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Published in: Journal of Diabetes & Metabolic Disorders 1/2021

01-06-2021 | Obesity | Research article

Hydro alcoholic green tea extract effect on high fat diet treated NMRI mice and 3T3L1 cells

Authors: Farnaz Banakar, Azadeh Ebrahim-Habibi, Mahsa Mohammad-Amoli, Raheleh Kheirbakhsh, Mahsa Sadeghi-Afjeh, Shadab Shahriari, Bagher Larijani

Published in: Journal of Diabetes & Metabolic Disorders | Issue 1/2021

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Abstract

Purpose

In order to counteract the obesity has epidemics, since current anti-obesity drugs effects remain limited, there is a need to provide new options. As a project aiming to assess potential anti obesity natural compounds, the effects of consumption of a minimal dose of green tea hydro alcoholic extract (GT) on adipocyte differentiation of 3T3L1 cell line were investigated.

Methods

Obesity was induced in female NMRI mice (which are less used overall) by the use of a high fat diet. Mice were divided into four groups of control (C), treated control (TC), obese (O) and treated obese (TO). TC and TO groups received 8 mg/Kg/day of GT for 8 weeks, and weighted weekly, after what biochemical and histological parameters were measured. GT was used at doses of 100,150 and 200 µg/ml on 3T3L1, and staining with Oil-red-O was done for estimation of fat droplet accumulation.

Results

Body weight was found to be affected significantly by GT. Blood glucose levels did not show significant changes between groups, while triglycerides levels of the O group was significantly higher than the C group, but the TO group showed no significant difference with the C group upon GT treatment. Liver and visceral fat tissues showed more normalized tissue and less fat accumulation in the TO group. TO and TC groups showed an ameliorated morphologic state of liver tissues. GT was also able to decrease fat droplet formation in a dose-dependent manner.

Conclusions

Adding a minimal amount of GT to the daily consumption may have preventive effects on fat accumulation in healthy subjects, while in obese cases, GT shows significant therapeutic effect.
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Metadata
Title
Hydro alcoholic green tea extract effect on high fat diet treated NMRI mice and 3T3L1 cells
Authors
Farnaz Banakar
Azadeh Ebrahim-Habibi
Mahsa Mohammad-Amoli
Raheleh Kheirbakhsh
Mahsa Sadeghi-Afjeh
Shadab Shahriari
Bagher Larijani
Publication date
01-06-2021
Publisher
Springer International Publishing
Keywords
Obesity
Obesity
Published in
Journal of Diabetes & Metabolic Disorders / Issue 1/2021
Electronic ISSN: 2251-6581
DOI
https://doi.org/10.1007/s40200-021-00794-3

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