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Cardiology and Therapy
Published in: Cardiology and Therapy 1/2017

Open Access 01-06-2017 | Review

The Rise and Fall of Anticoagulation with Bivalirudin During Percutaneous Coronary Interventions: A Review Article

Authors: Constantinos Andreou, Christos Maniotis, Michael Koutouzis

Published in: Cardiology and Therapy | Issue 1/2017

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Abstract

Bivalirudin is a direct thrombin inhibitor used during percutaneous coronary intervention (PCI). Treatment with bivalirudin compared to heparin plus glycoprotein IIb/IIIa inhibitors (GPI) reduced bleeding complications, but resulted in higher rates of ischemic events, including acute stent thrombosis in ST segment elevation myocardial infarction (STEMI) patients. Thus, it may be considered a reasonable alternative antithrombotic agent in patients at high risk of bleeding undergoing PCI. However its superiority over heparin alone is questioned particularly in the era of novel antiplatelet agents and transradial PCI.
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Metadata
Title
The Rise and Fall of Anticoagulation with Bivalirudin During Percutaneous Coronary Interventions: A Review Article
Authors
Constantinos Andreou
Christos Maniotis
Michael Koutouzis
Publication date
01-06-2017
Publisher
Springer Healthcare
Published in
Cardiology and Therapy / Issue 1/2017
Print ISSN: 2193-8261
Electronic ISSN: 2193-6544
DOI
https://doi.org/10.1007/s40119-017-0082-x

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