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Pain and Therapy

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Open Access 01-06-2016 | Original Research

Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs

Authors: David Castel, Michael Naveh, Arnon Aharon, Ofer Doron, Sigal Meilin

Published in: Pain and Therapy | Issue 1/2016

Abstract

Introduction

Local anesthetic infusion techniques have been reported to reduce opiate requirements and pain scores following different kinds of surgery, including orthopedic surgery, inguinal hernia, and Cesarean surgery in women.

Methods

PRF-108 and PRF-110 formulations were applied to the wound space in an incisional model in pigs to test the hypothesis that these formulations have better and longer analgesic effects than the commercially available ropivacaine solution (Naropin^®, AstraZeneca).

Results

The data show significantly better analgesic activity with PRF-108 and PRF-110 compared to ropivacaine. The duration of the analgesic efficacy of PRF-108 and PRF-110 was at least five times longer than that was measured following treatment with ropivacaine. The data further suggest that active clearance from the injection site (the wound) is much slower for PRF-108 and PRF-110 than for the commercial ropivacaine solution.

Conclusion

Assessing the local concentration of PRF compounds and commercially available ropivacaine solution suggests that active clearance from the injection site (the wound) is much slower for PRF-108 and PRF-110 than for ropivacaine.

Funding

PainReform.

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Title: Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs
Authors: David Castel
Michael Naveh
Arnon Aharon
Ofer Doron
Sigal Meilin
Publication date: 01-06-2016
Publisher: Springer Healthcare
Published in: Pain and Therapy / Issue 1/2016
Print ISSN: 2193-8237
Electronic ISSN: 2193-651X
DOI: https://doi.org/10.1007/s40122-015-0043-9

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Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs

Abstract

Introduction

Methods

Results

Conclusion

Funding

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Abstract

Introduction

Methods

Results

Conclusion

Funding

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