Skip to main content
Top
Published in: Infection 5/2016

01-10-2016 | Case Report

A case of pharyngeal diphtheria in Germany, June 2015

Authors: A. Berger, D. M. Meinel, A. Schaffer, R. Ziegler, J. Pitteroff, R. Konrad, Andreas Sing

Published in: Infection | Issue 5/2016

Login to get access

Abstract

Background

In June 2015, a 45-year-old man suffering from acute necrotic tonsillitis and throat phlegmon was hospitalized in Nuremberg, Germany. After emergency surgery the patient was initially treated with antibiotics.

Results

A throat swab grew a toxigenic Corynebacterium diphtheriae biovar mitis strain. The patient’s vaccination status was not documented and the patient was tested serologically for anti-diphtheria antibodies showing no protective immunity. Extensive control investigations were performed by the local health department showing no likely source of his infection.

Conclusion

No secondary cases were found and the patient completely recovered.
Literature
1.
go back to reference Konrad R, Berger A, Huber I, et al. Matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry as a tool for rapid diagnosis of potentially toxigenic Corynebacterium species in the laboratory management of diphtheria-associated bacteria. Euro Surveill. 2010;15 (pii: 19702). Konrad R, Berger A, Huber I, et al. Matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry as a tool for rapid diagnosis of potentially toxigenic Corynebacterium species in the laboratory management of diphtheria-associated bacteria. Euro Surveill. 2010;15 (pii: 19702).
2.
go back to reference Clinical Laboratory Standards Institute. Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria; approved guideline—second edition. CLSI 2010:M45-A2. Clinical Laboratory Standards Institute. Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria; approved guideline—second edition. CLSI 2010:M45-A2.
3.
go back to reference Schuhegger R, Lindermayer M, Kugler R, et al. Detection of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by a novel real-time PCR. J Clin Microbiol. 2008;46:2822–3.CrossRefPubMedPubMedCentral Schuhegger R, Lindermayer M, Kugler R, et al. Detection of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by a novel real-time PCR. J Clin Microbiol. 2008;46:2822–3.CrossRefPubMedPubMedCentral
4.
go back to reference Meinel DM, Margos G, Konrad R, Krebs S, Blum H, Sing A. Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin-encoding pathogenicity island. Genome Med. 2014;6:113.CrossRefPubMedPubMedCentral Meinel DM, Margos G, Konrad R, Krebs S, Blum H, Sing A. Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin-encoding pathogenicity island. Genome Med. 2014;6:113.CrossRefPubMedPubMedCentral
5.
go back to reference Bolt F, Cassiday P, Tondella ML, Dezoysa A, Efstratiou A, Sing A, et al. Multilocus sequence typing identifies evidence for recombination and two distinct lineages of Corynebacterium diphtheriae. J Clin Microbiol. 2010;48:4177–85.CrossRefPubMedPubMedCentral Bolt F, Cassiday P, Tondella ML, Dezoysa A, Efstratiou A, Sing A, et al. Multilocus sequence typing identifies evidence for recombination and two distinct lineages of Corynebacterium diphtheriae. J Clin Microbiol. 2010;48:4177–85.CrossRefPubMedPubMedCentral
7.
go back to reference Bonnet JM, Begg NT, World Health Organization. Control of diphtheria: guidance for consultants in communicable disease control. Commun Dis Public Health. 1999;2:242–9.PubMed Bonnet JM, Begg NT, World Health Organization. Control of diphtheria: guidance for consultants in communicable disease control. Commun Dis Public Health. 1999;2:242–9.PubMed
8.
go back to reference Galazka A. The changing epidemiology of diphtheria in the vaccine era. J Infect Dis. 2000;181:S2–9.CrossRefPubMed Galazka A. The changing epidemiology of diphtheria in the vaccine era. J Infect Dis. 2000;181:S2–9.CrossRefPubMed
10.
go back to reference Both L, White J, Mandal S, Efstratiou A. Access to diphtheria antitoxin for therapy and diagnostics. Euro Surveill. 2014;19 (pii: 20830). Both L, White J, Mandal S, Efstratiou A. Access to diphtheria antitoxin for therapy and diagnostics. Euro Surveill. 2014;19 (pii: 20830).
Metadata
Title
A case of pharyngeal diphtheria in Germany, June 2015
Authors
A. Berger
D. M. Meinel
A. Schaffer
R. Ziegler
J. Pitteroff
R. Konrad
Andreas Sing
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 5/2016
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-016-0882-2

Other articles of this Issue 5/2016

Infection 5/2016 Go to the issue