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American Journal of Clinical Dermatology

Published in:

01-10-2014 | Review Article

Dermatological Toxicity Associated with Targeted Therapies in Cancer: Optimal Management

Authors: Lucie Peuvrel, Brigitte Dréno

Published in: American Journal of Clinical Dermatology | Issue 5/2014

Abstract

Targeted therapies have developed rapidly over the last few years in the field of oncology thanks to a better understanding of carcinogenesis. They target pathways involved in signal transduction (EGFR, HER2, HER3, HER4, FLT3, RAS, RAF, MEK, KIT, RET, mTOR, SRC, EPH, SCF), tumor angiogenesis (VEGFR, TIE2), and tumor microenvironment (PDGFR, FGFR). They rarely cause the systemic adverse reactions generally associated with chemotherapy, but frequently cause disabling and specific skin toxicity. The impact on patient quality of life can be important both in terms of symptoms caused and of potentially aesthetic consequences. Inappropriate management can increase the risk of dose reduction or discontinuation of the cancer treatment. In this review, we will discuss skin toxicity associated with the main drug classes—EGFR, BRAF, MEK, mTOR, c-KIT, CTLA4, and SMO inhibitors, and anti-angiogenic agents. Targeted therapy-induced skin toxicities will be detailed in terms of symptoms, frequency, evolution, complications, and topical and oral treatments in order to improve their diagnosis and management.

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Title: Dermatological Toxicity Associated with Targeted Therapies in Cancer: Optimal Management
Authors: Lucie Peuvrel
Brigitte Dréno
Publication date: 01-10-2014
Publisher: Springer International Publishing
Published in: American Journal of Clinical Dermatology / Issue 5/2014
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI: https://doi.org/10.1007/s40257-014-0088-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Dermatological Toxicity Associated with Targeted Therapies in Cancer: Optimal Management

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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