Skip to main content
Top
Published in: Drugs & Aging 6/2015

Open Access 01-06-2015 | Original Research Article

Computerized Decision Support Improves Medication Review Effectiveness: An Experiment Evaluating the STRIP Assistant’s Usability

Authors: Michiel C. Meulendijk, Marco R. Spruit, A. Clara Drenth-van Maanen, Mattijs E. Numans, Sjaak Brinkkemper, Paul A. F. Jansen, Wilma Knol

Published in: Drugs & Aging | Issue 6/2015

Login to get access

Abstract

Background

Polypharmacy poses threats to patients’ health. The Systematic Tool to Reduce Inappropriate Prescribing (STRIP) is a drug optimization process for conducting medication reviews in primary care. To effectively and efficiently incorporate this method into daily practice, the STRIP Assistant—a decision support system that aims to assist physicians with the pharmacotherapeutic analysis of patients’ medical records—has been developed. It generates context-specific advice based on clinical guidelines.

Objective

The aim of this study was to validate the STRIP Assistant’s usability as a tool for physicians to optimize medical records for polypharmacy patients.

Methods

In an online experiment, 42 physicians were asked to optimize medical records for two comparable polypharmacy patients, one in their usual manner and one using the STRIP Assistant. Changes in effectiveness were measured by comparing respondents’ optimized medicine prescriptions with medication prepared by an expert panel of two geriatrician-pharmacologists. Efficiency was operationalized by recording the time the respondents took to optimize the two cases. User satisfaction was measured with the System Usability Scale (SUS). Independent and paired t tests were used for analysis.

Results

Medication optimization significantly improved with the STRIP Assistant. Appropriate decisions increased from 58 % without the STRIP Assistant to 76 % with it (p < 0.0001). Inappropriate decisions decreased from 42 % without the STRIP Assistant to 24 % with it (p < 0.0001). Participants spent significantly more time optimizing medication with the STRIP Assistant (24 min) than without it (13 min; p < 0.0001). They assigned it a below-average SUS score of 63.25.

Conclusion

The STRIP Assistant improves the effectiveness of medication reviews for polypharmacy patients.
Literature
2.
go back to reference Björkman I, Fastbom J, Schmidt I, et al. Drug–drug interactions in the elderly. Ann Pharmacother. 2002;36(11):1675–81.PubMedCrossRef Björkman I, Fastbom J, Schmidt I, et al. Drug–drug interactions in the elderly. Ann Pharmacother. 2002;36(11):1675–81.PubMedCrossRef
3.
go back to reference Claxton A, Cramer J, Pierce C. A systematic review of the association between dose regimens and medication adherence. Clin Ther. 2001;23(8):1296–310.PubMedCrossRef Claxton A, Cramer J, Pierce C. A systematic review of the association between dose regimens and medication adherence. Clin Ther. 2001;23(8):1296–310.PubMedCrossRef
4.
go back to reference Frazier SC. Health outcomes and polypharmacy in elderly individuals; an integrated literature review. J Gerontol Nurs. 2005;31(9):4–11.PubMedCrossRef Frazier SC. Health outcomes and polypharmacy in elderly individuals; an integrated literature review. J Gerontol Nurs. 2005;31(9):4–11.PubMedCrossRef
5.
go back to reference Kuyuma M, Endo H, Umegaki H. Factors influencing nonadherence with medication regimens in the elderly. Nihon Ronen Igakkai Zasshi. 2000;37:363–70.CrossRef Kuyuma M, Endo H, Umegaki H. Factors influencing nonadherence with medication regimens in the elderly. Nihon Ronen Igakkai Zasshi. 2000;37:363–70.CrossRef
6.
go back to reference Shi S, Mörike K, Klotz U. The clinical implications of ageing for rational drug therapy. Eur J Clin Pharmacol. 2008;64(2):183–99.PubMedCrossRef Shi S, Mörike K, Klotz U. The clinical implications of ageing for rational drug therapy. Eur J Clin Pharmacol. 2008;64(2):183–99.PubMedCrossRef
7.
go back to reference Sloane P, Gruber-Baldini A, Zimmerman S, et al. Medication undertreatment in assisted living settings. Arch Intern Med. 2004;164(18):2031–7.PubMedCrossRef Sloane P, Gruber-Baldini A, Zimmerman S, et al. Medication undertreatment in assisted living settings. Arch Intern Med. 2004;164(18):2031–7.PubMedCrossRef
8.
go back to reference Steinman M, Landefeld C, Rosenthal G, et al. Polypharmacy and prescribing quality in older people. J Am Geriatr Soc. 2006;54(10):1516–23.PubMedCrossRef Steinman M, Landefeld C, Rosenthal G, et al. Polypharmacy and prescribing quality in older people. J Am Geriatr Soc. 2006;54(10):1516–23.PubMedCrossRef
9.
go back to reference Wright R, Sloane R, Pieper C, et al. Underuse of indicated medications among physically frail older US veterans at the time of hospital discharge: results of a cross-sectional analysis of data from the Geriatric Evaluation and Management Drug Study. Am J Geriatr Pharmacother. 2009;7(5):271–80.PubMedCentralPubMedCrossRef Wright R, Sloane R, Pieper C, et al. Underuse of indicated medications among physically frail older US veterans at the time of hospital discharge: results of a cross-sectional analysis of data from the Geriatric Evaluation and Management Drug Study. Am J Geriatr Pharmacother. 2009;7(5):271–80.PubMedCentralPubMedCrossRef
10.
go back to reference Leendertse A, Egberts A, van den Bemt P, et al. Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands. Arch Intern Med. 2008;168(17):1890–6.PubMed Leendertse A, Egberts A, van den Bemt P, et al. Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands. Arch Intern Med. 2008;168(17):1890–6.PubMed
11.
go back to reference Stichting Farmaceutische Kengetallen. Polyfarmacie. Pharmaceutisch Weekblad. 2005;140(32). Stichting Farmaceutische Kengetallen. Polyfarmacie. Pharmaceutisch Weekblad. 2005;140(32).
12.
go back to reference Gallagher PF, O’Connor MN, O’Mahony D. Prevention of potentially inappropriate prescribing for elderly patients: a randomized controlled trial using STOPP/START criteria. Clin Pharmacol Ther. 2011;89(6):845–54.PubMedCrossRef Gallagher PF, O’Connor MN, O’Mahony D. Prevention of potentially inappropriate prescribing for elderly patients: a randomized controlled trial using STOPP/START criteria. Clin Pharmacol Ther. 2011;89(6):845–54.PubMedCrossRef
13.
go back to reference Dedhiya SD, Hancock E, Craig BA, et al. Incident use and outcomes associated with potentially inappropriate medication use in older adults. Am J Geriatr Pharmacother. 2010;8(6):562–70.PubMedCrossRef Dedhiya SD, Hancock E, Craig BA, et al. Incident use and outcomes associated with potentially inappropriate medication use in older adults. Am J Geriatr Pharmacother. 2010;8(6):562–70.PubMedCrossRef
14.
go back to reference Drenth-van Maanen AC, Van Marum RJ, Knol W, et al. Prescribing optimization method for improving prescribing in elderly patients receiving polypharmacy. Drugs Aging. 2009;26(8):1–15.CrossRef Drenth-van Maanen AC, Van Marum RJ, Knol W, et al. Prescribing optimization method for improving prescribing in elderly patients receiving polypharmacy. Drugs Aging. 2009;26(8):1–15.CrossRef
15.
go back to reference Sergi G, De Rui M, Sarti S, et al. Polypharmacy in the elderly: can comprehensive geriatric assessment reduce inappropriate medication use? Drugs Aging. 2011;28(7):509–18.PubMedCrossRef Sergi G, De Rui M, Sarti S, et al. Polypharmacy in the elderly: can comprehensive geriatric assessment reduce inappropriate medication use? Drugs Aging. 2011;28(7):509–18.PubMedCrossRef
16.
go back to reference Campanelli CM. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults: the American Geriatrics Society 2012 Beers Criteria Update Expert Panel. J Am Geriatr Soc. 2012;60(4):616–31.PubMedCentralCrossRef Campanelli CM. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults: the American Geriatrics Society 2012 Beers Criteria Update Expert Panel. J Am Geriatr Soc. 2012;60(4):616–31.PubMedCentralCrossRef
17.
go back to reference Gallagher P, Ryan C, Byrne S, et al. STOPP (Screening Tool of Older Person’s Prescriptions) and START (Screening Tool to Alert Doctors to Right Treatment): consensus validation. Int J Clin Pharmacol Ther. 2008;46(2):72–83.PubMedCrossRef Gallagher P, Ryan C, Byrne S, et al. STOPP (Screening Tool of Older Person’s Prescriptions) and START (Screening Tool to Alert Doctors to Right Treatment): consensus validation. Int J Clin Pharmacol Ther. 2008;46(2):72–83.PubMedCrossRef
18.
go back to reference Hanlon JT, Schmader KE, Samsa GP, et al. A method for assessing drug therapy appropriateness. J Clin Epidemiol. 1992;45(10):1045–51.PubMedCrossRef Hanlon JT, Schmader KE, Samsa GP, et al. A method for assessing drug therapy appropriateness. J Clin Epidemiol. 1992;45(10):1045–51.PubMedCrossRef
19.
go back to reference Leendertse AJ, De Koning FH, Goudswaard AN, et al. Preventing hospital admissions by reviewing medication (PHARM) in primary care: design of the cluster randomised, controlled, multi-centre PHARM-study. BMC Health Serv Res. 2011;7(11):4.CrossRef Leendertse AJ, De Koning FH, Goudswaard AN, et al. Preventing hospital admissions by reviewing medication (PHARM) in primary care: design of the cluster randomised, controlled, multi-centre PHARM-study. BMC Health Serv Res. 2011;7(11):4.CrossRef
20.
go back to reference Patterson SM, Hughes C, Kerse N, et al. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2014;10:CD008165.PubMed Patterson SM, Hughes C, Kerse N, et al. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2014;10:CD008165.PubMed
21.
go back to reference Anderson K, Stowasser D, Freeman C, et al. Prescriber barriers and enablers to minimising potentially inappropriate medications in adults: a systematic review and thematic synthesis. BMJ Open. 2014;4(12):e006544.PubMedCentralPubMedCrossRef Anderson K, Stowasser D, Freeman C, et al. Prescriber barriers and enablers to minimising potentially inappropriate medications in adults: a systematic review and thematic synthesis. BMJ Open. 2014;4(12):e006544.PubMedCentralPubMedCrossRef
22.
go back to reference Niquille A, Lattmann C, Bugnon O. Medication reviews led by community pharmacists in Switzerland: a qualitative survey to evaluate barriers and facilitators. Pharm Pract (Granada). 2010;8(1):35–42.PubMedCentralPubMed Niquille A, Lattmann C, Bugnon O. Medication reviews led by community pharmacists in Switzerland: a qualitative survey to evaluate barriers and facilitators. Pharm Pract (Granada). 2010;8(1):35–42.PubMedCentralPubMed
24.
go back to reference Topinková E, Baeyens JP, Michel JP, et al. Evidence-based strategies for the optimization of pharmacotherapy in older people. Drugs Aging. 2012;29(6):477–94.PubMedCrossRef Topinková E, Baeyens JP, Michel JP, et al. Evidence-based strategies for the optimization of pharmacotherapy in older people. Drugs Aging. 2012;29(6):477–94.PubMedCrossRef
25.
go back to reference Spinewine A, Fialová D, Byrne S. The role of the pharmacist in optimizing pharmacotherapy in older people. Drugs Aging. 2012;29(6):495–510.PubMedCrossRef Spinewine A, Fialová D, Byrne S. The role of the pharmacist in optimizing pharmacotherapy in older people. Drugs Aging. 2012;29(6):495–510.PubMedCrossRef
27.
go back to reference Bright TJ, Wong A, Dhurjati R, et al. Effect of clinical decision-support systems: a systematic review. Ann Intern Med. 2012;157(1):29–43.PubMedCrossRef Bright TJ, Wong A, Dhurjati R, et al. Effect of clinical decision-support systems: a systematic review. Ann Intern Med. 2012;157(1):29–43.PubMedCrossRef
28.
go back to reference Meulendijk MC, Spruit MR, Drenth-van Maanen AC, et al. General practitioners’ attitudes towards decision-supported prescribing: an analysis of the Dutch primary care sector. Health Inform J. 2013;19(4):247–63.CrossRef Meulendijk MC, Spruit MR, Drenth-van Maanen AC, et al. General practitioners’ attitudes towards decision-supported prescribing: an analysis of the Dutch primary care sector. Health Inform J. 2013;19(4):247–63.CrossRef
29.
go back to reference Meulendijk MC, Spruit MR, Jansen PAF, et al. STRIPA: a rule-based decision support system for medication reviews in primary care. In: Proceedings of the European Conference on Information Systems (ECIS) 2015. Münster, Germany; 2015. Meulendijk MC, Spruit MR, Jansen PAF, et al. STRIPA: a rule-based decision support system for medication reviews in primary care. In: Proceedings of the European Conference on Information Systems (ECIS) 2015. Münster, Germany; 2015.
31.
go back to reference De Groot DA, De Vries M, Joling KJ, et al. Specifying ICD9, ICPC and ATC codes for the STOPP/START criteria: a multidisciplinary consensus panel. Age Ageing. 2014;43(6):773–8.PubMedCrossRef De Groot DA, De Vries M, Joling KJ, et al. Specifying ICD9, ICPC and ATC codes for the STOPP/START criteria: a multidisciplinary consensus panel. Age Ageing. 2014;43(6):773–8.PubMedCrossRef
32.
go back to reference Pachidi S, Spruit M. Weerd Ivd. Understanding users’ behavior with software operation data mining. Comput Human Behav. 2014;30:583–94.CrossRef Pachidi S, Spruit M. Weerd Ivd. Understanding users’ behavior with software operation data mining. Comput Human Behav. 2014;30:583–94.CrossRef
35.
go back to reference Davis F. Perceived usefulness, perceived ease of use, and user acceptance of information technology. MIS Quarterly. 1989;13(3):319–40.CrossRef Davis F. Perceived usefulness, perceived ease of use, and user acceptance of information technology. MIS Quarterly. 1989;13(3):319–40.CrossRef
36.
go back to reference Venkatesh V, Davis FD. A theoretical extension of the technology acceptance model: four longitudinal field studies. Manag Sci. 2000;46(2):186–204.CrossRef Venkatesh V, Davis FD. A theoretical extension of the technology acceptance model: four longitudinal field studies. Manag Sci. 2000;46(2):186–204.CrossRef
37.
go back to reference Venkatesh V, Morris MG, Davis GB, et al. User acceptance of information technology: toward a unified view. MIS Quarterly. 2003;27(3):425–78. Venkatesh V, Morris MG, Davis GB, et al. User acceptance of information technology: toward a unified view. MIS Quarterly. 2003;27(3):425–78.
38.
go back to reference Hornbaek K. Current practice in measuring usability: challenges to usability studies and research. Int J Hum Comput Stud. 2006;64:79–102.CrossRef Hornbaek K. Current practice in measuring usability: challenges to usability studies and research. Int J Hum Comput Stud. 2006;64:79–102.CrossRef
39.
go back to reference ‘t hart H, Van Dijk J, De Goede M, et al. Onderzoeksmethoden. 6th ed. Amsterdam: Boom; 2003. ‘t hart H, Van Dijk J, De Goede M, et al. Onderzoeksmethoden. 6th ed. Amsterdam: Boom; 2003.
40.
go back to reference Brooke J. SUS: a quick and dirty usability scale. In: Jordan PW, Thomas B, McClelland IL, et al., editors. Usability evaluation in industry. Boca Raton: CRC Press; 1996. p. 189–94. Brooke J. SUS: a quick and dirty usability scale. In: Jordan PW, Thomas B, McClelland IL, et al., editors. Usability evaluation in industry. Boca Raton: CRC Press; 1996. p. 189–94.
41.
go back to reference Bangor A, Kortum PT, Miller JT. An empirical evaluation of the System Usability Scale. Int J Hum Comput Interact. 2008;24(6):574–94.CrossRef Bangor A, Kortum PT, Miller JT. An empirical evaluation of the System Usability Scale. Int J Hum Comput Interact. 2008;24(6):574–94.CrossRef
42.
go back to reference Bangor A, Kortum PT, Miller JT. Determining what individual SUS scores mean: adding an adjective rating scale. J Usability Stud. 2009;4(3):114–23. Bangor A, Kortum PT, Miller JT. Determining what individual SUS scores mean: adding an adjective rating scale. J Usability Stud. 2009;4(3):114–23.
43.
go back to reference Adomavicius G, Tuzhilin A. Toward the next generation of recommender systems: a survey of the state-of-the-art and possible extensions. IEEE Trans Knowl Data Eng. 2005;17(6):734–49.CrossRef Adomavicius G, Tuzhilin A. Toward the next generation of recommender systems: a survey of the state-of-the-art and possible extensions. IEEE Trans Knowl Data Eng. 2005;17(6):734–49.CrossRef
44.
go back to reference Eslami S, Abu-Hanna A, De Keizer NF, et al. Errors associated with applying decision support by suggesting default doses for aminoglycosides. Drug Saf. 2006;29(9):803–9.PubMedCrossRef Eslami S, Abu-Hanna A, De Keizer NF, et al. Errors associated with applying decision support by suggesting default doses for aminoglycosides. Drug Saf. 2006;29(9):803–9.PubMedCrossRef
45.
go back to reference Koppel R, Metlay JP, Cohen A, et al. Role of computerized physician order entry systems in facilitating medication errors. JAMA. 2005;293(10):1197–203.PubMedCrossRef Koppel R, Metlay JP, Cohen A, et al. Role of computerized physician order entry systems in facilitating medication errors. JAMA. 2005;293(10):1197–203.PubMedCrossRef
46.
go back to reference Ash JS, Berg M, Coiera E. Some unintended consequences of information technology in health care: the nature of patient care information system-related errors. J Am Med Inform Assoc. 2004;11(2):104–16.PubMedCentralPubMedCrossRef Ash JS, Berg M, Coiera E. Some unintended consequences of information technology in health care: the nature of patient care information system-related errors. J Am Med Inform Assoc. 2004;11(2):104–16.PubMedCentralPubMedCrossRef
47.
go back to reference Hornbæk K, Law ELC. Meta-analysis of correlations among usability measures. In: Proceedings of the SIGCHI Conference on Human Factors in Computing Systems; 2007. p. 617–26. Hornbæk K, Law ELC. Meta-analysis of correlations among usability measures. In: Proceedings of the SIGCHI Conference on Human Factors in Computing Systems; 2007. p. 617–26.
48.
go back to reference Nilsson EG, Følstad A. Effectiveness and efficiency as conflicting requirements in designing emergency mission reporting. I-UxSED; 2012. p. 20–5. Nilsson EG, Følstad A. Effectiveness and efficiency as conflicting requirements in designing emergency mission reporting. I-UxSED; 2012. p. 20–5.
49.
go back to reference O’Mahony D, O’Sullivan D, Byrne S, et al. STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing. 2015;44(2):213–8.PubMedCentralPubMedCrossRef O’Mahony D, O’Sullivan D, Byrne S, et al. STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing. 2015;44(2):213–8.PubMedCentralPubMedCrossRef
Metadata
Title
Computerized Decision Support Improves Medication Review Effectiveness: An Experiment Evaluating the STRIP Assistant’s Usability
Authors
Michiel C. Meulendijk
Marco R. Spruit
A. Clara Drenth-van Maanen
Mattijs E. Numans
Sjaak Brinkkemper
Paul A. F. Jansen
Wilma Knol
Publication date
01-06-2015
Publisher
Springer International Publishing
Published in
Drugs & Aging / Issue 6/2015
Print ISSN: 1170-229X
Electronic ISSN: 1179-1969
DOI
https://doi.org/10.1007/s40266-015-0270-0

Other articles of this Issue 6/2015

Drugs & Aging 6/2015 Go to the issue