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Clinical Pharmacokinetics
Published in: Clinical Pharmacokinetics 12/2018

01-12-2018 | Review article

Clinical Pharmacokinetics and Pharmacodynamics of Isavuconazole

Authors: Matthew W. McCarthy, Brad Moriyama, Ruta Petraitiene, Thomas J. Walsh, Vidmantas Petraitis

Published in: Clinical Pharmacokinetics | Issue 12/2018

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Abstract

In March 2015, the extended-spectrum triazole antifungal isavuconazole was granted approval by the US Food and Drug Administration and the European Medicines Agency for the treatment of invasive aspergillosis and mucormycosis. Isavuconaozle has activity against a broad range of yeasts, dimorphic fungi, and molds and is associated with fewer toxicities than voriconazole. It also has predictable pharmacokinetics in adults, fewer drug–drug interactions than many existing antifungal agents, and is available in both oral and β-cyclodextrin-free intravenous formulations. In this review, we explore what is known about the pharmacokinetics and pharmacodynamics of isavuconazole and look ahead to its expanding applications in clinical practice.
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Metadata
Title
Clinical Pharmacokinetics and Pharmacodynamics of Isavuconazole
Authors
Matthew W. McCarthy
Brad Moriyama
Ruta Petraitiene
Thomas J. Walsh
Vidmantas Petraitis
Publication date
01-12-2018
Publisher
Springer International Publishing
Published in
Clinical Pharmacokinetics / Issue 12/2018
Print ISSN: 0312-5963
Electronic ISSN: 1179-1926
DOI
https://doi.org/10.1007/s40262-018-0673-2

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