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Open Access 01-12-2007 | Research article

Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1and colorectal cancer risk

Authors: Lara Bethke, Emily Webb, Gabrielle Sellick, Matthew Rudd, Stephen Penegar, Laura Withey, Mobshra Qureshi, Richard Houlston

Published in: BMC Cancer | Issue 1/2007

Abstract

Background

Cytochrome P450 (CYP) enzymes have the potential to affect colorectal cancer (CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex hormones.

Methods

To investigate if common variants of CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1 and CYP19A1 influence CRC risk we genotyped 2,575 CRC cases and 2,707 controls for 20 single nucleotide polymorphisms (SNPs) that have not previously been shown to have functional consequence within these genes.

Results

There was a suggestion of increased risk, albeit insignificant after correction for multiple testing, of CRC for individuals homozygous for CYP1B1 rs162558 and heterozygous for CYP1A2 rs2069522 (odds ratio [OR] = 1.36, 95% confidence interval [CI]: 1.03–1.80 and OR = 1.34, 95% CI: 1.00–1.79 respectively).

Conclusion

This study provides some support for polymorphic variation in CYP1A2 and CYP1B1 playing a role in CRC susceptibility.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/7/123/prepub

Title: Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1and colorectal cancer risk
Authors: Lara Bethke
Emily Webb
Gabrielle Sellick
Matthew Rudd
Stephen Penegar
Laura Withey
Mobshra Qureshi
Richard Houlston
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2007
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/1471-2407-7-123

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