Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Infection
Published in: Infection 6/2016

01-12-2016 | Case Report

Carbapenem-resistant Lactobacillus intra-abdominal infection in a renal transplant recipient with a history of probiotic consumption

Authors: Jakapat Vanichanan, Violeta Chávez, Audrey Wanger, Aleksandra M. De Golovine, Karen J. Vigil

Published in: Infection | Issue 6/2016

Login to get access

Abstract

Background

Lactobacillus sp. is a low virulence bacterium, which rarely causes infection in immunocompetent individuals and usually is considered a contaminant. Normally this organism is susceptible to β-lactam antibiotics, yet resistant strains have been reported.

Case presentation and discussion

Here, we report a case of a 60-year-old renal transplant recipient who developed an intra-abdominal abscess which grew a carbapenem-resistant Lactobacillus casei. This is significant since it is the first report of a clinical isolate of Lactobacillus sp. that demonstrated both microbiological and clinical resistance to carbapenem use. Moreover, the probiotic supplement that the patient had taken also grew a similar organism raising the concern of probiotic associated infection in immunocompromised individual.
Literature
1.
Husni RN, Gordon SM, Washington JA, Longworth DL. Lactobacillus bacteremia and endocarditis: review of 45 cases. Clin Infect Dis. 1997;25:1048–55.CrossRefPubMed
2.
Cannon JP, Lee TA, Bolanos JT, Danziger LH. Pathogenic relevance of Lactobacillus: a retrospective review of over 200 cases. Eur J Clin Microbiol Infect Dis. 2005;24:31–40.CrossRefPubMed
3.
Salminen MK, Rautelin H, Tynkkynen S, Poussa T, Saxelin M, Valtonen V, Järvinen A. Lactobacillus bacteremia, clinical significance, and patient outcome, with special focus on L. rhamnosus GG. Clin Infect Dis. 2004;38:62–9.CrossRefPubMed
4.
Antony SJ, Stratton CW, Dummer JS. Lactobacillus bacteremia: description of the clinical course in adult patients without endocarditis. Clin Infect Dis. 1996;23:773–8.CrossRefPubMed
5.
Shields RK, Clancy CJ, Minces LR, Shigemura N, Kwak EJ, Silveira FP, et al. Epidemiology and outcomes of deep surgical site infections following lung transplantation. Am J Transplant. 2013;13:2137–45.CrossRefPubMed
6.
Robin F, Paillard C, Marchandin H, Demeocq F, Bonnet R, Hennequin C. Lactobacillus rhamnosus meningitis following recurrent episodes of bacteremia in child undergoing allogeneic hematopoietic stem cell transplantation. J Clin Microbiol. 2010;48:4317–9.CrossRefPubMedPubMedCentral
7.
Salminen MK, Rautelin H, Tynkkynen S, Poussa T, Saxelin M, Valtonen V, Järvinen A. Lactobacillus bacteremia, species identification, and antimicrobial susceptibility of 85 blood isolates. Clin Infect Dis. 2006;42:e35–44.CrossRefPubMed
8.
9.
Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG. ClustalW and ClustalX version 2 (2007). Bioinformatics. 2007;23(21):2947–8.CrossRefPubMed
10.
Patel R, Cockerill FR, Porayko MK, Osmon DR, Ilstrup DM, Keating MR. Lactobacillemia in liver transplant patients. Clin Infect Dis. 1994;18:207–12.CrossRefPubMed
11.
Carretto E, Barbarini D, Marzani FC, Fumagalli P, Monzillo V, Marone P, Emmi V. Catheter-related bacteremia due to Lactobacillus rhamnosus in a single-lung transplant recipient. Scan J Infect Dis. 2001;33:780–2.CrossRef
12.
Jones SD, Fullerton DA, Zamora MR, Badesch DB, Campbell DN, Grover FL. Transmission of Lactobacillus pneumonia by transplanted lung. Ann Thorac Surg. 1994;58:887–9.CrossRefPubMed
13.
Klare I, Konstabel C, Werner G, Huys G, Vankerckhoven V, Kahlmeter G, et al. Antimicrobial susceptibilities of Lactobacillus, Pediococcus and Lactococcus human isolates and cultures intended for probiotic or nutritional use. J Antimicrob Chemother. 2007;59:900–12.CrossRefPubMed
14.
Goldstein EJ, Citron DM, Merriam CV, Warren YA, Tyrrell KL, Fernandez H. Comparative in vitro activities of ertapenem (MK-0826) against 469 less frequently identified anaerobes isolated from human infections. Antimicrob Agents Chemother. 2002;46:1136–40.CrossRefPubMedPubMedCentral
15.
Murray PR, Niles AC. In vitro activity of meropenem (SM-7338), imipenem and five other antibiotics against anaerobic clinical isolates. Diagn Microbiol Infect Dis. 1990;13:57–61.CrossRefPubMed
16.
17.
Rayes N, Seehofer D, Theruvath T, Schiller RA, Langrehr JM, Jonas S, Bengmark S, Neuhaus P. Supply of pre-and probiotics reduces bacterial infection rates after liver transplantation- a randomized, double-blind trial. Am J Transplant. 2005;5:125–30.CrossRefPubMed
18.
Besselink MG, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM, et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet. 2008;371:651–9.CrossRefPubMed
19.
Vahabnezhad Z, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47:437–9.CrossRefPubMed
20.
Luong ML, Sareyyupoglu B, Nguyen MH, Silveira FP, Shields RK, Potoski BA, et al. Lactobacillus probiotic use in cardiothoracic transplant recipients: a link to invasive Lactobacillus infection. Transpl Infect Dis. 2010;12:561–4.CrossRefPubMed
Metadata
Title
Carbapenem-resistant Lactobacillus intra-abdominal infection in a renal transplant recipient with a history of probiotic consumption
Authors
Jakapat Vanichanan
Violeta Chávez
Audrey Wanger
Aleksandra M. De Golovine
Karen J. Vigil
Publication date
01-12-2016
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 6/2016
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-016-0903-1

Other articles of this Issue 6/2016

Infection 6/2016 Go to the issue

Original Paper

Intensified colonisation screening according to the recommendations of the German Commission for Hospital Hygiene and Infectious Diseases Prevention (KRINKO): identification and containment of a Serratia marcescens outbreak in the neonatal intensive care unit, Jena, Germany, 2013–2014

Original Paper

CAND-LO 2014–15 study: changing epidemiology of candidemia in Lombardy (Italy)

Correspondence

Letter to the editor of infection in response to de Francesco et al., a cluster of invasive listeriosis in Brescia, Italy

Brief Report

HCV NS3 naturally occurring variants in HIV/HCV coinfected DAA-naïve patients: consideration for HCV genotyping resistance testing

Original Paper

Synchronous multifocal necrotizing fasciitis prognostic factors: a retrospective case series study in a single center

Original Paper

Three-dimensional compared to two-dimensional transesophageal echocardiography for diagnosis of infective endocarditis

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits