMed
15.
go back to reference Kamya MR, Byakika-Kibwika P, Gasasira AF, Havlir D, Rosenthal PJ, Dorsey G, Achan J: The effect of HIV on malaria in the context of the current standard of care for HIV-infected populations in Africa. Future Virol. 2012, 7: 699-708. 10.2217/fvl.12.59.PubMedCentralCrossRefPubMed Kamya MR, Byakika-Kibwika P, Gasasira AF, Havlir D, Rosenthal PJ, Dorsey G, Achan J: The effect of HIV on malaria in the context of the current standard of care for HIV-infected populations in Africa. Future Virol. 2012, 7: 699-708. 10.2217/fvl.12.59.PubMedCentralCrossRefPubMed
16.
go back to reference Gasasira AF, Kamya MR, Achan J, Mebrahtu T, Kalyango JN, Ruel T, Charlebois E, Staedke SG, Kekitiinwa A, Rosenthal PJ: High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. Clin Infect Dis. 2008, 46: 985-991. 10.1086/529192.CrossRefPubMed Gasasira AF, Kamya MR, Achan J, Mebrahtu T, Kalyango JN, Ruel T, Charlebois E, Staedke SG, Kekitiinwa A, Rosenthal PJ: High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. Clin Infect Dis. 2008, 46: 985-991. 10.1086/529192.CrossRefPubMed
17.
go back to reference Kwara A, Shah D, Renner L: Outcome of hospital admissions in HIV-infected children at the Korle Bu Teaching Hospital, Accra, Ghana. West Afr J Med. 2010, 29: 379-383.PubMed Kwara A, Shah D, Renner L: Outcome of hospital admissions in HIV-infected children at the Korle Bu Teaching Hospital, Accra, Ghana. West Afr J Med. 2010, 29: 379-383.PubMed
18.
go back to reference Tabi M, Frimpong S: HIV infection of women in African countries. Int J Nurs Rev. 2003, 50: 242-250. 10.1046/j.1466-7657.2003.00206.x.CrossRef Tabi M, Frimpong S: HIV infection of women in African countries. Int J Nurs Rev. 2003, 50: 242-250. 10.1046/j.1466-7657.2003.00206.x.CrossRef
20.
go back to reference Owusu-Agyei S, Asante KP, Adjuik M, Adjei G, Awini E, Adams M, Newton S, Dosoo D, Dery D, Agyeman-Budu A: Epidemiology of malaria in the forest-savanna transitional zone of Ghana. Malar J. 2009, 8: 220-10.1186/1475-2875-8-220.PubMedCentralCrossRefPubMed Owusu-Agyei S, Asante KP, Adjuik M, Adjei G, Awini E, Adams M, Newton S, Dosoo D, Dery D, Agyeman-Budu A: Epidemiology of malaria in the forest-savanna transitional zone of Ghana. Malar J. 2009, 8: 220-10.1186/1475-2875-8-220.PubMedCentralCrossRefPubMed
21.
go back to reference Ampofo W, Torpey K, Mukadi Y, Koram K, Nolan K, Amenyah R, Kaitoo E, Antwi P, Ofori-Adjei D, Lamptey P: Normal CD4+ T lymphocyte levels in HIV seronegative individuals in the Manya/Yilo Krobo communities in the Eastern region of Ghana. Viral Immunol. 2006, 19: 260-266. 10.1089/vim.2006.19.260.CrossRefPubMed Ampofo W, Torpey K, Mukadi Y, Koram K, Nolan K, Amenyah R, Kaitoo E, Antwi P, Ofori-Adjei D, Lamptey P: Normal CD4+ T lymphocyte levels in HIV seronegative individuals in the Manya/Yilo Krobo communities in the Eastern region of Ghana. Viral Immunol. 2006, 19: 260-266. 10.1089/vim.2006.19.260.CrossRefPubMed
22.
go back to reference Tshikuka JMG, Matindii BA, Kilauzi AL, Mengema B, Mafuta J, Eloko EMG, Bulaïmu-Lukeba AM, Itetya JL: Severity of outcomes associated to types of HIV coinfection with TB and malaria in a setting where the three pandemics overlap. J Community Health. 2012, 37: 1234-1238. 10.1007/s10900-012-9559-7.CrossRef Tshikuka JMG, Matindii BA, Kilauzi AL, Mengema B, Mafuta J, Eloko EMG, Bulaïmu-Lukeba AM, Itetya JL: Severity of outcomes associated to types of HIV coinfection with TB and malaria in a setting where the three pandemics overlap. J Community Health. 2012, 37: 1234-1238. 10.1007/s10900-012-9559-7.CrossRef
23.
go back to reference Davies DH, Halablab MA, Clarke J, Cox FEG, Young TWK: Infection and Immunity. 2002, Pennsylvania, U.S.A: Taylor and Francis Lifelines, 1-31. The immune system Davies DH, Halablab MA, Clarke J, Cox FEG, Young TWK: Infection and Immunity. 2002, Pennsylvania, U.S.A: Taylor and Francis Lifelines, 1-31. The immune system
25.
go back to reference Goering RV, Dockrell HM, Zuckerman M, Wakelin D, Roitt IM, Mims C, Chiodini PL: Mims’ Medical Microbiology. 2008, Philadelphia: Mosby Elsevier, 4 Goering RV, Dockrell HM, Zuckerman M, Wakelin D, Roitt IM, Mims C, Chiodini PL: Mims’ Medical Microbiology. 2008, Philadelphia: Mosby Elsevier, 4
26.
go back to reference Brentlinger PE, Behrens CB, Kublin JG: Challenges in the prevention, diagnosis, and treatment of malaria in human immunodeficiency virus infected adults in sub-Saharan Africa. Arch Intern Med. 1827, 2007: 167- Brentlinger PE, Behrens CB, Kublin JG: Challenges in the prevention, diagnosis, and treatment of malaria in human immunodeficiency virus infected adults in sub-Saharan Africa. Arch Intern Med. 1827, 2007: 167-
27.
go back to reference Flateau C, Le Loup G, Pialoux G: Consequences of HIV infection on malaria and therapeutic implications: a systematic review. Lancet Infect Dis. 2011, 11: 541-556. 10.1016/S1473-3099(11)70031-7.CrossRefPubMed Flateau C, Le Loup G, Pialoux G: Consequences of HIV infection on malaria and therapeutic implications: a systematic review. Lancet Infect Dis. 2011, 11: 541-556. 10.1016/S1473-3099(11)70031-7.CrossRefPubMed
28.
go back to reference Anglaret X, Dakoury-Dogbo N, Bonard D, Touré S, Combe P, Ouassa T, Menan H, N’Dri-Yoman T, Dabis F, Salamon R: Causes and empirical treatment of fever in HIV-infected adult outpatients, Abidjan, Cote d’Ivoire. AIDS. 2002, 16: 909-918. 10.1097/00002030-200204120-00011.CrossRefPubMed Anglaret X, Dakoury-Dogbo N, Bonard D, Touré S, Combe P, Ouassa T, Menan H, N’Dri-Yoman T, Dabis F, Salamon R: Causes and empirical treatment of fever in HIV-infected adult outpatients, Abidjan, Cote d’Ivoire. AIDS. 2002, 16: 909-918. 10.1097/00002030-200204120-00011.CrossRefPubMed
29.
go back to reference Berg A, Patel S, Langeland N, Blomberg B: Falciparum malaria and HIV-1 in hospitalized adults in Maputo, Mozambique: does HIV-infection obscure the malaria diagnosis. Malar J. 2008, 7: 252-10.1186/1475-2875-7-252.PubMedCentralCrossRefPubMed Berg A, Patel S, Langeland N, Blomberg B: Falciparum malaria and HIV-1 in hospitalized adults in Maputo, Mozambique: does HIV-infection obscure the malaria diagnosis. Malar J. 2008, 7: 252-10.1186/1475-2875-7-252.PubMedCentralCrossRefPubMed
30.
go back to reference Peters RP, Zijlstra EE, Schijffelen MJ, Walsh AL, Joaki G, Kumwenda JJ, Kublin JG, Molyneux ME, Lewis DK: A prospective study of bloodstream infections as cause of fever in Malawi: clinical predictors and implications for management. Trop Med Int Health. 2004, 9: 928-934. 10.1111/j.1365-3156.2004.01288.x.CrossRefPubMed Peters RP, Zijlstra EE, Schijffelen MJ, Walsh AL, Joaki G, Kumwenda JJ, Kublin JG, Molyneux ME, Lewis DK: A prospective study of bloodstream infections as cause of fever in Malawi: clinical predictors and implications for management. Trop Med Int Health. 2004, 9: 928-934. 10.1111/j.1365-3156.2004.01288.x.CrossRefPubMed
31.
go back to reference Souteyrand YP, Collard V, Moatti JP, Grubb I, Guerma T: Free care at the point of service delivery: a key component for reaching universal access to HIV/AIDS treatment in developing countries. AIDS. 2008, 22: S161-S168. 10.1097/01.aids.0000327637.59672.02.CrossRefPubMed Souteyrand YP, Collard V, Moatti JP, Grubb I, Guerma T: Free care at the point of service delivery: a key component for reaching universal access to HIV/AIDS treatment in developing countries. AIDS. 2008, 22: S161-S168. 10.1097/01.aids.0000327637.59672.02.CrossRefPubMed
32.
go back to reference Ansah EK, Narh-Bana S, Asiamah S, Dzordzordzi V, Biantey K, Dickson K, Gyapong JO, Koram KA, Greenwood BM, Mills A: Effect of removing direct payment for health care on utilisation and health outcomes in Ghanaian children: a randomised controlled trial. PLoS Med. 2009, 6: e1000007-PubMedCentralPubMed Ansah EK, Narh-Bana S, Asiamah S, Dzordzordzi V, Biantey K, Dickson K, Gyapong JO, Koram KA, Greenwood BM, Mills A: Effect of removing direct payment for health care on utilisation and health outcomes in Ghanaian children: a randomised controlled trial. PLoS Med. 2009, 6: e1000007-PubMedCentralPubMed
Metadata
Title
Prevalence of clinically captured and confirmed malaria among HIV seropositve clinic attendants in five hospitals in Ghana
Authors
Dennis Adu-Gyasi
Caterina I Fanello
Frank Baiden
John DH Porter
Dan Korbel
George Adjei
Emmanuel Mahama
Alexander Manu
Kwaku Poku Asante
Sam Newton
Seth Owusu-Agyei
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2013
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-12-382

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