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Published in: BMC Infectious Diseases 1/2013

Open Access 01-12-2013 | Research article

Implementation of tuberculosis infection control in health facilities in Mukono and Wakiso districts, Uganda

Authors: Esther Buregyeya, Fred Nuwaha, Suzanne Verver, Bart Criel, Robert Colebunders, Rhoda Wanyenze, Joan N Kalyango, Achilles Katamba, Ellen MH Mitchell

Published in: BMC Infectious Diseases | Issue 1/2013

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Abstract

Background

Tuberculosis infection control (TBIC) is rarely implemented in the health facilities in resource limited settings. Understanding the reasons for low level of implementation is critical. The study aim was to assess TBIC practices and barriers to implementation in two districts in Uganda.

Methods

We conducted a cross-sectional study in 51 health facilities in districts of Mukono and Wakiso. The study included: a facility survey, observations of practices and eight focus group discussions with health workers.

Results

Quantitative: Only 16 facilities (31%) had a TBIC plan. Five facilities (10%) were screening patients for cough. Two facilities (4%) reported providing masks to patients with cough. Ventilation in the waiting areas was inadequate for TBIC in 43% (22/51) of the facilities. No facility possessed N95 particulate respirators.
Qualitative: Barriers that hamper implementation of TBIC elicited included: under-staffing, lack of space for patient separation, lack of funds to purchase masks, and health workers not appreciating the importance of TBIC.

Conclusion

TBIC measures were not implemented in health facilities in the two Ugandan districts where the survey was done. Health system factors like lack of staff, space and funds are barriers to implement TBIC. Effective implementation of TBIC measures occurs when the fundamental health system building blocks -governance and stewardship, financing, infrastructure, procurement and supply chain management are in place and functioning appropriately.
Literature
1.
go back to reference WHO: WHO policy on TB infection control in health-care facilities, congregate settings and households. 2009, Geneva: World Health Organization, 11-15. WHO: WHO policy on TB infection control in health-care facilities, congregate settings and households. 2009, Geneva: World Health Organization, 11-15.
2.
go back to reference Bucher HC, Griffith LE, Guyatt GH, Sudre P, Naef M, et al: Isoniazid prophylaxis for tuberculosis in HIV infection: a meta-analysis of randomized controlled trials. AIDS. 1999, 13: 501-507. 10.1097/00002030-199903110-00009.CrossRefPubMed Bucher HC, Griffith LE, Guyatt GH, Sudre P, Naef M, et al: Isoniazid prophylaxis for tuberculosis in HIV infection: a meta-analysis of randomized controlled trials. AIDS. 1999, 13: 501-507. 10.1097/00002030-199903110-00009.CrossRefPubMed
3.
go back to reference Daley CL, Small PM, Schecter GF: An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus: an analysis using restriction-fragment-length polymorphisms. N Engl J Med. 1992, 326: 231-251. 10.1056/NEJM199201233260404.CrossRefPubMed Daley CL, Small PM, Schecter GF: An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus: an analysis using restriction-fragment-length polymorphisms. N Engl J Med. 1992, 326: 231-251. 10.1056/NEJM199201233260404.CrossRefPubMed
4.
go back to reference Shafer RW, Singh SP, Larkin C, Small PM: Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in an immunocompetent patient. Tuber Lung Dis. 1995, 76: 575-577. 10.1016/0962-8479(95)90537-5.CrossRefPubMed Shafer RW, Singh SP, Larkin C, Small PM: Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in an immunocompetent patient. Tuber Lung Dis. 1995, 76: 575-577. 10.1016/0962-8479(95)90537-5.CrossRefPubMed
5.
go back to reference Alonso-Echanove J, Granich RM, Laszlo A, Chu G, Borja N, et al: Occupational transmission of Mycobacterium tuberculosis to health care workers in a university hospital in Lima, Peru. Clin Infect Dis. 2001, 33: 589-596. 10.1086/321892.CrossRefPubMed Alonso-Echanove J, Granich RM, Laszlo A, Chu G, Borja N, et al: Occupational transmission of Mycobacterium tuberculosis to health care workers in a university hospital in Lima, Peru. Clin Infect Dis. 2001, 33: 589-596. 10.1086/321892.CrossRefPubMed
6.
go back to reference Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, et al: Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet. 2006, 368: 1575-1580. 10.1016/S0140-6736(06)69573-1.CrossRefPubMed Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, et al: Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet. 2006, 368: 1575-1580. 10.1016/S0140-6736(06)69573-1.CrossRefPubMed
7.
go back to reference Joshi R, Reingold AL, Menzies D, Pai M: Tuberculosis among health-care workers in low- and middle-income countries: A systematic review. PloS Medicine. 2006, 3: e494-10.1371/journal.pmed.0030494.CrossRefPubMedPubMedCentral Joshi R, Reingold AL, Menzies D, Pai M: Tuberculosis among health-care workers in low- and middle-income countries: A systematic review. PloS Medicine. 2006, 3: e494-10.1371/journal.pmed.0030494.CrossRefPubMedPubMedCentral
8.
go back to reference Kassim S, Zuber P, Wiktor SZ, Diomande FV, Coulibaly IM, et al: Tuberculin skin testing to assess the occupational risk of Mycobacterium tuberculosis infection among health care workers in Abidjan, Cote d'Ivoire. Int J Tuberc Lung Dis. 2000, 4: 321-326.PubMed Kassim S, Zuber P, Wiktor SZ, Diomande FV, Coulibaly IM, et al: Tuberculin skin testing to assess the occupational risk of Mycobacterium tuberculosis infection among health care workers in Abidjan, Cote d'Ivoire. Int J Tuberc Lung Dis. 2000, 4: 321-326.PubMed
9.
go back to reference O'Donnell MR, Jarand J, Loveday M, Padayatchi N, Zelnick J, et al: High incidence of hospital admissions with multidrug-resistant and extensively drug-resistant tuberculosis among South African health care workers. Ann Intern Med. 2010, 153: 516-522. 10.7326/0003-4819-153-8-201010190-00008.CrossRefPubMedPubMedCentral O'Donnell MR, Jarand J, Loveday M, Padayatchi N, Zelnick J, et al: High incidence of hospital admissions with multidrug-resistant and extensively drug-resistant tuberculosis among South African health care workers. Ann Intern Med. 2010, 153: 516-522. 10.7326/0003-4819-153-8-201010190-00008.CrossRefPubMedPubMedCentral
10.
go back to reference WHO: Guidelines for the prevention of tuberculosis in health care facilities in resource -limited settings. 1999, Geneva: World Health Organization WHO: Guidelines for the prevention of tuberculosis in health care facilities in resource -limited settings. 1999, Geneva: World Health Organization
11.
go back to reference FMOH: Guidelines for prevention of transmission of tuberculosis in health care facilities, congregate and community settings in Ethiopia. 2009, Ethiopia: Federal Ministry of Health FMOH: Guidelines for prevention of transmission of tuberculosis in health care facilities, congregate and community settings in Ethiopia. 2009, Ethiopia: Federal Ministry of Health
12.
go back to reference Menzies D, Joshi R, Pai M: Risk of tuberculosis infection and disease associated with work in health care settings. Int J Tuberc Lung Dis. 2007, 11: 593-605.PubMed Menzies D, Joshi R, Pai M: Risk of tuberculosis infection and disease associated with work in health care settings. Int J Tuberc Lung Dis. 2007, 11: 593-605.PubMed
13.
go back to reference Lukoye D, Cobelens FG, Ezati N, Kirimunda S, Adatu FE, et al: Rates of anti-tuberculosis drug resistance in Kampala-Uganda are low and not associated with HIV infection. PLoS One. 2011, 6: e16130-10.1371/journal.pone.0016130.CrossRefPubMedPubMedCentral Lukoye D, Cobelens FG, Ezati N, Kirimunda S, Adatu FE, et al: Rates of anti-tuberculosis drug resistance in Kampala-Uganda are low and not associated with HIV infection. PLoS One. 2011, 6: e16130-10.1371/journal.pone.0016130.CrossRefPubMedPubMedCentral
14.
go back to reference WHO: WHO Policy on TB Infection Controlin Health-Care Facilities, Congregate Settings and Households. 2009, In: Department WST, editor WHO: WHO Policy on TB Infection Controlin Health-Care Facilities, Congregate Settings and Households. 2009, In: Department WST, editor
15.
go back to reference Albuquerque da Costa P, Trajman A, de Queiroz C, Mello F, Goudinho S, Monteiro Vieira Silva MA, et al: Administrative measures for preventing Mycobacterium tuberculosis infection among healthcare workers in a teaching hospital in Rio de Janeiro, Brazil. J Hosp Infect. 2009, 72: 57-64. 10.1016/j.jhin.2009.01.016.CrossRefPubMedPubMedCentral Albuquerque da Costa P, Trajman A, de Queiroz C, Mello F, Goudinho S, Monteiro Vieira Silva MA, et al: Administrative measures for preventing Mycobacterium tuberculosis infection among healthcare workers in a teaching hospital in Rio de Janeiro, Brazil. J Hosp Infect. 2009, 72: 57-64. 10.1016/j.jhin.2009.01.016.CrossRefPubMedPubMedCentral
16.
go back to reference Dharmadhikari AS, Mphahlele M, Stoltz A, Venter K, Mathebula R, et al: Surgical face masks worn by patients with multidrug-resistant tuberculosis: impact on infectivity of air on a hospital ward. Am J Respir Crit Care Med. 2012, 185: 1104-1109. 10.1164/rccm.201107-1190OC.CrossRefPubMedPubMedCentral Dharmadhikari AS, Mphahlele M, Stoltz A, Venter K, Mathebula R, et al: Surgical face masks worn by patients with multidrug-resistant tuberculosis: impact on infectivity of air on a hospital ward. Am J Respir Crit Care Med. 2012, 185: 1104-1109. 10.1164/rccm.201107-1190OC.CrossRefPubMedPubMedCentral
17.
go back to reference Shenoi SV, Escombe AR, Friedland G: Transmission of drug-susceptible and drug-resistant tuberculosis and the critical importance of airborne infection control in the era of HIV infection and highly active antiretroviral therapy rollouts. Clin Infect Dis. 2010, 50 (Suppl 3): S231-S237.CrossRefPubMedPubMedCentral Shenoi SV, Escombe AR, Friedland G: Transmission of drug-susceptible and drug-resistant tuberculosis and the critical importance of airborne infection control in the era of HIV infection and highly active antiretroviral therapy rollouts. Clin Infect Dis. 2010, 50 (Suppl 3): S231-S237.CrossRefPubMedPubMedCentral
18.
go back to reference Jensen PA, Lambert LA, Iademarco MF, Ridzon R: Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings, 2005. MMWR Recomm Rep. 2005, 54: 1-141.PubMed Jensen PA, Lambert LA, Iademarco MF, Ridzon R: Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings, 2005. MMWR Recomm Rep. 2005, 54: 1-141.PubMed
19.
go back to reference Jelip J, Mathew GG, Yusin T, Dony JF, Singh N, et al: Risk factors of tuberculosis among health care workers in Sabah, Malaysia. Tuberculosis (Edinb). 2004, 84: 19-23. 10.1016/j.tube.2003.08.015.CrossRef Jelip J, Mathew GG, Yusin T, Dony JF, Singh N, et al: Risk factors of tuberculosis among health care workers in Sabah, Malaysia. Tuberculosis (Edinb). 2004, 84: 19-23. 10.1016/j.tube.2003.08.015.CrossRef
20.
go back to reference Luksamijarulkul P, Supapvanit C, Loosereewanich P, Aiumlaor P: Risk assessment towards tuberculosis among hospital personnel: administrative control, risk exposure, use of protective barriers and microbial air quality. Southeast Asian J Trop Med Public Health. 2004, 35: 1005-1011.PubMed Luksamijarulkul P, Supapvanit C, Loosereewanich P, Aiumlaor P: Risk assessment towards tuberculosis among hospital personnel: administrative control, risk exposure, use of protective barriers and microbial air quality. Southeast Asian J Trop Med Public Health. 2004, 35: 1005-1011.PubMed
21.
go back to reference Menzies D, Fanning A, Yuan L, Fitzgerald M: Tuberculosis among health care workers. N Engl J Med. 1995, 332: 92-98. 10.1056/NEJM199501123320206.CrossRefPubMed Menzies D, Fanning A, Yuan L, Fitzgerald M: Tuberculosis among health care workers. N Engl J Med. 1995, 332: 92-98. 10.1056/NEJM199501123320206.CrossRefPubMed
22.
go back to reference Biscotto CR, Pedroso ER, Starling CE, Roth VR: Evaluation of N95 respirator use as a tuberculosis control measure in a resource-limited setting. Int J Tuberc Lung Dis. 2005, 9: 545-549.PubMed Biscotto CR, Pedroso ER, Starling CE, Roth VR: Evaluation of N95 respirator use as a tuberculosis control measure in a resource-limited setting. Int J Tuberc Lung Dis. 2005, 9: 545-549.PubMed
23.
go back to reference Alvaran MS, Butz A, Larson E: Opinions, knowledge, and self-reported practices related to infection control among nursing personnel in long-term care settings. Am J Infect Control. 1994, 22: 367-370. 10.1016/0196-6553(94)90036-1.CrossRefPubMed Alvaran MS, Butz A, Larson E: Opinions, knowledge, and self-reported practices related to infection control among nursing personnel in long-term care settings. Am J Infect Control. 1994, 22: 367-370. 10.1016/0196-6553(94)90036-1.CrossRefPubMed
24.
go back to reference Madan AK, Raafat A, Hunt JP, Rentz D, Wahle MJ, et al: Barrier precautions in trauma: is knowledge enough?. J Trauma. 2002, 52: 540-543. 10.1097/00005373-200203000-00020.CrossRefPubMed Madan AK, Raafat A, Hunt JP, Rentz D, Wahle MJ, et al: Barrier precautions in trauma: is knowledge enough?. J Trauma. 2002, 52: 540-543. 10.1097/00005373-200203000-00020.CrossRefPubMed
26.
go back to reference UBOS (2009/10): Uganda national household survey. Kampala. 2009, Uganda: Bureau of Statistics UBOS (2009/10): Uganda national household survey. Kampala. 2009, Uganda: Bureau of Statistics
27.
go back to reference MOH: Uganda AIDS indicator survey 2011. 2012, Kampala: Ministry of Health Uganda MOH: Uganda AIDS indicator survey 2011. 2012, Kampala: Ministry of Health Uganda
28.
go back to reference Buregyeya E, Nuwaha F, Wanyenze RK, Mitchell EMH, Criel B: Utilization of HIV and Tuberculosis Services by Health Care Workers in Uganda. 2012, Uganda: Implications for Occupational Health Policies and Implementation, PloS ONE In press Buregyeya E, Nuwaha F, Wanyenze RK, Mitchell EMH, Criel B: Utilization of HIV and Tuberculosis Services by Health Care Workers in Uganda. 2012, Uganda: Implications for Occupational Health Policies and Implementation, PloS ONE In press
29.
go back to reference MOH: Uganda health sector strategic plan;. 2000, /01-2004/05 MOH: Uganda health sector strategic plan;. 2000, /01-2004/05
30.
go back to reference MOH: Uganda national guidelines for tuberculosis infection control in health care facilities, congregate settings and households. 2011, Kampala: Ministry of Health MOH: Uganda national guidelines for tuberculosis infection control in health care facilities, congregate settings and households. 2011, Kampala: Ministry of Health
31.
go back to reference RHRU: Implementing TB infection control in health care facilities. 2009, Johannesburg: Reproductive Health & HIV Research Unit of the University of the Witwatersrand, South Africa RHRU: Implementing TB infection control in health care facilities. 2009, Johannesburg: Reproductive Health & HIV Research Unit of the University of the Witwatersrand, South Africa
32.
go back to reference Kanjee Z, Catterick K, Moll AP, Amico KR, Friedland GH: Tuberculosis infection control in rural South Africa: survey of knowledge, attitude and practice in hospital staff. J Hosp Infect. 2011, 79: 333-338. 10.1016/j.jhin.2011.06.017.CrossRefPubMed Kanjee Z, Catterick K, Moll AP, Amico KR, Friedland GH: Tuberculosis infection control in rural South Africa: survey of knowledge, attitude and practice in hospital staff. J Hosp Infect. 2011, 79: 333-338. 10.1016/j.jhin.2011.06.017.CrossRefPubMed
33.
go back to reference Ogbonnaya LU, Chukwu JN, Uwakwe KA, Oyibo PG, Ndukwe CD: The status of tuberculosis infection control measures in health care facilities rendering joint TB/HIV services in "German Leprosy and Tuberculosis Relief Association" supported states in Nigeria. Niger J Clin Pract. 2011, 14: 270-275. 10.4103/1119-3077.86765.CrossRefPubMed Ogbonnaya LU, Chukwu JN, Uwakwe KA, Oyibo PG, Ndukwe CD: The status of tuberculosis infection control measures in health care facilities rendering joint TB/HIV services in "German Leprosy and Tuberculosis Relief Association" supported states in Nigeria. Niger J Clin Pract. 2011, 14: 270-275. 10.4103/1119-3077.86765.CrossRefPubMed
34.
go back to reference Adams AS, Soumerai SB, Lomas J, Ross-Degnan D: Evidence of self-report bias in assessing adherence to guidelines. Int J Qual Health Care. 1999, 11: 187-192. 10.1093/intqhc/11.3.187.CrossRefPubMed Adams AS, Soumerai SB, Lomas J, Ross-Degnan D: Evidence of self-report bias in assessing adherence to guidelines. Int J Qual Health Care. 1999, 11: 187-192. 10.1093/intqhc/11.3.187.CrossRefPubMed
35.
go back to reference Naikoba S, Hayward A: The effectiveness of interventions aimed at increasing handwashing in healthcare workers - a systematic review. J Hosp Infect. 2001, 47: 173-180. 10.1053/jhin.2000.0882.CrossRefPubMed Naikoba S, Hayward A: The effectiveness of interventions aimed at increasing handwashing in healthcare workers - a systematic review. J Hosp Infect. 2001, 47: 173-180. 10.1053/jhin.2000.0882.CrossRefPubMed
36.
go back to reference WHO: Everybody business: strengthening health systems to improve health outcomes: WHO’s framework for action. 2007, Geneva: World Health Organization WHO: Everybody business: strengthening health systems to improve health outcomes: WHO’s framework for action. 2007, Geneva: World Health Organization
37.
go back to reference Pittet D, Simon A, Hugonnet S, Pessoa-Silva CL, Sauvan V, et al: Hand hygiene among physicians: performance, beliefs, and perceptions. Ann Intern Med. 2004, 141: 1-8. 10.7326/0003-4819-141-1-200407060-00008.CrossRefPubMed Pittet D, Simon A, Hugonnet S, Pessoa-Silva CL, Sauvan V, et al: Hand hygiene among physicians: performance, beliefs, and perceptions. Ann Intern Med. 2004, 141: 1-8. 10.7326/0003-4819-141-1-200407060-00008.CrossRefPubMed
38.
go back to reference Woith W, Volchenkov G, Larson J: Barriers and motivators affecting tuberculosis infection control practices of Russian health care workers. Int J Tuberc Lung Dis. 2012, 16: 1092-1096. 10.5588/ijtld.10.0779.CrossRefPubMedPubMedCentral Woith W, Volchenkov G, Larson J: Barriers and motivators affecting tuberculosis infection control practices of Russian health care workers. Int J Tuberc Lung Dis. 2012, 16: 1092-1096. 10.5588/ijtld.10.0779.CrossRefPubMedPubMedCentral
39.
go back to reference Robins CS, Ware NC, dosReis S, Willging CE, Chung JY, et al: Dialogues on mixed-methods and mental health services research: anticipating challenges, building solutions. Psychiatr Serv. 2008, 59: 727-731. 10.1176/appi.ps.59.7.727.CrossRefPubMedPubMedCentral Robins CS, Ware NC, dosReis S, Willging CE, Chung JY, et al: Dialogues on mixed-methods and mental health services research: anticipating challenges, building solutions. Psychiatr Serv. 2008, 59: 727-731. 10.1176/appi.ps.59.7.727.CrossRefPubMedPubMedCentral
Metadata
Title
Implementation of tuberculosis infection control in health facilities in Mukono and Wakiso districts, Uganda
Authors
Esther Buregyeya
Fred Nuwaha
Suzanne Verver
Bart Criel
Robert Colebunders
Rhoda Wanyenze
Joan N Kalyango
Achilles Katamba
Ellen MH Mitchell
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2013
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/1471-2334-13-360

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