Skip to main content
Top
Published in: Infection 3/2017

01-06-2017 | Case Report

Invasive cutaneous infection due to Scopulariopsis brevicaulis unsuccessfully treated with high-dose micafungin in a neutropenic patient

Authors: Daniela Gavril, Paul-Louis Woerther, Aicha Ben Lakhdar, Linda Mahjoubi, Emilie Routier, Elisabeth Chachaty, Bertrand Gachot, Stephane De Botton, Jean-Baptiste Micol, Christophe Willekens

Published in: Infection | Issue 3/2017

Login to get access

Abstract

Scopulariopsis brevicaulis onychomycosis with local cutaneous invasion was diagnosed in an acute leukemia patient and unsuccessfully treated with high-dose micafungin, based on antifungal susceptibility testing. This case should alert clinicians to the possible severe evolution of onychomycosis in neutropenic patients and suggests that surgery should be preferred in such a situation.
Literature
2.
go back to reference Iwen PC, Schutte SD, Florescu DF, Noel-Hurst RK, Sigler L. Invasive Scopulariopsis brevicaulis infection in an immunocompromised patient and review of prior cases caused by Scopulariopsis and Microascus species. Med Mycol. 2012;50:561–9.CrossRefPubMed Iwen PC, Schutte SD, Florescu DF, Noel-Hurst RK, Sigler L. Invasive Scopulariopsis brevicaulis infection in an immunocompromised patient and review of prior cases caused by Scopulariopsis and Microascus species. Med Mycol. 2012;50:561–9.CrossRefPubMed
3.
go back to reference Tortorano AM, Richardson M, Roilides E, et al. ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others. Clin Microbiol Infect. 2014;20:27–46.CrossRefPubMed Tortorano AM, Richardson M, Roilides E, et al. ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others. Clin Microbiol Infect. 2014;20:27–46.CrossRefPubMed
4.
go back to reference Skora M, Bulanda M, Jagielski T. In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species. Antimicrob Agents Chemother. 2015;59:5827–9.CrossRefPubMedPubMedCentral Skora M, Bulanda M, Jagielski T. In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species. Antimicrob Agents Chemother. 2015;59:5827–9.CrossRefPubMedPubMedCentral
5.
go back to reference Cuenca-Estrella M, Gomez-Lopez A, Buitrago MJ, Mellado E, Garcia-Effron G, Rodriguez-Tudela JL. In vitro activities of 10 combinations of antifungal agents against the multiresistant pathogen Scopulariopsis brevicaulis. Antimicrob Agents Chemother. 2006;50:2248–50.CrossRefPubMedPubMedCentral Cuenca-Estrella M, Gomez-Lopez A, Buitrago MJ, Mellado E, Garcia-Effron G, Rodriguez-Tudela JL. In vitro activities of 10 combinations of antifungal agents against the multiresistant pathogen Scopulariopsis brevicaulis. Antimicrob Agents Chemother. 2006;50:2248–50.CrossRefPubMedPubMedCentral
6.
go back to reference Odero V, Garcia-Agudo L, Guerrero I, Aznar P, Garcia-Martos P, Rodriguez-Iglesias M. Antifungal susceptibility of clinical isolates of Scopulariopsis species. Rev Esp Quimioter. 2014;27:17–21.PubMed Odero V, Garcia-Agudo L, Guerrero I, Aznar P, Garcia-Martos P, Rodriguez-Iglesias M. Antifungal susceptibility of clinical isolates of Scopulariopsis species. Rev Esp Quimioter. 2014;27:17–21.PubMed
7.
go back to reference Alvarez E, Garcia-Hermoso D, Sutton DA, et al. Molecular phylogeny and proposal of two new species of the emerging pathogenic fungus Saksenaea. J Clin Microbiol. 2010;48:4410–6.CrossRefPubMedPubMedCentral Alvarez E, Garcia-Hermoso D, Sutton DA, et al. Molecular phylogeny and proposal of two new species of the emerging pathogenic fungus Saksenaea. J Clin Microbiol. 2010;48:4410–6.CrossRefPubMedPubMedCentral
8.
go back to reference Garcia-Hermoso D, Hoinard D, Gantier JC, Grenouillet F, Dromer F, Dannaoui E. Molecular and phenotypic evaluation of Lichtheimia corymbifera (formerly Absidia corymbifera) complex isolates associated with human mucormycosis: rehabilitation of L. ramosa. J Clin Microbiol. 2009;47:3862–70.CrossRefPubMedPubMedCentral Garcia-Hermoso D, Hoinard D, Gantier JC, Grenouillet F, Dromer F, Dannaoui E. Molecular and phenotypic evaluation of Lichtheimia corymbifera (formerly Absidia corymbifera) complex isolates associated with human mucormycosis: rehabilitation of L. ramosa. J Clin Microbiol. 2009;47:3862–70.CrossRefPubMedPubMedCentral
Metadata
Title
Invasive cutaneous infection due to Scopulariopsis brevicaulis unsuccessfully treated with high-dose micafungin in a neutropenic patient
Authors
Daniela Gavril
Paul-Louis Woerther
Aicha Ben Lakhdar
Linda Mahjoubi
Emilie Routier
Elisabeth Chachaty
Bertrand Gachot
Stephane De Botton
Jean-Baptiste Micol
Christophe Willekens
Publication date
01-06-2017
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 3/2017
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-016-0971-2

Other articles of this Issue 3/2017

Infection 3/2017 Go to the issue