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Drugs & Aging

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01-05-2018 | Systematic Review

Medications and Prescribing Patterns as Factors Associated with Hospitalizations from Long-Term Care Facilities: A Systematic Review

Authors: Kate N. Wang, J. Simon Bell, Esa Y. H. Chen, Julia F. M. Gilmartin-Thomas, Jenni Ilomäki

Published in: Drugs & Aging | Issue 5/2018

Abstract

Background

Residents of long-term care facilities (LTCFs) are at high risk of hospitalization. Medications are a potentially modifiable risk factor for hospitalizations.

Objective

Our objective was to systematically review the association between medications or prescribing patterns and hospitalizations from LTCFs.

Methods

We searched MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and International Pharmaceutical Abstracts (IPA) from inception to August 2017 for longitudinal studies reporting associations between medications or prescribing patterns and hospitalizations. Two independent investigators completed the study selection, data extraction and quality assessment using the Joanna Briggs Institute Critical Appraisal Tools.

Results

Three randomized controlled trials (RCTs), 22 cohort studies, five case–control studies, one case-time-control study and one case-crossover study, investigating 13 different medication classes and two prescribing patterns were included. An RCT demonstrated that high-dose influenza vaccination reduced all-cause hospitalization compared with standard-dose vaccination (risk ratio [RR] 0.93; 95% confidence interval [CI] 0.88–0.98). Another RCT found no difference in hospitalization rates between oseltamivir as influenza treatment and oseltamivir as treatment plus prophylaxis (treatment = 4.7%, treatment and prophylaxis = 3.5%; p = 0.7). The third RCT found no difference between multivitamin/mineral supplementation and hospitalization (odds ratio [OR] 0.94; 95% CI 0.74–1.20) or emergency department visits (OR 1.05; 95% CI 0.76–1.47). Two cohort studies demonstrated influenza vaccination reduced hospitalization. Four studies suggested polypharmacy and potentially inappropriate medications (PIMs) increased all-cause hospitalization. However, associations between polypharmacy (two studies), PIMs (one study) and fall-related hospitalizations were inconsistent. Inconsistent associations were found between psychotropic medications with all-cause and cause-specific hospitalizations (11 studies). Warfarin, nonsteroidal anti-inflammatory drugs, pantoprazole and vinpocetine but not long-term acetylsalicylic acid (aspirin), statins, trimetazidine, digoxin or β-blockers were associated with all-cause or cause-specific hospitalizations in single studies of specific resident populations. Most cohort studies assessed prevalent rather than incident medication exposure, and no studies considered time-varying medication use.

Conclusion

High-quality evidence suggests influenza vaccination reduces hospitalization. Polypharmacy and PIMs are consistently associated with increased all-cause hospitalization.

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Grabowski DC, Stewart KA, Broderick SM, Coots LA. Predictors of nursing home hospitalization: a review of the literature. Med Care Res Rev. 2007;65(1):3–39.CrossRef

Ouslander JG, Lamb G, Perloe M, Givens JH, Kluge L, Rutland T, et al. Potentially avoidable hospitalizations of nursing home residents: frequency, causes, and costs. J Am Geriatr Soc. 2010;58(4):627–35.CrossRefPubMed

Saliba D, Kington R, Buchanan J, Bell R, Wang M, Lee M, et al. Appropriateness of the decision to transfer nursing facility residents to the hospital. J Am Geriatr Soc. 2000;48(2):154–63.CrossRefPubMed

Hirsch CH, Sommers L, Olsen A, Mullen L, Winograd CH. The natural history of functional morbidity in hospitalized older patients. J Am Geriatr Soc. 1990;38(12):1296–303.CrossRefPubMed

Covinsky KE, Palmer RM, Fortinsky RH, Counsell SR, Stewart AL, Kresevic D, et al. Loss of independence in activities of daily living in older adults hospitalized with medical illnesses: increased vulnerability with age. J Am Geriatr Soc. 2003;51(4):451–8.CrossRefPubMed

Torio CM, Moore BJ. National inpatient hospital costs: the most expensive conditions by payer 2013. In: Statistical brief 204. Agency for Healthcare Research and Quality, Rockville. 2016. https://www.hcup-us.ahrq.gov/reports/statbriefs/sb204-Most-Expensive-Hospital-Conditions.jsp. Accessed 16 Sept 2017.

Castle NG, Mor V. Hospitalization of nursing home residents: a review of the literature, 1980–1995. Med Care Res Rev. 1996;53(2):123–48.CrossRefPubMed

Graverholt B, Forsetlund L, Jamtvedt G. Reducing hospital admissions from nursing homes: a systematic review. BMC Health Serv Res. 2014;14:36.CrossRefPubMedPubMedCentral

Konetzka RT, Spector W, Limcangco MR. Reducing hospitalizations from long-term care settings. Med Care Res Rev. 2008;65(1):40–66.CrossRefPubMed

10.

Murray LM, Laditka SB. Care transitions by older adults from nursing homes to hospitals: implications for long-term care practice, geriatrics education, and research. J Am Med Dir Assoc. 2010;11(4):231–8.CrossRefPubMed

11.

Roughead EE, Semple SJ. Medication safety in acute care in Australia: where are we now? Part 1: a review of the extent and causes of medication problems 2002–2008. Aust N Z Health Policy. 2009;6(18). https://doi.org/10.1186/1743-8462-6-18.

12.

Jokanovic N, Tan ECK, Dooley MJ, Kirkpatrick CM, Bell JS. Prevalence and factors associated with polypharmacy in long-term care facilities: a systematic review. J Am Med Dir Assoc. 2015;16(6):535.CrossRefPubMed

13.

Nguyen JK, Fouts MM, Kotabe SE, Lo E. Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. Am J Geriatr Pharmacother. 2006;4(1):36–41. https://doi.org/10.1016/j.amjopharm.2006.03.002.CrossRefPubMed

14.

Fleg JL, Aronow WS, Frishman WH. Cardiovascular drug therapy in the elderly: benefits and challenges. Nat Rev Cardiol. 2011;8(1):13–28.CrossRefPubMed

15.

Sanford AM, Orrell M, Tolson D, Abbatecola AM, Arai H, Bauer JM, et al. An international definition for nursing home. J Am Med Dir Assoc. 2015;16(3):181–4. https://doi.org/10.1016/j.jamda.2014.12.013.CrossRefPubMed

16.

Critical appraisal tools. Joanna Briggs Institute. 2016. http://joannabriggs.org/research/critical-appraisal-tools.html. Accessed 26 Sept 2017.

17.

Chan TC, Luk JK, Shea YF, Lau KH, Chan FH, Yu GK, et al. Continuous use of antipsychotics and its association with mortality and hospitalization in institutionalized Chinese older adults: an 18-month prospective cohort study. Int Psychogeriatr. 2011;23(10):1640–8.CrossRefPubMed

18.

Cherubini A, Eusebi P, Dell’Aquila G, Landi F, Gasperini B, Bacuccoli R, et al. Predictors of hospitalization in Italian nursing home residents: the U.L.I.S.S.E. project. J Am Med Dir Assoc. 2012;13(1):84. https://doi.org/10.1016/j.jamda.2011.04.001.CrossRefPubMed

19.

Cooper JW, Freeman MH, Cook CL, Burfield AH. Psychotropic and psychoactive drugs and hospitalization rates in nursing facility residents. Pharm Pract (Granada). 2007;5(3):140–4.CrossRef

20.

Dedhiya SD, Hancock E, Craig BA, Doebbeling CC, Thomas J 3rd. Incident use and outcomes associated with potentially inappropriate medication use in older adults. Am J Geriatr Pharmacother. 2010;8(6):562–70.CrossRefPubMed

21.

Eaton CB, Lapane KL, Murphy JB, Hume AL. Effect of statin (HMG-Co-A-Reductase Inhibitor) use on 1-year mortality and hospitalization rates in older patients with cardiovascular disease living in nursing homes. J Am Geriatr Soc. 2002;50(8):1389–95.CrossRefPubMed

22.

Gorisek Miksic N, Ursic T, Simonovic Z, Lusa L, Lobnik Rojko P, Petrovec M, et al. Oseltamivir prophylaxis in controlling influenza outbreak in nursing homes: a comparison between three different approaches. Infection. 2015;43(1):73–81.CrossRefPubMed

23.

Jung HY, Meucci M, Unruh MA, Mor V, Dosa D. Antipsychotic use in nursing home residents admitted with hip fracture. J Am Geriatr Soc. 2013;61(1):101–6.CrossRefPubMed

24.

Lalic S, Sluggett JK, Ilomaki J, Wimmer B, Tan ECK, Robson L, et al. Polypharmacy and medication regimen complexity as risk factors for hospitalization among residents of long-term care facilities: a prospective cohort study. J Am Med Dir Assoc. 2016;17(11):1067.e1–6.CrossRef

25.

Lapane KL, Hume AL, Barbour MM, Lipsitz LA. Does aspirin attenuate the effect of angiotensin-converting enzyme inhibitors on health outcomes of very old patients with heart failure? J Am Geriatr Soc. 2002;50(7):1198–204.CrossRefPubMed

26.

Lapane KL, Spooner JJ, Mucha L, Straus WL. Effect of nonsteroidal anti-inflammatory drug use on the rate of gastrointestinal hospitalizations among people living in long-term care. J Am Geriatr Soc. 2001;49(5):577–84. https://doi.org/10.1046/j.1532-5415.2001.49117.x.CrossRefPubMed

27.

Lau DT, Kasper JD, Potter DE, Lyles A, Bennett RG. Hospitalization and death associated with potentially inappropriate medication prescriptions among elderly nursing home residents. Arch Intern Med. 2005;17(11):68–74. https://doi.org/10.1016/j.jamda.2016.08.019.CrossRef

28.

Leung AY, Kwan CW, Chi I. Residents with Alzheimer’s disease in long-term care facilities in Hong Kong: patterns of hospitalization and emergency room use. Aging Ment Health. 2013;17(8):959–65.CrossRefPubMed

29.

Patriarca PA, Weber JA, Parker RA. Efficacy of influenza vaccine in nursing homes. Reduction in illness and complications during an influenza A (H3N2) epidemic. J Am Med Assoc. 1985;253(8):1136–9.CrossRef

30.

Rochon PA, Normand SL, Gomes T, Gill SS, Anderson GM, Melo M, et al. Antipsychotic therapy and short-term serious events in older adults with dementia. Arch Intern Med. 2008;168(10):1090–6.CrossRefPubMed

31.

Ruggiero C, Dell’Aquila G, Gasperini B, Onder G, Grp US. Potentially inappropriate drug prescriptions and risk of hospitalization among older, Italian, nursing home residents: the ULISSE project. Drugs Aging. 2010;27(9):747–58.CrossRefPubMed

32.

Simoni-Wastila L, Ryder PT, Qian J, Zuckerman IH, Shaffer T, Zhao L. Association of antipsychotic use with hospital events and mortality among medicare beneficiaries residing in long-term care facilities. Am J Geriatr Psychiatry. 2009;17(5):417–27. https://doi.org/10.1097/JGP.0b013e31819b8936.CrossRefPubMedPubMedCentral

33.

Deguchi Y, Nishimura K. Efficacy of influenza vaccine in elderly persons in welfare nursing homes: reduction in risks of mortality and morbidity during an influenza A (H3N2) epidemic. J Gerontol A Biol Sci Med Sci. 2001;56(6):391–4.CrossRef

34.

Steinman MA, Zullo AR, Lee Y, et al. Association of β-blockers with functional outcomes, death, and rehospitalization in older nursing home residents after acute myocardial infarction. JAMA Intern Med. 2017;177(2):254–62.CrossRefPubMedPubMedCentral

35.

Liperoti R, Pedone C, Lapane KL, Mor V, Bernabei R, Gambassi G. Venous thromboembolism among elderly patients treated with atypical and conventional antipsychotic agents. Arch Intern Med. 2005;165(22):2677–82.CrossRefPubMed

36.

Lackner TE, Heard T, Glunz S, Gann N, Babington M, Malone DC. Gastrointestinal disease control after histamine-2-receptor antagonist dose modification for renal impairment in frail chronically Ill elderly patients. J Am Geriatr Soc. 2003;51(5):650–6.CrossRefPubMed

37.

Bor A, Matuz M, Csatordai M, Szalai G, Balint A, Benko R, et al. Medication use and risk of falls among nursing home residents: a retrospective cohort study. Int J Clin Pharm. 2017;39(2):408–15.CrossRefPubMed

38.

Sheriff HM, Thogaripally MR, Panjrath G, Arundel C, Zeng Q, Fonarow GC, et al. Digoxin and 30-day all-cause readmission in long-term care residents hospitalized for heart failure. J Am Med Dir Assoc. 2017;18(9):761–5. https://doi.org/10.1016/j.jamda.2017.03.016.CrossRefPubMedPubMedCentral

39.

Quilliam BJ, Lapane KL, Eaton CB, Mor V. Effect of antiplatelet and anticoagulant agents on risk of hospitalization for bleeding among a population of elderly nursing home stroke survivors. Stroke. 2001;32(10):2299–304.CrossRefPubMed

40.

Liperoti R, Gambassi G, Lapane KL, Chiang C, Pedone C, Mor V, et al. Cerebrovascular events among elderly nursing home patients treated with conventional or atypical antipsychotics. J Clin Psychiatry. 2005;66(9):1090–6.CrossRefPubMed

41.

Liperoti R, Gambassi G, Lapane KL, Chiang C, Pedone C, Mor V, et al. Conventional and atypical antipsychotics and the risk of hospitalization for ventricular arrhythmias or cardiac arrest. Arch Intern Med. 2005;165(6):696–701.CrossRefPubMed

42.

Liperoti R, Onder G, Lapane KL, Mor V, Friedman JH, Bernabei R, et al. Conventional or atypical antipsychotics and the risk of femur fracture among elderly patients: results of a case-control study. J Clin Psychiatry. 2007;68(6):929–34.CrossRefPubMed

43.

Ryan-Atwood TE, Hutchinson-Kern M, Ilomaki J, Dooley MJ, Poole SG, Kirkpatrick CM, et al. Medication use and fall-related hospital admissions from long-term care facilities: a hospital-based case-control study. Drugs Aging. 2017;34(8):625–33.CrossRefPubMed

44.

Booy R, Lindley RI, Dwyer DE, Yin JK, Heron LG, Moffatt CR, et al. Treating and preventing influenza in aged care facilities: a cluster randomised controlled trial. PLoS One. 2012;7(10):e46509. https://doi.org/10.1371/journal.pone.0046509.CrossRefPubMedPubMedCentral

45.

Liu BA, McGeer A, McArthur MA, Simor AE, Aghdassi E, Davis L, et al. Effect of multivitamin and mineral supplementation on episodes of infection in nursing home residents: a randomized, placebo-controlled study. J Am Geriatr Soc. 2007;55(1):35–42.CrossRefPubMed

46.

Gravenstein S, Davidson HE, Taljaard M, Ogarek J, Gozalo P, Han L, et al. Comparative effectiveness of high-dose versus standard-dose influenza vaccination on numbers of US nursing home residents admitted to hospital: a cluster-randomised trial. Lancet Respir Med. 2017;5(9):738–46.CrossRefPubMed

47.

Price SD, Holman CD, Sanfilippo FM, Emery JD. Are high-care nursing home residents at greater risk of unplanned hospital admission than other elderly patients when exposed to Beers potentially inappropriate medications? Geriatr Gerontol Int. 2014;14(4):934–41.CrossRefPubMed

48.

Berry SD, Lee Y, Cai S, Dore DD. Nonbenzodiazepine sleep medication use and hip fractures in nursing home residents. JAMA Intern Med. 2013;173(9):754–61. https://doi.org/10.1001/jamainternmed.2013.3795.CrossRefPubMedPubMedCentral

49.

Lattanzio F, Mussi C, Scafato E, Ruggiero C, Dell’Aquila G, Pedone C, et al. Health care for older people in Italy: The U.L.I.S.S.E. project (Un Link Informatico sui Servizi Sanitari Esistenti per l’anziano—a computerized network on health care services for older people). J Nutr Health Aging. 2010;14(3):238–42.CrossRefPubMed

50.

Bernabei R, Gambassi G, Lapane K, Sgadari A, Landi F, Gatsonis C, et al. Characteristics of the SAGE database: a new resource for research on outcomes in long-term care. SAGE (Systematic Assessment of Geriatric drug use via Epidemiology) Study Group. J Gerontol A Biol Sci Med Sci. 1999;54(1):25–33.CrossRef

51.

Lund JL, Richardson DB, Sturmer T. The active comparator, new user study design in pharmacoepidemiology: historical foundations and contemporary application. Curr Epidemiol Rep. 2015;2(4):221–8. https://doi.org/10.1007/s40471-015-0053-5.CrossRefPubMedPubMedCentral

52.

Ray WA. Evaluating medication effects outside of clinical trials: new-user designs. Am J Epidemiol. 2003;158(9):915–20. https://doi.org/10.1093/aje/kwg231.CrossRefPubMed

53.

Divac N, Prostran M, Jakovcevski I, Cerovac N. Second-generation antipsychotics and extrapyramidal adverse effects. BioMed Res Int. 2014;2014:6. https://doi.org/10.1155/2014/656370.CrossRef

54.

Kleijer BC, van Marum RJ, Egberts AC, Jansen PA, Knol W, Heerdink ER. Risk of cerebrovascular events in elderly users of antipsychotics. J Psychopharmacol. 2009;23(8):909–14. https://doi.org/10.1177/0269881108093583.CrossRefPubMed

55.

Dose-response relationship. In: Pettygrove S, editor. Encyclopædia Britannica: Encyclopædia Britannica, inc.; 2016.

56.

Dettori JR. Loss to follow-up. Evid Based Spine Care J. 2011;2(1):7–10. https://doi.org/10.1055/s-0030-1267080.CrossRefPubMedPubMedCentral

57.

American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60(4):616–31. https://doi.org/10.1111/j.1532-5415.2012.03923.x.CrossRef

58.

Levy HB, Marcus E-L, Christen C. Adverse reactions/medication safety: beyond the Beers criteria: a comparative overview of explicit criteria. Ann Pharmacother. 2010;44(12):1968–75. https://doi.org/10.1345/aph.1P426.CrossRefPubMed

59.

Steinman MA, Beizer JL, DuBeau CE, Laird RD, Lundebjerg NE, Mulhausen P. How to use the AGS 2015 Beers criteria—a guide for patients, clinicians, health systems, and payors. J Am Geriatr Soc. 2015;63(12):e1–7. https://doi.org/10.1111/jgs.13701.CrossRefPubMed

60.

Gallagher P, Ryan C, Byrne S, Kennedy J, O’Mahony D. STOPP (Screening tool of older person’s prescriptions) and START (Screening tool to alert doctors to right treatment). Consensus validation. Int J Clin Pharmacol Ther. 2008;46(2):72–83.CrossRefPubMed

61.

Grace AR, Briggs R, Kieran RE, Corcoran RM, Romero-Ortuno R, Coughlan TL, et al. A comparison of Beers and STOPP criteria in assessing potentially inappropriate medications in nursing home residents attending the emergency department. J Am Med Dir Assoc. 2014;15(11):830–4. https://doi.org/10.1016/j.jamda.2014.08.008.CrossRefPubMed

62.

van der Stelt CA, Windsant-van Vermeulen, den Tweel AM, Egberts AC, van den Bemt PM, Leendertse AJ, Hermens WA, et al. The association between potentially inappropriate prescribing and medication-related hospital admissions in older patients: a nested case control study. Drug Saf. 2016;39(1):79–87. https://doi.org/10.1007/s40264-015-0361-1.CrossRefPubMed

63.

Lee WJ, Chen LK, Tang GJ, Lan TY. The impact of influenza vaccination on hospitalizations and mortality among frail older people. J Am Med Dir Assoc. 2014;15(4):256–60. https://doi.org/10.1016/j.jamda.2013.12.003.CrossRefPubMed

64.

Nichol KL, Margolis KL, Wouremna J, von Sternberg T. Effectiveness of influenza vaccine in the elderly. Gerontology. 1996;42(5):274–9.CrossRefPubMed

65.

Chan TC, Hung IF, Luk JK, Shea YF, Chan FH, Woo PC, et al. Prevention of mortality and pneumonia among nursing home older adults by dual pneumococcal and seasonal influenza vaccination during a pandemic caused by novel pandemic influenza A (H1N1). J Am Med Dir Assoc. 2012;13(8):698–703. https://doi.org/10.1016/j.jamda.2012.05.009.CrossRefPubMed

66.

Chan TC, Fan-Ngai Hung I, Ka-Hay Luk J, Chu LW, Hon-Wai Chan F. Effectiveness of influenza vaccination in institutionalized older adults: a systematic review. J Am Med Dir Assoc. 2014;15(3):226.e1-6. https://doi.org/10.1016/j.jamda.2013.10.008.

67.

Welliver R, Monto AS, Carewicz O, Schatteman E, Hassman M, Hedrick J, et al. Effectiveness of oseltamivir in preventing influenza in household contacts: a randomized controlled trial. JAMA. 2001;285(6):748–54.CrossRefPubMed

68.

van der Sande MA, Meijer A, Şen-Kerpiclik F, Enserink R, Cools HJ, Overduin P, et al. Effectiveness of post-exposition prophylaxis with oseltamivir in nursing homes: a randomised controlled trial over four seasons. Emerg Themes Epidemiol. 2014;11(1):13. https://doi.org/10.1186/1742-7622-11-13.CrossRefPubMedPubMedCentral

69.

Jefferson T, Jones M, Doshi P, Spencer EA, Onakpoya I, Heneghan CJ. Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments. BMJ. 2014;348(g2545). https://doi.org/10.1136/bmj.g2545.

70.

Pengo V, Legnani C, Noventa F, Palareti G. Oral anticoagulant therapy in patients with nonrheumatic atrial fibrillation and risk of bleeding. A multicenter inception cohort study. Thromb Haemost. 2001;85(3):418–22.CrossRefPubMed

71.

Bleeding during antithrombotic therapy in patients with atrial fibrillation. The stroke prevention in atrial fibrillation investigators. Arch Intern Med. 1996;156(4):409–16.

72.

Jhund P, McMurray JJV. Does aspirin reduce the benefit of an angiotensin-converting enzyme inhibitor? Circulation. 2006;113(22):2566.CrossRefPubMed

73.

Leor J, Reicher-Reiss H, Goldbourt U, Boyko V, Gottlieb S, Battler A, et al. Aspirin and mortality in patients treated with angiotensin-converting enzyme inhibitors: a cohort study of 11,575 patients with coronary artery disease. J Am Coll Cardiol. 1999;33(7):1920–5. https://doi.org/10.1016/S0735-1097(99)00129-1.CrossRefPubMed

74.

Ittaman SV, VanWormer JJ, Rezkalla SH. The role of aspirin in the prevention of cardiovascular disease. Clin Med Res. 2014;12(3–4):147–54. https://doi.org/10.3121/cmr.2013.1197.CrossRefPubMedPubMedCentral

75.

Ahmed A. Digoxin and reduction in mortality and hospitalization in geriatric heart failure: importance of low doses and low serum concentrations. J Gerontol A Biol Sci Med Sci. 2007;62(3):323–9.CrossRefPubMedPubMedCentral

76.

Scott D, Blizzard L, Fell J, Jones G. Statin therapy, muscle function and falls risk in community-dwelling older adults. QJM. 2009;102(9):625–33. https://doi.org/10.1093/qjmed/hcp093.CrossRefPubMed

77.

Pedro-Botet J, Climent E, Chillarón JJ, Toro R, Benaiges D, Flores-Le Roux JA. Statins for primary cardiovascular prevention in the elderly. J Geriatr Cardiol. 2015;12(4):431–8. https://doi.org/10.11909/j.issn.1671-5411.2015.04.016.PubMedPubMedCentralCrossRef

78.

Zhou X, Chen J. Is treatment with trimetazidine beneficial in patients with chronic heart failure? PLoS One. 2014;9(5):e94660. https://doi.org/10.1371/journal.pone.0094660.CrossRefPubMedPubMedCentral

79.

Di Napoli P, Di Giovanni P, Gaeta MA, Taccardi AA, Barsotti A. Trimetazidine and reduction in mortality and hospitalization in patients with ischemic dilated cardiomyopathy: a post hoc analysis of the Villa Pini d’Abruzzo Trimetazidine Trial. J Cardiovasc Pharmacol. 2007;50(5):585–9. https://doi.org/10.1097/FJC.0b013e31814fa9cb.CrossRefPubMed

80.

Chen Y, Liu B, Glass K, Du W, Banks E, Kirk M. Use of proton pump inhibitors and the risk of hospitalization for infectious gastroenteritis. PLoS One. 2016;11(12):e0168618. https://doi.org/10.1371/journal.pone.0168618.CrossRefPubMedPubMedCentral

81.

Lewis JR, Barre D, Zhu K, Ivey KL, Lim EM, Hughes J, et al. Long-term proton pump inhibitor therapy and falls and fractures in elderly women: a prospective cohort study. J Bone Miner Res. 2014;29(11):2489–97. https://doi.org/10.1002/jbmr.2279.CrossRefPubMed

82.

Pello Lázaro AM, Cristóbal C, Franco-Peláez JA, Tarín N, Aceña Á, Carda R, et al. Use of proton-pump inhibitors predicts heart failure and death in patients with coronary artery disease. PLoS One. 2017;12(1):e0169826. https://doi.org/10.1371/journal.pone.0169826.CrossRefPubMedPubMedCentral

83.

Gabriel SE, Jaakkimainen L, Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs: a meta-analysis. Ann Intern Med. 1991;115(10):787–96. https://doi.org/10.7326/0003-4819-115-10-787.CrossRefPubMed

84.

Peng S, Duggan A. Gastrointestinal adverse effects of non-steroidal anti-inflammatory drugs. Expert Opin Drug Saf. 2005;4(2):157–69. https://doi.org/10.1517/14740338.4.2.157.CrossRefPubMed

85.

Yachimski PS, Friedman LS. Gastrointestinal bleeding in the elderly. Nat Clin Pract Gastroenterol Hepatol. 2008;5(2):80–93.CrossRefPubMed

86.

Cameron ID, Murray GR, Gillespie LD, Robertson MC, Hill KD, Cumming RG, et al. Interventions for preventing falls in older people in nursing care facilities and hospitals. Cochrane Database Syst Rev. 2010;(1):CD005465. https://doi.org/10.1002/14651858.cd005465.pub2.

87.

Marcum ZA, Perera S, Thorpe JM, Switzer GE, Gray SL, Castle NG, et al. Anticholinergic use and recurrent falls in community-dwelling older adults: findings from the health ABC study. Ann Pharmacother. 2015;49(11):1214–21. https://doi.org/10.1177/1060028015596998.CrossRefPubMedPubMedCentral

88.

Toot S, Devine M, Akporobaro A, Orrell M. Causes of hospital admission for people with dementia: a systematic review and meta-analysis. J Am Med Dir Assoc. 2013;14(7):463–70. https://doi.org/10.1016/j.jamda.2013.01.011.CrossRefPubMed

Title: Medications and Prescribing Patterns as Factors Associated with Hospitalizations from Long-Term Care Facilities: A Systematic Review
Authors: Kate N. Wang
J. Simon Bell
Esa Y. H. Chen
Julia F. M. Gilmartin-Thomas
Jenni Ilomäki
Publication date: 01-05-2018
Publisher: Springer International Publishing
Published in: Drugs & Aging / Issue 5/2018
Print ISSN: 1170-229X
Electronic ISSN: 1179-1969
DOI: https://doi.org/10.1007/s40266-018-0537-3

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At a glance: The STEP trials

Springer Medicine

Abstract

Background

Objective

Methods

Results

Conclusion

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