Skip to main content
Top
Published in: Sports Medicine 8/2018

01-08-2018 | Systematic Review

The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta–Analysis

Authors: Kyle Southward, Kay J. Rutherfurd-Markwick, Ajmol Ali

Published in: Sports Medicine | Issue 8/2018

Login to get access

Abstract

Background

Caffeine is a widely used ergogenic aid with most research suggesting it confers the greatest effects during endurance activities. Despite the growing body of literature around the use of caffeine as an ergogenic aid, there are few recent meta-analyses that quantitatively assess the effect of caffeine on endurance exercise.

Objectives

To summarise studies that have investigated the ergogenic effects of caffeine on endurance time-trial performance and to quantitatively analyse the results of these studies to gain a better understanding of the magnitude of the ergogenic effect of caffeine on endurance time-trial performance.

Methods

A systematic review was carried out on randomised placebo-controlled studies investigating the effects of caffeine on endurance performance and a meta-analysis was conducted to determine the ergogenic effect of caffeine on endurance time-trial performance.

Results

Forty-six studies met the inclusion criteria and were included in the meta-analysis. Caffeine has a small but evident effect on endurance performance when taken in moderate doses (3–6 mg/kg) as well as an overall improvement following caffeine compared to placebo in mean power output (3.03 ± 3.07%; effect size = 0.23 ± 0.15) and time-trial completion time (2.22 ± 2.59%; effect size = 0.41 ± 0.2). However, differences in responses to caffeine ingestion have been shown, with two studies reporting slower time-trial performance, while five studies reported lower mean power output during the time–trial.

Conclusion

Caffeine can be used effectively as an ergogenic aid when taken in moderate doses, such as during sports when a small increase in endurance performance can lead to significant differences in placements as athletes are often separated by small margins.
Literature
1.
go back to reference Christensen PM, Shirai Y, Ritz C, Nordsborg NB. Caffeine and bicarbonate for speed. A meta-analysis of legal supplements potential for improving intense endurance exercise performance. Front Physiol. 2017;8:240.CrossRefPubMedPubMedCentral Christensen PM, Shirai Y, Ritz C, Nordsborg NB. Caffeine and bicarbonate for speed. A meta-analysis of legal supplements potential for improving intense endurance exercise performance. Front Physiol. 2017;8:240.CrossRefPubMedPubMedCentral
2.
go back to reference Del Coso J, Munoz G, Munoz-Guerra J, Muñoz G, Muñoz-Guerra J. Prevalence of caffeine use in elite athletes following its removal from the World Anti-Doping Agency list of banned substances. Appl Physiol Nutr Metab. 2011;36:555–61.CrossRefPubMed Del Coso J, Munoz G, Munoz-Guerra J, Muñoz G, Muñoz-Guerra J. Prevalence of caffeine use in elite athletes following its removal from the World Anti-Doping Agency list of banned substances. Appl Physiol Nutr Metab. 2011;36:555–61.CrossRefPubMed
3.
go back to reference Graham TE. Caffeine and exercise—metabolism, endurance and performance. Sports Med. 2001;31:785–807.CrossRefPubMed Graham TE. Caffeine and exercise—metabolism, endurance and performance. Sports Med. 2001;31:785–807.CrossRefPubMed
5.
go back to reference Doherty M, Smith PM. Effects of Caffeine ingestion on exercise testing: a meta-analysis. Int J Sport Nutr Exerc Metab. 2004;14:626–46.CrossRefPubMed Doherty M, Smith PM. Effects of Caffeine ingestion on exercise testing: a meta-analysis. Int J Sport Nutr Exerc Metab. 2004;14:626–46.CrossRefPubMed
6.
go back to reference Doherty M, Smith PM. Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scand J Med Sci Sports. 2005;15:69–78.CrossRefPubMed Doherty M, Smith PM. Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scand J Med Sci Sports. 2005;15:69–78.CrossRefPubMed
7.
go back to reference Hopkins WG, Schabort EJ, Hawley JA. Reliability of power in physical performance tests. Sports Med. 2001;31:211–34.CrossRefPubMed Hopkins WG, Schabort EJ, Hawley JA. Reliability of power in physical performance tests. Sports Med. 2001;31:211–34.CrossRefPubMed
8.
go back to reference Tarnopolsky MA. Caffeine and endurance performance. Sports Med. 1994;18:109–25.CrossRef Tarnopolsky MA. Caffeine and endurance performance. Sports Med. 1994;18:109–25.CrossRef
11.
13.
go back to reference Souza DB, Del Coso J, Casonatto J, Polito MD. Acute effects of caffeine-containing energy drinks on physical performance: a systematic review and meta-analysis. Eur J Nutr. 2017;56:13–27.CrossRefPubMed Souza DB, Del Coso J, Casonatto J, Polito MD. Acute effects of caffeine-containing energy drinks on physical performance: a systematic review and meta-analysis. Eur J Nutr. 2017;56:13–27.CrossRefPubMed
14.
go back to reference Ganio MS, Klau JF, Casa DJ, Armstrong LE, Maresh CM. Effect of Caffeine on sport-specific endurance performance: a systematic review. J.Strength Cond Res. 2009;23:315–24.CrossRefPubMed Ganio MS, Klau JF, Casa DJ, Armstrong LE, Maresh CM. Effect of Caffeine on sport-specific endurance performance: a systematic review. J.Strength Cond Res. 2009;23:315–24.CrossRefPubMed
15.
go back to reference Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1.CrossRefPubMedPubMedCentral Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1.CrossRefPubMedPubMedCentral
16.
go back to reference Kamimori GH, Karyekar CS, Otterstetter R, Cox DS, Balkin TJ, Belenky GL, et al. The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers. Int J Pharm. 2002;234:159–67.CrossRefPubMed Kamimori GH, Karyekar CS, Otterstetter R, Cox DS, Balkin TJ, Belenky GL, et al. The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers. Int J Pharm. 2002;234:159–67.CrossRefPubMed
17.
go back to reference Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003;83:713–21.PubMed Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003;83:713–21.PubMed
18.
go back to reference Hopkins WG, Marshall SW, Batterham AM, Hanin J. Progressive Statistics for Studies in Sports Medicine and Exercise Science. Med Sci Sports Exerc. 2009;41:3–12.CrossRefPubMed Hopkins WG, Marshall SW, Batterham AM, Hanin J. Progressive Statistics for Studies in Sports Medicine and Exercise Science. Med Sci Sports Exerc. 2009;41:3–12.CrossRefPubMed
19.
go back to reference Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ [Internet]. Br Med J. 1997;315:629–34.CrossRef Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ [Internet]. Br Med J. 1997;315:629–34.CrossRef
20.
go back to reference Astorino TA, Cottrell T, Talhami Lozano A, Aburto-Pratt K, Duhon J. Effect of caffeine on RPE and perceptions of pain, arousal, and pleasure/displeasure during a cycling time trial in endurance trained and active men. Physiol Behav. 2012;106:211–7.CrossRefPubMed Astorino TA, Cottrell T, Talhami Lozano A, Aburto-Pratt K, Duhon J. Effect of caffeine on RPE and perceptions of pain, arousal, and pleasure/displeasure during a cycling time trial in endurance trained and active men. Physiol Behav. 2012;106:211–7.CrossRefPubMed
21.
go back to reference Ganio MS, Johnson EC, Klau JF, Anderson JM, Casa DJ, Maresh CM, et al. Effect of ambient temperature on caffeine ergogenicity during endurance exercise. Eur J Appl Physiol. 2011;111:1135–46.CrossRefPubMed Ganio MS, Johnson EC, Klau JF, Anderson JM, Casa DJ, Maresh CM, et al. Effect of ambient temperature on caffeine ergogenicity during endurance exercise. Eur J Appl Physiol. 2011;111:1135–46.CrossRefPubMed
22.
go back to reference Mc Naughton LR, Lovell RJ, Siegler JC, Midgley AW, Sandstrom M, Bentley DJ. The effects of caffeine ingestion on time trial cycling performance. J Sports Med Phys Fitness. 2008;48:320–5.PubMed Mc Naughton LR, Lovell RJ, Siegler JC, Midgley AW, Sandstrom M, Bentley DJ. The effects of caffeine ingestion on time trial cycling performance. J Sports Med Phys Fitness. 2008;48:320–5.PubMed
23.
go back to reference Ivy JL, Costill DL, Fink WJ, Lower RW. Influence of caffeine and carbohydrate feedings on endurance performance. Med Sci Sports. 1979;11:6–11.CrossRefPubMed Ivy JL, Costill DL, Fink WJ, Lower RW. Influence of caffeine and carbohydrate feedings on endurance performance. Med Sci Sports. 1979;11:6–11.CrossRefPubMed
24.
go back to reference Hogervorst E, Riedel W, Kovacs E, Brouns F, Jolles J. Caffeine Improves Cognitive Performance After Strenuous Physical Exercise. Int J Sports Med. 1999;20:354–61.CrossRefPubMed Hogervorst E, Riedel W, Kovacs E, Brouns F, Jolles J. Caffeine Improves Cognitive Performance After Strenuous Physical Exercise. Int J Sports Med. 1999;20:354–61.CrossRefPubMed
25.
go back to reference Anderson ME, Bruce CR, Fraser SF, Stepto NK, Klein R, Hopkins WG, et al. Improved 2000-meter rowing performance in competitive oarswomen after caffeine ingestion. Int J Sport Nutr Exerc Metab. 2000;10:464–75.CrossRefPubMed Anderson ME, Bruce CR, Fraser SF, Stepto NK, Klein R, Hopkins WG, et al. Improved 2000-meter rowing performance in competitive oarswomen after caffeine ingestion. Int J Sport Nutr Exerc Metab. 2000;10:464–75.CrossRefPubMed
26.
go back to reference Bruce CR, Anderson ME, Fraser SF, Stepto NK, Klein R, Hopkins WG, et al. Enhancement of 2000-m rowing performance after caffeine ingestion. Med Sci Sports Exerc. 2000;32:1958–63.CrossRefPubMed Bruce CR, Anderson ME, Fraser SF, Stepto NK, Klein R, Hopkins WG, et al. Enhancement of 2000-m rowing performance after caffeine ingestion. Med Sci Sports Exerc. 2000;32:1958–63.CrossRefPubMed
27.
go back to reference Bridge CA, Jones MA. The effect of caffeine ingestion on 8 km run performance in a field setting. J Sports Sci. 2006;24:433–9.CrossRefPubMed Bridge CA, Jones MA. The effect of caffeine ingestion on 8 km run performance in a field setting. J Sports Sci. 2006;24:433–9.CrossRefPubMed
28.
go back to reference Wiles JD, Coleman D, Tegerdine M, Swaine IL. The effects of caffeine ingestion on performance time, speed and power during a laboratory-based 1 km cycling time-trial. J Sports Sci. 2006;24:1165–71.CrossRefPubMed Wiles JD, Coleman D, Tegerdine M, Swaine IL. The effects of caffeine ingestion on performance time, speed and power during a laboratory-based 1 km cycling time-trial. J Sports Sci. 2006;24:1165–71.CrossRefPubMed
30.
go back to reference Kovacs EMR, Stegen JHCH, Brouns F. Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance. J Appl Physiol. 1998;85:709–15.CrossRefPubMed Kovacs EMR, Stegen JHCH, Brouns F. Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance. J Appl Physiol. 1998;85:709–15.CrossRefPubMed
31.
go back to reference Spence AL, Sim M, Landers G, Peeling P. A comparison of caffeine versus pseudoephedrine on cycling time-trial performance. Int J Sport Nutr Exerc Metab. 2013;23:507–12.CrossRefPubMed Spence AL, Sim M, Landers G, Peeling P. A comparison of caffeine versus pseudoephedrine on cycling time-trial performance. Int J Sport Nutr Exerc Metab. 2013;23:507–12.CrossRefPubMed
32.
go back to reference van Nieuwenhoven MA, Brouns F, Kovacs EMR. The effect of two sports drinks and water on GI Complaints And Performance During an 18-km run. Int J Sports Med. 2005;26:281–5.CrossRefPubMed van Nieuwenhoven MA, Brouns F, Kovacs EMR. The effect of two sports drinks and water on GI Complaints And Performance During an 18-km run. Int J Sports Med. 2005;26:281–5.CrossRefPubMed
33.
go back to reference Hulston CJ, Jeukendrup AE. Substrate metabolism and exercise performance with caffeine and carbohydrate intake. Med Sci Sports Exerc. 2008;40:2096–104.CrossRefPubMed Hulston CJ, Jeukendrup AE. Substrate metabolism and exercise performance with caffeine and carbohydrate intake. Med Sci Sports Exerc. 2008;40:2096–104.CrossRefPubMed
34.
go back to reference Hunter AM, St Clair Gibson A, Collins M, Lambert M, Noakes TD. Caffeine ingestion does not alter performance during a 100-km cycling time-trial performance. Int J Sport Nutr Exerc Metab. 2002;12:438–52.CrossRefPubMed Hunter AM, St Clair Gibson A, Collins M, Lambert M, Noakes TD. Caffeine ingestion does not alter performance during a 100-km cycling time-trial performance. Int J Sport Nutr Exerc Metab. 2002;12:438–52.CrossRefPubMed
35.
go back to reference Miller B, O’Connor H, Orr R, Ruell P, Cheng HL, Chow CM. Combined caffeine and carbohydrate ingestion: effects on nocturnal sleep and exercise performance in athletes. Eur J Appl Physiol. 2014;114:2529–37.CrossRefPubMed Miller B, O’Connor H, Orr R, Ruell P, Cheng HL, Chow CM. Combined caffeine and carbohydrate ingestion: effects on nocturnal sleep and exercise performance in athletes. Eur J Appl Physiol. 2014;114:2529–37.CrossRefPubMed
36.
go back to reference Loy BD, O’Connor PJ, Lindheimer JB, Covert SF. Caffeine is ergogenic for adenosine A2A receptor gene (ADORA2A) T allele homozygotes: a pilot study. J Caffeine Res. 2015;5:73–81.CrossRef Loy BD, O’Connor PJ, Lindheimer JB, Covert SF. Caffeine is ergogenic for adenosine A2A receptor gene (ADORA2A) T allele homozygotes: a pilot study. J Caffeine Res. 2015;5:73–81.CrossRef
37.
go back to reference Roelands B, Buyse L, Pauwels F, Delbeke F, Deventer K, Meeusen R. No effect of caffeine on exercise performance in high ambient temperature. Eur J Appl Physiol. 2011;111:3089–95.CrossRefPubMed Roelands B, Buyse L, Pauwels F, Delbeke F, Deventer K, Meeusen R. No effect of caffeine on exercise performance in high ambient temperature. Eur J Appl Physiol. 2011;111:3089–95.CrossRefPubMed
38.
go back to reference Cohen BS, Nelson AG, Prevost MC, Thompson GD, Marx BD, Morris GS. Effects of caffeine ingestion on endurance racing in heat and humidity. Eur J Appl Physiol Occup Physiol. 1996;73:358–63.CrossRefPubMed Cohen BS, Nelson AG, Prevost MC, Thompson GD, Marx BD, Morris GS. Effects of caffeine ingestion on endurance racing in heat and humidity. Eur J Appl Physiol Occup Physiol. 1996;73:358–63.CrossRefPubMed
39.
go back to reference MacIntosh BR, Wright BM. Caffeine ingestion and performance of a 1,500-metre swim. Can J Appl Physiol. 1995;20:168–77.CrossRefPubMed MacIntosh BR, Wright BM. Caffeine ingestion and performance of a 1,500-metre swim. Can J Appl Physiol. 1995;20:168–77.CrossRefPubMed
40.
go back to reference Jacobson TL, Febbraio MA, Arkinstall MJ, Hawley JA. Effect of caffeine co-ingested with carbohydrate or fat on metabolism and performance in endurance-trained men. Exp Physiol. 2001;86:137–44.CrossRefPubMed Jacobson TL, Febbraio MA, Arkinstall MJ, Hawley JA. Effect of caffeine co-ingested with carbohydrate or fat on metabolism and performance in endurance-trained men. Exp Physiol. 2001;86:137–44.CrossRefPubMed
41.
go back to reference Skinner TL, Jenkins DG, Coombes JS, Taaffe DR, Leveritt MD. Dose response of caffeine on 2000-m rowing performance. Med Sci Sports Exerc. 2010;42:571–6.CrossRefPubMed Skinner TL, Jenkins DG, Coombes JS, Taaffe DR, Leveritt MD. Dose response of caffeine on 2000-m rowing performance. Med Sci Sports Exerc. 2010;42:571–6.CrossRefPubMed
42.
go back to reference Bortolotti H, Altimari LR, Vitor-Costa M, Cyrino ES. Performance during a 20-km cycling time-trial after caffeine ingestion. J Int Soc Sports Nutr. 2014;11:45.CrossRefPubMedPubMedCentral Bortolotti H, Altimari LR, Vitor-Costa M, Cyrino ES. Performance during a 20-km cycling time-trial after caffeine ingestion. J Int Soc Sports Nutr. 2014;11:45.CrossRefPubMedPubMedCentral
43.
go back to reference Astorino TA, Cottrell T, Lozano AT, Aburto-Pratt K, Duhon J. Ergogenic effects of Caffeine on simulated time-trial performance are independent of fitness Level. J Caffeine Res. 2011;1:179–85.CrossRef Astorino TA, Cottrell T, Lozano AT, Aburto-Pratt K, Duhon J. Ergogenic effects of Caffeine on simulated time-trial performance are independent of fitness Level. J Caffeine Res. 2011;1:179–85.CrossRef
45.
go back to reference Stadheim HK, Nossum EM, Olsen R, Spencer M, Jensen J. Caffeine improves performance in double poling during acute exposure to 2000-m altitude. J Appl Physiol. 2015;119:1501–9.CrossRefPubMed Stadheim HK, Nossum EM, Olsen R, Spencer M, Jensen J. Caffeine improves performance in double poling during acute exposure to 2000-m altitude. J Appl Physiol. 2015;119:1501–9.CrossRefPubMed
46.
go back to reference Acker-Hewitt TL, Shafer BM, Saunders MJ, Goh Q, Luden ND. Independent and combined effects of carbohydrate and caffeine ingestion on aerobic cycling performance in the fed state. Appl Physiol Nutr Metab. 2012;37:276–83.CrossRefPubMed Acker-Hewitt TL, Shafer BM, Saunders MJ, Goh Q, Luden ND. Independent and combined effects of carbohydrate and caffeine ingestion on aerobic cycling performance in the fed state. Appl Physiol Nutr Metab. 2012;37:276–83.CrossRefPubMed
47.
go back to reference Carr AJ, Gore CJ, Dawson B. Induced alkalosis and caffeine supplementation: effects on 2000-m rowing performance. Int J Sport Nutr Exerc Metab. 2011;21:357–64.CrossRefPubMed Carr AJ, Gore CJ, Dawson B. Induced alkalosis and caffeine supplementation: effects on 2000-m rowing performance. Int J Sport Nutr Exerc Metab. 2011;21:357–64.CrossRefPubMed
48.
go back to reference Church DD, Hoffman JR, LaMonica MB, Riffe JJ, Hoffman MW, Baker KM, et al. The effect of an acute ingestion of Turkish coffee on reaction time and time trial performance. J Int Soc Sports Nutr BioMed Central. 2015;12:37.CrossRef Church DD, Hoffman JR, LaMonica MB, Riffe JJ, Hoffman MW, Baker KM, et al. The effect of an acute ingestion of Turkish coffee on reaction time and time trial performance. J Int Soc Sports Nutr BioMed Central. 2015;12:37.CrossRef
49.
go back to reference O’Rourke MP, O’Brien BJ, Knez W, Paton CD. Caffeine has a small effect on 5-km running performance of well-trained and recreational runners. J Sci Med Sport. 2008;11:231–3.CrossRefPubMed O’Rourke MP, O’Brien BJ, Knez W, Paton CD. Caffeine has a small effect on 5-km running performance of well-trained and recreational runners. J Sci Med Sport. 2008;11:231–3.CrossRefPubMed
50.
go back to reference Desbrow B, Barret CM, Minahan CL, Grant GD, Leveritt MD. Caffeine, cycling performance, and exogenous CHO oxidation. Med Sci Sport Exerc. 2009;41:1744–51.CrossRef Desbrow B, Barret CM, Minahan CL, Grant GD, Leveritt MD. Caffeine, cycling performance, and exogenous CHO oxidation. Med Sci Sport Exerc. 2009;41:1744–51.CrossRef
51.
go back to reference Kilding AE, Overton C, Gleave J. Effects of Caffeine, sodium bicarbonate, and their combined ingestion on high-intensity cycling performance. Int J Sport Nutr Exerc Metab. 2012;22:175–83.CrossRefPubMed Kilding AE, Overton C, Gleave J. Effects of Caffeine, sodium bicarbonate, and their combined ingestion on high-intensity cycling performance. Int J Sport Nutr Exerc Metab. 2012;22:175–83.CrossRefPubMed
52.
go back to reference Dean S, Braakhuis A, Paton C. The effects of EGCG on Fat oxidation and endurance performance in male cyclists. Int J Sport Nutr Exerc Metab. 2009;19:624–44.CrossRefPubMed Dean S, Braakhuis A, Paton C. The effects of EGCG on Fat oxidation and endurance performance in male cyclists. Int J Sport Nutr Exerc Metab. 2009;19:624–44.CrossRefPubMed
53.
go back to reference Bell DG, McLellan TM, Sabiston CM. Effect of ingesting caffeine and ephedrine on 10-km run performance. Med Sci Sports Exerc. 2002;34:344–9.CrossRefPubMed Bell DG, McLellan TM, Sabiston CM. Effect of ingesting caffeine and ephedrine on 10-km run performance. Med Sci Sports Exerc. 2002;34:344–9.CrossRefPubMed
54.
go back to reference Astorino TA, Cottrell T, Lozano AT, Aburto-Pratt K, Duhon J. Increases in cycling performance in response to caffeine ingestion are repeatable. Nutr Res. 2012;32:78–84.CrossRefPubMed Astorino TA, Cottrell T, Lozano AT, Aburto-Pratt K, Duhon J. Increases in cycling performance in response to caffeine ingestion are repeatable. Nutr Res. 2012;32:78–84.CrossRefPubMed
55.
go back to reference Skinner TL, Jenkins DG, Taaffe DR, Leveritt MD, Coombes JS. Coinciding exercise with peak serum caffeine does not improve cycling performance. J Sci Med Sport. 2013;16:54–9.CrossRefPubMed Skinner TL, Jenkins DG, Taaffe DR, Leveritt MD, Coombes JS. Coinciding exercise with peak serum caffeine does not improve cycling performance. J Sci Med Sport. 2013;16:54–9.CrossRefPubMed
56.
go back to reference Womack CJ, Saunders MJ, Bechtel MK, Bolton DJ, Martin M, Luden ND, et al. The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine. J Int Soc Sports Nutr. 2012;9(1):7.CrossRefPubMedPubMedCentral Womack CJ, Saunders MJ, Bechtel MK, Bolton DJ, Martin M, Luden ND, et al. The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine. J Int Soc Sports Nutr. 2012;9(1):7.CrossRefPubMedPubMedCentral
57.
go back to reference Desbrow B, Biddulph C, Devlin B, Grant GD, Anoopkumar-Dukie S, Leveritt MD. The effects of different doses of caffeine on endurance cycling time trial performance. J Sports Sci. 2012;30:115–20.CrossRefPubMed Desbrow B, Biddulph C, Devlin B, Grant GD, Anoopkumar-Dukie S, Leveritt MD. The effects of different doses of caffeine on endurance cycling time trial performance. J Sports Sci. 2012;30:115–20.CrossRefPubMed
58.
go back to reference Gonçalves LS, Painelli VS, Yamaguchi G, de Oliveira LF, Saunders B, da Silva RP, et al. Dispelling the myth that habitual caffeine consumption influences the performance response to acute caffeine supplementation. J Appl Physiol. 2017;123:213–20.CrossRefPubMed Gonçalves LS, Painelli VS, Yamaguchi G, de Oliveira LF, Saunders B, da Silva RP, et al. Dispelling the myth that habitual caffeine consumption influences the performance response to acute caffeine supplementation. J Appl Physiol. 2017;123:213–20.CrossRefPubMed
59.
go back to reference Irwin C, Desbrow B, Ellis A, O’Keeffe B, Grant G, Leveritt M. Caffeine withdrawal and high-intensity endurance cycling performance. J Sports Sci. 2011;29:509–15.CrossRefPubMed Irwin C, Desbrow B, Ellis A, O’Keeffe B, Grant G, Leveritt M. Caffeine withdrawal and high-intensity endurance cycling performance. J Sports Sci. 2011;29:509–15.CrossRefPubMed
60.
go back to reference Graham-Paulson T, Perret C, Goosey-Tolfrey V. Improvements in cycling but not handcycling 10 km time trial performance in habitual caffeine users. Nutrients. 2016;8:393.CrossRefPubMedCentral Graham-Paulson T, Perret C, Goosey-Tolfrey V. Improvements in cycling but not handcycling 10 km time trial performance in habitual caffeine users. Nutrients. 2016;8:393.CrossRefPubMedCentral
61.
go back to reference Quinlivan A, Irwin C, Grant GD, Anoopkumar-Dukie S, Skinner T, Leveritt M, et al. The effects of red bull energy drink compared with caffeine on cycling time-trial performance. Int J Sports Physiol Perform. 2015;10:897–901.CrossRefPubMed Quinlivan A, Irwin C, Grant GD, Anoopkumar-Dukie S, Skinner T, Leveritt M, et al. The effects of red bull energy drink compared with caffeine on cycling time-trial performance. Int J Sports Physiol Perform. 2015;10:897–901.CrossRefPubMed
62.
go back to reference de Santos R, Dal Molin P, Kiss MA, Silva-Cavalcante MD, Correia-Oliveira CR, Bertuzzi R, Bishop DJ, et al. Caffeine Alters Anaerobic Distribution and Pacing during a 4000-m Cycling Time Trial. PLoS One. 2013;8:e75399.CrossRefPubMedCentral de Santos R, Dal Molin P, Kiss MA, Silva-Cavalcante MD, Correia-Oliveira CR, Bertuzzi R, Bishop DJ, et al. Caffeine Alters Anaerobic Distribution and Pacing during a 4000-m Cycling Time Trial. PLoS One. 2013;8:e75399.CrossRefPubMedCentral
63.
go back to reference Glaister M, Pattison JR, Muniz-Pumares D, Patterson SD, Foley P. Effects of dietary nitrate, caffeine, and their combination on 20-km cycling time trial performance. J Strength Cond Res. 2015;29:165–74.CrossRefPubMed Glaister M, Pattison JR, Muniz-Pumares D, Patterson SD, Foley P. Effects of dietary nitrate, caffeine, and their combination on 20-km cycling time trial performance. J Strength Cond Res. 2015;29:165–74.CrossRefPubMed
64.
go back to reference Walker GJ, Dziubak A, Houghton L, Prendergast C, Lim L, Bishop NC. The effect of caffeine ingestion on human neutrophil oxidative burst responses following time-trial cycling. J Sports Sci. 2008;26:611–9.CrossRefPubMed Walker GJ, Dziubak A, Houghton L, Prendergast C, Lim L, Bishop NC. The effect of caffeine ingestion on human neutrophil oxidative burst responses following time-trial cycling. J Sports Sci. 2008;26:611–9.CrossRefPubMed
65.
go back to reference Pitchford NW, Fell JW, Leveritt MD, Desbrow B, Shing CM. Effect of caffeine on cycling time-trial performance in the heat. J Sci Med Sport. 2014;17:445–9.CrossRefPubMed Pitchford NW, Fell JW, Leveritt MD, Desbrow B, Shing CM. Effect of caffeine on cycling time-trial performance in the heat. J Sci Med Sport. 2014;17:445–9.CrossRefPubMed
66.
go back to reference Stadheim HK, Kvamme B, Olsen R, Drevon CA, Ivy JL, Jensen J. Caffeine increases performance in cross-country double-poling time trial exercise. Med Sci Sport Exerc. 2013;45:2175–83.CrossRef Stadheim HK, Kvamme B, Olsen R, Drevon CA, Ivy JL, Jensen J. Caffeine increases performance in cross-country double-poling time trial exercise. Med Sci Sport Exerc. 2013;45:2175–83.CrossRef
67.
go back to reference Hodgson AB, Randell RK, Jeukendrup AE. The Metabolic and Performance Effects of Caffeine Compared to Coffee during Endurance Exercise. PLoS One. 2013;8:59561.CrossRef Hodgson AB, Randell RK, Jeukendrup AE. The Metabolic and Performance Effects of Caffeine Compared to Coffee during Endurance Exercise. PLoS One. 2013;8:59561.CrossRef
69.
go back to reference Cox GR, Desbrow B, Montgomery PG, Anderson ME, Bruce CR, Macrides TA, et al. Effect of different protocols of caffeine intake on metabolism and endurance performance. J Appl Physiol. 2002;93:990–9.CrossRefPubMed Cox GR, Desbrow B, Montgomery PG, Anderson ME, Bruce CR, Macrides TA, et al. Effect of different protocols of caffeine intake on metabolism and endurance performance. J Appl Physiol. 2002;93:990–9.CrossRefPubMed
70.
go back to reference Conway KJ, Orr R, Stannard SR. Effect of a divided caffeine dose on endurance cycling performance, postexercise urinary caffeine concentration, and plasma paraxanthine. J Appl Physiol. 2003;94:1557–62.CrossRefPubMed Conway KJ, Orr R, Stannard SR. Effect of a divided caffeine dose on endurance cycling performance, postexercise urinary caffeine concentration, and plasma paraxanthine. J Appl Physiol. 2003;94:1557–62.CrossRefPubMed
72.
go back to reference Christensen PM, Petersen MH, Friis SN, Bangsbo J. Caffeine, but not bicarbonate, improves 6 min maximal performance in elite rowers. Appl Physiol Nutr Metab. 2014;39:1058–63.CrossRefPubMed Christensen PM, Petersen MH, Friis SN, Bangsbo J. Caffeine, but not bicarbonate, improves 6 min maximal performance in elite rowers. Appl Physiol Nutr Metab. 2014;39:1058–63.CrossRefPubMed
73.
go back to reference Black CD, Waddell DE, Gonglach AR. Caffeine’s ergogenic effects on cycling: Neuromuscular and perceptual factors. Med Sci Sports Exerc. 2015;47(6):1145–58.CrossRefPubMed Black CD, Waddell DE, Gonglach AR. Caffeine’s ergogenic effects on cycling: Neuromuscular and perceptual factors. Med Sci Sports Exerc. 2015;47(6):1145–58.CrossRefPubMed
74.
go back to reference Saunders B, de Oliveira LF, da Silva RP, de Salles Painelli V, Gonçalves LS, Yamaguchi G, et al. Placebo in sports nutrition: a proof-of-principle study involving caffeine supplementation. Scand J Med Sci Sports. 2017;27(11):1240–7.CrossRefPubMed Saunders B, de Oliveira LF, da Silva RP, de Salles Painelli V, Gonçalves LS, Yamaguchi G, et al. Placebo in sports nutrition: a proof-of-principle study involving caffeine supplementation. Scand J Med Sci Sports. 2017;27(11):1240–7.CrossRefPubMed
75.
go back to reference Wallman KE, Goh JW, Guelfi KJ. Effects of caffeine on exercise performance in sedentary females. J Sport Sci Med. 2010;9:183–9. Wallman KE, Goh JW, Guelfi KJ. Effects of caffeine on exercise performance in sedentary females. J Sport Sci Med. 2010;9:183–9.
76.
go back to reference Beaumont RE, James LJ. Effect of a moderate caffeine dose on endurance cycle performance and thermoregulation during prolonged exercise in the heat. J Sci Med Sport. 2017;20(11):1024–8.CrossRefPubMed Beaumont RE, James LJ. Effect of a moderate caffeine dose on endurance cycle performance and thermoregulation during prolonged exercise in the heat. J Sci Med Sport. 2017;20(11):1024–8.CrossRefPubMed
77.
go back to reference Ganio MS, Johnson EC, Lopez RM, Stearns RL, Emmanuel H, Anderson JM, et al. Caffeine lowers muscle pain during exercise in hot but not cool environments. Physiol Behav. 2011;102:429–35.CrossRefPubMed Ganio MS, Johnson EC, Lopez RM, Stearns RL, Emmanuel H, Anderson JM, et al. Caffeine lowers muscle pain during exercise in hot but not cool environments. Physiol Behav. 2011;102:429–35.CrossRefPubMed
78.
go back to reference Laurence G, Wallman K, Guelfi K. Effects of caffeine on time trial performance in sedentary men. J Sports Sci. 2012;30:1235–40.CrossRefPubMed Laurence G, Wallman K, Guelfi K. Effects of caffeine on time trial performance in sedentary men. J Sports Sci. 2012;30:1235–40.CrossRefPubMed
79.
go back to reference Collomp K, Candau R, Millet G, Mucci P, Borrani F, Préfaut C, et al. Effects of salbutamol and caffeine ingestion on exercise metabolism and performance. Int J Sports Med. 2002;23:549–54.CrossRefPubMed Collomp K, Candau R, Millet G, Mucci P, Borrani F, Préfaut C, et al. Effects of salbutamol and caffeine ingestion on exercise metabolism and performance. Int J Sports Med. 2002;23:549–54.CrossRefPubMed
80.
go back to reference Jenkins NT, Trilk JL, Singhal A, O’Connor PJ, Cureton KJ. Ergogenic effects of low doses of caffeine on cycling performance. Int J Sport Nutr Exerc Metab. 2008;18:328–42.CrossRefPubMed Jenkins NT, Trilk JL, Singhal A, O’Connor PJ, Cureton KJ. Ergogenic effects of low doses of caffeine on cycling performance. Int J Sport Nutr Exerc Metab. 2008;18:328–42.CrossRefPubMed
81.
go back to reference Loy BD, O’Connor PJ, Lindheimer JB, Covert SF. Caffeine is ergogenic for adenosine A 2A receptor gene (ADORA2A) T allele homozygotes: a pilot Study. J Caffeine Res. 2015;5:73–81.CrossRef Loy BD, O’Connor PJ, Lindheimer JB, Covert SF. Caffeine is ergogenic for adenosine A 2A receptor gene (ADORA2A) T allele homozygotes: a pilot Study. J Caffeine Res. 2015;5:73–81.CrossRef
82.
go back to reference Hopkins WG. How to interpret changes in an athletic performance test. Sportscience. 2004;8:1–7. Hopkins WG. How to interpret changes in an athletic performance test. Sportscience. 2004;8:1–7.
83.
go back to reference Magkos F, Kavouras SA. Caffeine Use in Sports, Pharmacokinetics in Man, and Cellular Mechanisms of Action. Crit Rev Food Sci Nutr. 2005;45:535–62.CrossRefPubMed Magkos F, Kavouras SA. Caffeine Use in Sports, Pharmacokinetics in Man, and Cellular Mechanisms of Action. Crit Rev Food Sci Nutr. 2005;45:535–62.CrossRefPubMed
84.
go back to reference Chung W, Kang J, Park C, Cho M, Cha Y. Effect of age and smoking on in vivo CYP1A2, flavin-containing monooxygenase, and xanthine oxidase activities in Koreans: determination by caffeine metabolism. Clin Pharmacol Ther. 2000;67:258–66.CrossRefPubMed Chung W, Kang J, Park C, Cho M, Cha Y. Effect of age and smoking on in vivo CYP1A2, flavin-containing monooxygenase, and xanthine oxidase activities in Koreans: determination by caffeine metabolism. Clin Pharmacol Ther. 2000;67:258–66.CrossRefPubMed
85.
go back to reference Abernethy DR, Todd EL. Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin. 1985;28:425–8.CrossRef Abernethy DR, Todd EL. Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin. 1985;28:425–8.CrossRef
87.
88.
go back to reference Butler MA, Iwasakit M, Guengericht FP, Kadlubar FF. Human cytochrome P-450PA (P-450IA2), the phenacetin O-deet-hylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Biochemistry. 1989;86:7696–700. Butler MA, Iwasakit M, Guengericht FP, Kadlubar FF. Human cytochrome P-450PA (P-450IA2), the phenacetin O-deet-hylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Biochemistry. 1989;86:7696–700.
89.
go back to reference Sachse C, Brockmöller J, Bauer S, Roots I. Functional significance of a C → A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol. 1999;47:445–9.CrossRefPubMedPubMedCentral Sachse C, Brockmöller J, Bauer S, Roots I. Functional significance of a C → A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol. 1999;47:445–9.CrossRefPubMedPubMedCentral
90.
go back to reference Ghotbi R, Christensen M, Roh H-K, Ingelman-Sundberg M, Aklillu E, Bertilsson L. Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans. Eur J Clin Pharmacol. 2007;63:537–46.CrossRefPubMed Ghotbi R, Christensen M, Roh H-K, Ingelman-Sundberg M, Aklillu E, Bertilsson L. Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans. Eur J Clin Pharmacol. 2007;63:537–46.CrossRefPubMed
91.
go back to reference Djordjevic N, Ghotbi R, Jankovic S, Aklillu E. Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 −163C > A polymorphism. Eur J Clin Pharmacol. 2010;66:697–703.CrossRefPubMed Djordjevic N, Ghotbi R, Jankovic S, Aklillu E. Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 −163C > A polymorphism. Eur J Clin Pharmacol. 2010;66:697–703.CrossRefPubMed
92.
go back to reference Desbrow B, Leveritt M. Awareness and Use of Caffeine by Athletes Competing at the 2005 Ironman Triathlon World Championships. Int J Sport Nutr Exerc Metab. 2006;16:545–58.CrossRefPubMed Desbrow B, Leveritt M. Awareness and Use of Caffeine by Athletes Competing at the 2005 Ironman Triathlon World Championships. Int J Sport Nutr Exerc Metab. 2006;16:545–58.CrossRefPubMed
93.
go back to reference IAAF.ORG. IAAF Top Lists Half marathon [Internet]. [cited 2017 Nov 12]. IAAF.ORG. IAAF Top Lists Half marathon [Internet]. [cited 2017 Nov 12].
Metadata
Title
The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta–Analysis
Authors
Kyle Southward
Kay J. Rutherfurd-Markwick
Ajmol Ali
Publication date
01-08-2018
Publisher
Springer International Publishing
Published in
Sports Medicine / Issue 8/2018
Print ISSN: 0112-1642
Electronic ISSN: 1179-2035
DOI
https://doi.org/10.1007/s40279-018-0939-8

Other articles of this Issue 8/2018

Sports Medicine 8/2018 Go to the issue