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Published in: Infection 2/2016

01-04-2016 | Case Report

Late-onset cytomegalovirus infection complicated by Guillain–Barre syndrome in a kidney transplant recipient: case report and review of the literature

Authors: E. Shaban, R. Gohh, B. M. Knoll

Published in: Infection | Issue 2/2016

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Abstract

Cytomegalovirus (CMV) infection remains a common infection after solid-organ transplantation. In the general population CMV disease is associated with Guillain–Barre syndrome (GBS), an autoimmune disease leading to an acute peripheral neuropathy, in 1 of 1000 cases. Interestingly, GBS is a rarely observed complication in solid-organ transplant recipients, possibly related to maintenance immunosuppression. We describe a case of CMV infection complicated by GBS in a kidney transplant recipient and review the literature.
Literature
1.
go back to reference Arthurs SK, Eid AJ, Pedersen RA, et al. Delayed-onset primary cytomegalovirus disease and the risk of allograft failure and mortality after kidney transplantation. Clin Infect Dis. 2008;46:840–6.CrossRefPubMed Arthurs SK, Eid AJ, Pedersen RA, et al. Delayed-onset primary cytomegalovirus disease and the risk of allograft failure and mortality after kidney transplantation. Clin Infect Dis. 2008;46:840–6.CrossRefPubMed
2.
go back to reference Harvala H, Stewart C, Muller K, et al. High risk of cytomegalovirus infection following solid organ transplantation despite prophylactic therapy. J Med Virol. 2013;85:893–8.CrossRefPubMed Harvala H, Stewart C, Muller K, et al. High risk of cytomegalovirus infection following solid organ transplantation despite prophylactic therapy. J Med Virol. 2013;85:893–8.CrossRefPubMed
3.
go back to reference Hammond SP, Martin ST, Roberts K, et al. Cytomegalovirus disease in lung transplantation: impact of recipient seropositivity and duration of antiviral prophylaxis. Transpl Infect Dis. 2013;15:163–70.CrossRefPubMed Hammond SP, Martin ST, Roberts K, et al. Cytomegalovirus disease in lung transplantation: impact of recipient seropositivity and duration of antiviral prophylaxis. Transpl Infect Dis. 2013;15:163–70.CrossRefPubMed
4.
go back to reference Mendez-Eirin E, Paniagua-Martín MJ, Marzoa-Rivas R, et al. Cumulative incidence of cytomegalovirus infection and disease after heart transplantation in the last decade: effect of preemptive therapy. Transplant Proc. 2012;44:2660–2.CrossRefPubMed Mendez-Eirin E, Paniagua-Martín MJ, Marzoa-Rivas R, et al. Cumulative incidence of cytomegalovirus infection and disease after heart transplantation in the last decade: effect of preemptive therapy. Transplant Proc. 2012;44:2660–2.CrossRefPubMed
6.
go back to reference Orlikowski D, Porcher R, Sivadon-Tardy V, et al. Guillain-Barré syndrome following primary cytomegalovirus infection: a prospective cohort study. Clin Infect Dis. 2011;52:837–44.CrossRefPubMed Orlikowski D, Porcher R, Sivadon-Tardy V, et al. Guillain-Barré syndrome following primary cytomegalovirus infection: a prospective cohort study. Clin Infect Dis. 2011;52:837–44.CrossRefPubMed
7.
go back to reference De Maar EF, Kas-Deelen DM, de Jager AE, et al. Inflammatory demyelinating polyneuropathy in a kidney transplant patient with cytomegalovirus infection. Nephrol Dial Transplant. 1999;14:2228–30.CrossRefPubMed De Maar EF, Kas-Deelen DM, de Jager AE, et al. Inflammatory demyelinating polyneuropathy in a kidney transplant patient with cytomegalovirus infection. Nephrol Dial Transplant. 1999;14:2228–30.CrossRefPubMed
8.
go back to reference El-Sabrout RA, Radovancevic B, Ankoma-Sey V, Van Buren CT. Guillain-Barré syndrome after solid organ transplantation. Transplantation. 2001;71:1311–6.CrossRefPubMed El-Sabrout RA, Radovancevic B, Ankoma-Sey V, Van Buren CT. Guillain-Barré syndrome after solid organ transplantation. Transplantation. 2001;71:1311–6.CrossRefPubMed
9.
go back to reference Keithi-Reddy SR, Chakravarthi RM, Hussaini SM, Venkatapuram RR, Murthy JM. Cytomegalovirus disease with Guillain-Barré syndrome in a cadaver renal allograft recipient: cause or coincidence. Int Urol Nephrol. 2007;39:967–70.CrossRefPubMed Keithi-Reddy SR, Chakravarthi RM, Hussaini SM, Venkatapuram RR, Murthy JM. Cytomegalovirus disease with Guillain-Barré syndrome in a cadaver renal allograft recipient: cause or coincidence. Int Urol Nephrol. 2007;39:967–70.CrossRefPubMed
10.
go back to reference Garcia AT, García HA, Mazuecos BA, Lancho NC. Guillain-Barre syndrome in kidney transplant. Nefrologia. 2010;30:260–1. Garcia AT, García HA, Mazuecos BA, Lancho NC. Guillain-Barre syndrome in kidney transplant. Nefrologia. 2010;30:260–1.
11.
go back to reference Hodowanec AC, Simon DM. Late primary cytomegalovirus infection presenting with acute inflammatory demyelinating polyneuropathy in a heart transplant recipient. Transpl Infect Dis. 2012;14:E116–20.CrossRefPubMed Hodowanec AC, Simon DM. Late primary cytomegalovirus infection presenting with acute inflammatory demyelinating polyneuropathy in a heart transplant recipient. Transpl Infect Dis. 2012;14:E116–20.CrossRefPubMed
12.
go back to reference Yuki N, Kuwabara S. Axonal Guillain-Barré syndrome: carbohydrate mimicry and pathophysiology. J Peripher Nerv Syst. 2007;12:238–49.CrossRefPubMed Yuki N, Kuwabara S. Axonal Guillain-Barré syndrome: carbohydrate mimicry and pathophysiology. J Peripher Nerv Syst. 2007;12:238–49.CrossRefPubMed
13.
go back to reference Hafer-Macko CE, Sheikh KA, Li CY, et al. Immune attack on the Schwann cell surface in acute inflammatory demyelinating polyneuropathy. Ann Neurol. 1996;39:625–35.CrossRefPubMed Hafer-Macko CE, Sheikh KA, Li CY, et al. Immune attack on the Schwann cell surface in acute inflammatory demyelinating polyneuropathy. Ann Neurol. 1996;39:625–35.CrossRefPubMed
14.
go back to reference Sawai S, Satoh M, Mori M, et al. Moesin is a possible target molecule for cytomegalovirus-related Guillain-Barré syndrome. Neurology. 2014;83:113–7.CrossRefPubMed Sawai S, Satoh M, Mori M, et al. Moesin is a possible target molecule for cytomegalovirus-related Guillain-Barré syndrome. Neurology. 2014;83:113–7.CrossRefPubMed
15.
go back to reference Suthanthiran M, Morris RE, Strom TB. Immunosuppressants: cellular and molecular mechanisms of action. Am J Kidney Dis. 1996;28:159–72.CrossRefPubMed Suthanthiran M, Morris RE, Strom TB. Immunosuppressants: cellular and molecular mechanisms of action. Am J Kidney Dis. 1996;28:159–72.CrossRefPubMed
Metadata
Title
Late-onset cytomegalovirus infection complicated by Guillain–Barre syndrome in a kidney transplant recipient: case report and review of the literature
Authors
E. Shaban
R. Gohh
B. M. Knoll
Publication date
01-04-2016
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 2/2016
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-015-0819-1

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