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Published in: Infection 4/2014

01-08-2014 | Brief Report

Echocardiographic screening for pulmonary arterial hypertension in HIV-positive patients

Authors: H. ten Freyhaus, D. Vogel, C. Lehmann, T. Kümmerle, C. Wyen, G. Fätkenheuer, S. Rosenkranz

Published in: Infection | Issue 4/2014

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Abstract

Human immunodeficiency virus (HIV) infection is associated with an increased risk for pulmonary arterial hypertension (PAH). Upon the screening of 220 asymptomatic HIV-positive individuals by echocardiography, we detected and confirmed HIV-associated PAH in 0.45 % of cases. Mild elevations of systolic pulmonary arterial pressure most probably owing to left ventricular diastolic dysfunction were found in 7.7 % of cases, without progress after 2 years. We suggest that the screening of asymptomatic HIV-positive patients for PAH should not be performed.
Literature
2.
go back to reference D’Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med. 1991;115:343–9.PubMedCrossRef D’Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med. 1991;115:343–9.PubMedCrossRef
4.
go back to reference Mehta NJ, Khan IA, Mehta RN, Sepkowitz DA. HIV-related pulmonary hypertension: analytic review of 131 cases. Chest. 2000;118:1133–41.PubMedCrossRef Mehta NJ, Khan IA, Mehta RN, Sepkowitz DA. HIV-related pulmonary hypertension: analytic review of 131 cases. Chest. 2000;118:1133–41.PubMedCrossRef
5.
go back to reference Rudski LG, Lai WW, Afilalo J, Hua L, Handschumacher MD, Chandrasekaran K, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2010;23:685–713; quiz 786–8. doi:10.1016/j.echo.2010.05.010.PubMedCrossRef Rudski LG, Lai WW, Afilalo J, Hua L, Handschumacher MD, Chandrasekaran K, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2010;23:685–713; quiz 786–8. doi:10.​1016/​j.​echo.​2010.​05.​010.PubMedCrossRef
6.
go back to reference Sitbon O, Lascoux-Combe C, Delfraissy JF, Yeni PG, Raffi F, De Zuttere D, et al. Prevalence of HIV-related pulmonary arterial hypertension in the current antiretroviral therapy era. Am J Respir Crit Care Med. 2008;177:108–13. doi:10.1164/rccm.200704-541OC.PubMedCrossRef Sitbon O, Lascoux-Combe C, Delfraissy JF, Yeni PG, Raffi F, De Zuttere D, et al. Prevalence of HIV-related pulmonary arterial hypertension in the current antiretroviral therapy era. Am J Respir Crit Care Med. 2008;177:108–13. doi:10.​1164/​rccm.​200704-541OC.PubMedCrossRef
7.
go back to reference Reinsch N, Neuhaus K, Esser S, Potthoff A, Hower M, Brockmeyer NH, et al. Prevalence of cardiac diastolic dysfunction in HIV-infected patients: results of the HIV-HEART study. HIV Clin Trials. 2010;11:156–62. doi:10.1310/hct1103-156.PubMedCrossRef Reinsch N, Neuhaus K, Esser S, Potthoff A, Hower M, Brockmeyer NH, et al. Prevalence of cardiac diastolic dysfunction in HIV-infected patients: results of the HIV-HEART study. HIV Clin Trials. 2010;11:156–62. doi:10.​1310/​hct1103-156.PubMedCrossRef
10.
go back to reference Helleberg M, Kronborg G, Larsen CS, Pedersen G, Pedersen C, Gerstoft J, et al. Causes of death among Danish HIV patients compared with population controls in the period 1995–2008. Infection. 2012;40:627–34. doi:10.1007/s15010-012-0293-y.PubMedCrossRef Helleberg M, Kronborg G, Larsen CS, Pedersen G, Pedersen C, Gerstoft J, et al. Causes of death among Danish HIV patients compared with population controls in the period 1995–2008. Infection. 2012;40:627–34. doi:10.​1007/​s15010-012-0293-y.PubMedCrossRef
Metadata
Title
Echocardiographic screening for pulmonary arterial hypertension in HIV-positive patients
Authors
H. ten Freyhaus
D. Vogel
C. Lehmann
T. Kümmerle
C. Wyen
G. Fätkenheuer
S. Rosenkranz
Publication date
01-08-2014
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 4/2014
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-014-0610-8

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