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BMC Infectious Diseases
Published in: BMC Infectious Diseases 6/2014

Open Access 01-09-2014 | Review

HIV and hepatitis C co-infection in Europe, Israel and Argentina: a EuroSIDA perspective

Authors: Lars Peters, Amanda Mocroft, Jens Lundgren, Daniel Grint, Ole Kirk, Jürgen Kurt Rockstroh

Published in: BMC Infectious Diseases | Special Issue 6/2014

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Excerpt

The EuroSIDA observational cohort study was initiated in 1993 by Jens Lundgren (Copenhagen HIV Programme) and Andrew Phillips (University College London) as the successor of the AIDS in Europe Study, with the main objective of assessing the impact of antiretroviral drugs on outcomes for the general population of HIV-infected patients living in Europe. As of April 2014 EuroSIDA included 18,786 patients followed at 111 hospitals in 34 European countries plus Argentina and Israel. Since its inception, EuroSIDA has provided data published in 202 papers in peer-reviewed journals, among them 14 papers on hepatitis C virus (HCV) co-infection [1‐14] . …
Literature
1.
Grint D, Peters L, Reekie J, Soriano V, Kirk O, Knysz B, et al: Stability of hepatitis C virus (HCV) RNA levels among interferon-naive HIV/HCV-coinfected individuals treated with combination antiretroviral therapy. HIV Med. 2013, 14: 370-378. 10.1111/hiv.12033.PubMedCrossRef
2.
Grint D, Peters L, Schwarze-Zander C, Beniowski M, Pradier C, Battegay M, et al: Temporal changes and regional differences in treatment uptake of hepatitis C therapy in EuroSIDA. HIV Med. 2013
3.
Grint D, Peters L, Rockstroh JK, de WS, Mitsura VM, Knysz B, et al: Increased incidence of antiretroviral drug discontinuation among patients with viremic hepatitis C virus coinfection and high hyaluronic acid, a marker of liver fibrosis. AIDS. 2014, 28: 577-587. 10.1097/QAD.0000000000000069.PubMedCrossRef
4.
Mocroft A, Soriano V, Rockstroh J, Reiss P, Kirk O, de WS, et al: Is there evidence for an increase in the death rate from liver-related disease in patients with HIV?. AIDS. 2005, 19: 2117-2125. 10.1097/01.aids.0000194799.43799.ea.PubMedCrossRef
5.
Mocroft A, Rockstroh J, Soriano V, Ledergerber B, Kirk O, Vinogradova E, et al: Are specific antiretrovirals associated with an increased risk of discontinuation due to toxicities or patient/physician choice in patients with hepatitis C virus coinfection?. Antivir Ther. 2005, 10: 779-790.PubMed
6.
Mocroft A, Phillips AN, Soriano V, Rockstroh J, Blaxhult A, Katlama C, et al: Reasons for stopping antiretrovirals used in an initial highly active antiretroviral regimen: increased incidence of stopping due to toxicity or patient/physician choice in patients with hepatitis C coinfection. AIDS Res Hum Retroviruses. 2005, 21: 527-536. 10.1089/aid.2005.21.527.PubMedCrossRef
7.
Mocroft A, Rockstroh J, Soriano V, Kirk O, Viard JP, Caplinskas S, et al: Limited but increasing use of treatment for hepatitis C across Europe in patients coinfected with HIV and hepatitis C. Scand J Infect Dis. 2006, 38: 1092-1097. 10.1080/00365540600786515.PubMedCrossRef
8.
Peters L, Mocroft A, Soriano V, Rockstroh JK, Losso M, Valerio L, et al: Hepatitis C virus coinfection does not influence the CD4 cell recovery in HIV-1-infected patients with maximum virologic suppression. J Acquir Immune Defic Syndr. 2009, 50: 457-463. 10.1097/QAI.0b013e318198a0e1.PubMedCrossRef
9.
Peters L, Grint D, Lundgren JD, Rockstroh JK, Soriano V, Reiss P, et al: Hepatitis C virus viremia increases the incidence of chronic kidney disease in HIV-infected patients. AIDS. 2012, 26: 1917-1926. 10.1097/QAD.0b013e3283574e71.PubMedCrossRef
10.
Peters L, Mocroft A, Soriano V, Rockstroh J, Rauch A, Karlsson A, et al: Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients. PLoS ONE. 2013, 8: e64283-10.1371/journal.pone.0064283.PubMedCentralPubMedCrossRef
11.
Peters L, Mocroft A, Soriano V, Rockstroh J, Kirkby N, Reiss P, et al: High rate of hepatitis C virus (HCV) recurrence in HIV-infected individuals with spontaneous HCV RNA clearance. HIV Med. 2014
12.
Rockstroh JK, Mocroft A, Soriano V, Tural C, Losso MH, Horban A, et al: Influence of hepatitis C virus infection on HIV-1 disease progression and response to highly active antiretroviral therapy. J Infect Dis. 2005, 192: 992-1002. 10.1086/432762.PubMedCrossRef
13.
Rockstroh JK, Peters L, Grint D, Soriano V, Reiss P, Monforte A, et al: Does hepatitis C viremia or genotype predict the risk of mortality in individuals co-infected with HIV?. J Hepatol. 2013, 59: 213-220. 10.1016/j.jhep.2013.04.005.PubMedCrossRef
14.
Soriano V, Mocroft A, Rockstroh J, Ledergerber B, Knysz B, Chaplinskas S, et al: Spontaneous viral clearance, viral load, and genotype distribution of hepatitis C virus (HCV) in HIV-infected patients with anti-HCV antibodies in Europe. J Infect Dis. 2008, 198: 1337-1344. 10.1086/592171.PubMedCrossRef
15.
Kowalska JD, Mocroft A, Ledergerber B, Florence E, Ristola M, Begovac J, et al: A standardized algorithm for determining the underlying cause of death in HIV infection as AIDS or non-AIDS related: results from the EuroSIDA study. HIV Clin Trials. 2011, 12: 109-117. 10.1310/hct1202-109.PubMedCrossRef
16.
Vogel M, Deterding K, Wiegand J, Gruner NH, Baumgarten A, Jung MC, et al: Initial presentation of acute hepatitis C virus (HCV) infection among HIV-negative and HIV-positive individuals-experience from 2 large German networks on the study of acute HCV infection. Clin Infect Dis. 2009, 49: 317-319.PubMedCrossRef
17.
Matthews GV, Hellard M, Haber P, Yeung B, Marks P, Baker D, et al: Characteristics and treatment outcomes among HIV-infected individuals in the Australian Trial in Acute Hepatitis C. Clin Infect Dis. 2009, 48: 650-658. 10.1086/596770.PubMedCentralPubMedCrossRef
18.
Boesecke C, Grint D, Lundgren JD, Monforte AD, Mitsura VM, Kirk O, et al: Increases in acute hepatitis C (HCV) incidence across Europe: Which regions and patient groups are affected?. 2013
19.
Grint D, LPJKRARTTKLIKMGPDOKJDL: Liver-related death among HIV/HCV coinfected individuals, implications for the era of directly acting antivirals. 2014
20.
Iloeje UH, Yang HI, Su J, Jen CL, You SL, Chen CJ: Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology. 2006, 130: 678-686. 10.1053/j.gastro.2005.11.016.PubMedCrossRef
21.
Clausen LN, Astvad K, Ladelund S, Larsen MV, Schonning K, Benfield T: Hepatitis C viral load, genotype 3 and interleukin-28B CC genotype predict mortality in HIV and hepatitis C-coinfected individuals. AIDS. 2012, 26: 1509-1516. 10.1097/QAD.0b013e3283553581.PubMedCrossRef
22.
Goedert JJ, Hatzakis A, Sherman KE, Eyster ME: Lack of association of hepatitis C virus load and genotype with risk of end-stage liver disease in patients with human immunodeficiency virus coinfection. J Infect Dis. 2001, 184: 1202-1205. 10.1086/323665.PubMedCrossRef
23.
Sulkowski MS, Thomas DL, Chaisson RE, Moore RD: Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection. JAMA. 2000, 283: 74-80. 10.1001/jama.283.1.74.PubMedCrossRef
24.
Nunez M, Miralles C, Berdun MA, Losada E, Aguirrebengoa K, Ocampo A, et al: Role of Weight-Based Ribavirin Dosing and Extended Duration of Therapy in Chronic Hepatitis C in HIV-Infected Patients: The PRESCO Trial. AIDS Res Hum Retroviruses. 2007, 23: 972-982. 10.1089/aid.2007.0011.PubMedCrossRef
25.
Torriani FJ, Rodriguez-Torres M, Rockstroh JK, Lissen E, Gonzalez-Garcia J, Lazzarin A, et al: Peginterferon Alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patients. N Engl J Med. 2004, 351: 438-450. 10.1056/NEJMoa040842.PubMedCrossRef
26.
Muir AJ: The rapid evolution of treatment strategies for hepatitis C. Am J Gastroenterol. 2014, 109: 628-635. 10.1038/ajg.2014.66.PubMedCrossRef
Metadata
Title
HIV and hepatitis C co-infection in Europe, Israel and Argentina: a EuroSIDA perspective
Authors
Lars Peters
Amanda Mocroft
Jens Lundgren
Daniel Grint
Ole Kirk
Jürgen Kurt Rockstroh
Publication date
01-09-2014
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue Special Issue 6/2014
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/1471-2334-14-S6-S13

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