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Published in: Ophthalmology and Therapy 3/2019

Open Access 01-09-2019 | Cycloplegia | Original Research

The Effect of Cycloplegia on the Ocular Biometric and Anterior Segment Parameters: A Cross-Sectional Study

Authors: Hamed Momeni-Moghaddam, Nasim Maddah, James S. Wolffsohn, Mohammad Etezad-Razavi, Siamak Zarei-Ghanavati, Amir Akhavan Rezayat, Majid Moshirfar

Published in: Ophthalmology and Therapy | Issue 3/2019

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Abstract

Introduction

To evaluate the effects of cycloplegia on the biometric components and anterior segment parameters of the eye.

Methods

In this cross-sectional study, changes to axial length (AL), anterior chamber depth (ACD) lens thickness, anterior chamber angle (ACA) and volume, corneal thickness in the pupil center (PC), corneal curvature (CC) and white-to-white (WTW) following cycloplegia induced by tropicamide 1% in 42 eyes of patients aged 23–58 years were assessed. Biometric components and anterior segment parameters were measured using an IOLMaster 700 (Carl Zeiss Meditec, Jena, Germany) and a Pentacam HR (Oculus Optikgeräte GmbH, Wetzlar, Germany), respectively.

Results

Significant statistical changes in ACD (increased by 0.06 ± 0.05 mm; p < 0.001), anterior chamber volume (increased by 15.19 ± 10.32 mm3; p < 0.001), ACA (decreased by 2.18 ± 10.20°; p = 0.029) and lens thickness (decreased by 0.02 ± 0.03 mm; p < 0.001) were observed post-cycloplegia, while the changes in CC, corneal thickness in the PC, WTW and AL were not statistically different (p > 0.05). Also, a significant inferior displacement of the PC along the vertical axes was seen (p = 0.020).

Conclusion

Cycloplegia resulted in a deeper ACD and thinner lens thickness. These changes should be considered in determining intraocular lens (IOL) power to prevent refractive surprises in cataract surgery and also in the phakic IOL implantation.
Literature
1.
go back to reference Arici C, Turk A, Ceylan OM, Kola M, Hurmeric V. Effects of 1% cyclopentolate hydrochloride on anterior segment parameters obtained with Pentacam in young adults. Arq Bras Oftalmol. 2014;77:228–32.CrossRefPubMed Arici C, Turk A, Ceylan OM, Kola M, Hurmeric V. Effects of 1% cyclopentolate hydrochloride on anterior segment parameters obtained with Pentacam in young adults. Arq Bras Oftalmol. 2014;77:228–32.CrossRefPubMed
2.
go back to reference Cheng H-C, Hsieh Y-T. Short-term refractive change and ocular parameter changes after cycloplegia. Optom Vis Sci. 2014;91:1113–7.CrossRefPubMed Cheng H-C, Hsieh Y-T. Short-term refractive change and ocular parameter changes after cycloplegia. Optom Vis Sci. 2014;91:1113–7.CrossRefPubMed
3.
go back to reference Niyaz L, Can E, Seymen Z, Eraydin B. Comparison of anterior segment parameters obtained by dual-Scheimpflug analyzer before and after cycloplegia in children. J Pediatr Ophthalmol Strabismus. 2016;53:234–7.CrossRefPubMed Niyaz L, Can E, Seymen Z, Eraydin B. Comparison of anterior segment parameters obtained by dual-Scheimpflug analyzer before and after cycloplegia in children. J Pediatr Ophthalmol Strabismus. 2016;53:234–7.CrossRefPubMed
4.
go back to reference Guler E, Guragac FB, Tenlik A, Yagci R, Arslanyilmaz Z, Balci M. Influences of topical cyclopentolate on anterior chamber parameters with a dual-Scheimpflug analyzer in healthy children. J Pediatr Ophthalmol Strabismus. 2015;52:26–30.CrossRefPubMed Guler E, Guragac FB, Tenlik A, Yagci R, Arslanyilmaz Z, Balci M. Influences of topical cyclopentolate on anterior chamber parameters with a dual-Scheimpflug analyzer in healthy children. J Pediatr Ophthalmol Strabismus. 2015;52:26–30.CrossRefPubMed
5.
go back to reference Huang J, McAlinden C, Su B, et al. The effect of cycloplegia on the lenstar and the IOLMaster biometry. Optom Vis Sci. 2012;89:1691–6.CrossRefPubMed Huang J, McAlinden C, Su B, et al. The effect of cycloplegia on the lenstar and the IOLMaster biometry. Optom Vis Sci. 2012;89:1691–6.CrossRefPubMed
6.
go back to reference Arriola-Villalobos P, Díaz-Valle D, Garzon N, et al. Effect of pharmacologic pupil dilation on OLCR optical biometry measurements for IOL predictions. Eur J Ophthalmol. 2014;24:53–7.CrossRefPubMed Arriola-Villalobos P, Díaz-Valle D, Garzon N, et al. Effect of pharmacologic pupil dilation on OLCR optical biometry measurements for IOL predictions. Eur J Ophthalmol. 2014;24:53–7.CrossRefPubMed
7.
go back to reference Chang SW, Lo AY, Su PF. Anterior segment biometry changes with cycloplegia in myopic adults. Optom Vis Sci. 2016;93:12–8.CrossRefPubMed Chang SW, Lo AY, Su PF. Anterior segment biometry changes with cycloplegia in myopic adults. Optom Vis Sci. 2016;93:12–8.CrossRefPubMed
8.
go back to reference Gimbel HV, Norton NR, Amritanand A. Angle-supported phakic intraocular lenses for the correction of myopia: three-year follow-up. J Cataract Refract Surg. 2015;41:2179–89.CrossRefPubMed Gimbel HV, Norton NR, Amritanand A. Angle-supported phakic intraocular lenses for the correction of myopia: three-year follow-up. J Cataract Refract Surg. 2015;41:2179–89.CrossRefPubMed
9.
go back to reference Kamiya K, Shimizu K, Igarashi A, et al. Posterior chamber phakic intraocular lens implantation: comparative, multicentre study in 351 eyes with low-to-moderate or high myopia. Br J Ophthalmol. 2018;102:177–81.CrossRefPubMed Kamiya K, Shimizu K, Igarashi A, et al. Posterior chamber phakic intraocular lens implantation: comparative, multicentre study in 351 eyes with low-to-moderate or high myopia. Br J Ophthalmol. 2018;102:177–81.CrossRefPubMed
10.
go back to reference Palamar M, Egrilmez S, Uretmen O, Yagci A, Kose S. Influences of cyclopentolate hydrochloride on anterior segment parameters with Pentacam in children. Acta Ophthalmol. 2011;89:e461–5.CrossRefPubMed Palamar M, Egrilmez S, Uretmen O, Yagci A, Kose S. Influences of cyclopentolate hydrochloride on anterior segment parameters with Pentacam in children. Acta Ophthalmol. 2011;89:e461–5.CrossRefPubMed
11.
go back to reference Arici C, Turk A, Ceylan OM, Kola M. The effect of topical 1% cyclopentolate on IOLMaster biometry. Optom Vis Sci. 2014;91:1343–7.CrossRefPubMed Arici C, Turk A, Ceylan OM, Kola M. The effect of topical 1% cyclopentolate on IOLMaster biometry. Optom Vis Sci. 2014;91:1343–7.CrossRefPubMed
12.
go back to reference Özyol P, Özyol E, Baldemir E. Changes in ocular parameters and intraocular lens powers in aging cycloplegic eyes. Am J Ophthalmol. 2017;173:76–83.CrossRefPubMed Özyol P, Özyol E, Baldemir E. Changes in ocular parameters and intraocular lens powers in aging cycloplegic eyes. Am J Ophthalmol. 2017;173:76–83.CrossRefPubMed
13.
go back to reference Cheung SW, Chan R, Cheng R, Cho P. Effect of cycloplegia on axial length and anterior chamber depth measurements in children. Clin Exp Optom. 2009;92:476–81.CrossRefPubMed Cheung SW, Chan R, Cheng R, Cho P. Effect of cycloplegia on axial length and anterior chamber depth measurements in children. Clin Exp Optom. 2009;92:476–81.CrossRefPubMed
15.
go back to reference Khambhiphant B, Chatbunchachai N, Pongpirul K. The effect of pupillary dilatation on IOL power measurement by using the IOLMaster. Int Ophthalmol. 2015;35:853–9.CrossRefPubMed Khambhiphant B, Chatbunchachai N, Pongpirul K. The effect of pupillary dilatation on IOL power measurement by using the IOLMaster. Int Ophthalmol. 2015;35:853–9.CrossRefPubMed
16.
go back to reference Rodriguez-Raton A, Jimenez-Alvarez M, Arteche-Limousin L, Mediavilla-Pena E, Larrucea-Martinez I. Effect of pupil dilation on biometry measurements with partial coherence interferometry and its effect on IOL power formula calculation. Eur J Ophthalmol. 2015;25:309–14.CrossRefPubMed Rodriguez-Raton A, Jimenez-Alvarez M, Arteche-Limousin L, Mediavilla-Pena E, Larrucea-Martinez I. Effect of pupil dilation on biometry measurements with partial coherence interferometry and its effect on IOL power formula calculation. Eur J Ophthalmol. 2015;25:309–14.CrossRefPubMed
17.
go back to reference Arriola-Villalobos P, Almendral-Gomez J, Garzon N, et al. Effect of pharmacological pupil dilation on measurements and IOL power calculation made using the new swept-source optical coherence tomography-based optical biometer. J Fr Ophtalmol. 2016;39:859–65.CrossRefPubMed Arriola-Villalobos P, Almendral-Gomez J, Garzon N, et al. Effect of pharmacological pupil dilation on measurements and IOL power calculation made using the new swept-source optical coherence tomography-based optical biometer. J Fr Ophtalmol. 2016;39:859–65.CrossRefPubMed
18.
go back to reference Higashiyama T, Iwasa M, Ohji M. Changes in the anterior segment after cycloplegia with a biometer using swept-source optical coherence tomography. PLoS One. 2017;12:e0183378.CrossRefPubMedPubMedCentral Higashiyama T, Iwasa M, Ohji M. Changes in the anterior segment after cycloplegia with a biometer using swept-source optical coherence tomography. PLoS One. 2017;12:e0183378.CrossRefPubMedPubMedCentral
19.
go back to reference Malyugin BE, Shpak AA, Pokrovskiy DF. Accommodative changes in anterior chamber depth in patients with high myopia. J Cataract Refract Surg. 2012;38:1403–7.CrossRefPubMed Malyugin BE, Shpak AA, Pokrovskiy DF. Accommodative changes in anterior chamber depth in patients with high myopia. J Cataract Refract Surg. 2012;38:1403–7.CrossRefPubMed
20.
go back to reference Adler G, Shahar J, Kesner R, et al. Effect of pupil size on biometry measurements using the IOLMaster. Am J Ophthalmol. 2015;159:940–4.CrossRefPubMed Adler G, Shahar J, Kesner R, et al. Effect of pupil size on biometry measurements using the IOLMaster. Am J Ophthalmol. 2015;159:940–4.CrossRefPubMed
21.
go back to reference Gao L, Zhuo X, Kwok AK, Yu N, Ma L, Wang J. The change in ocular refractive components after cycloplegia in children. Jpn J Ophthalmol. 2002;46:293–8.CrossRefPubMed Gao L, Zhuo X, Kwok AK, Yu N, Ma L, Wang J. The change in ocular refractive components after cycloplegia in children. Jpn J Ophthalmol. 2002;46:293–8.CrossRefPubMed
22.
go back to reference Saitoh K, Yoshida K, Hamatsu Y, Tazawa Y. Changes in the shape of the anterior and posterior corneal surfaces caused by mydriasis and miosis: detailed analysis. J Cataract Refract Surg. 2004;30:1024–30.CrossRefPubMed Saitoh K, Yoshida K, Hamatsu Y, Tazawa Y. Changes in the shape of the anterior and posterior corneal surfaces caused by mydriasis and miosis: detailed analysis. J Cataract Refract Surg. 2004;30:1024–30.CrossRefPubMed
23.
go back to reference Shao Y, Tao A, Jiang H, et al. Age-related changes in the anterior segment biometry during accommodation. Investig Ophthalmol Vis Sci. 2015;56:3522–30.CrossRef Shao Y, Tao A, Jiang H, et al. Age-related changes in the anterior segment biometry during accommodation. Investig Ophthalmol Vis Sci. 2015;56:3522–30.CrossRef
Metadata
Title
The Effect of Cycloplegia on the Ocular Biometric and Anterior Segment Parameters: A Cross-Sectional Study
Authors
Hamed Momeni-Moghaddam
Nasim Maddah
James S. Wolffsohn
Mohammad Etezad-Razavi
Siamak Zarei-Ghanavati
Amir Akhavan Rezayat
Majid Moshirfar
Publication date
01-09-2019
Publisher
Springer Healthcare
Published in
Ophthalmology and Therapy / Issue 3/2019
Print ISSN: 2193-8245
Electronic ISSN: 2193-6528
DOI
https://doi.org/10.1007/s40123-019-0187-5

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