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Journal of Diabetes & Metabolic Disorders

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01-06-2021 | Olanzapine | Research article

Beneficial effect of Zingiber officinale on olanzapine-induced weight gain and metabolic changes

Authors: Mrityunjaya B. Ullagaddi, B. M. Patil, Pukar Khanal

Published in: Journal of Diabetes & Metabolic Disorders | Issue 1/2021

Abstract

Aim

The present study aimed to investigate the effect of Zingiber officinale (ZO) extract on weight gain, food intake, locomotor activity, and lipid and glucose metabolism in olanzapine-treated rats.

Methods

The hydroalcoholic extract of ZO was prepared by macerating the coarse dry powder in 70% v/v ethanol for 7 days, filtered, and concentrated under reduced pressure. Animals were divided into six groups containing six animals in each. Three doses of extract (100, 200, and 400 mg/kg, p.o.) were co-administered with olanzapine 2 mg/kg i.p for 21 days. Bodyweight and food intake were recorded at the interval of three days and locomotor activity once a week. At the end of the study oral glucose tolerance test was performed followed by the estimation of lipid profile.

Results

Co-administration of hydroalcoholic extract of ZO with olanzapine ameliorated olanzapine-induced weight gain and hyperphagia. Similarly, ZO extract also improved pancreatic β-cell function and glucose and lipid metabolism.

Conclusions

ZO extract ameliorated olanzapine-induced weight gain and hyperphagia by improving pancreatic β-cell functions and lipid metabolism.

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Title: Beneficial effect of Zingiber officinale on olanzapine-induced weight gain and metabolic changes
Authors: Mrityunjaya B. Ullagaddi
B. M. Patil
Pukar Khanal
Publication date: 01-06-2021
Publisher: Springer International Publishing
Keyword: Olanzapine
Published in: Journal of Diabetes & Metabolic Disorders / Issue 1/2021
Electronic ISSN: 2251-6581
DOI: https://doi.org/10.1007/s40200-020-00695-x

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Conclusions

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