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Published in: Current Oral Health Reports 2/2020

01-06-2020 | Rheumatoid Arthritis | Systemic Diseases (N Buduneli, Section Editor)

Association Between Rheumatoid Arthritis and Periodontitis: Recent Progress

Authors: Nazurah Nik Eezammuddeen, Rathna Devi Vaithilingam, Norul Husna Mohamad Hassan, Peter Mark Bartold

Published in: Current Oral Health Reports | Issue 2/2020

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Abstract

Purpose of Review

While a number of reviews have been published in recent years covering all aspects of the relationship between rheumatoid arthritis and periodontitis, this review considers only the very most recent advances in the field by reporting on studies published from January 2018 to August 2019.

Recent Findings

The number of published studies that have investigated this relationship has increased dramatically in recent years. These studies have established a number of important biochemical, cellular, genetic and microbiological processes that link these two conditions at the clinical level.

Summary

There is now very good evidence to support a relationship between RA and periodontitis. It is clear that very good progress is being made but there is need for continuing investigations to better identify the defining mechanism(s) that drive this intriguing relationship.
Literature
2.
go back to reference Snyderman R, McCarty GA. Analogous mechanisms of tissue destruction in rheumatoid arthritis and periodontal disease. In: Genco RJ, Mergenhagen SE, editors. Host-parasite interaction in periodontal diseases. Washington, DC: American Society of Microbiology; 1982. p. 354–62. Snyderman R, McCarty GA. Analogous mechanisms of tissue destruction in rheumatoid arthritis and periodontal disease. In: Genco RJ, Mergenhagen SE, editors. Host-parasite interaction in periodontal diseases. Washington, DC: American Society of Microbiology; 1982. p. 354–62.
3.
go back to reference Moen K, Brun J, Valen M, Skartveit L, Eribe E, Olsen I, et al. Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs. Clin Exp Rheumatol. 2006;24(6):656–63.PubMed Moen K, Brun J, Valen M, Skartveit L, Eribe E, Olsen I, et al. Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs. Clin Exp Rheumatol. 2006;24(6):656–63.PubMed
4.
go back to reference Rosenstein ED, Greenwald RA, Kushner LJ, Weissmann G. Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation. 2004;28(6):311–8.PubMedCrossRef Rosenstein ED, Greenwald RA, Kushner LJ, Weissmann G. Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation. 2004;28(6):311–8.PubMedCrossRef
5.
go back to reference Golub L, Payne J, Reinhardt R, Nieman G. Can systemic diseases co-induce (not just exacerbate) periodontitis? A hypothetical “two-hit” model. J Dent Res. 2006;85(2):102–5.PubMedCrossRef Golub L, Payne J, Reinhardt R, Nieman G. Can systemic diseases co-induce (not just exacerbate) periodontitis? A hypothetical “two-hit” model. J Dent Res. 2006;85(2):102–5.PubMedCrossRef
6.
go back to reference Bartold PM, Marshall R, Haynes D. Periodontitis and rheumatoid arthritis: a review. J Periodontol. 2005;76:2066–74.PubMedCrossRef Bartold PM, Marshall R, Haynes D. Periodontitis and rheumatoid arthritis: a review. J Periodontol. 2005;76:2066–74.PubMedCrossRef
7.
go back to reference Linden GJ, Herzberg MC. Workshop periodontitis and systemic diseases: a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol. 2013;40:S20–S3.PubMedCrossRef Linden GJ, Herzberg MC. Workshop periodontitis and systemic diseases: a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol. 2013;40:S20–S3.PubMedCrossRef
8.
go back to reference Bartold PM, Lopez-Oliva I. Rheumatoid arthritis and periodontitis: an update 2012-2017. Periodontol 2000. In Press 2020. Bartold PM, Lopez-Oliva I. Rheumatoid arthritis and periodontitis: an update 2012-2017. Periodontol 2000. In Press 2020.
9.
go back to reference Mobini M, Maboudi A, Mohammadpour RA. Periodontitis in rheumatoid arthritis patients, abundance and association with disease activity. Med J Islam Repub Iran. 2017;31:44.PubMedPubMedCentralCrossRef Mobini M, Maboudi A, Mohammadpour RA. Periodontitis in rheumatoid arthritis patients, abundance and association with disease activity. Med J Islam Repub Iran. 2017;31:44.PubMedPubMedCentralCrossRef
11.
go back to reference Nik-Azis N-M, Mohd-fadzilah F, Mohd-Shahrir M-S, Baharin B, Mohd N. Impact of rheumatoid arthritis functional status on oral and periodontal health in a multi-ethnic population. Sains Malays. 2019;48(3):645–52.CrossRef Nik-Azis N-M, Mohd-fadzilah F, Mohd-Shahrir M-S, Baharin B, Mohd N. Impact of rheumatoid arthritis functional status on oral and periodontal health in a multi-ethnic population. Sains Malays. 2019;48(3):645–52.CrossRef
12.
go back to reference Jung ES, Choi YY, Lee KH. Relationship between rheumatoid arthritis and periodontal disease in Korean adults: data from the Sixth Korea National Health and Nutrition Examination Survey, 2013 to 2015. J Periodontol. 2019;90(4):350–7.PubMedCrossRef Jung ES, Choi YY, Lee KH. Relationship between rheumatoid arthritis and periodontal disease in Korean adults: data from the Sixth Korea National Health and Nutrition Examination Survey, 2013 to 2015. J Periodontol. 2019;90(4):350–7.PubMedCrossRef
13.
go back to reference Wan-Mohamad WM, Jia SK, Ghazali WSW, Taib H. Anti-cyclic citrullinated peptide antibody and periodontal status in rheumatoid arthritis patients. Pak J Med Sci. 2018;34(4):907.CrossRef Wan-Mohamad WM, Jia SK, Ghazali WSW, Taib H. Anti-cyclic citrullinated peptide antibody and periodontal status in rheumatoid arthritis patients. Pak J Med Sci. 2018;34(4):907.CrossRef
14.
go back to reference Kim J-W, Park J-B, Yim HW, Lee J, Kwok S-K, Ju JH, et al. Rheumatoid arthritis is associated with early tooth loss: results from Korea National Health and Nutrition Examination Survey V to VI. Korean J Intern Med. 2018;34(6):1381.PubMedPubMedCentralCrossRef Kim J-W, Park J-B, Yim HW, Lee J, Kwok S-K, Ju JH, et al. Rheumatoid arthritis is associated with early tooth loss: results from Korea National Health and Nutrition Examination Survey V to VI. Korean J Intern Med. 2018;34(6):1381.PubMedPubMedCentralCrossRef
15.
go back to reference Kim J-H, Choi IA, Lee JY, Kim K-H, Kim S, Koo K-T, et al. Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults. J Periodontal Implant Sci. 2018;48(6):347–59.PubMedPubMedCentralCrossRef Kim J-H, Choi IA, Lee JY, Kim K-H, Kim S, Koo K-T, et al. Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults. J Periodontal Implant Sci. 2018;48(6):347–59.PubMedPubMedCentralCrossRef
16.
go back to reference Antal M, Battancs E, Bocskai M, Braunitzer G, Kovács L. An observation on the severity of periodontal disease in past cigarette smokers suffering from rheumatoid arthritis- evidence for a long-term effect of cigarette smoke exposure? BMC Oral Health. 2018;18(1):82.PubMedPubMedCentralCrossRef Antal M, Battancs E, Bocskai M, Braunitzer G, Kovács L. An observation on the severity of periodontal disease in past cigarette smokers suffering from rheumatoid arthritis- evidence for a long-term effect of cigarette smoke exposure? BMC Oral Health. 2018;18(1):82.PubMedPubMedCentralCrossRef
17.
go back to reference Rodríguez-Lozano B, González-Febles J, Garnier-Rodríguez JL, Dadlani S, Bustabad-Reyes S, Sanz M, et al. Association between severity of periodontitis and clinical activity in rheumatoid arthritis patients: a case–control study. Arthritis Res Ther. 2019;21(1):27.PubMedPubMedCentralCrossRef Rodríguez-Lozano B, González-Febles J, Garnier-Rodríguez JL, Dadlani S, Bustabad-Reyes S, Sanz M, et al. Association between severity of periodontitis and clinical activity in rheumatoid arthritis patients: a case–control study. Arthritis Res Ther. 2019;21(1):27.PubMedPubMedCentralCrossRef
18.
go back to reference Zhao R, Gu C, Zhang Q, Zhou W, Feng G, Feng X, et al. Periodontal disease in Chinese patients with rheumatoid arthritis: a case control study. Oral Dis. 2019;00:1–7. Zhao R, Gu C, Zhang Q, Zhou W, Feng G, Feng X, et al. Periodontal disease in Chinese patients with rheumatoid arthritis: a case control study. Oral Dis. 2019;00:1–7.
19.
go back to reference Sacks JJ, Luo YH, Helmick CG. Prevalence of specific types of arthritis and other rheumatic conditions in the ambulatory health care system in the United States, 2001–2005. Arthritis Care Res (Hoboken). 2010;62(4):460–4.CrossRef Sacks JJ, Luo YH, Helmick CG. Prevalence of specific types of arthritis and other rheumatic conditions in the ambulatory health care system in the United States, 2001–2005. Arthritis Care Res (Hoboken). 2010;62(4):460–4.CrossRef
21.
go back to reference de Pablo P, Dietrich T, McAlindon TE. Association of periodontal disease and tooth loss with rheumatoid arthritis in the US population. J Rheumatol. 2008;35(1):70–6.PubMed de Pablo P, Dietrich T, McAlindon TE. Association of periodontal disease and tooth loss with rheumatoid arthritis in the US population. J Rheumatol. 2008;35(1):70–6.PubMed
22.
go back to reference Chen H-H, Huang N, Chen Y-M, Chen T-J, Chou P, Lee Y-L, et al. Association between a history of periodontitis and the risk of rheumatoid arthritis: a nationwide, population-based, case–control study. Ann Rheum Dis. 2013;72(7):1206–11.PubMedCrossRef Chen H-H, Huang N, Chen Y-M, Chen T-J, Chou P, Lee Y-L, et al. Association between a history of periodontitis and the risk of rheumatoid arthritis: a nationwide, population-based, case–control study. Ann Rheum Dis. 2013;72(7):1206–11.PubMedCrossRef
23.
go back to reference de Oliveira FR, de Brito SR, Magno MB, Carvalho Almeida APCPS, Fagundes NCF, Maia LC, et al. Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis. Ther Adv Musculoskelet Dis. 2019;11:1–16. de Oliveira FR, de Brito SR, Magno MB, Carvalho Almeida APCPS, Fagundes NCF, Maia LC, et al. Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis. Ther Adv Musculoskelet Dis. 2019;11:1–16.
24.
go back to reference Kobayashi T, Kido J-I, Ishihara Y, Omori K, Ito S, Matsuura T, et al. The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: a pilot case-control study. J Periodontol. 2018;89(3):315–24.PubMedCrossRef Kobayashi T, Kido J-I, Ishihara Y, Omori K, Ito S, Matsuura T, et al. The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: a pilot case-control study. J Periodontol. 2018;89(3):315–24.PubMedCrossRef
26.
go back to reference Jeong SH, Nam Y, Jung H, Kim J, Rim YA, Park N, et al. Interrupting oral infection of Porphyromonas gingivalis with anti-FimA antibody attenuates bacterial dissemination to the arthritic joint and improves experimental arthritis. Exp Mol Med. 2018;50:e460.PubMedPubMedCentralCrossRef Jeong SH, Nam Y, Jung H, Kim J, Rim YA, Park N, et al. Interrupting oral infection of Porphyromonas gingivalis with anti-FimA antibody attenuates bacterial dissemination to the arthritic joint and improves experimental arthritis. Exp Mol Med. 2018;50:e460.PubMedPubMedCentralCrossRef
27.
go back to reference Courbon G, Rinaudo-Gaujous M, Blasco-Baque V, Auger I, Caire R, Mijola L, et al. Porphyromonas gingivalis experimentally induces periodontitis and an anti-CCP2-associated arthritis in the rat. Ann Rheum Dis. 2019;78(5):594–9.PubMedCrossRef Courbon G, Rinaudo-Gaujous M, Blasco-Baque V, Auger I, Caire R, Mijola L, et al. Porphyromonas gingivalis experimentally induces periodontitis and an anti-CCP2-associated arthritis in the rat. Ann Rheum Dis. 2019;78(5):594–9.PubMedCrossRef
29.
go back to reference Lübcke PM, Ebbers MN, Volzke J, Bull J, Kneitz S, Engelmann R, et al. Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss. Sci Rep. 2019;9(1):8128.PubMedPubMedCentralCrossRef Lübcke PM, Ebbers MN, Volzke J, Bull J, Kneitz S, Engelmann R, et al. Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss. Sci Rep. 2019;9(1):8128.PubMedPubMedCentralCrossRef
30.
go back to reference Ogrendik M. Rheumatoid arthritis is linked to oral bacteria: etiological association. Mod Rheumatol. 2009;19(5):453–6.PubMedCrossRef Ogrendik M. Rheumatoid arthritis is linked to oral bacteria: etiological association. Mod Rheumatol. 2009;19(5):453–6.PubMedCrossRef
31.
go back to reference Martinez-Martinez RE, Abud-Mendoza C, Patiño-Marin N, Rizo-Rodríguez JC, Little JW, Loyola-Rodríguez JP. Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol. 2009;36(12):1004–10.PubMedCrossRef Martinez-Martinez RE, Abud-Mendoza C, Patiño-Marin N, Rizo-Rodríguez JC, Little JW, Loyola-Rodríguez JP. Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol. 2009;36(12):1004–10.PubMedCrossRef
32.
go back to reference Reichert S, Haffner M, Keyßer G, Schäfer C, Stein JM, Schaller HG, et al. Detection of oral bacterial DNA in synovial fluid. J Clin Periodontol. 2013;40(6):591–8.PubMedCrossRef Reichert S, Haffner M, Keyßer G, Schäfer C, Stein JM, Schaller HG, et al. Detection of oral bacterial DNA in synovial fluid. J Clin Periodontol. 2013;40(6):591–8.PubMedCrossRef
33.
go back to reference Totaro MC, Cattani P, Ria F, Tolusso B, Gremese E, Fedele AL, et al. Porphyromonas gingivalis and the pathogenesis of rheumatoid arthritis: analysis of various compartments including the synovial tissue. Arthritis Res Ther. 2013;15(3):R66.PubMedPubMedCentralCrossRef Totaro MC, Cattani P, Ria F, Tolusso B, Gremese E, Fedele AL, et al. Porphyromonas gingivalis and the pathogenesis of rheumatoid arthritis: analysis of various compartments including the synovial tissue. Arthritis Res Ther. 2013;15(3):R66.PubMedPubMedCentralCrossRef
34.
go back to reference McGraw WT, Potempa J, Farley D, Travis J. Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun. 1999;67(7):3248–56.PubMedPubMedCentralCrossRef McGraw WT, Potempa J, Farley D, Travis J. Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun. 1999;67(7):3248–56.PubMedPubMedCentralCrossRef
35.
go back to reference Mikuls TR, Thiele GM, Deane KD, Payne JB, O'Dell JR, Yu F, et al. Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis Rheum. 2012;64(11):3522–30.PubMedCrossRef Mikuls TR, Thiele GM, Deane KD, Payne JB, O'Dell JR, Yu F, et al. Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis Rheum. 2012;64(11):3522–30.PubMedCrossRef
36.
go back to reference Liao F, Li Z, Wang Y, Shi B, Gong Z, Cheng X. Porphyromonas gingivalis may play an important role in the pathogenesis of periodontitis-associated rheumatoid arthritis. Med Hypotheses. 2009;72(6):732–5.PubMedCrossRef Liao F, Li Z, Wang Y, Shi B, Gong Z, Cheng X. Porphyromonas gingivalis may play an important role in the pathogenesis of periodontitis-associated rheumatoid arthritis. Med Hypotheses. 2009;72(6):732–5.PubMedCrossRef
37.
go back to reference Potempa J, Mydel P, Koziel J. The case for periodontitis in the pathogenesis of rheumatoid arthritis. Nat Rev Rheumatol. 2017;13(10):606–20.PubMedCrossRef Potempa J, Mydel P, Koziel J. The case for periodontitis in the pathogenesis of rheumatoid arthritis. Nat Rev Rheumatol. 2017;13(10):606–20.PubMedCrossRef
38.
go back to reference Konig MF, Abusleme L, Reinholdt J, Palmer RJ, Teles RP, Sampson K, et al. Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci Transl Med. 2016;8(369):369ra176.PubMedPubMedCentralCrossRef Konig MF, Abusleme L, Reinholdt J, Palmer RJ, Teles RP, Sampson K, et al. Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci Transl Med. 2016;8(369):369ra176.PubMedPubMedCentralCrossRef
39.
go back to reference Kriauciunas A, Gleiznys A, Gleiznys D, Janužis G. The influence of Porphyromonas gingivalis bacterium causing periodontal disease on the pathogenesis of rheumatoid arthritis: systematic review of literature. Cureus. 2019;11(5). Kriauciunas A, Gleiznys A, Gleiznys D, Janužis G. The influence of Porphyromonas gingivalis bacterium causing periodontal disease on the pathogenesis of rheumatoid arthritis: systematic review of literature. Cureus. 2019;11(5).
40.
go back to reference Ayala-Herrera JL, Abud-Mendoza C, Gonzalez-Amaro RF, Espinosa-Cristobal LF, Martínez-Martínez RE. Distribution of Porphyromonas gingivalis fimA genotypes in patients affected by rheumatoid arthritis and periodontitis. Acta Odontol Scand. 2018;76(7):520–4.PubMedCrossRef Ayala-Herrera JL, Abud-Mendoza C, Gonzalez-Amaro RF, Espinosa-Cristobal LF, Martínez-Martínez RE. Distribution of Porphyromonas gingivalis fimA genotypes in patients affected by rheumatoid arthritis and periodontitis. Acta Odontol Scand. 2018;76(7):520–4.PubMedCrossRef
41.
go back to reference Bender P, Egger A, Westermann M, Taudte N, Sculean A, Potempa J, et al. Expression of human and Porphyromonas gingivalis glutaminyl cyclases in periodontitis and rheumatoid arthritis—a pilot study. Arch Oral Biol. 2019;97:223–30.PubMedCrossRef Bender P, Egger A, Westermann M, Taudte N, Sculean A, Potempa J, et al. Expression of human and Porphyromonas gingivalis glutaminyl cyclases in periodontitis and rheumatoid arthritis—a pilot study. Arch Oral Biol. 2019;97:223–30.PubMedCrossRef
42.
go back to reference Mankia K, Cheng Z, Do N, Hunt L, Meade J, Kang J, et al. An increased prevalence of periodontal disease and Porphyromonas gingivalis in anti-CCP positive individuals at-risk of rheumatoid arthritis: a target for prevention? JAMA Netw Open. In Press 2019. Mankia K, Cheng Z, Do N, Hunt L, Meade J, Kang J, et al. An increased prevalence of periodontal disease and Porphyromonas gingivalis in anti-CCP positive individuals at-risk of rheumatoid arthritis: a target for prevention? JAMA Netw Open. In Press 2019.
43.
go back to reference Corrêa JD, Fernandes GR, Calderaro DC, Mendonça SMS, Silva JM, Albiero ML, et al. Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients. Sci Rep. 2019;9(1):8379.PubMedPubMedCentralCrossRef Corrêa JD, Fernandes GR, Calderaro DC, Mendonça SMS, Silva JM, Albiero ML, et al. Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients. Sci Rep. 2019;9(1):8379.PubMedPubMedCentralCrossRef
44.
go back to reference Eriksson K, Fei G, Lundmark A, Benchimol D, Lee L, Hu YOO, et al. Periodontal health and oral microbiota in patients with rheumatoid arthritis. J Clin Med. 2019;8(5):630.PubMedCentralCrossRef Eriksson K, Fei G, Lundmark A, Benchimol D, Lee L, Hu YOO, et al. Periodontal health and oral microbiota in patients with rheumatoid arthritis. J Clin Med. 2019;8(5):630.PubMedCentralCrossRef
45.
go back to reference Herrera JLA, Patrón LA, Martínez REM, Pérez RAD, Mendoza CA, Castro BH. Filifactor alocis and Dialister pneumosintes in a Mexican population affected by periodontitis and rheumatoid arthritis: an exploratory study. Microbiol Immunol. 2019;63:392–5.CrossRef Herrera JLA, Patrón LA, Martínez REM, Pérez RAD, Mendoza CA, Castro BH. Filifactor alocis and Dialister pneumosintes in a Mexican population affected by periodontitis and rheumatoid arthritis: an exploratory study. Microbiol Immunol. 2019;63:392–5.CrossRef
46.
go back to reference Beyer K, Zaura E, Brandt BW, Buijs MJ, Brun JG, Crielaard W, et al. Subgingival microbiome of rheumatoid arthritis patients in relation to their disease status and periodontal health. PLoS One. 2018;13(9):e0202278.PubMedPubMedCentralCrossRef Beyer K, Zaura E, Brandt BW, Buijs MJ, Brun JG, Crielaard W, et al. Subgingival microbiome of rheumatoid arthritis patients in relation to their disease status and periodontal health. PLoS One. 2018;13(9):e0202278.PubMedPubMedCentralCrossRef
47.
go back to reference Lopez-Oliva I, Paropkari AD, Saraswat S, Serban S, Yonel Z, Sharma P, et al. Dysbiotic subgingival microbial communities in periodontally healthy patients with rheumatoid arthritis. Arthritis Rheumatol. 2018;70(7):1008–13.PubMedPubMedCentralCrossRef Lopez-Oliva I, Paropkari AD, Saraswat S, Serban S, Yonel Z, Sharma P, et al. Dysbiotic subgingival microbial communities in periodontally healthy patients with rheumatoid arthritis. Arthritis Rheumatol. 2018;70(7):1008–13.PubMedPubMedCentralCrossRef
48.
go back to reference Wegner N, Lundberg K, Kinloch A, Fisher B, Malmström V, Feldmann M, et al. Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol Rev. 2010;233(1):34–54.PubMedCrossRef Wegner N, Lundberg K, Kinloch A, Fisher B, Malmström V, Feldmann M, et al. Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol Rev. 2010;233(1):34–54.PubMedCrossRef
49.
go back to reference van Gaalen FA, Visser H, Huizinga TW. A comparison of the diagnostic accuracy and prognostic value of the first and second anti-cyclic citrullinated peptides (CCP1 and CCP2) autoantibody tests for rheumatoid arthritis. Ann Rheum Dis. 2005;64(10):1510–2.PubMedPubMedCentralCrossRef van Gaalen FA, Visser H, Huizinga TW. A comparison of the diagnostic accuracy and prognostic value of the first and second anti-cyclic citrullinated peptides (CCP1 and CCP2) autoantibody tests for rheumatoid arthritis. Ann Rheum Dis. 2005;64(10):1510–2.PubMedPubMedCentralCrossRef
50.
go back to reference Schellekens GA, De Jong B, Van den Hoogen F, Van de Putte L, van Venrooij WJ. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest. 1998;101(1):273–81.PubMedPubMedCentralCrossRef Schellekens GA, De Jong B, Van den Hoogen F, Van de Putte L, van Venrooij WJ. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest. 1998;101(1):273–81.PubMedPubMedCentralCrossRef
51.
go back to reference Schellekens GA, Visser H, De Jong BA, Van Den Hoogen FH, Hazes JM, Breedveld FC, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000;43(1):155–63.PubMedCrossRef Schellekens GA, Visser H, De Jong BA, Van Den Hoogen FH, Hazes JM, Breedveld FC, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000;43(1):155–63.PubMedCrossRef
52.
go back to reference György B, Tóth E, Tarcsa E, Falus A, Buzás EI. Citrullination: a posttranslational modification in health and disease. Int J Biochem Cell Biol. 2006;38(10):1662–77.PubMedCrossRef György B, Tóth E, Tarcsa E, Falus A, Buzás EI. Citrullination: a posttranslational modification in health and disease. Int J Biochem Cell Biol. 2006;38(10):1662–77.PubMedCrossRef
53.
54.
go back to reference Mangat P, Wegner N, Venables PJ, Potempa J. Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis? Arthritis Res Ther. 2010;12(3):209.PubMedPubMedCentralCrossRef Mangat P, Wegner N, Venables PJ, Potempa J. Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis? Arthritis Res Ther. 2010;12(3):209.PubMedPubMedCentralCrossRef
55.
go back to reference Nesse W, Westra J, van der Wal JE, Abbas F, Nicholas AP, Vissink A, et al. The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formation. J Clin Periodontol. 2012;39(7):599–607.PubMedCrossRef Nesse W, Westra J, van der Wal JE, Abbas F, Nicholas AP, Vissink A, et al. The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formation. J Clin Periodontol. 2012;39(7):599–607.PubMedCrossRef
56.
go back to reference Harvey G, Fitzsimmons T, Dhamarpatni A, Marchant C, Haynes D, Bartold P. Expression of peptidylarginine deiminase-2 and-4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva. J Periodontal Res. 2013;48(2):252–61.PubMedCrossRef Harvey G, Fitzsimmons T, Dhamarpatni A, Marchant C, Haynes D, Bartold P. Expression of peptidylarginine deiminase-2 and-4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva. J Periodontal Res. 2013;48(2):252–61.PubMedCrossRef
57.
go back to reference Loutan L, Alpizar-Rodriguez D, Courvoisier DS, Finckh A, Mombelli A, Giannopoulou C. Periodontal status correlates with anti-citrullinated protein antibodies in first-degree relatives of individuals with rheumatoid arthritis. J Clin Periodontol. 2019;46(7):690–8.PubMed Loutan L, Alpizar-Rodriguez D, Courvoisier DS, Finckh A, Mombelli A, Giannopoulou C. Periodontal status correlates with anti-citrullinated protein antibodies in first-degree relatives of individuals with rheumatoid arthritis. J Clin Periodontol. 2019;46(7):690–8.PubMed
58.
go back to reference Shi J, van Veelen PA, Mahler M, Janssen GM, Drijfhout JW, Huizinga TW, et al. Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies. Autoimmun Rev. 2014;13(3):225–30.PubMedCrossRef Shi J, van Veelen PA, Mahler M, Janssen GM, Drijfhout JW, Huizinga TW, et al. Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies. Autoimmun Rev. 2014;13(3):225–30.PubMedCrossRef
59.
go back to reference Bright R, Proudman S, Rosenstein E, Bartold P. Is there a link between carbamylation and citrullination in periodontal disease and rheumatoid arthritis? Med Hypotheses. 2015;84(6):570–6.PubMedCrossRef Bright R, Proudman S, Rosenstein E, Bartold P. Is there a link between carbamylation and citrullination in periodontal disease and rheumatoid arthritis? Med Hypotheses. 2015;84(6):570–6.PubMedCrossRef
60.
go back to reference Mydel P, Wang Z, Brisslert M, Hellvard A, Dahlberg LE, Hazen SL, et al. Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis. J Immunol. 2010;184(12):6882–90.PubMedCrossRef Mydel P, Wang Z, Brisslert M, Hellvard A, Dahlberg LE, Hazen SL, et al. Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis. J Immunol. 2010;184(12):6882–90.PubMedCrossRef
61.
go back to reference Steinbrecher UP, Fisher M, Witztum JL, Curtiss LK. Immunogenicity of homologous low density lipoprotein after methylation, ethylation, acetylation, or carbamylation: generation of antibodies specific for derivatized lysine. J Lipid Res. 1984;25(10):1109–16.PubMed Steinbrecher UP, Fisher M, Witztum JL, Curtiss LK. Immunogenicity of homologous low density lipoprotein after methylation, ethylation, acetylation, or carbamylation: generation of antibodies specific for derivatized lysine. J Lipid Res. 1984;25(10):1109–16.PubMed
62.
go back to reference Verheul MK, Vierboom MP, Bert A, Toes RE, Trouw LA. Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis. Arthritis Res Ther. 2017;19(1):246.PubMedPubMedCentralCrossRef Verheul MK, Vierboom MP, Bert A, Toes RE, Trouw LA. Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis. Arthritis Res Ther. 2017;19(1):246.PubMedPubMedCentralCrossRef
63.
go back to reference Bright R, Thiele GM, Manavis J, Mikuls TR, Payne JB, Bartold P. Gingival tissue, an extrasynovial source of malondialdehyde-acetaldehyde adducts, citrullinated and carbamylated proteins. J Periodontal Res. 2018;53(1):139–43.PubMedCrossRef Bright R, Thiele GM, Manavis J, Mikuls TR, Payne JB, Bartold P. Gingival tissue, an extrasynovial source of malondialdehyde-acetaldehyde adducts, citrullinated and carbamylated proteins. J Periodontal Res. 2018;53(1):139–43.PubMedCrossRef
64.
go back to reference Kaneko C, Kobayashi T, Ito S, Sugita N, Murasawa A, Nakazono K, et al. Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: a pilot case-control study. PLoS One. 2018;13(2):e0192365.PubMedPubMedCentralCrossRef Kaneko C, Kobayashi T, Ito S, Sugita N, Murasawa A, Nakazono K, et al. Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: a pilot case-control study. PLoS One. 2018;13(2):e0192365.PubMedPubMedCentralCrossRef
65.
go back to reference McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. New Engl J Med. 2011;365(23):2205–19.PubMedCrossRef McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. New Engl J Med. 2011;365(23):2205–19.PubMedCrossRef
66.
go back to reference Kinane DF, Preshaw PM, Loos BG, Periodontology. Host-response: understanding the cellular and molecular mechanisms of host-microbial interactions—Consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol. 2011;38:44–8.PubMedCrossRef Kinane DF, Preshaw PM, Loos BG, Periodontology. Host-response: understanding the cellular and molecular mechanisms of host-microbial interactions—Consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol. 2011;38:44–8.PubMedCrossRef
67.
go back to reference Kaur S, White S, Bartold P. Periodontal disease and rheumatoid arthritis: a systematic review. J Dent Res. 2013;92(5):399–408.PubMedCrossRef Kaur S, White S, Bartold P. Periodontal disease and rheumatoid arthritis: a systematic review. J Dent Res. 2013;92(5):399–408.PubMedCrossRef
68.
go back to reference Javed F, Ahmed HB, Mikami T, Almas K, Romanos GE, Al-Hezaimi K. Cytokine profile in the gingival crevicular fluid of rheumatoid arthritis patients with chronic periodontitis. J Investig Clin Dent. 2014;5(1):1–8.PubMedCrossRef Javed F, Ahmed HB, Mikami T, Almas K, Romanos GE, Al-Hezaimi K. Cytokine profile in the gingival crevicular fluid of rheumatoid arthritis patients with chronic periodontitis. J Investig Clin Dent. 2014;5(1):1–8.PubMedCrossRef
69.
go back to reference Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis? J Clin Periodontol. 2011;38:60–84.PubMedCrossRef Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis? J Clin Periodontol. 2011;38:60–84.PubMedCrossRef
70.
go back to reference Choy EH, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. New Engl J Med. 2001;344(12):907–16.PubMedCrossRef Choy EH, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. New Engl J Med. 2001;344(12):907–16.PubMedCrossRef
71.
go back to reference Thilagar S, Theyagarajan R, Sudhakar U, Suresh S, Saketharaman P, Ahamed N. Comparison of serum tumor necrosis factor-α levels in rheumatoid arthritis individuals with and without chronic periodontitis: a biochemical study. J Indian Soc Periodontol. 2018;22(2):116.PubMedPubMedCentralCrossRef Thilagar S, Theyagarajan R, Sudhakar U, Suresh S, Saketharaman P, Ahamed N. Comparison of serum tumor necrosis factor-α levels in rheumatoid arthritis individuals with and without chronic periodontitis: a biochemical study. J Indian Soc Periodontol. 2018;22(2):116.PubMedPubMedCentralCrossRef
72.
go back to reference •• Cosgarea R, Tristiu R, Dumitru RB, Arweiler NB, Rednic S, Sirbu CI, et al. Effects of non-surgical periodontal therapy on periodontal laboratory and clinical data as well as on disease activity in patients with rheumatoid arthritis. Clin Oral Investig. 2019;23(1):141–51. In patients with RA and CP, non-surgical periodontal therapy is a relevant modality not only to improve the periodontal condition but also to decrease RA activity. PubMedCrossRef •• Cosgarea R, Tristiu R, Dumitru RB, Arweiler NB, Rednic S, Sirbu CI, et al. Effects of non-surgical periodontal therapy on periodontal laboratory and clinical data as well as on disease activity in patients with rheumatoid arthritis. Clin Oral Investig. 2019;23(1):141–51. In patients with RA and CP, non-surgical periodontal therapy is a relevant modality not only to improve the periodontal condition but also to decrease RA activity. PubMedCrossRef
73.
go back to reference •• Äyräväinen L, Heikkinen AM, Kuuliala A, Ahola K, Koivuniemi R, Laasonen L, et al. Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status. Ann Med. 2018;50(4):333–44. Concentrations of inflammatory biomarkers in serum and saliva are different between patients with RA and healthy controls. Concentrations of MMP-8 and of IL-6 in serum were elevated in patients with chronic RA reflecting joint inflammation and the burden of established RA. Concentrations of MMP-8 in saliva were elevated already at early stage RA. Level of salivary MMP-8 was associated with poor periodontal health both in patients with early and chronic RA. PubMedCrossRef •• Äyräväinen L, Heikkinen AM, Kuuliala A, Ahola K, Koivuniemi R, Laasonen L, et al. Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status. Ann Med. 2018;50(4):333–44. Concentrations of inflammatory biomarkers in serum and saliva are different between patients with RA and healthy controls. Concentrations of MMP-8 and of IL-6 in serum were elevated in patients with chronic RA reflecting joint inflammation and the burden of established RA. Concentrations of MMP-8 in saliva were elevated already at early stage RA. Level of salivary MMP-8 was associated with poor periodontal health both in patients with early and chronic RA. PubMedCrossRef
74.
go back to reference Schmalz G, Davarpanah I, Jager J, Mausberg RF, Krohn-Grimberghe B, Schmidt J, et al. MMP-8 and TIMP-1 are associated to periodontal inflammation in patients with rheumatoid arthritis under methotrexate immunosuppression—first results of a cross-sectional study. J Microbiol Immunol Infect. 2019;52(3):386–94.PubMedCrossRef Schmalz G, Davarpanah I, Jager J, Mausberg RF, Krohn-Grimberghe B, Schmidt J, et al. MMP-8 and TIMP-1 are associated to periodontal inflammation in patients with rheumatoid arthritis under methotrexate immunosuppression—first results of a cross-sectional study. J Microbiol Immunol Infect. 2019;52(3):386–94.PubMedCrossRef
75.
go back to reference Panezai J, Ghaffar A, Altamash M, Engström P-E, Larsson A. Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis. PLoS One. 2018;13(6):e0197235.PubMedPubMedCentralCrossRef Panezai J, Ghaffar A, Altamash M, Engström P-E, Larsson A. Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis. PLoS One. 2018;13(6):e0197235.PubMedPubMedCentralCrossRef
76.
go back to reference Kindstedt E, Johansson L, Palmqvist P, Koskinen Holm C, Kokkonen H, Johansson I, et al. Association between marginal jawbone loss and onset of rheumatoid arthritis and relationship to plasma levels of RANKL. Arthritis Rheumatol. 2018;70(4):508–15.PubMedCrossRef Kindstedt E, Johansson L, Palmqvist P, Koskinen Holm C, Kokkonen H, Johansson I, et al. Association between marginal jawbone loss and onset of rheumatoid arthritis and relationship to plasma levels of RANKL. Arthritis Rheumatol. 2018;70(4):508–15.PubMedCrossRef
77.
go back to reference Beyer K, Lie SA, Kjellevold M, Dahl L, Brun JG, Bolstad AI. Marine ω-3, vitamin D levels, disease outcome and periodontal status in rheumatoid arthritis outpatients. Nutrition. 2018;55:116–24.PubMedCrossRef Beyer K, Lie SA, Kjellevold M, Dahl L, Brun JG, Bolstad AI. Marine ω-3, vitamin D levels, disease outcome and periodontal status in rheumatoid arthritis outpatients. Nutrition. 2018;55:116–24.PubMedCrossRef
78.
go back to reference •• Ziebolz D, Rupprecht A, Schmickler J, Bothmann L, Krämer J, Patschan D, et al. Association of different immunosuppressive medications with periodontal condition in patients with rheumatoid arthritis: results from a cross-sectional study. J Periodontol. 2018;89(11):1310–7. RA medication is associated with periodontal inflammation, without differences in periodontal disease severity. Thereby, combination of MTX + TNF-α shows an increased potential to periodontal inflammation. Additionally, several differences in prevalence of selected bacteria were detected. PubMedCrossRef •• Ziebolz D, Rupprecht A, Schmickler J, Bothmann L, Krämer J, Patschan D, et al. Association of different immunosuppressive medications with periodontal condition in patients with rheumatoid arthritis: results from a cross-sectional study. J Periodontol. 2018;89(11):1310–7. RA medication is associated with periodontal inflammation, without differences in periodontal disease severity. Thereby, combination of MTX + TNF-α shows an increased potential to periodontal inflammation. Additionally, several differences in prevalence of selected bacteria were detected. PubMedCrossRef
79.
go back to reference Cobb CM. Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing. J Clin Periodontol. 2002;29:22–32.CrossRef Cobb CM. Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing. J Clin Periodontol. 2002;29:22–32.CrossRef
80.
go back to reference Zhao X, Liu Z, Shu D, Xiong Y, He M, Xu S, et al. Association of periodontitis with rheumatoid arthritis and the effect of non-surgical periodontal treatment on disease activity in patients with rheumatoid arthritis. Med Sci Monit. 2018;24:5802.PubMedPubMedCentralCrossRef Zhao X, Liu Z, Shu D, Xiong Y, He M, Xu S, et al. Association of periodontitis with rheumatoid arthritis and the effect of non-surgical periodontal treatment on disease activity in patients with rheumatoid arthritis. Med Sci Monit. 2018;24:5802.PubMedPubMedCentralCrossRef
81.
go back to reference Kaushal S, Singh AK, Lal N, Das SK, Mahdi AA. Effect of periodontal therapy on disease activity in patients of rheumatoid arthritis with chronic periodontitis. J Oral Biol Craniofac Res. 2019;9(2):128–32.PubMedPubMedCentralCrossRef Kaushal S, Singh AK, Lal N, Das SK, Mahdi AA. Effect of periodontal therapy on disease activity in patients of rheumatoid arthritis with chronic periodontitis. J Oral Biol Craniofac Res. 2019;9(2):128–32.PubMedPubMedCentralCrossRef
82.
go back to reference Monsarrat P, Fernandez de Grado G, Constantin A, Willmann C, Nabet C, Sixou M, et al. The effect of periodontal treatment on patients with rheumatoid arthritis: ESPERA randomised controlled trial. Joint Bone Spine. 2019;86(5):600–9.PubMedCrossRef Monsarrat P, Fernandez de Grado G, Constantin A, Willmann C, Nabet C, Sixou M, et al. The effect of periodontal treatment on patients with rheumatoid arthritis: ESPERA randomised controlled trial. Joint Bone Spine. 2019;86(5):600–9.PubMedCrossRef
84.
go back to reference Hashimoto H, Hashimoto S, Muto A, Dewake N, Shimazaki Y. Influence of plaque control on the relationship between rheumatoid arthritis and periodontal health status among Japanese rheumatoid arthritis patients. J Periodontol. 2018;89(9):1033–42.PubMedCrossRef Hashimoto H, Hashimoto S, Muto A, Dewake N, Shimazaki Y. Influence of plaque control on the relationship between rheumatoid arthritis and periodontal health status among Japanese rheumatoid arthritis patients. J Periodontol. 2018;89(9):1033–42.PubMedCrossRef
85.
go back to reference Chapple IL, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89:S74–84.PubMedCrossRef Chapple IL, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89:S74–84.PubMedCrossRef
86.
go back to reference Khare N, Vanza B, Sagar D, Saurav K, Chauhan R, Mishra S. Nonsurgical periodontal therapy decreases the severity of rheumatoid arthritis: a case-control study. J Contemp Dent Pract. 2016;17(6):484–8.PubMedCrossRef Khare N, Vanza B, Sagar D, Saurav K, Chauhan R, Mishra S. Nonsurgical periodontal therapy decreases the severity of rheumatoid arthritis: a case-control study. J Contemp Dent Pract. 2016;17(6):484–8.PubMedCrossRef
87.
go back to reference Al-Katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD. Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol. 2007;13(3):134–7.PubMedCrossRef Al-Katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD. Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol. 2007;13(3):134–7.PubMedCrossRef
88.
go back to reference Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO III, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569–81.PubMedCrossRef Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO III, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569–81.PubMedCrossRef
89.
90.
go back to reference Han JY, Reynolds MA. Effect of anti-rheumatic agents on periodontal parameters and biomarkers of inflammation: a systematic review and meta-analysis. J Periodontal Implant Sci. 2012;42(1):3–12.PubMedPubMedCentralCrossRef Han JY, Reynolds MA. Effect of anti-rheumatic agents on periodontal parameters and biomarkers of inflammation: a systematic review and meta-analysis. J Periodontal Implant Sci. 2012;42(1):3–12.PubMedPubMedCentralCrossRef
91.
go back to reference Kadkhoda Z, Amirzargar A, Esmaili Z, Vojdanian M, Akbari S. Effect of TNF-α blockade in gingival crevicular fluid on periodontal condition of patients with rheumatoid arthritis. Iran J Immunol. 2016;13(3):197–203.PubMed Kadkhoda Z, Amirzargar A, Esmaili Z, Vojdanian M, Akbari S. Effect of TNF-α blockade in gingival crevicular fluid on periodontal condition of patients with rheumatoid arthritis. Iran J Immunol. 2016;13(3):197–203.PubMed
92.
go back to reference Kobayashi T, Yoshie H. Host responses in the link between periodontitis and rheumatoid arthritis. Curr Oral Health Rep. 2015;2(1):1–8.PubMedCrossRef Kobayashi T, Yoshie H. Host responses in the link between periodontitis and rheumatoid arthritis. Curr Oral Health Rep. 2015;2(1):1–8.PubMedCrossRef
93.
go back to reference Coat J, Demoersman J, Beuzit S, Cornec D, Devauchelle-Pensec V, Saraux A, et al. Anti-B lymphocyte immunotherapy is associated with improvement of periodontal status in subjects with rheumatoid arthritis. J Clin Periodontol. 2015;42(9):817–23.PubMedCrossRef Coat J, Demoersman J, Beuzit S, Cornec D, Devauchelle-Pensec V, Saraux A, et al. Anti-B lymphocyte immunotherapy is associated with improvement of periodontal status in subjects with rheumatoid arthritis. J Clin Periodontol. 2015;42(9):817–23.PubMedCrossRef
94.
go back to reference Jung G-U, Han J-Y, Hwang K-G, Park C-J, Stathopoulou PG, Fiorellini JP. Effects of conventional synthetic disease-modifying antirheumatic drugs on response to periodontal treatment in patients with rheumatoid arthritis. Biomed Res Int. 2018;2018:1465402. https://doi.org/10.1155/2018/1465402. Jung G-U, Han J-Y, Hwang K-G, Park C-J, Stathopoulou PG, Fiorellini JP. Effects of conventional synthetic disease-modifying antirheumatic drugs on response to periodontal treatment in patients with rheumatoid arthritis. Biomed Res Int. 2018;2018:1465402. https://​doi.​org/​10.​1155/​2018/​1465402.
95.
go back to reference Rinaudo-Gaujous M, Blasco-Baque V, Miossec P, Gaudin P, Farge P, Roblin X, et al. Infliximab induced a dissociated response of severe periodontal biomarkers in rheumatoid arthritis patients. J Clin Med. 2019;8(5):751.PubMedCentralCrossRef Rinaudo-Gaujous M, Blasco-Baque V, Miossec P, Gaudin P, Farge P, Roblin X, et al. Infliximab induced a dissociated response of severe periodontal biomarkers in rheumatoid arthritis patients. J Clin Med. 2019;8(5):751.PubMedCentralCrossRef
96.
go back to reference Savioli C, Ribeiro ACM, Fabri GMC, Calich AL, Carvalho J, Silva CA, et al. Persistent periodontal disease hampers anti-tumor necrosis factor treatment response in rheumatoid arthritis. J Clin Rheumatol. 2012;18(4):180–4.PubMed Savioli C, Ribeiro ACM, Fabri GMC, Calich AL, Carvalho J, Silva CA, et al. Persistent periodontal disease hampers anti-tumor necrosis factor treatment response in rheumatoid arthritis. J Clin Rheumatol. 2012;18(4):180–4.PubMed
97.
go back to reference Lee YH, Lew PH, Cheah CW, Rahman MT, Baharuddin NA, Vaithilingam RD. Potential mechanisms linking periodontitis to rheumatoid arthritis. J Int Acad Periodontol. 2019;21(3):99–110.PubMed Lee YH, Lew PH, Cheah CW, Rahman MT, Baharuddin NA, Vaithilingam RD. Potential mechanisms linking periodontitis to rheumatoid arthritis. J Int Acad Periodontol. 2019;21(3):99–110.PubMed
Metadata
Title
Association Between Rheumatoid Arthritis and Periodontitis: Recent Progress
Authors
Nazurah Nik Eezammuddeen
Rathna Devi Vaithilingam
Norul Husna Mohamad Hassan
Peter Mark Bartold
Publication date
01-06-2020
Publisher
Springer International Publishing
Published in
Current Oral Health Reports / Issue 2/2020
Electronic ISSN: 2196-3002
DOI
https://doi.org/10.1007/s40496-020-00264-4

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