Skip to main content
Top
Published in: Infection 6/2015

01-12-2015 | Case Report

Necrotizing mycosis due to Verruconis gallopava in an immunocompetent patient

Authors: Christian Geltner, Sieglinde Sorschag, Birgit Willinger, Thomas Jaritz, Zoran Saric, Cornelia Lass-Flörl

Published in: Infection | Issue 6/2015

Login to get access

Abstract

Verruconis gallopava is a dematiaceous mould usually causing saprophytic infection in immunosuppressed host. Only a few cases have been published even in immunocompromised states. We present a rare case of pulmonary involvement in an immunocompetent patient with recurrent disease. The mid-aged woman had no evidence of any disease causing impaired immune response. Recurrent disease shows pulmonary infiltrates and symptoms of allergic bronchopulmonary mycosis. We describe an emerging pathogen that has been found in an immunocompetent host. Eradication was not possible despite the use of several different antifungal drugs. Further recurrence of infection in the described patient is probable.
Literature
1.
go back to reference Shoham S, Pic-Aluas L, Taylor J, Cortez K, Rinaldi MG, Shea Y, Walsh TJ. Transplant-associated Ochroconis gallopava infections. Transpl Infect Dis. 2008;10:442–8.CrossRefPubMed Shoham S, Pic-Aluas L, Taylor J, Cortez K, Rinaldi MG, Shea Y, Walsh TJ. Transplant-associated Ochroconis gallopava infections. Transpl Infect Dis. 2008;10:442–8.CrossRefPubMed
2.
go back to reference Rossmann SN, Cernoch PL, Davis JR. Dematiaceous fungi are an increasing cause of human disease. Clin Infect Dis. 1996;22:73–80.CrossRefPubMed Rossmann SN, Cernoch PL, Davis JR. Dematiaceous fungi are an increasing cause of human disease. Clin Infect Dis. 1996;22:73–80.CrossRefPubMed
3.
go back to reference Singh N, Chang FY, Gayowski T, Marino IR. Infections due to dematiaceous fungi in organ transplant recipients: case report and review. Clin Infect Dis. 1997;24:369–74.CrossRefPubMed Singh N, Chang FY, Gayowski T, Marino IR. Infections due to dematiaceous fungi in organ transplant recipients: case report and review. Clin Infect Dis. 1997;24:369–74.CrossRefPubMed
4.
go back to reference Meriden Z, Marr KA, Lederman HM, Illei PB, Villa K, Riedel S, Caroll KC, Zhang SX. Ochroconis gallopava infection in a patient with chronic granulomatous disease: case report and review of the literature. Med Mycol. 2012;50:883–9.CrossRefPubMed Meriden Z, Marr KA, Lederman HM, Illei PB, Villa K, Riedel S, Caroll KC, Zhang SX. Ochroconis gallopava infection in a patient with chronic granulomatous disease: case report and review of the literature. Med Mycol. 2012;50:883–9.CrossRefPubMed
5.
go back to reference Mayer N, Bastani B. A case of pulmonary cavitary lesion due to Dactylaria constricta var. gallopava in a renal transplant patient. Nephrology. 2009;14:262.CrossRefPubMed Mayer N, Bastani B. A case of pulmonary cavitary lesion due to Dactylaria constricta var. gallopava in a renal transplant patient. Nephrology. 2009;14:262.CrossRefPubMed
6.
go back to reference Burns KEA, Ohori NP, Iacono AT. Dactylaria gallopava infection presenting as a pulmonary nodule in a single-lung transplant recipient. J Heart Lung Transplant. 2000;19:900–2.CrossRefPubMed Burns KEA, Ohori NP, Iacono AT. Dactylaria gallopava infection presenting as a pulmonary nodule in a single-lung transplant recipient. J Heart Lung Transplant. 2000;19:900–2.CrossRefPubMed
7.
go back to reference Mancini MC, McGinnis MR. Dactylaria infection of a human being: pulmonary disease in a heart transplant recipient. J Heart Lung Transpl. 1992;11:827–30. Mancini MC, McGinnis MR. Dactylaria infection of a human being: pulmonary disease in a heart transplant recipient. J Heart Lung Transpl. 1992;11:827–30.
8.
go back to reference Wang TK, Chiu W, Chim S, Chan TM, Wong SS, Ho PL. Disseminated Ochroconis gallopavum infection in a renal transplant recipient: the first reported case and a review of the literature. Clin Nephrol. 2003;60:415–23. doi:10.5414/CNP60415.CrossRefPubMed Wang TK, Chiu W, Chim S, Chan TM, Wong SS, Ho PL. Disseminated Ochroconis gallopavum infection in a renal transplant recipient: the first reported case and a review of the literature. Clin Nephrol. 2003;60:415–23. doi:10.​5414/​CNP60415.CrossRefPubMed
9.
go back to reference Sides EH, Benson JD, Padhye AA. Phaeohyphomycotic brain abscess due to Ochroconis gallopavum in a patient with malignant lymphoma of a large cell type. J Med Vet Mycol. 1991;29:317–22.CrossRefPubMed Sides EH, Benson JD, Padhye AA. Phaeohyphomycotic brain abscess due to Ochroconis gallopavum in a patient with malignant lymphoma of a large cell type. J Med Vet Mycol. 1991;29:317–22.CrossRefPubMed
10.
go back to reference Fukushima N, Mannen K, Okamoto S, Shinogi T, Nishimoto K, Sueoka E. Disseminated Ochroconis gallopavum infection in a chronic lymphocytic leukemia: a case report and review of the literature on hematological malignancies. Intern Med. 2005;44:879–82.CrossRefPubMed Fukushima N, Mannen K, Okamoto S, Shinogi T, Nishimoto K, Sueoka E. Disseminated Ochroconis gallopavum infection in a chronic lymphocytic leukemia: a case report and review of the literature on hematological malignancies. Intern Med. 2005;44:879–82.CrossRefPubMed
11.
go back to reference Qureshi ZA, Kwak EJ, Nguyen MH, Silveira FP. Ochroconis gallopava: a dematiaceous mold causing infections in transplant recipients. Clin Transplant. 2012;26:E17–23.CrossRefPubMed Qureshi ZA, Kwak EJ, Nguyen MH, Silveira FP. Ochroconis gallopava: a dematiaceous mold causing infections in transplant recipients. Clin Transplant. 2012;26:E17–23.CrossRefPubMed
12.
go back to reference Odell JA, Alvarez S, Cvitkovich DG, Cortese DA, McComb BL. Multiple lung abscesses due to Ochroconis gallopavum, a dematiaceous fungus, in a nonimmunocompromised wood pulp worker. Chest. 2000;118:1503–5.CrossRefPubMed Odell JA, Alvarez S, Cvitkovich DG, Cortese DA, McComb BL. Multiple lung abscesses due to Ochroconis gallopavum, a dematiaceous fungus, in a nonimmunocompromised wood pulp worker. Chest. 2000;118:1503–5.CrossRefPubMed
13.
go back to reference Hollingsworth JW, Shofer S, Zaas A. Successful treatment of Ochroconis gallopavum infection in an immunocompetent host. Infection. 2007;35:367–9.CrossRefPubMed Hollingsworth JW, Shofer S, Zaas A. Successful treatment of Ochroconis gallopavum infection in an immunocompetent host. Infection. 2007;35:367–9.CrossRefPubMed
14.
go back to reference Samerpitak K, Van der Linde E, Choi HJ, Gerrits van den Ende AHG, Machouart M, Gueidan C, de Hoog GS. Taxonomy of Ochroconis, genus including opportunistic pathogens on humans and animals. Fungal Divers. 2014;65:89–126. doi:10.1007/s13225-013-0253-6.CrossRef Samerpitak K, Van der Linde E, Choi HJ, Gerrits van den Ende AHG, Machouart M, Gueidan C, de Hoog GS. Taxonomy of Ochroconis, genus including opportunistic pathogens on humans and animals. Fungal Divers. 2014;65:89–126. doi:10.​1007/​s13225-013-0253-6.CrossRef
15.
go back to reference Lass-Flörl C, Mayr A, Perkhofer S, Hinterberger G, Hausdorfer J, Speth C, Fille M. Activities of antifungal agents against yeasts and filamentous fungi: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing. Antimicrob Agents Chemother. 2008;52:3637–41. doi:10.1128/AAC.00662-08 [Epub 2008 Aug 11].PubMedCentralCrossRefPubMed Lass-Flörl C, Mayr A, Perkhofer S, Hinterberger G, Hausdorfer J, Speth C, Fille M. Activities of antifungal agents against yeasts and filamentous fungi: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing. Antimicrob Agents Chemother. 2008;52:3637–41. doi:10.​1128/​AAC.​00662-08 [Epub 2008 Aug 11].PubMedCentralCrossRefPubMed
16.
17.
go back to reference Seyedmousavi S, Samerpitak K, Rijs AJM, Melchers WJG, Mouton JW, Verweij PE, de Hoog GS. Antifungal Susceptibility Patterns of Opportunistic Fungi in the Genera Verruconis and Ochroconis. Antimicrob Agents Chemother. 2014;58:3285–92.PubMedCentralCrossRefPubMed Seyedmousavi S, Samerpitak K, Rijs AJM, Melchers WJG, Mouton JW, Verweij PE, de Hoog GS. Antifungal Susceptibility Patterns of Opportunistic Fungi in the Genera Verruconis and Ochroconis. Antimicrob Agents Chemother. 2014;58:3285–92.PubMedCentralCrossRefPubMed
18.
go back to reference Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyian-nis DP, Marr KA, Morrison VA, Segal BH, Steinbach WJ, Stevens DA, Van Burik JA, Wingard JR, Patterson TF. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2008;46:327–60.CrossRefPubMed Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyian-nis DP, Marr KA, Morrison VA, Segal BH, Steinbach WJ, Stevens DA, Van Burik JA, Wingard JR, Patterson TF. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2008;46:327–60.CrossRefPubMed
19.
go back to reference Fricker-Hidalgo H, Coltey B, Llerena C, Renversez JC, Grillot R, Pin I, Pelloux H, Pinel C. Recombinant allergens combined with biological markers in the diagnosis of allergic bronchopulmonary aspergillosis in cystic fibrosis patients. Clin Vaccine Immunol. 2010;17:1330–6. doi:10.1128/CVI.00200-10.PubMedCentralCrossRefPubMed Fricker-Hidalgo H, Coltey B, Llerena C, Renversez JC, Grillot R, Pin I, Pelloux H, Pinel C. Recombinant allergens combined with biological markers in the diagnosis of allergic bronchopulmonary aspergillosis in cystic fibrosis patients. Clin Vaccine Immunol. 2010;17:1330–6. doi:10.​1128/​CVI.​00200-10.PubMedCentralCrossRefPubMed
Metadata
Title
Necrotizing mycosis due to Verruconis gallopava in an immunocompetent patient
Authors
Christian Geltner
Sieglinde Sorschag
Birgit Willinger
Thomas Jaritz
Zoran Saric
Cornelia Lass-Flörl
Publication date
01-12-2015
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 6/2015
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-015-0757-y

Other articles of this Issue 6/2015

Infection 6/2015 Go to the issue

Images in Infection

Alopecia syphilitica diffusa