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Cancer Cell International
Published in: Cancer Cell International 1/2008

Open Access 01-12-2008 | Primary research

S100A4 overexpression proves to be independent marker for breast cancer progression

Authors: Nawfal I Ismail, Gurjeet Kaur, Hasnah Hashim, Mohammed S Hassan

Published in: Cancer Cell International | Issue 1/2008

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Abstract

Background

Breast cancer is the most common cancer and cause of deaths in women around the world. Oncogene amplification usually occurs late in tumor progression and correlates well with aggressiveness of tumor. In fact the function of the S100A4 protein and its role in metastasis is unclear at present. The purpose of the study was to determine the expression of S100A4 protein in the invasion status and metastatic potential of breast cancer by using tissue microarray and to determine its role in breast cancer based on the expression of S100A4 gene product.

Methods

S100A4 protein expression was examined by immunohistochemistry (IHC) using commercially available tissue microarray containing malignant and normal breast tissue cores from 216 patients.

Results

S100A4 was absent in normal breast tissues while positive in 45.1% of infiltrating ductal carcinoma (IDC) node negative and 48.8% of infiltrating lobular carcinoma node negative. In paired samples, S100A4 protein was expressed in 13.5% of IDC node positive cases and 35.1% of matched lymph node metastasis.

Conclusion

S100A4 protein expression appears widely expressed in early and advanced breast cancer stages compared with normal breast. Our study suggests S100A4 may play a role in breast cancer progression and may prove to be an independent marker of breast cancer which appears to be down regulated in more advanced stages of breast cancer.
Appendix
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Metadata
Title
S100A4 overexpression proves to be independent marker for breast cancer progression
Authors
Nawfal I Ismail
Gurjeet Kaur
Hasnah Hashim
Mohammed S Hassan
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2008
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/1475-2867-8-12

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