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01-03-2020 | Gingival Diseases | Host Parasite Interactions in Periodontal Disease (C Genco and D Kinane, Section Editors)

The Gastrointestinal Microbiome in Chronic Renal Diseases

Authors: Mark A. Bryniarski, Sarah E. M. Hoffman, Rabi Yacoub

Published in: Current Oral Health Reports | Issue 1/2020

Abstract

Purpose of Review

The relationship between microorganisms within the gastrointestinal tract and the renal function of the host is reciprocal. The objective of the current review is therefore twofold. First, we aim to demonstrate the emerging role of gastrointestinal microbiome dysbiosis in the pathogenesis and progression of chronic kidney disease. Second, we highlight specific mechanisms as to how microbiome dysbiosis is provoked in chronic kidney disease.

Recent Findings

Current work has shown that microbiome dysbiosis can directly and indirectly influence renal physiology and contribute to the onset and development of chronic kidney disease, such as by stimulating hypertension. It is also becoming evident that the composition and function of both the intestinal and oral microbiomes are adversely impacted by chronic kidney disease, which can further exacerbate dysbiosis.

Summary

This review discusses the current knowledge on the associations between the gastrointestinal microbiome and renal health, to which Dr. Robert Genco has contributed substantially. As we mourn his loss, we celebrate his lifelong dedication to the advancement of research at the University at Buffalo and the microbiome research community worldwide.

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Title: The Gastrointestinal Microbiome in Chronic Renal Diseases
Authors: Mark A. Bryniarski
Sarah E. M. Hoffman
Rabi Yacoub
Publication date: 01-03-2020
Publisher: Springer International Publishing
Keywords: Gingival Diseases
Chronic Kidney Disease
Published in: Current Oral Health Reports / Issue 1/2020
Electronic ISSN: 2196-3002
DOI: https://doi.org/10.1007/s40496-020-00258-2

At a glance: The STEP trials

Springer Medicine

The Gastrointestinal Microbiome in Chronic Renal Diseases

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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The Buffalo OsteoPerio Studies: Summary of Our Findings and the Unique Contributions of Robert J. Genco, DDS, PhD

On the Role of Mentorship in Team Science

Persistence of Tannerella forsythia and Fusobacterium nucleatum in Dental Plaque: a Strategic Alliance

Robert J. Genco: A Legacy of Lifelong Innovation and Inspiration