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BMC Clinical Pathology
Published in: BMC Clinical Pathology 1/2011

Open Access 01-12-2011 | Research article

Immunohistochemical detection of laminin-1 and Ki-67 in radicular cysts and keratocystic odontogenic tumors

Authors: Mohamed S Ayoub, Houry M Baghdadi, Moataz El-Kholy

Published in: BMC Clinical Pathology | Issue 1/2011

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Abstract

Background

Odontogenic cysts are those which arise from the epithelium associated with the development of teeth. Some odontogenic cysts were found to have special biological features that make them distinct from other lesions. This study was conducted to detect the immunoepxression of laminin-1 and Ki-67 in both radicular cysts (RCs) and keratocystic odontogenic tumors (KCOTs) and to examine the possible predictive value of these markers.

Methods

Thirteen cases of RCs and twelve cases of KCOTs were included in this study. Antibodies against laminin-1 and Ki-67 were used as primary antibodies.

Results

ten cases out of thirteen cases of RCs were immunopositive to laminin-1. The immunonegative cases of RCs showed high degree of inflammation inside the connective tissue wall. One case out of twelve cases of KCOTs was immunopositive to laminin-1 and the rest were immunonegative. Seven cases out of thirteen cases of RCs showed immunopositivity for Ki-67 with increased numbers of immunopositive cells when the inflammation was severe in the connective tissue wall. All KCOTS were immunopositive to Ki-67.

Conclusions

The benign nature of radicular cysts and the aggressive behavior of keratocystic odontogenic tumors could be explained by the expression of laminin and Ki-67. Laminin-1 and Ki-67 could be valuable markers for the prediction of the biologic behavior of cystic lesions.
Appendix
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Metadata
Title
Immunohistochemical detection of laminin-1 and Ki-67 in radicular cysts and keratocystic odontogenic tumors
Authors
Mohamed S Ayoub
Houry M Baghdadi
Moataz El-Kholy
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Clinical Pathology / Issue 1/2011
Electronic ISSN: 1472-6890
DOI
https://doi.org/10.1186/1472-6890-11-4

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