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Published in: American Journal of Clinical Dermatology 5/2014

01-10-2014 | Review Article

Neutrophilic Dermatoses: An Update

Authors: Afsaneh Alavi, Dusan Sajic, Felipe B. Cerci, Danny Ghazarian, Misha Rosenbach, Joseph Jorizzo

Published in: American Journal of Clinical Dermatology | Issue 5/2014

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Abstract

Neutrophilic dermatoses constitute a heterogeneous group of dermatologic diseases, which are unified by the predominance of neutrophils within the inflammatory infiltrate on histopathology. The aims of this review were to provide an update on the clinical and histologic presentation of the main neutrophilic dermatoses and to develop a guide for clinical practice. A structured literature search of PubMed, Medline, and Embase was performed, using the key words “neutrophilic disorders”, “cutaneous small vessel vasculitis”, “Sweet’s syndrome”, “bowel associated dermatosis arthritis syndrome”, “Behcet’s”, “palisaded neutrophilic and granulomatous dermatosis”, “rheumatoid neutrophilic dermatitis”, and “pyoderma gangrenosum”. Related articles were screened for key terms and were included if appropriate. This group contains a wide spectrum of unique disorders, each with its own histologic and clinical subtleties, making specific diagnosis of a given entity within the group diagnostically challenging. The fact that overlapping forms of neutrophilic dermatoses, which share features of multiple neutrophilic dermatoses, are not uncommon makes the diagnoses more challenging.
Literature
1.
go back to reference Jorizzo JL, Solomon AR, Zanolli MD, Leshin B. Neutrophilic vascular reactions. J Am Acad Dermatol. 1988;19(6):983–1005.PubMedCrossRef Jorizzo JL, Solomon AR, Zanolli MD, Leshin B. Neutrophilic vascular reactions. J Am Acad Dermatol. 1988;19(6):983–1005.PubMedCrossRef
2.
4.
go back to reference Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Arthritis Rheum. 2013;65(1):1–11.PubMedCrossRef Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Arthritis Rheum. 2013;65(1):1–11.PubMedCrossRef
5.
go back to reference Russell JP, Gibson LE. Primary cutaneous small vessel vasculitis: approach to diagnosis and treatment. Int J Dermatol. 2006;45(1):3–13.PubMedCrossRef Russell JP, Gibson LE. Primary cutaneous small vessel vasculitis: approach to diagnosis and treatment. Int J Dermatol. 2006;45(1):3–13.PubMedCrossRef
6.
go back to reference Sais G, Vidaller A, Jucgla A, Servitje O, Condom E, Peyri J. Prognostic factors in leukocytoclastic vasculitis: a clinicopathologic study of 160 patients. Arch Dermatol. 1998;134(3):309–15.PubMedCrossRef Sais G, Vidaller A, Jucgla A, Servitje O, Condom E, Peyri J. Prognostic factors in leukocytoclastic vasculitis: a clinicopathologic study of 160 patients. Arch Dermatol. 1998;134(3):309–15.PubMedCrossRef
7.
go back to reference Ekenstam E, Callen JP. Cutaneous leukocytoclastic vasculitis: clinical and laboratory features of 82 patients seen in private practice. Arch Dermatol. 1984;120(4):484–9.CrossRef Ekenstam E, Callen JP. Cutaneous leukocytoclastic vasculitis: clinical and laboratory features of 82 patients seen in private practice. Arch Dermatol. 1984;120(4):484–9.CrossRef
8.
go back to reference Caucanas M, Heylen A, Rolland F, Muller G, Olemans C, Sass U, et al. Associated pyoderma gangrenosum, erythema elevatum diutinum, and Sweet’s syndrome: the concept of neutrophilic disease. Int J Dermatol. 2013;52(10):1185–8.PubMed Caucanas M, Heylen A, Rolland F, Muller G, Olemans C, Sass U, et al. Associated pyoderma gangrenosum, erythema elevatum diutinum, and Sweet’s syndrome: the concept of neutrophilic disease. Int J Dermatol. 2013;52(10):1185–8.PubMed
9.
go back to reference Swerlick RA, Lawley TJ. Cutaneous vasculitis: its relationship to systemic disease. Med Clin N Am. 1989;73(5):1221–35.PubMed Swerlick RA, Lawley TJ. Cutaneous vasculitis: its relationship to systemic disease. Med Clin N Am. 1989;73(5):1221–35.PubMed
10.
go back to reference Carlson JA, Ng BT, Chen KR. Cutaneous vasculitis update: diagnostic criteria, classification, epidemiology, etiology, pathogenesis, evaluation and prognosis. Am J Dermatopathol. 2005;27(6):504–28.PubMedCrossRef Carlson JA, Ng BT, Chen KR. Cutaneous vasculitis update: diagnostic criteria, classification, epidemiology, etiology, pathogenesis, evaluation and prognosis. Am J Dermatopathol. 2005;27(6):504–28.PubMedCrossRef
11.
go back to reference Peuvrel L, Quereux G, Brocard A, Saint-Jean M, Freour E, Josselin N, et al. Atypical cutaneous vasculitis under lapatinib. Eur J Dermatol. 2013;23(4):540–1.PubMed Peuvrel L, Quereux G, Brocard A, Saint-Jean M, Freour E, Josselin N, et al. Atypical cutaneous vasculitis under lapatinib. Eur J Dermatol. 2013;23(4):540–1.PubMed
12.
go back to reference Novoa RA, Honda K, Koon HB, Gerstenblith MR. Vasculitis and panniculitis associated with vemurafenib. J Am Acad Dermatol. 2012;67(6):e271–2.PubMedCrossRef Novoa RA, Honda K, Koon HB, Gerstenblith MR. Vasculitis and panniculitis associated with vemurafenib. J Am Acad Dermatol. 2012;67(6):e271–2.PubMedCrossRef
13.
go back to reference Podjasek JO, Wetter DA, Pittelkow MR, Wada DA. Cutaneous small-vessel vasculitis associated with solid organ malignancies: the Mayo Clinic experience, 1996–2009. J Am Acad Dermatol. 2012;66(2):e55–65.PubMedCrossRef Podjasek JO, Wetter DA, Pittelkow MR, Wada DA. Cutaneous small-vessel vasculitis associated with solid organ malignancies: the Mayo Clinic experience, 1996–2009. J Am Acad Dermatol. 2012;66(2):e55–65.PubMedCrossRef
14.
go back to reference Ingraffea A, Donohue K, Wilkel C, Falanga V. Cutaneous vasculitis in two patients taking an herbal supplement containing black cohosh. J Am Acad Dermatol. 2007;56(5 Suppl):S124–6.PubMedCrossRef Ingraffea A, Donohue K, Wilkel C, Falanga V. Cutaneous vasculitis in two patients taking an herbal supplement containing black cohosh. J Am Acad Dermatol. 2007;56(5 Suppl):S124–6.PubMedCrossRef
15.
go back to reference Podjasek JO, Wetter DA, Pittelkow MR, Wada DA. Henoch-Schonlein purpura associated with solid-organ malignancies: three case reports and a literature review. Acta Derm Venereol. 2012;92(4):388–92.PubMedCrossRef Podjasek JO, Wetter DA, Pittelkow MR, Wada DA. Henoch-Schonlein purpura associated with solid-organ malignancies: three case reports and a literature review. Acta Derm Venereol. 2012;92(4):388–92.PubMedCrossRef
16.
go back to reference Lever WF, Schaumburg-Lever S. Histopathology of the skin. Philadelphia: JB Lippincott; 1990. Lever WF, Schaumburg-Lever S. Histopathology of the skin. Philadelphia: JB Lippincott; 1990.
17.
go back to reference Zax RH, Hodge SJ, Callen JP. Cutaneous leukocytoclastic vasculitis: serial histopathologic evaluation demonstrates the dynamic nature of the infiltrate. Arch Dermatol. 1990;126(1):69–72.PubMedCrossRef Zax RH, Hodge SJ, Callen JP. Cutaneous leukocytoclastic vasculitis: serial histopathologic evaluation demonstrates the dynamic nature of the infiltrate. Arch Dermatol. 1990;126(1):69–72.PubMedCrossRef
18.
go back to reference Bahrami S, Malone JC, Webb KG, Callen JP. Tissue eosinophilia as an indicator of drug-induced cutaneous small-vessel vasculitis. Arch Dermatol. 2006;142(2):155–61.PubMedCrossRef Bahrami S, Malone JC, Webb KG, Callen JP. Tissue eosinophilia as an indicator of drug-induced cutaneous small-vessel vasculitis. Arch Dermatol. 2006;142(2):155–61.PubMedCrossRef
19.
go back to reference Haeberle MT, Adams WB, Callen JP. Treatment of severe cutaneous small-vessel vasculitis with mycophenolate mofetil. Arch Dermatol. 2012;148(8):887–8.PubMedCrossRef Haeberle MT, Adams WB, Callen JP. Treatment of severe cutaneous small-vessel vasculitis with mycophenolate mofetil. Arch Dermatol. 2012;148(8):887–8.PubMedCrossRef
20.
21.
go back to reference Rochet NM, Chavan RN, Cappel MA, Wada DA, Gibson LE. Sweet syndrome: clinical presentation, associations, and response to treatment in 77 patients. J Am Acad Dermatol. 2013;69(4):557–64.PubMedCrossRef Rochet NM, Chavan RN, Cappel MA, Wada DA, Gibson LE. Sweet syndrome: clinical presentation, associations, and response to treatment in 77 patients. J Am Acad Dermatol. 2013;69(4):557–64.PubMedCrossRef
22.
go back to reference Anzalone CL, Cohen PR. Acute febrile neutrophilic dermatosis (Sweet’s syndrome). Curr Opin Hematol. 2013;20(1):26–35.PubMedCrossRef Anzalone CL, Cohen PR. Acute febrile neutrophilic dermatosis (Sweet’s syndrome). Curr Opin Hematol. 2013;20(1):26–35.PubMedCrossRef
23.
go back to reference Paydas S. Sweet’s syndrome: a revisit for hematologists and oncologists. Crit Rev Oncol/Hematol. 2013;86(1):85–95.CrossRef Paydas S. Sweet’s syndrome: a revisit for hematologists and oncologists. Crit Rev Oncol/Hematol. 2013;86(1):85–95.CrossRef
24.
go back to reference Cohen PR. Neutrophilic dermatoses: a review of current treatment options. Am J Clin Dermatol. 2009;10(5):301–12.PubMedCrossRef Cohen PR. Neutrophilic dermatoses: a review of current treatment options. Am J Clin Dermatol. 2009;10(5):301–12.PubMedCrossRef
25.
go back to reference Marzano AV, Ishak RS, Saibeni S, Crosti C, Meroni PL, Cugno M. Autoinflammatory skin disorders in inflammatory bowel diseases, pyoderma gangrenosum and Sweet’s syndrome: a comprehensive review and disease classification criteria. Clin Rev Allergy Immunol. 2013;45(2):202–10.PubMedCrossRef Marzano AV, Ishak RS, Saibeni S, Crosti C, Meroni PL, Cugno M. Autoinflammatory skin disorders in inflammatory bowel diseases, pyoderma gangrenosum and Sweet’s syndrome: a comprehensive review and disease classification criteria. Clin Rev Allergy Immunol. 2013;45(2):202–10.PubMedCrossRef
26.
go back to reference Walker DC, Cohen PR. Trimethoprim-sulfamethoxazole-associated acute febrile neutrophilic dermatosis: case report and review of drug-induced Sweet’s syndrome. J Am Acad Dermatol. 1996;34(5 Pt 2):918–23.PubMedCrossRef Walker DC, Cohen PR. Trimethoprim-sulfamethoxazole-associated acute febrile neutrophilic dermatosis: case report and review of drug-induced Sweet’s syndrome. J Am Acad Dermatol. 1996;34(5 Pt 2):918–23.PubMedCrossRef
27.
go back to reference Bonamigo RR, Razera F, Olm GS. Neutrophilic dermatoses: part I. An Bras Dermatol. 2011;86(1):11–25 (quiz 26–7).PubMedCrossRef Bonamigo RR, Razera F, Olm GS. Neutrophilic dermatoses: part I. An Bras Dermatol. 2011;86(1):11–25 (quiz 26–7).PubMedCrossRef
28.
go back to reference Parsapour K, Reep MD, Gohar K, Shah V, Church A, Shwayder TA. Familial Sweet’s syndrome in 2 brothers, both seen in the first 2 weeks of life. J Am Acad Dermatol. 2003;49(1):132–8.PubMedCrossRef Parsapour K, Reep MD, Gohar K, Shah V, Church A, Shwayder TA. Familial Sweet’s syndrome in 2 brothers, both seen in the first 2 weeks of life. J Am Acad Dermatol. 2003;49(1):132–8.PubMedCrossRef
29.
go back to reference Razera F, Olm GS, Bonamigo RR. Neutrophilic dermatoses: part II. An Bras Dermatol. 2011;86(2):195–209 (quiz 210–1).PubMedCrossRef Razera F, Olm GS, Bonamigo RR. Neutrophilic dermatoses: part II. An Bras Dermatol. 2011;86(2):195–209 (quiz 210–1).PubMedCrossRef
30.
go back to reference Vanourny J, Swick BL. Sweet syndrome with systemic inflammatory response syndrome. Arch Dermatol. 2012;148:969–70. Vanourny J, Swick BL. Sweet syndrome with systemic inflammatory response syndrome. Arch Dermatol. 2012;148:969–70.
32.
go back to reference Requena L, Kutzner H, Palmedo G, Pascual M, Fernandez-Herrera J, Fraga J, et al. Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes. Arch Dermatol. 2005;141(7):834–42.PubMedCrossRef Requena L, Kutzner H, Palmedo G, Pascual M, Fernandez-Herrera J, Fraga J, et al. Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes. Arch Dermatol. 2005;141(7):834–42.PubMedCrossRef
33.
go back to reference Chavan RN, Cappel MA, Ketterling RP, Wada DA, Rochet NM, Knudson R, et al. Histiocytoid Sweet syndrome may indicate leukemia cutis: a novel application of fluorescence in situ hybridization. J Am Acad Dermatol. 2014;70(6):1021–7.PubMedCrossRef Chavan RN, Cappel MA, Ketterling RP, Wada DA, Rochet NM, Knudson R, et al. Histiocytoid Sweet syndrome may indicate leukemia cutis: a novel application of fluorescence in situ hybridization. J Am Acad Dermatol. 2014;70(6):1021–7.PubMedCrossRef
34.
go back to reference Raza S, Kirkland RS, Patel AA, Shortridge JR, Freter C. Insight into Sweet’s syndrome and associated-malignancy: a review of the current literature. Int J Oncol. 2013;42(5):1516–22. Raza S, Kirkland RS, Patel AA, Shortridge JR, Freter C. Insight into Sweet’s syndrome and associated-malignancy: a review of the current literature. Int J Oncol. 2013;42(5):1516–22.
35.
go back to reference Halawai A, Abiad F, Abbas O. Bariatric surgery and its effects on the skin and skin diseases. Obes Surg. 2013;23:408–13. Halawai A, Abiad F, Abbas O. Bariatric surgery and its effects on the skin and skin diseases. Obes Surg. 2013;23:408–13.
36.
go back to reference Dicken CH, Seehafer JR. Bowel bypass syndrome. Arch Dermatol. 1979;115:837–9. Dicken CH, Seehafer JR. Bowel bypass syndrome. Arch Dermatol. 1979;115:837–9.
37.
go back to reference Tu J, Chan JJ, Yu LL. Bowel bypass syndrome/bowel-associated dermatosis arthritis syndrome post laparoscopic gastric bypass surgery. Aust J Dermatol. 2011;52:e5–7. Tu J, Chan JJ, Yu LL. Bowel bypass syndrome/bowel-associated dermatosis arthritis syndrome post laparoscopic gastric bypass surgery. Aust J Dermatol. 2011;52:e5–7.
38.
go back to reference Jorizzo JL, Apisarnthanarax P, Subrt P, Hebert AA, Henry JC, Raimer SS, et al. Bowel-bypass syndrome without bowel bypass. Bowel-associated dermatosis-arthritis syndrome. Arch Int Med. 1983;143:457–61. Jorizzo JL, Apisarnthanarax P, Subrt P, Hebert AA, Henry JC, Raimer SS, et al. Bowel-bypass syndrome without bowel bypass. Bowel-associated dermatosis-arthritis syndrome. Arch Int Med. 1983;143:457–61.
39.
go back to reference Slater GH, Kerlin P, Georghiou PR, Fielding GA. Bowel-associated dermatosis-arthritis syndrome after biliopancreatic diversion. Obes Surg. 2004;14:133–5. Slater GH, Kerlin P, Georghiou PR, Fielding GA. Bowel-associated dermatosis-arthritis syndrome after biliopancreatic diversion. Obes Surg. 2004;14:133–5.
40.
go back to reference Prpic-Massari L, Kastelan M, Brajac I, Cabrijan L, Zamolo G, Massari D. Bowel-associated dermatosis–arthritis syndrome in a patient with appendicitis. Med Sci Monit. 2007;13(8):CS97–100.PubMed Prpic-Massari L, Kastelan M, Brajac I, Cabrijan L, Zamolo G, Massari D. Bowel-associated dermatosis–arthritis syndrome in a patient with appendicitis. Med Sci Monit. 2007;13(8):CS97–100.PubMed
41.
go back to reference Mendoza-Pinto C, Garcia-Carrasco M, Jimenez-Hernandez M, Jimenez Hernandez C, Riebeling-Navarro C, Nava Zavala A, et al. Etiopathogenesis of Behcet’s disease. Autoimmun Rev. 2010;9:241–5. Mendoza-Pinto C, Garcia-Carrasco M, Jimenez-Hernandez M, Jimenez Hernandez C, Riebeling-Navarro C, Nava Zavala A, et al. Etiopathogenesis of Behcet’s disease. Autoimmun Rev. 2010;9:241–5.
42.
go back to reference Davatchi F, Shahram F, Chams-Davatchi C, Shams H, Nadji A, Akhlaghi M, et al. Behcet’s disease: from East to West. Clin Rheumatol. 2010;29:823–33. Davatchi F, Shahram F, Chams-Davatchi C, Shams H, Nadji A, Akhlaghi M, et al. Behcet’s disease: from East to West. Clin Rheumatol. 2010;29:823–33.
43.
go back to reference Davatchi F, Shahram F, Chams-Davatchi C, Shams H, Nadji A, Akhlaghi M, et al. Behcet’s disease in Iran: analysis of 6500 cases. Int J Rheum Dis. 2010;13(4):367–73.PubMedCrossRef Davatchi F, Shahram F, Chams-Davatchi C, Shams H, Nadji A, Akhlaghi M, et al. Behcet’s disease in Iran: analysis of 6500 cases. Int J Rheum Dis. 2010;13(4):367–73.PubMedCrossRef
44.
go back to reference Hatemi G, Seyahi E, Fresko I, Hamuryudan V. Behcet’s syndrome: a critical digest of the recent literature. Clin Exp Rheumatol. 2012;30(3 Suppl 72):S80–9. Hatemi G, Seyahi E, Fresko I, Hamuryudan V. Behcet’s syndrome: a critical digest of the recent literature. Clin Exp Rheumatol. 2012;30(3 Suppl 72):S80–9.
45.
go back to reference Zhou ZY, Chen SL, Shen N, Lu Y. Cytokines and Behcet’s disease. Autoimmun Rev. 2012;11:699–704. Zhou ZY, Chen SL, Shen N, Lu Y. Cytokines and Behcet’s disease. Autoimmun Rev. 2012;11:699–704.
46.
go back to reference Emmi G, Silvestri E, Ciucciarelli L, Squatrito D, Emmi L. Anti-IL1 blocking agents in drug-resistant Behcet’s syndrome: our little case series. Clin Exp Rheum. Epub 2014 Apr 7. Emmi G, Silvestri E, Ciucciarelli L, Squatrito D, Emmi L. Anti-IL1 blocking agents in drug-resistant Behcet’s syndrome: our little case series. Clin Exp Rheum. Epub 2014 Apr 7.
47.
go back to reference Urbaniak P, Hasler P, Kretzschmar S. Refractory neuro-Behcet treated by tocilizumab: a case report. Clin Exp Rheumatol. 2012;30(3 Suppl 72):S73–5.PubMed Urbaniak P, Hasler P, Kretzschmar S. Refractory neuro-Behcet treated by tocilizumab: a case report. Clin Exp Rheumatol. 2012;30(3 Suppl 72):S73–5.PubMed
48.
49.
go back to reference Wilmoth GJ, Perniciaro C. Cutaneous extravascular necrotizing granuloma (Winkelmann granuloma): confirmation of the association with systemic disease. J Am Acad Dermatol. 1996;34(5 Pt 1):753–9.PubMedCrossRef Wilmoth GJ, Perniciaro C. Cutaneous extravascular necrotizing granuloma (Winkelmann granuloma): confirmation of the association with systemic disease. J Am Acad Dermatol. 1996;34(5 Pt 1):753–9.PubMedCrossRef
50.
go back to reference Kim SK, Park CK, Park YW, Jun JB, Yoo DH, Bae SC. Palisaded neutrophilic granulomatous dermatitis presenting as an unusual skin manifestation in a patient with Behcet’s disease. Scand J Rheumatol. 2005;34(4):324–7.PubMedCrossRef Kim SK, Park CK, Park YW, Jun JB, Yoo DH, Bae SC. Palisaded neutrophilic granulomatous dermatitis presenting as an unusual skin manifestation in a patient with Behcet’s disease. Scand J Rheumatol. 2005;34(4):324–7.PubMedCrossRef
51.
go back to reference Hantash BM, Chiang D, Kohler S, Fiorentino D. Palisaded neutrophilic and granulomatous dermatitis associated with limited systemic sclerosis. J Am Acad Dermatol. 2008;58(4):661–4.PubMedCrossRef Hantash BM, Chiang D, Kohler S, Fiorentino D. Palisaded neutrophilic and granulomatous dermatitis associated with limited systemic sclerosis. J Am Acad Dermatol. 2008;58(4):661–4.PubMedCrossRef
52.
go back to reference Kreuter A, Rose C, Zillikens D, Altmeyer P. Bullous rheumatoid neutrophilic dermatosis. J Am Acad Dermatol. 2005;52(5):916–8.PubMedCrossRef Kreuter A, Rose C, Zillikens D, Altmeyer P. Bullous rheumatoid neutrophilic dermatosis. J Am Acad Dermatol. 2005;52(5):916–8.PubMedCrossRef
53.
go back to reference Fujio Y, Funakoshi T, Nakayama K, Amagai M, Ohyama M. Rheumatoid neutrophilic dermatosis with tense blister formation: a case report and review of the literature. Australas J Dermatol. 2012;.;55((1):):e12–4. Fujio Y, Funakoshi T, Nakayama K, Amagai M, Ohyama M. Rheumatoid neutrophilic dermatosis with tense blister formation: a case report and review of the literature. Australas J Dermatol. 2012;.;55((1):):e12–4.
54.
go back to reference Sangueza OP, Caudell MD, Mengesha YM, Davis LS, Barnes CJ, Griffin JE, et al. Palisaded neutrophilic granulomatous dermatitis in rheumatoid arthritis. J Am Acad Dermatol. 2002;47(2):251–7.PubMedCrossRef Sangueza OP, Caudell MD, Mengesha YM, Davis LS, Barnes CJ, Griffin JE, et al. Palisaded neutrophilic granulomatous dermatitis in rheumatoid arthritis. J Am Acad Dermatol. 2002;47(2):251–7.PubMedCrossRef
55.
go back to reference Biswas A, Chittari K, van Gey Pittius D, Stephens M, Tan BB. Palisaded neutrophilic and granulomatous dermatitis in a child with type I diabetes mellitus and coeliac disease. Br J Dermatol. 2008;159(2):488–9.PubMedCrossRef Biswas A, Chittari K, van Gey Pittius D, Stephens M, Tan BB. Palisaded neutrophilic and granulomatous dermatitis in a child with type I diabetes mellitus and coeliac disease. Br J Dermatol. 2008;159(2):488–9.PubMedCrossRef
56.
go back to reference Germanas JP, Mehrabi D, Carder KR. Palisaded neutrophilic granulomatous dermatitis in a 12-year-old girl with systemic lupus erythematosus. J Am Acad Dermatol. 2006;55(2 Suppl):S60–2.PubMedCrossRef Germanas JP, Mehrabi D, Carder KR. Palisaded neutrophilic granulomatous dermatitis in a 12-year-old girl with systemic lupus erythematosus. J Am Acad Dermatol. 2006;55(2 Suppl):S60–2.PubMedCrossRef
57.
go back to reference Hunt RD, Hartman RD, Molho-Pessach V, Votava HJ, Schaffer JV. Palisaded neutrophilic and granulomatous dermatitis in an adolescent girl with perinuclear antineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis and arthritis. J Am Acad Dermatol. 2012;67(4):e164–6.PubMedCrossRef Hunt RD, Hartman RD, Molho-Pessach V, Votava HJ, Schaffer JV. Palisaded neutrophilic and granulomatous dermatitis in an adolescent girl with perinuclear antineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis and arthritis. J Am Acad Dermatol. 2012;67(4):e164–6.PubMedCrossRef
58.
go back to reference Chu P, Connolly MK, LeBoit PE. The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. Arch Dermatol. 1994;130(10):1278–83.PubMedCrossRef Chu P, Connolly MK, LeBoit PE. The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. Arch Dermatol. 1994;130(10):1278–83.PubMedCrossRef
59.
go back to reference Ergun T, Inanc N, Tuney D, Kotiloglu EK, Seckin D, Tetik C, et al. Skin manifestations of rheumatoid arthritis: a study of 215 Turkish patients. Int J Dermatol. 2008;47(9):894–902.PubMedCrossRef Ergun T, Inanc N, Tuney D, Kotiloglu EK, Seckin D, Tetik C, et al. Skin manifestations of rheumatoid arthritis: a study of 215 Turkish patients. Int J Dermatol. 2008;47(9):894–902.PubMedCrossRef
60.
go back to reference Bremner R, Simpson E, White CR, Morrison L, Deodhar A. Palisaded neutrophilic and granulomatous dermatitis: an unusual cutaneous manifestation of immune-mediated disorders. Semin Arthritis Rheum. 2004;34(3):610–6.PubMedCrossRef Bremner R, Simpson E, White CR, Morrison L, Deodhar A. Palisaded neutrophilic and granulomatous dermatitis: an unusual cutaneous manifestation of immune-mediated disorders. Semin Arthritis Rheum. 2004;34(3):610–6.PubMedCrossRef
61.
go back to reference Edgerton CC, Oglesby RJ, Bray D. Rheumatoid neutrophilic dermatitis. J Clin Rheum. 2006;12(5):266–7.CrossRef Edgerton CC, Oglesby RJ, Bray D. Rheumatoid neutrophilic dermatitis. J Clin Rheum. 2006;12(5):266–7.CrossRef
62.
go back to reference Yamamoto T, Ohkubo H, Nishioka K. Skin manifestations associated with rheumatoid arthritis. J Dermatol. 1995;22(5):324–9.PubMed Yamamoto T, Ohkubo H, Nishioka K. Skin manifestations associated with rheumatoid arthritis. J Dermatol. 1995;22(5):324–9.PubMed
63.
go back to reference Bevin AA, Steger J, Mannino S. Rheumatoid neutrophilic dermatitis. Cutis. 2006;78(2):133–6.PubMed Bevin AA, Steger J, Mannino S. Rheumatoid neutrophilic dermatitis. Cutis. 2006;78(2):133–6.PubMed
64.
go back to reference Sanchez JL, Cruz A. Rheumatoid neutrophilic dermatitis. J Am Acad Dermatol. 1990;22(5 Pt 2):922–5.PubMedCrossRef Sanchez JL, Cruz A. Rheumatoid neutrophilic dermatitis. J Am Acad Dermatol. 1990;22(5 Pt 2):922–5.PubMedCrossRef
65.
go back to reference Hirota TK, Keough GC, David-Bajar K, McCollough ML. Rheumatoid neutrophilic dermatitis. Cutis. 1997;60(4):203–5.PubMed Hirota TK, Keough GC, David-Bajar K, McCollough ML. Rheumatoid neutrophilic dermatitis. Cutis. 1997;60(4):203–5.PubMed
66.
go back to reference Setterfield JF, Shirlaw PJ, Challacombe SJ, Black MM. Pyoderma gangrenosum associated with severe oropharyngeal involvement and IgA paraproteinaemia. Br J Dermatol. 2001;144(2):393–6.PubMedCrossRef Setterfield JF, Shirlaw PJ, Challacombe SJ, Black MM. Pyoderma gangrenosum associated with severe oropharyngeal involvement and IgA paraproteinaemia. Br J Dermatol. 2001;144(2):393–6.PubMedCrossRef
67.
go back to reference Ahronowitz I, Harp J, Shinkai K. Etiology and management of pyoderma gangrenosum: a comprehensive review. Am J Clin Dermatol. 2012;13(3):191–211.PubMedCrossRef Ahronowitz I, Harp J, Shinkai K. Etiology and management of pyoderma gangrenosum: a comprehensive review. Am J Clin Dermatol. 2012;13(3):191–211.PubMedCrossRef
68.
go back to reference Perry HO, Winkelmann RK. Bullous pyoderma gangrenosum and leukemia. Arch Dermatol. 1972;106(6):901–5.PubMedCrossRef Perry HO, Winkelmann RK. Bullous pyoderma gangrenosum and leukemia. Arch Dermatol. 1972;106(6):901–5.PubMedCrossRef
69.
go back to reference O’Loughlin S, Perry HO. A diffuse pustular eruption associated with ulcerative colitis. Arch Dermatol. 1978;114(7):1061–4.PubMedCrossRef O’Loughlin S, Perry HO. A diffuse pustular eruption associated with ulcerative colitis. Arch Dermatol. 1978;114(7):1061–4.PubMedCrossRef
70.
go back to reference Su WP, Davis MD, Weenig RH, Powell FC, Perry HO. Pyoderma gangrenosum: clinicopathologic correlation and proposed diagnostic criteria. Int J Dermatol. 2004;43(11):790–800.PubMedCrossRef Su WP, Davis MD, Weenig RH, Powell FC, Perry HO. Pyoderma gangrenosum: clinicopathologic correlation and proposed diagnostic criteria. Int J Dermatol. 2004;43(11):790–800.PubMedCrossRef
71.
go back to reference Brooklyn TN, Dunnill MG, Shetty A, Bowden JJ, Williams JD, Griffiths CE, et al. Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial. Gut. 2006;55(4):505–9.PubMedCrossRefPubMedCentral Brooklyn TN, Dunnill MG, Shetty A, Bowden JJ, Williams JD, Griffiths CE, et al. Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial. Gut. 2006;55(4):505–9.PubMedCrossRefPubMedCentral
72.
go back to reference Dinarello CA. A clinical perspective of IL-1beta as the gatekeeper of inflammation. Eur J Immunol. 2011;41(5):1203–17.PubMedCrossRef Dinarello CA. A clinical perspective of IL-1beta as the gatekeeper of inflammation. Eur J Immunol. 2011;41(5):1203–17.PubMedCrossRef
73.
go back to reference Hadi A, Lebwohl M. Clinical features of pyoderma gangrenosum and current diagnostic trends. J Am Acad Dermatol. 2011;64(5):950–4.PubMedCrossRef Hadi A, Lebwohl M. Clinical features of pyoderma gangrenosum and current diagnostic trends. J Am Acad Dermatol. 2011;64(5):950–4.PubMedCrossRef
74.
go back to reference Weenig RH, Davis MD, Dahl PR, Su WP. Skin ulcers misdiagnosed as pyoderma gangrenosum. N Engl J Med. 2002;347(18):1412–8.PubMedCrossRef Weenig RH, Davis MD, Dahl PR, Su WP. Skin ulcers misdiagnosed as pyoderma gangrenosum. N Engl J Med. 2002;347(18):1412–8.PubMedCrossRef
Metadata
Title
Neutrophilic Dermatoses: An Update
Authors
Afsaneh Alavi
Dusan Sajic
Felipe B. Cerci
Danny Ghazarian
Misha Rosenbach
Joseph Jorizzo
Publication date
01-10-2014
Publisher
Springer International Publishing
Published in
American Journal of Clinical Dermatology / Issue 5/2014
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI
https://doi.org/10.1007/s40257-014-0092-6

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