Skip to main content
Top
Published in: Drugs & Aging 2/2015

01-02-2015 | Review Article

Pharmacological Management of Behavioral and Psychiatric Symptoms in Older Adults with Intellectual Disability

Authors: Nicole Eady, Ken Courtenay, André Strydom

Published in: Drugs & Aging | Issue 2/2015

Login to get access

Abstract

Given medical and social advances, the life expectancy of individuals with intellectual disability (ID) has increased dramatically, leading to a generation of older individuals with such disabilities. This review focuses on the pharmacological treatment of behavioral and psychiatric symptoms and disorders in older adults with ID. Older adults with ID often present with medical co-morbidities and mental health issues. Medication management of behavioral and psychiatric problems is complicated by a higher risk for adverse events, lack of decision-making capacity, and complex care networks. Some studies have shown that individuals with ID and co-morbid mental disorders are undertreated in comparison with those with similar disorders in the general population, resulting in poorer outcomes. However, older adults with ID are also at risk of polypharmacy, and older age is a risk factor for development of side effects. A general principle is that medication treatment for psychiatric disorders in older individuals with ID should be started at low dosages and increased cautiously while monitoring response and side effects. The use of psychotropic drugs for older individuals with ID and behavioral problems remains controversial, particularly in those with dementia.
Literature
1.
go back to reference Maulik P, Mascherenhas MN, Mathers CD, Dua T, Saxena S. Prevalance of intellectual disability: a meta-analysis of population-based studies. Res Dev Disabil. 2011;32:419–36.CrossRefPubMed Maulik P, Mascherenhas MN, Mathers CD, Dua T, Saxena S. Prevalance of intellectual disability: a meta-analysis of population-based studies. Res Dev Disabil. 2011;32:419–36.CrossRefPubMed
3.
go back to reference Matthews T, Weston N, Baxter H, Felce D, Kerr M. A general practice-based prevalence study of epilepsy among adults with intellectual disabilities and of its association with psychiatric disorder, behaviour disturbance and carer stress. J Intellect Disabil Res. 2008;52(2):163–73.CrossRefPubMed Matthews T, Weston N, Baxter H, Felce D, Kerr M. A general practice-based prevalence study of epilepsy among adults with intellectual disabilities and of its association with psychiatric disorder, behaviour disturbance and carer stress. J Intellect Disabil Res. 2008;52(2):163–73.CrossRefPubMed
4.
go back to reference Cooper S-A, Smiley E, Morrison J, Williamson A, Allan L. Mental ill-health in adults with intellectual disabilities: prevalence and associated factors. Br J Psychiatry. 2007;190(1):27–35.CrossRefPubMed Cooper S-A, Smiley E, Morrison J, Williamson A, Allan L. Mental ill-health in adults with intellectual disabilities: prevalence and associated factors. Br J Psychiatry. 2007;190(1):27–35.CrossRefPubMed
5.
go back to reference Bittles AH, Petterson BA, Sullivan SG, Hussain R, Glasson EJ, Montgomery PD. The influence of intellectual disability on life expectancy. J Gerontol A Biol Sci Med Sci. 2002;57(7):M470–2.CrossRefPubMed Bittles AH, Petterson BA, Sullivan SG, Hussain R, Glasson EJ, Montgomery PD. The influence of intellectual disability on life expectancy. J Gerontol A Biol Sci Med Sci. 2002;57(7):M470–2.CrossRefPubMed
6.
go back to reference Glasson E, Sullivan S, Hussain R, Petterson B, Montgomery P, Bittles A. The changing survival profile of people with Down’s syndrome: implications for genetic counselling. Clin Genet. 2002;62(5):390–3.CrossRefPubMed Glasson E, Sullivan S, Hussain R, Petterson B, Montgomery P, Bittles A. The changing survival profile of people with Down’s syndrome: implications for genetic counselling. Clin Genet. 2002;62(5):390–3.CrossRefPubMed
8.
go back to reference Strydom A, Shooshtari S, Lee L, Raykar V, Torr J, Tsiouris J, et al. Dementia in older adults with intellectual disabilities—epidemiology, presentation, and diagnosis. J Policy Pract Intellect Disabil. 2010;7(2):96–110.CrossRef Strydom A, Shooshtari S, Lee L, Raykar V, Torr J, Tsiouris J, et al. Dementia in older adults with intellectual disabilities—epidemiology, presentation, and diagnosis. J Policy Pract Intellect Disabil. 2010;7(2):96–110.CrossRef
9.
go back to reference Haveman M, Heller T, Lee L, Maaskant M, Shooshtari S, Strydom A. Major health risks in aging persons with intellectual disabilities: an overview of recent studies. J Policy Pract Intellect Disabil. 2010;7(1):59–69.CrossRef Haveman M, Heller T, Lee L, Maaskant M, Shooshtari S, Strydom A. Major health risks in aging persons with intellectual disabilities: an overview of recent studies. J Policy Pract Intellect Disabil. 2010;7(1):59–69.CrossRef
10.
go back to reference Jansen J, Rozeboom W, Penning C, Evenhuis HM. Prevalence and incidence of myocardial infarction and cerebrovascular accident in ageing persons with intellectual disability. J Intellect Disabil Res. 2013;57(7):681–5.CrossRefPubMed Jansen J, Rozeboom W, Penning C, Evenhuis HM. Prevalence and incidence of myocardial infarction and cerebrovascular accident in ageing persons with intellectual disability. J Intellect Disabil Res. 2013;57(7):681–5.CrossRefPubMed
11.
go back to reference Haveman M, Perry J, Salvador-Carulla L, Walsh PN, Kerr M, Van Schrojenstein Lantman-de Valk H, et al. Ageing and health status in adults with intellectual disabilities: Results of the European POMONA II study. J Intellect Dev Disabil. 2011;36(1):49–60. Haveman M, Perry J, Salvador-Carulla L, Walsh PN, Kerr M, Van Schrojenstein Lantman-de Valk H, et al. Ageing and health status in adults with intellectual disabilities: Results of the European POMONA II study. J Intellect Dev Disabil. 2011;36(1):49–60.
12.
go back to reference Deb S, Kwok H, Bertelli M, Salvador-Carulla L, Bradley E, Torr J, et al. International guide to prescribing psychotropic medication for the management of problem behaviours in adults with intellectual disabilities. World Psychiatry. 2009;8(3):181–6.PubMedCentralPubMed Deb S, Kwok H, Bertelli M, Salvador-Carulla L, Bradley E, Torr J, et al. International guide to prescribing psychotropic medication for the management of problem behaviours in adults with intellectual disabilities. World Psychiatry. 2009;8(3):181–6.PubMedCentralPubMed
13.
go back to reference Sawyer A, Lake JK, Lunsky Y, Liu S-K, Desarkar P. Psychopharmacological treatment of challenging behaviours in adults with autism and intellectual disabilities: a systematic review. Res Autism Spectr Disord. 2014;8(7):803–13.CrossRef Sawyer A, Lake JK, Lunsky Y, Liu S-K, Desarkar P. Psychopharmacological treatment of challenging behaviours in adults with autism and intellectual disabilities: a systematic review. Res Autism Spectr Disord. 2014;8(7):803–13.CrossRef
14.
go back to reference Strydom A, Livingston G, King M, Hassiotis A. Prevalence of dementia in intellectual disability using different diagnostic criteria. Br J Psychiatry. 2007;191(2):150–7.CrossRefPubMed Strydom A, Livingston G, King M, Hassiotis A. Prevalence of dementia in intellectual disability using different diagnostic criteria. Br J Psychiatry. 2007;191(2):150–7.CrossRefPubMed
15.
go back to reference Strydom A, Hassiotis A, Livingston G. Mental health and social care needs of older people with intellectual disabilities. J Appl Res Intellect Disabil. 2005;18(3):229–35.CrossRef Strydom A, Hassiotis A, Livingston G. Mental health and social care needs of older people with intellectual disabilities. J Appl Res Intellect Disabil. 2005;18(3):229–35.CrossRef
16.
go back to reference Häβler F, Thome J, Reis O. Polypharmacy in the treatment of subjects with intellectual disability. J Neural Transm. 2014;25:1–8. Häβler F, Thome J, Reis O. Polypharmacy in the treatment of subjects with intellectual disability. J Neural Transm. 2014;25:1–8.
17.
go back to reference Richards M, Maughan B, Hardy R, Hall I, Strydom A, Wadsworth M. Long-term affective disorder in people with mild learning disability. Br J Psychiatry. 2001;179(6):523–7.CrossRefPubMed Richards M, Maughan B, Hardy R, Hall I, Strydom A, Wadsworth M. Long-term affective disorder in people with mild learning disability. Br J Psychiatry. 2001;179(6):523–7.CrossRefPubMed
18.
go back to reference Hermans H, Evenhuis HM. Factors associated with depression and anxiety in older adults with intellectual disabilities: results of the healthy ageing and intellectual disabilities study. Int J Geriatr Psychiatry. 2013;28(7):691–9.CrossRefPubMed Hermans H, Evenhuis HM. Factors associated with depression and anxiety in older adults with intellectual disabilities: results of the healthy ageing and intellectual disabilities study. Int J Geriatr Psychiatry. 2013;28(7):691–9.CrossRefPubMed
19.
go back to reference Hermans H, Beekman ATF, Evenhuis HM. Prevalence of depression and anxiety in older users of formal Dutch intellectual disability services. J Affect Disord. 2013;144(1–2):94–100.CrossRefPubMed Hermans H, Beekman ATF, Evenhuis HM. Prevalence of depression and anxiety in older users of formal Dutch intellectual disability services. J Affect Disord. 2013;144(1–2):94–100.CrossRefPubMed
20.
go back to reference Wu C-S, Desarkar P, Palucka A, Lunsky Y, Liu S-K. Acute inpatient treatment, hospitalization course and direct costs in bipolar patients with intellectual disability. Res Dev Disabil. 2013;34(11):4062–72.CrossRefPubMed Wu C-S, Desarkar P, Palucka A, Lunsky Y, Liu S-K. Acute inpatient treatment, hospitalization course and direct costs in bipolar patients with intellectual disability. Res Dev Disabil. 2013;34(11):4062–72.CrossRefPubMed
21.
go back to reference Tsiouris JA, Kim S-Y, Brown WT, Pettinger J, Cohen IL. Prevalence of psychotropic drug use in adults with intellectual disability: positive and negative findings from a large scale study. J Autism Dev Disord. 2013;43(3):719–31.CrossRefPubMed Tsiouris JA, Kim S-Y, Brown WT, Pettinger J, Cohen IL. Prevalence of psychotropic drug use in adults with intellectual disability: positive and negative findings from a large scale study. J Autism Dev Disord. 2013;43(3):719–31.CrossRefPubMed
22.
go back to reference National Institute for Health and Care Excellence. Dementia: supporting people with dementia and their carers in health and social care. London: NICE; 2006. National Institute for Health and Care Excellence. Dementia: supporting people with dementia and their carers in health and social care. London: NICE; 2006.
23.
go back to reference American Psychiatric Association. Practice guideline for the treatment of patients with major depressive disorder. Arlington: APA; 2010. American Psychiatric Association. Practice guideline for the treatment of patients with major depressive disorder. Arlington: APA; 2010.
24.
go back to reference Paton C, Flynn A, Shingleton-Smith A, McIntyre S, Bhaumik S, Rasmussen J, et al. Nature and quality of antipsychotic prescribing practice in UK psychiatry of learning disability services: findings of a national audit. J Intellect Disabil Res. 2011;55:655–74.CrossRef Paton C, Flynn A, Shingleton-Smith A, McIntyre S, Bhaumik S, Rasmussen J, et al. Nature and quality of antipsychotic prescribing practice in UK psychiatry of learning disability services: findings of a national audit. J Intellect Disabil Res. 2011;55:655–74.CrossRef
25.
go back to reference Deb S, Farmah BK, Arshad E, Deb T, Roy M, Unwin GL. The effectiveness of aripiprazole in the management of problem behaviour in people with intellectual disabilities, developmental disabilities and/or autistic spectrum disorder—a systematic review. Res Dev Disabil. 2014;35(3):711–25.CrossRefPubMed Deb S, Farmah BK, Arshad E, Deb T, Roy M, Unwin GL. The effectiveness of aripiprazole in the management of problem behaviour in people with intellectual disabilities, developmental disabilities and/or autistic spectrum disorder—a systematic review. Res Dev Disabil. 2014;35(3):711–25.CrossRefPubMed
26.
go back to reference Cohen D, Raffin M, Canitano R, Bodeau N, Bonnot O, Perisse D, et al. Risperidone or aripiprazole in children and adolescents with autism and/or intellectual disability: A Bayesian meta-analysis of efficacy and secondary effects. Res Autism Spectr Disord. 2013;7(1):167–75.CrossRef Cohen D, Raffin M, Canitano R, Bodeau N, Bonnot O, Perisse D, et al. Risperidone or aripiprazole in children and adolescents with autism and/or intellectual disability: A Bayesian meta-analysis of efficacy and secondary effects. Res Autism Spectr Disord. 2013;7(1):167–75.CrossRef
27.
go back to reference De Leon J, Greenlee B, Barber J, Sabaawi M, Singh N. Practical guidelines for the use of new generation antipsychotic drugs (except clozapine) in adult individuals with intellectual disabilities. Res Dev Disabil. 2009;30(4):613–69.CrossRefPubMed De Leon J, Greenlee B, Barber J, Sabaawi M, Singh N. Practical guidelines for the use of new generation antipsychotic drugs (except clozapine) in adult individuals with intellectual disabilities. Res Dev Disabil. 2009;30(4):613–69.CrossRefPubMed
28.
go back to reference Sabaawi M, Singh N, de Leon J. Guidelines for the use of clozapine in individuals with developmental disabilities. Res Dev Disabil. 2006;27(3):309–36.CrossRefPubMed Sabaawi M, Singh N, de Leon J. Guidelines for the use of clozapine in individuals with developmental disabilities. Res Dev Disabil. 2006;27(3):309–36.CrossRefPubMed
29.
go back to reference Teeluckdharry S, Sharma S, O’Rourke E, Tharian P, Gondalekar A, Nainar F, et al. Monitoring metabolic side effects of atypical antipsychotics in people with an intellectual disability. J Intellect Disabil. 2013;17(3):223–35.CrossRefPubMed Teeluckdharry S, Sharma S, O’Rourke E, Tharian P, Gondalekar A, Nainar F, et al. Monitoring metabolic side effects of atypical antipsychotics in people with an intellectual disability. J Intellect Disabil. 2013;17(3):223–35.CrossRefPubMed
30.
go back to reference De Kuijper G, Mulder H, Evenhuis H, Scholte F, Visser F, Hoekstra PJ. Determinants of physical health parameters in individuals with intellectual disability who use long-term antipsychotics. Res Dev Disabil. 2013;34(9):2799–809.CrossRefPubMed De Kuijper G, Mulder H, Evenhuis H, Scholte F, Visser F, Hoekstra PJ. Determinants of physical health parameters in individuals with intellectual disability who use long-term antipsychotics. Res Dev Disabil. 2013;34(9):2799–809.CrossRefPubMed
31.
go back to reference Donepezil Galantamine. Rivastigmine and memantine for the treatment of Alzheimer’s disease. London: National Institute for Health and Clinical Excellence; 2011. Donepezil Galantamine. Rivastigmine and memantine for the treatment of Alzheimer’s disease. London: National Institute for Health and Clinical Excellence; 2011.
32.
go back to reference Sheehan R, Ali A, Hassiotis A. Dementia in intellectual disability. Curr Opin Psychiatry. 2014;27(2):143–8.CrossRefPubMed Sheehan R, Ali A, Hassiotis A. Dementia in intellectual disability. Curr Opin Psychiatry. 2014;27(2):143–8.CrossRefPubMed
33.
go back to reference Rogers SL, Doody RS, Pratt RD, Leni JR. Long-term efficacy and safety of donepezil in the treatment of Alzheimer’s disease: final analysis of a US multicentre open-label study. Eur Neuropsychopharmacol. 2000;10(3):195–203.CrossRefPubMed Rogers SL, Doody RS, Pratt RD, Leni JR. Long-term efficacy and safety of donepezil in the treatment of Alzheimer’s disease: final analysis of a US multicentre open-label study. Eur Neuropsychopharmacol. 2000;10(3):195–203.CrossRefPubMed
34.
go back to reference Cummings J, McRae T, Zhang R. Effects of donepezil on neuropsychiatric symptoms in patients with dementia and severe behavioural disorders. Am J Geriatr Psychiatry. 2006;14(7):605–12.CrossRefPubMed Cummings J, McRae T, Zhang R. Effects of donepezil on neuropsychiatric symptoms in patients with dementia and severe behavioural disorders. Am J Geriatr Psychiatry. 2006;14(7):605–12.CrossRefPubMed
35.
go back to reference Bond M, Rogers G, Peters J, Anderson R, Hoyle M, Miners A, et al. The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer’s disease (review of Technology Appraisal No. 111): a systematic review and economic model. 2012. http://www.ncbi.nlm.nih.gov/books/NBK97263/. Cited 2014 Nov 7. Bond M, Rogers G, Peters J, Anderson R, Hoyle M, Miners A, et al. The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer’s disease (review of Technology Appraisal No. 111): a systematic review and economic model. 2012. http://​www.​ncbi.​nlm.​nih.​gov/​books/​NBK97263/​. Cited 2014 Nov 7.
36.
go back to reference Segal-Gidan F, Cherry D, Jones R, Williams B, Hewett L, Chodosh J. Alzheimer’s disease management guideline: update 2008. Alzheimers Dement. 2011;7(3):e51–9.CrossRefPubMed Segal-Gidan F, Cherry D, Jones R, Williams B, Hewett L, Chodosh J. Alzheimer’s disease management guideline: update 2008. Alzheimers Dement. 2011;7(3):e51–9.CrossRefPubMed
37.
go back to reference Hort J, O’Brien JT, Gainotti G, Pirttila T, Popescu BO, Rektorova I, et al. EFNS guidelines for the diagnosis and management of Alzheimer’s disease. Eur J Neurol. 2010;17(10):1236–48.CrossRefPubMed Hort J, O’Brien JT, Gainotti G, Pirttila T, Popescu BO, Rektorova I, et al. EFNS guidelines for the diagnosis and management of Alzheimer’s disease. Eur J Neurol. 2010;17(10):1236–48.CrossRefPubMed
38.
go back to reference Schupf N, Zigman WB, Tang MX, Pang D, Mayeux R, Mehta P, et al. Change in plasma Aβ peptides and onset of dementia in adults with Down syndrome. Neurology. 2010;75:1639–44.CrossRefPubMedCentralPubMed Schupf N, Zigman WB, Tang MX, Pang D, Mayeux R, Mehta P, et al. Change in plasma Aβ peptides and onset of dementia in adults with Down syndrome. Neurology. 2010;75:1639–44.CrossRefPubMedCentralPubMed
39.
go back to reference Lott IT, Osann K, Doran E, Nelson L. Down syndrome and Alzheimer disease: response to donepezil. Arch Neurol. 2002;59(7):1133–6.CrossRefPubMed Lott IT, Osann K, Doran E, Nelson L. Down syndrome and Alzheimer disease: response to donepezil. Arch Neurol. 2002;59(7):1133–6.CrossRefPubMed
40.
go back to reference Prasher VP, Huxley A, Haque MS. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Down syndrome and Alzheimer’s disease—pilot study. Int J Geriatr Psychiatry. 2002;17(3):270–8.CrossRefPubMed Prasher VP, Huxley A, Haque MS. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Down syndrome and Alzheimer’s disease—pilot study. Int J Geriatr Psychiatry. 2002;17(3):270–8.CrossRefPubMed
41.
go back to reference Prasher VP, Adams C, Holder R. Long term safety and efficacy of donepezil in the treatment of dementia in Alzheimer’s disease in adults with Down syndrome: open label study. Int J Geriatr Psychiatry. 2003;18(6):549–51.CrossRefPubMed Prasher VP, Adams C, Holder R. Long term safety and efficacy of donepezil in the treatment of dementia in Alzheimer’s disease in adults with Down syndrome: open label study. Int J Geriatr Psychiatry. 2003;18(6):549–51.CrossRefPubMed
42.
go back to reference Prasher VP, Sachdeva N, Adams C, Haque MS. Rivastigmine transdermal patches in the treatment of dementia in Alzheimer’s disease in adults with Down syndrome: pilot study. Int J Geriatr Psychiatry. 2013;28(2):219–20.CrossRefPubMed Prasher VP, Sachdeva N, Adams C, Haque MS. Rivastigmine transdermal patches in the treatment of dementia in Alzheimer’s disease in adults with Down syndrome: pilot study. Int J Geriatr Psychiatry. 2013;28(2):219–20.CrossRefPubMed
43.
go back to reference Prasher VP, Fung N, Adams C. Rivastigmine in the treatment of dementia in Alzheimer’s disease in adults with Down syndrome. Int J Geriatr Psychiatry. 2005;20(5):496–7.CrossRefPubMed Prasher VP, Fung N, Adams C. Rivastigmine in the treatment of dementia in Alzheimer’s disease in adults with Down syndrome. Int J Geriatr Psychiatry. 2005;20(5):496–7.CrossRefPubMed
44.
go back to reference Hanney M, Prasher V, Williams N, Jones E, Aarsland D, Corbett A, et al. Memantine for dementia in adults older than 40 years with Down’s syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial. Lancet. 2012;379:528–36.CrossRefPubMed Hanney M, Prasher V, Williams N, Jones E, Aarsland D, Corbett A, et al. Memantine for dementia in adults older than 40 years with Down’s syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial. Lancet. 2012;379:528–36.CrossRefPubMed
45.
go back to reference Strydom A, Chan T, King M, Hassiotis A, Livingston G. Incidence of dementia in older adults with intellectual disabilities. Res Dev Disabil. 2013;34(6):1881–5.CrossRefPubMed Strydom A, Chan T, King M, Hassiotis A, Livingston G. Incidence of dementia in older adults with intellectual disabilities. Res Dev Disabil. 2013;34(6):1881–5.CrossRefPubMed
46.
go back to reference Bush A, Beail N. Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis. Am J Ment Retard. 2004;109(2):83–97.CrossRefPubMed Bush A, Beail N. Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis. Am J Ment Retard. 2004;109(2):83–97.CrossRefPubMed
47.
go back to reference Schneider LS, Tariot PN, Dagerman KS, Davis SM, Hsiao JK, Ismail MS, et al. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer’s disease. N Engl J Med. 2006;355(15):1525–38.CrossRefPubMed Schneider LS, Tariot PN, Dagerman KS, Davis SM, Hsiao JK, Ismail MS, et al. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer’s disease. N Engl J Med. 2006;355(15):1525–38.CrossRefPubMed
49.
go back to reference Dementia and People with Learning Disabilities: Guidance on assessment, diagnosis, treatment and support of people with learning disabilities who develop dementia. London: Royal College of Psychiatrists and The British Psychological Society; 2009. Dementia and People with Learning Disabilities: Guidance on assessment, diagnosis, treatment and support of people with learning disabilities who develop dementia. London: Royal College of Psychiatrists and The British Psychological Society; 2009.
51.
go back to reference Sajith SG, Clarke D. Melatonin and sleep disorders associated with intellectual disability: a clinical review. J Intellect Disabil Res. 2007;51(1):2–13.CrossRefPubMed Sajith SG, Clarke D. Melatonin and sleep disorders associated with intellectual disability: a clinical review. J Intellect Disabil Res. 2007;51(1):2–13.CrossRefPubMed
52.
go back to reference Edelsohn GA, Schuster JM, Castelnovo K, Terhorst L, Parthasarathy M. Psychotropic prescribing for persons with intellectual disabilities and other psychiatric disorders. Psychiatr Serv. 2014;65(2):201–7.CrossRefPubMed Edelsohn GA, Schuster JM, Castelnovo K, Terhorst L, Parthasarathy M. Psychotropic prescribing for persons with intellectual disabilities and other psychiatric disorders. Psychiatr Serv. 2014;65(2):201–7.CrossRefPubMed
Metadata
Title
Pharmacological Management of Behavioral and Psychiatric Symptoms in Older Adults with Intellectual Disability
Authors
Nicole Eady
Ken Courtenay
André Strydom
Publication date
01-02-2015
Publisher
Springer International Publishing
Published in
Drugs & Aging / Issue 2/2015
Print ISSN: 1170-229X
Electronic ISSN: 1179-1969
DOI
https://doi.org/10.1007/s40266-014-0236-7

Other articles of this Issue 2/2015

Drugs & Aging 2/2015 Go to the issue