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01-12-2018 | Epidemiology (M Laine, Section Editor)

Herpesviral Infection in Periapical Periodontitis

Authors: Aleksandar Jakovljevic, Miroslav Andric, Aleksandra Knezevic, Maja Miletic, Katarina Beljic-Ivanovic, Jelena Milasin, Mohammad Sabeti

Published in: Current Oral Health Reports | Issue 4/2018

Abstract

Purpose of Review

This review describes the most recent findings on herpesviral infections and offers current concepts of herpesviral role in the pathogenesis of periapical periodontitis.

Recent Findings

Thirty articles reported data on herpesviral infection in periapical periodontitis. Epstein-Barr virus and human cytomegalovirus are the most frequently detected herpesviruses in periapical samples. The main hypothesis postulates a bidirectional herpesviral-bacterial relationship in the etiopathogenesis of periapical periodontitis. A high heterogeneity of herpesviruses incidence was registered within the studies, in part, due to various methodological approaches used in laboratory testing, different inclusion criteria, study design, seroprevalence of herpesviruses, and sociodemographic characteristics of investigated populations.

Summary

Herpesviruses have been shown to potentially impair local host defense in periapical tissue. Although it has been demonstrated that endodontic pathogenic bacteria are able to reactivate herpesviruses, further, in vitro studies should provide more data on herpesviruses as a factor in the pathogenesis of the periapical pathoses. It is, therefore, necessary to investigate potential benefits of antiviral therapy in well-designed controlled longitudinal studies.

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Title: Herpesviral Infection in Periapical Periodontitis
Authors: Aleksandar Jakovljevic
Miroslav Andric
Aleksandra Knezevic
Maja Miletic
Katarina Beljic-Ivanovic
Jelena Milasin
Mohammad Sabeti
Publication date: 01-12-2018
Publisher: Springer International Publishing
Published in: Current Oral Health Reports / Issue 4/2018
Electronic ISSN: 2196-3002
DOI: https://doi.org/10.1007/s40496-018-0198-7

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Herpesviral Infection in Periapical Periodontitis

Abstract

Purpose of Review

Recent Findings

Summary

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