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Respiratory Research
Published in: Respiratory Research 1/2006

Open Access 01-12-2006 | Review

The genetics of chronic obstructive pulmonary disease

Authors: Alice M Wood, Robert A Stockley

Published in: Respiratory Research | Issue 1/2006

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Abstract

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease caused by the interaction of genetic susceptibility and environmental influences. There is increasing evidence that genes link to disease pathogenesis and heterogeneity by causing variation in protease anti-protease systems, defence against oxidative stress and inflammation. The main methods of genomic research for complex disease traits are described, together with the genes implicated in COPD thus far, their roles in disease causation and the future for this area of investigation.
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Metadata
Title
The genetics of chronic obstructive pulmonary disease
Authors
Alice M Wood
Robert A Stockley
Publication date
01-12-2006
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2006
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/1465-9921-7-130

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