Skip to main content
Top
Published in: Drugs & Aging 2/2018

01-02-2018 | Original Research Article

Polypharmacy in Home Care in Europe: Cross-Sectional Data from the IBenC Study

Authors: Silvia Giovannini, Henriëtte G. van der Roest, Angelo Carfì, Harriet Finne-Soveri, Vjenka Garms-Homolová, Anja Declercq, Pálmi V. Jónsson, Hein van Hout, Davide L. Vetrano, Ester Manes Gravina, Roberto Bernabei, Graziano Onder

Published in: Drugs & Aging | Issue 2/2018

Login to get access

Abstract

Background

Home care (HC) patients are characterized by a high level of complexity, which is reflected by the prevalence of multimorbidity and the correlated high drug consumption. This study assesses prevalence and factors associated with polypharmacy in a sample of HC patients in Europe.

Methods

We conducted a cross-sectional analysis on 1873 HC patients from six European countries participating in the Identifying best practices for care-dependent elderly by Benchmarking Costs and outcomes of community care (IBenC) project. Data were collected using the interResident Assessment Instrument (interRAI) instrument for HC. Polypharmacy status was categorized into three groups: non-polypharmacy (0–4 drugs), polypharmacy (5–9 drugs), and excessive polypharmacy (≥ 10 drugs). Multinomial logistic regressions were used to identify variables associated with polypharmacy and excessive polypharmacy.

Results

Polypharmacy was observed in 730 (39.0%) HC patients and excessive polypharmacy in 433 (23.1%). As compared with non-polypharmacy, excessive polypharmacy was directly associated with chronic disease but also with female sex (odds ratio [OR] 1.58; 95% confidence interval [CI] 1.17–2.13), pain (OR 1.51; 95% CI 1.15–1.98), dyspnea (OR 1.37; 95% CI 1.01–1.89), and falls (OR 1.55; 95% CI 1.01–2.40). An inverse association with excessive polypharmacy was shown for age (OR 0.69; 95% CI 0.56–0.83).

Conclusions

Polypharmacy and excessive polypharmacy are common among HC patients in Europe. Factors associated with polypharmacy status include not only co-morbidity but also specific symptoms and age.
Literature
2.
go back to reference Leichsenring K, Billings J, Nies H. Long-term care in Europe. Improving policy and practice. New York: Palgrave Macmillan; 2013.CrossRef Leichsenring K, Billings J, Nies H. Long-term care in Europe. Improving policy and practice. New York: Palgrave Macmillan; 2013.CrossRef
5.
go back to reference Onder G, Finne-Soveri H, Soldato M, Liperoti R, Lattanzio F, Bernabei R, et al. Distress of caregivers of older adults receiving home care in European countries: results from the AgeD in HOme Care Study. Am J Geriatr Psychiatry. 2009;17(10):899–906.CrossRefPubMed Onder G, Finne-Soveri H, Soldato M, Liperoti R, Lattanzio F, Bernabei R, et al. Distress of caregivers of older adults receiving home care in European countries: results from the AgeD in HOme Care Study. Am J Geriatr Psychiatry. 2009;17(10):899–906.CrossRefPubMed
6.
go back to reference Lalic S, Sluggett JK, Ilomäki J, Wimmer BC, Tan EC, Robson L, et al. Polypharmacy and medication regimen complexity as risk factors for hospitalization among residents of long-term care facilities: a prospective cohort study. J Am Med Dir Assoc. 2016;17(11):1067.e1–6.CrossRef Lalic S, Sluggett JK, Ilomäki J, Wimmer BC, Tan EC, Robson L, et al. Polypharmacy and medication regimen complexity as risk factors for hospitalization among residents of long-term care facilities: a prospective cohort study. J Am Med Dir Assoc. 2016;17(11):1067.e1–6.CrossRef
7.
go back to reference Cherubini A, Corsonello A, Lattanzio F. Polypharmacy in nursing home residents: what is the way forward? J Am Med Dir Assoc. 2016;17(1):4–6.CrossRefPubMed Cherubini A, Corsonello A, Lattanzio F. Polypharmacy in nursing home residents: what is the way forward? J Am Med Dir Assoc. 2016;17(1):4–6.CrossRefPubMed
8.
go back to reference Kojima T, Akishita M, Nakamura T, Nomura K, Ogawa S, Iijima K, et al. Polypharmacy as a risk for fall occurrence in geriatric outpatients. Geriatr Gerontol Int. 2012;12(3):425–30.CrossRefPubMed Kojima T, Akishita M, Nakamura T, Nomura K, Ogawa S, Iijima K, et al. Polypharmacy as a risk for fall occurrence in geriatric outpatients. Geriatr Gerontol Int. 2012;12(3):425–30.CrossRefPubMed
9.
go back to reference Nobili A, Pasina L, Tettamanti M, Lucca U, Riva E, Marzona I, et al. Potentially severe drug interactions in elderly outpatients: results of an observational study of an administrative prescription database. J Clin Pharm Ther. 2009;34(4):377–86.CrossRefPubMed Nobili A, Pasina L, Tettamanti M, Lucca U, Riva E, Marzona I, et al. Potentially severe drug interactions in elderly outpatients: results of an observational study of an administrative prescription database. J Clin Pharm Ther. 2009;34(4):377–86.CrossRefPubMed
10.
go back to reference Poudel A, Peel NM, Nissen LM, Mitchell CA, Gray LC, Hubbard RE. Adverse Outcomes in relation to polypharmacy in robust and frail older hospital patients. J Am Med Dir Assoc. 2016;17(8):767.e7–13.CrossRef Poudel A, Peel NM, Nissen LM, Mitchell CA, Gray LC, Hubbard RE. Adverse Outcomes in relation to polypharmacy in robust and frail older hospital patients. J Am Med Dir Assoc. 2016;17(8):767.e7–13.CrossRef
11.
go back to reference Onder G, Giovannini S, Sganga F, Manes-Gravina E, Topinkova E, Finne-Soveri H, Garms-Homolová V, Declercq A, van der Roest HG, Jónsson PV, van Hout H, Bernabei R. Interactions between drugs and geriatric syndromes in nursing home and home care: results from Shelter and IBenC projects. Aging Clin Exp Res. 2018. https://doi.org/10.1007/s40520-018-0893-1.PubMed Onder G, Giovannini S, Sganga F, Manes-Gravina E, Topinkova E, Finne-Soveri H, Garms-Homolová V, Declercq A, van der Roest HG, Jónsson PV, van Hout H, Bernabei R. Interactions between drugs and geriatric syndromes in nursing home and home care: results from Shelter and IBenC projects. Aging Clin Exp Res. 2018. https://​doi.​org/​10.​1007/​s40520-018-0893-1.PubMed
12.
go back to reference Bernabei R, Landi F, Onder G, Liperoti R, Gambassi G. Second and third generation assessment instruments: the birth of standardization in geriatric care. J Gerontol A Biol Sci Med Sci. 2008;63:308–13.CrossRefPubMed Bernabei R, Landi F, Onder G, Liperoti R, Gambassi G. Second and third generation assessment instruments: the birth of standardization in geriatric care. J Gerontol A Biol Sci Med Sci. 2008;63:308–13.CrossRefPubMed
13.
14.
go back to reference Onder G, Liperoti R, Foebel A, Fialova D, Topinkova E, van der Roest HG, et al. SHELTER project. Polypharmacy and mortality among nursing home residents with advanced cognitive impairment: results from the SHELTER study. J Am Med Dir Assoc. 2013;14(6):450.e7–12.CrossRef Onder G, Liperoti R, Foebel A, Fialova D, Topinkova E, van der Roest HG, et al. SHELTER project. Polypharmacy and mortality among nursing home residents with advanced cognitive impairment: results from the SHELTER study. J Am Med Dir Assoc. 2013;14(6):450.e7–12.CrossRef
15.
go back to reference Onder G, Liperoti R, Fialova D, Topinkova E, Tosato M, Danese P, et al. SHELTER Project. Polypharmacy in nursing home in Europe: results from the SHELTER study. J Gerontol A Biol Sci Med Sci. 2012;67(6):698–704.CrossRefPubMed Onder G, Liperoti R, Fialova D, Topinkova E, Tosato M, Danese P, et al. SHELTER Project. Polypharmacy in nursing home in Europe: results from the SHELTER study. J Gerontol A Biol Sci Med Sci. 2012;67(6):698–704.CrossRefPubMed
16.
go back to reference Morris JN, Fries BE, Mehr DR, Hawes C, Phillips C, Mor V, et al. The MDS Cognitive Performance Scale. J Gerontol. 1994;49:174–82.CrossRef Morris JN, Fries BE, Mehr DR, Hawes C, Phillips C, Mor V, et al. The MDS Cognitive Performance Scale. J Gerontol. 1994;49:174–82.CrossRef
17.
go back to reference Morris JN, Fries BE, Morris SA. Scaling ADLs within the MDS. J Gerontol. 1999;4:M546–53.CrossRef Morris JN, Fries BE, Morris SA. Scaling ADLs within the MDS. J Gerontol. 1999;4:M546–53.CrossRef
18.
go back to reference Burrows AB, Morris JN, Simon SE, Hirdes JP, Phillips C. Development of a minimum data set-based depression rating scale for use in nursing homes. Age Ageing. 2000;29:165–72.CrossRefPubMed Burrows AB, Morris JN, Simon SE, Hirdes JP, Phillips C. Development of a minimum data set-based depression rating scale for use in nursing homes. Age Ageing. 2000;29:165–72.CrossRefPubMed
19.
go back to reference Onder G, Pedone C, Landi F, Cesari M, Della Vedova C, Bernabei R, et al. Adverse drug reactions as cause of hospital admissions: results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA). J Am Geriatr Soc. 2002;50(12):1962–8.CrossRefPubMed Onder G, Pedone C, Landi F, Cesari M, Della Vedova C, Bernabei R, et al. Adverse drug reactions as cause of hospital admissions: results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA). J Am Geriatr Soc. 2002;50(12):1962–8.CrossRefPubMed
20.
go back to reference Kojima T, Akishita M, Kameyama Y, Yamaguchi K, Yamamoto H, Eto M, et al. High risk of adverse drug reactions in elderly patients taking six or more drugs: analysis of inpatient database. Geriatr Gerontol Int. 2012;12(4):761–2.CrossRefPubMed Kojima T, Akishita M, Kameyama Y, Yamaguchi K, Yamamoto H, Eto M, et al. High risk of adverse drug reactions in elderly patients taking six or more drugs: analysis of inpatient database. Geriatr Gerontol Int. 2012;12(4):761–2.CrossRefPubMed
21.
go back to reference Chiu MH, Lee HD, Hwang HF, Wang SC, Lin MR. Medication use and fall-risk assessment for falls in an acute care hospital. Geriatr Gerontol Int. 2015;15(7):856–63.CrossRefPubMed Chiu MH, Lee HD, Hwang HF, Wang SC, Lin MR. Medication use and fall-risk assessment for falls in an acute care hospital. Geriatr Gerontol Int. 2015;15(7):856–63.CrossRefPubMed
22.
go back to reference Díaz-Gutiérrez MJ, Martínez-Cengotitabengoa M, Sáez de Adana E, Cano AI, Martínez-Cengotitabengoa MT, Besga A, et al. Relationship between the use of benzodiazepines and falls in older adults: a systematic review. Maturitas. 2017;101:17–22.CrossRefPubMed Díaz-Gutiérrez MJ, Martínez-Cengotitabengoa M, Sáez de Adana E, Cano AI, Martínez-Cengotitabengoa MT, Besga A, et al. Relationship between the use of benzodiazepines and falls in older adults: a systematic review. Maturitas. 2017;101:17–22.CrossRefPubMed
23.
go back to reference Bloch F, Thibaud M, Dugué B, Brèque C, Rigaud AS, Kemoun G. Psychotropic drugs and falls in the elderly people: updated literature review and meta-analysis. J Aging Health. 2011;23(2):329–46.CrossRefPubMed Bloch F, Thibaud M, Dugué B, Brèque C, Rigaud AS, Kemoun G. Psychotropic drugs and falls in the elderly people: updated literature review and meta-analysis. J Aging Health. 2011;23(2):329–46.CrossRefPubMed
24.
go back to reference Fried TR, Tinetti ME, Iannone L. Primary care clinicians’ experiences with treatment decision making for older persons with multiple conditions. Arch Intern Med. 2011;171(1):75–80.PubMed Fried TR, Tinetti ME, Iannone L. Primary care clinicians’ experiences with treatment decision making for older persons with multiple conditions. Arch Intern Med. 2011;171(1):75–80.PubMed
25.
go back to reference Lattanzio F, Laino I, Pedone C, Corica F, Maltese G, Salerno G, et al. PharmacosurVeillance in the elderly Care (PVC) Study Group. Geriatric conditions and adverse drug reactions in elderly hospitalized patients. J Am Med Dir Assoc. 2012;13(2):96–9.CrossRefPubMed Lattanzio F, Laino I, Pedone C, Corica F, Maltese G, Salerno G, et al. PharmacosurVeillance in the elderly Care (PVC) Study Group. Geriatric conditions and adverse drug reactions in elderly hospitalized patients. J Am Med Dir Assoc. 2012;13(2):96–9.CrossRefPubMed
26.
go back to reference Onder G, Petrovic M, Tangiisuran B, Meinardi MC, Markito-Notenboom WP, Somers A, et al. Development and validation of a score to assess risk of adverse drug reactions among in-hospital patients 65 years or older: the GerontoNet ADR risk score. Arch Intern Med. 2010;170(13):1142–8.CrossRefPubMed Onder G, Petrovic M, Tangiisuran B, Meinardi MC, Markito-Notenboom WP, Somers A, et al. Development and validation of a score to assess risk of adverse drug reactions among in-hospital patients 65 years or older: the GerontoNet ADR risk score. Arch Intern Med. 2010;170(13):1142–8.CrossRefPubMed
27.
go back to reference Onder G, van der Cammen TJ, Petrovic M, Somers A, Rajkumar C. Strategies to reduce the risk of iatrogenic illness in complex older adults. Age Ageing. 2013;42(3):284–91.CrossRefPubMed Onder G, van der Cammen TJ, Petrovic M, Somers A, Rajkumar C. Strategies to reduce the risk of iatrogenic illness in complex older adults. Age Ageing. 2013;42(3):284–91.CrossRefPubMed
28.
go back to reference Marcum ZA, Amuan ME, Hanlon JT, Aspinall SL, Handler SM, Ruby CM, et al. Prevalence of unplanned hospitalizations caused by adverse drug reactions in older veterans. J Am Geriatr Soc. 2012;60(1):34–41.CrossRefPubMed Marcum ZA, Amuan ME, Hanlon JT, Aspinall SL, Handler SM, Ruby CM, et al. Prevalence of unplanned hospitalizations caused by adverse drug reactions in older veterans. J Am Geriatr Soc. 2012;60(1):34–41.CrossRefPubMed
29.
go back to reference van Nordennen RT, Lavrijsen JC, Heesterbeek MJ, Bor H, Vissers KC, Koopmans RT. Changes in prescribed drugs between admission and the end of life in patients admitted to palliative care facilities. J Am Med Dir Assoc. 2016;17(6):514–8.CrossRefPubMed van Nordennen RT, Lavrijsen JC, Heesterbeek MJ, Bor H, Vissers KC, Koopmans RT. Changes in prescribed drugs between admission and the end of life in patients admitted to palliative care facilities. J Am Med Dir Assoc. 2016;17(6):514–8.CrossRefPubMed
30.
go back to reference Weston AL, Weinstein AM, Barton C, Yaffe K. Potentially inappropriate medication use in older adults with mild cognitive impairment. J Gerontol A Biol Sci Med Sci. 2010;65(3):318–21.CrossRefPubMed Weston AL, Weinstein AM, Barton C, Yaffe K. Potentially inappropriate medication use in older adults with mild cognitive impairment. J Gerontol A Biol Sci Med Sci. 2010;65(3):318–21.CrossRefPubMed
31.
go back to reference Onder G, Lattanzio F, Battaglia M, Cerullo F, Sportiello R, Bernabei R, et al. The risk of adverse drug reactions in older patients: beyond drug metabolism. Curr Drug Metab. 2011;12(7):647–51.CrossRefPubMed Onder G, Lattanzio F, Battaglia M, Cerullo F, Sportiello R, Bernabei R, et al. The risk of adverse drug reactions in older patients: beyond drug metabolism. Curr Drug Metab. 2011;12(7):647–51.CrossRefPubMed
32.
go back to reference Holmes HM. Rational prescribing for patients with a reduced life expectancy. Clin Pharmacol Ther. 2009;85(1):103–7.CrossRefPubMed Holmes HM. Rational prescribing for patients with a reduced life expectancy. Clin Pharmacol Ther. 2009;85(1):103–7.CrossRefPubMed
Metadata
Title
Polypharmacy in Home Care in Europe: Cross-Sectional Data from the IBenC Study
Authors
Silvia Giovannini
Henriëtte G. van der Roest
Angelo Carfì
Harriet Finne-Soveri
Vjenka Garms-Homolová
Anja Declercq
Pálmi V. Jónsson
Hein van Hout
Davide L. Vetrano
Ester Manes Gravina
Roberto Bernabei
Graziano Onder
Publication date
01-02-2018
Publisher
Springer International Publishing
Published in
Drugs & Aging / Issue 2/2018
Print ISSN: 1170-229X
Electronic ISSN: 1179-1969
DOI
https://doi.org/10.1007/s40266-018-0521-y

Other articles of this Issue 2/2018

Drugs & Aging 2/2018 Go to the issue