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BMC Anesthesiology
Published in: BMC Anesthesiology 1/2011

Open Access 01-12-2011 | Research article

High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study

Authors: Jan Willem Kuiper, Frans B Plötz, AB Johan Groeneveld, Jack J Haitsma, Serge Jothy, Rosanna Vaschetto, Haibo Zhang, Arthur S Slutsky

Published in: BMC Anesthesiology | Issue 1/2011

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Abstract

Background

To examine whether acute lung injury from direct and indirect origins differ in susceptibility to ventilator-induced lung injury (VILI) and resultant systemic inflammatory responses.

Methods

Rats were challenged by acid instillation or 24 h of sepsis induced by cecal ligation and puncture, followed by mechanical ventilation (MV) with either a low tidal volume (Vt) of 6 mL/kg and 5 cm H2O positive end-expiratory pressure (PEEP; LVt acid, LVt sepsis) or with a high Vt of 15 mL/kg and no PEEP (HVt acid, HVt sepsis). Rats sacrificed immediately after acid instillation and non-ventilated septic animals served as controls. Hemodynamic and respiratory variables were monitored. After 4 h, lung wet to dry (W/D) weight ratios, histological lung injury and plasma mediator concentrations were measured.

Results

Oxygenation and lung compliance decreased after acid instillation as compared to sepsis. Additionally, W/D weight ratios and histological lung injury scores increased after acid instillation as compared to sepsis. MV increased W/D weight ratio and lung injury score, however this effect was mainly attributable to HVt ventilation after acid instillation. Similarly, effects of HVt on oxygenation were only observed after acid instillation. HVt during sepsis did not further affect oxygenation, compliance, W/D weight ratio or lung injury score. Plasma interleukin-6 and tumour necrosis factor-α concentrations were increased after acid instillation as compared to sepsis, but plasma intercellular adhesion molecule-1 concentration increased during sepsis only. In contrast to lung injury parameters, no additional effects of HVt MV after acid instillation on plasma mediator concentrations were observed.

Conclusions

During MV more severe lung injury develops after acid instillation as compared to sepsis. HVt causes VILI after acid instillation, but not during sepsis. However, this differential effect was not observed in the systemic release of mediators.
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Metadata
Title
High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study
Authors
Jan Willem Kuiper
Frans B Plötz
AB Johan Groeneveld
Jack J Haitsma
Serge Jothy
Rosanna Vaschetto
Haibo Zhang
Arthur S Slutsky
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Anesthesiology / Issue 1/2011
Electronic ISSN: 1471-2253
DOI
https://doi.org/10.1186/1471-2253-11-26

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