Skip to main content
Top
Published in: Infection 5/2015

01-10-2015 | Case Report

A rare case of Waterhouse-Friderichsen syndrome caused by Capnocytophaga canimorsus in an immunocompetent patient

Authors: Joseph David Cooper, Robert Patrick Dorion, Joseph Lorenzo Smith

Published in: Infection | Issue 5/2015

Login to get access

Abstract

A 53-year-old Caucasian male with hypertension and active tobacco abuse presented to a community hospital with a 2-day history of vague abdominal pain, myalgia and increased lethargy after being bitten on his right hand by the family dog while camping just 3 days prior to symptom onset. He expired within 90 min upon arrival to our intensive care unit. Pre-mortem blood cultures grew a fastidious Gram-negative aerobic rod that was identified as Capnocytophaga canimorsus. Autopsy findings showed multi-organ disseminated intravascular coagulopathy with microthrombi along with bilateral adrenal hemorrhage and necrosis of the adrenal glands consistent with Waterhouse-Friderichsen syndrome. This case contributes to the medical literature as a rare presentation of Capnocytophaga canimorsus infection in an otherwise immunocompetent patient and stresses the importance of a thorough history taking and physical examination by clinicians along with prompt administration of appropriate antibiotics.
Literature
1.
go back to reference Macrea M, McNamee M, Martin TJ. Acute onset of fever, chills, and lethargy in a 36-year-old woman. Chest. 2008;133:1505–7.CrossRefPubMed Macrea M, McNamee M, Martin TJ. Acute onset of fever, chills, and lethargy in a 36-year-old woman. Chest. 2008;133:1505–7.CrossRefPubMed
2.
go back to reference Cleuziou C, Binard A, Devauchelle-Pensec V, et al. beware man’s best friend. Spine. 2010;35:1520–1.CrossRef Cleuziou C, Binard A, Devauchelle-Pensec V, et al. beware man’s best friend. Spine. 2010;35:1520–1.CrossRef
3.
go back to reference Stiegler D, Gilbert JD, Warner MS, et al. Fatal dog bite in the absence of significant trauma: capnocytophaga canimorsus infection and unexpected death. Am J Forensic Med Pathol. 2010;31:198–9.CrossRefPubMed Stiegler D, Gilbert JD, Warner MS, et al. Fatal dog bite in the absence of significant trauma: capnocytophaga canimorsus infection and unexpected death. Am J Forensic Med Pathol. 2010;31:198–9.CrossRefPubMed
4.
go back to reference Pers C, Gahrn-Hansen B, Frederiksen W. Capnocytophaga canimorsus septicemia in Denmark, 1982-1995: review of 39 cases. Clin Infect Dis. 1996;23:71–5.CrossRefPubMed Pers C, Gahrn-Hansen B, Frederiksen W. Capnocytophaga canimorsus septicemia in Denmark, 1982-1995: review of 39 cases. Clin Infect Dis. 1996;23:71–5.CrossRefPubMed
5.
go back to reference Hammoud D, Nassar R, Griffey M. Capnocytophaga canimorsus septicemia caused by a dog bite in an asplenic patient. Kans J Med. 2011;4(1):14–7. Hammoud D, Nassar R, Griffey M. Capnocytophaga canimorsus septicemia caused by a dog bite in an asplenic patient. Kans J Med. 2011;4(1):14–7.
6.
go back to reference Chaudhuri AK, Hartley RB, Maddocks AC. Waterhouse-Friderichsen syndrome caused by a DF-2 bacterium in a splenectomised patient. J Clin Pathol. 1981;34:172–3.PubMedCentralCrossRefPubMed Chaudhuri AK, Hartley RB, Maddocks AC. Waterhouse-Friderichsen syndrome caused by a DF-2 bacterium in a splenectomised patient. J Clin Pathol. 1981;34:172–3.PubMedCentralCrossRefPubMed
7.
go back to reference Mirza I, Wolk J, Toth L, et al. Waterhouse-Friderichsen syndrome secondary to Capnocytophaga canimorsus septicemia and demonstration of bacteremia by peripheral blood smear. Arch Pathol Lab Med. 2000;124:859–63.PubMed Mirza I, Wolk J, Toth L, et al. Waterhouse-Friderichsen syndrome secondary to Capnocytophaga canimorsus septicemia and demonstration of bacteremia by peripheral blood smear. Arch Pathol Lab Med. 2000;124:859–63.PubMed
8.
go back to reference Verghese A, Hamati F, Berk S, et al. Susceptibility of dysgonic fermenter 2 to antimicrobial agents in vitro. Antimicrob Agents Chemother. 1988;32:78–80.PubMedCentralCrossRefPubMed Verghese A, Hamati F, Berk S, et al. Susceptibility of dysgonic fermenter 2 to antimicrobial agents in vitro. Antimicrob Agents Chemother. 1988;32:78–80.PubMedCentralCrossRefPubMed
9.
go back to reference Shin H, Mally M, Meyer S, et al. Resistance of Capnocytophaga canimorsus to killing by human complement and polymorphonuclear leukocytes. Infect Immun. 2009;77:2262–71.PubMedCentralCrossRefPubMed Shin H, Mally M, Meyer S, et al. Resistance of Capnocytophaga canimorsus to killing by human complement and polymorphonuclear leukocytes. Infect Immun. 2009;77:2262–71.PubMedCentralCrossRefPubMed
10.
go back to reference Fischer LJ, Weyant RS, White EH, et al. Intracellular multiplication and toxic destruction of cultured macrophages by Capnocytophaga canimorsus. Infect Immun. 1995;63:3484–90.PubMedCentralPubMed Fischer LJ, Weyant RS, White EH, et al. Intracellular multiplication and toxic destruction of cultured macrophages by Capnocytophaga canimorsus. Infect Immun. 1995;63:3484–90.PubMedCentralPubMed
11.
go back to reference Brenner DJ, Hollis DG, Fanning GR, et al. Capnocytophaga canimorsus sp. nov. (formerly CDC group DF-2), a cause of localized wound infection following dog bite. J Clin Microbiol. 1989;27:231–5.PubMedCentralPubMed Brenner DJ, Hollis DG, Fanning GR, et al. Capnocytophaga canimorsus sp. nov. (formerly CDC group DF-2), a cause of localized wound infection following dog bite. J Clin Microbiol. 1989;27:231–5.PubMedCentralPubMed
12.
go back to reference Bonatti H, Rossboth DW, Nachbaur D, et al. A series of infections due to Capnocytophaga spp in immuno suppressed and immunocompetent patients. Clin Microbiol Infect. 2003;9:380–7.CrossRefPubMed Bonatti H, Rossboth DW, Nachbaur D, et al. A series of infections due to Capnocytophaga spp in immuno suppressed and immunocompetent patients. Clin Microbiol Infect. 2003;9:380–7.CrossRefPubMed
13.
go back to reference Tuuminen T, Viiri H, Vuorinen S. The Capnocytophaga canimorsus isolate that caused sepsis in an immuno sufficient man was transmitted by the large pine weevil hylobiusabietis. J Clin Microbiol. 2014;52:2716–7.PubMedCentralCrossRefPubMed Tuuminen T, Viiri H, Vuorinen S. The Capnocytophaga canimorsus isolate that caused sepsis in an immuno sufficient man was transmitted by the large pine weevil hylobiusabietis. J Clin Microbiol. 2014;52:2716–7.PubMedCentralCrossRefPubMed
Metadata
Title
A rare case of Waterhouse-Friderichsen syndrome caused by Capnocytophaga canimorsus in an immunocompetent patient
Authors
Joseph David Cooper
Robert Patrick Dorion
Joseph Lorenzo Smith
Publication date
01-10-2015
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 5/2015
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-015-0740-7

Other articles of this Issue 5/2015

Infection 5/2015 Go to the issue