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Drugs & Aging
Published in: Drugs & Aging 10/2016

01-10-2016 | Review Article

Leukotriene Receptor Antagonists for the Treatment of Asthma in Elderly Patients

Authors: Hoang Kim Tu Trinh, Ga-Young Ban, Ji-Ho Lee, Hae-Sim Park

Published in: Drugs & Aging | Issue 10/2016

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Abstract

Elderly asthma (EA) is regarded as a distinct phenotype of asthma and is associated with age-related changes in airway structure and alterations in lung function and immune responses. EA is difficult to diagnose because of aging and co-morbidities, and overlaps with fixed airway obstructive disease. Novel modalities to differentiate between EA and chronic obstructive pulmonary disease (COPD) are necessary. A multifaceted approach, including clinical history, smoking habits, atopy, and measurement of lung function, is mandatory to differentiate asthma from COPD. There are a variety of co-morbidities with EA, of which COPD, upper airway diseases, depression, obesity, and hypertension are the most common, and these co-morbidities can affect the control status of EA. However, leukotriene receptor antagonists (LTRAs) can facilitate the management of EA, and thus addition of an LTRA to inhaled corticosteroid (ICS) monotherapy or ICS plus long-acting β2-agonist therapy improves symptoms in EA patients. LTRA treatment is safe and beneficial in patients who are unable to use inhalation devices properly or who have co-morbid diseases. Therefore, clinical studies targeting a specific population of EA patients are warranted to help achieve a better therapeutic strategy in EA patients.
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Metadata
Title
Leukotriene Receptor Antagonists for the Treatment of Asthma in Elderly Patients
Authors
Hoang Kim Tu Trinh
Ga-Young Ban
Ji-Ho Lee
Hae-Sim Park
Publication date
01-10-2016
Publisher
Springer International Publishing
Published in
Drugs & Aging / Issue 10/2016
Print ISSN: 1170-229X
Electronic ISSN: 1179-1969
DOI
https://doi.org/10.1007/s40266-016-0401-2

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