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Clinical Oral Investigations

Published in:

01-03-2015 | Original Article

Effect of oral appliance on endothelial function in sleep apnea

Authors: Ching-Chi Lin, Huey-Yuan Wang, Chung-Hsin Chiu, Shwu-Fang Liaw

Published in: Clinical Oral Investigations | Issue 2/2015

Abstract

Objectives

This study evaluated the effects of mandibular advancement device (MAD) on serum levels of nitric oxide derivatives and endothelial function by endothelium-dependent flow-mediated dilation (FMD) in obstructive sleep apnea syndrome (OSAS).

Methods

Thirty patients with moderately severe-to-severe OSAS who desired MAD and 15 healthy controls were prospectively enrolled. FMD was measured by high-resolution B-mode ultrasonography, while serum NO_x level from peripheral blood samples was measured by ELISA. All subjects participated in the sleep studies, which were repeated 2 months after MAD in OSAS patients.

Results

Serum NO_x level and FMD were lower in patients with OSAS than in controls prior to MAD. Serum NO_x levels in 19 of 30 patients with OSAS, the designated MAD responders, increased from 11.8 ± 5.8 μM pre-MAD to 22.7 ± 4.9 μM post-MAD. The FMD increased from 5.9 ± 4.6 pre-MAD to 10.5 ± 4.8 post-MAD. For the 11 unresponsive patients, serum NO_x and FMD remained impaired after MAD.

Conclusions

Successful treatment of OSAS with MAD can restore serum levels of NO_x and FMD.

Clinical relevance

Endothelial function can be improved following effective treatment of OSAS using MAD.

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Title: Effect of oral appliance on endothelial function in sleep apnea
Authors: Ching-Chi Lin
Huey-Yuan Wang
Chung-Hsin Chiu
Shwu-Fang Liaw
Publication date: 01-03-2015
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 2/2015
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-014-1234-1

At a glance: The STEP trials

Springer Medicine

Effect of oral appliance on endothelial function in sleep apnea

Abstract

Objectives

Methods

Results

Conclusions

Clinical relevance

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Clinical relevance

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