Skip to main content
Top
Published in: Acta Neurologica Belgica 2/2017

01-06-2017 | Original Article

Persistent cognitive deficits after whiplash injury: a comparative study with mild traumatic brain injury patients and healthy volunteers

Authors: Kurt Beeckmans, Cleo Crunelle, Silke Van Ingelgom, Karla Michiels, Eva Dierckx, Patrick Vancoillie, Henri Hauman, Bernard Sabbe

Published in: Acta Neurologica Belgica | Issue 2/2017

Login to get access

Abstract

In this study, we evaluated persistent cognitive deficits in whiplash injury (WI) patients and compared these to cognitive functioning in mild traumatic brain injury (MTBI) patients and healthy controls (HC). Sixty-one patients suffering from a WI were compared with 57 patients suffering from a MTBI and with 30 HC. They were examined with an extensive neuropsychological test battery assessing attention, memory, and visuospatial and executive functions. In both patient groups, participants showed persistent cognitive symptoms (more than 6 months post-injury). The two patient groups did not differ significantly with regard to measurements of attention, memory, and visuospatial and executive functions. The WI group, as compared to the HC group, was found to be significantly more deficient in speed of performance during sustained and divided attention, focused attention, alternating attention, the storage of new auditory-verbal unrelated information into memory, the long-term delayed recall of stored auditory-verbal related information from memory, abstract reasoning and accuracy of performance during planning and problem solving. No differences could be found between both groups concerning speed of information processing, visuospatial abilities and verbal fluency.
Literature
1.
go back to reference Ettlin TM, Kischka U, Reichmann S, Radii EW, Heim SB, Wengen D, Benson DF (1992) Cerebral symptoms after whiplash injury of the neck: a prospective clinical and neuropsychological study of whiplash injury. J Neurol Neurosurg Psychiatry 55:943–948CrossRefPubMedPubMedCentral Ettlin TM, Kischka U, Reichmann S, Radii EW, Heim SB, Wengen D, Benson DF (1992) Cerebral symptoms after whiplash injury of the neck: a prospective clinical and neuropsychological study of whiplash injury. J Neurol Neurosurg Psychiatry 55:943–948CrossRefPubMedPubMedCentral
2.
go back to reference Taylor AE, Cox CA, Mallis A (1996) Persistent neuropsychological deficits following whiplash: evidence for chronic mild traumatic brain injury? Arch Phys Med Rehabil 77:529–535CrossRefPubMed Taylor AE, Cox CA, Mallis A (1996) Persistent neuropsychological deficits following whiplash: evidence for chronic mild traumatic brain injury? Arch Phys Med Rehabil 77:529–535CrossRefPubMed
3.
go back to reference Radanov BP, Dvorak J (1996) Impaired cognitive functioning after whiplash injury of the cervical spine. Spine 21:392–397CrossRefPubMed Radanov BP, Dvorak J (1996) Impaired cognitive functioning after whiplash injury of the cervical spine. Spine 21:392–397CrossRefPubMed
4.
go back to reference Blokhorst M, Swinkels M, Lof O, Lousberg R, Zilvold G (2002) The influence of “state” related factors on focused attention following whiplash associated disorder. J Clin Exp Neuropsychol 24:471–478CrossRefPubMed Blokhorst M, Swinkels M, Lof O, Lousberg R, Zilvold G (2002) The influence of “state” related factors on focused attention following whiplash associated disorder. J Clin Exp Neuropsychol 24:471–478CrossRefPubMed
5.
go back to reference Bosma FK, Kessels RP (2002) Cognitive impairments, psychological dysfunction, and coping styles in patients with chronic whiplash syndrome. Neuropsychiatry Neuropsychol Behav Neurol 15:56–65PubMed Bosma FK, Kessels RP (2002) Cognitive impairments, psychological dysfunction, and coping styles in patients with chronic whiplash syndrome. Neuropsychiatry Neuropsychol Behav Neurol 15:56–65PubMed
6.
go back to reference Antepohl W, Kiviloog L, Andersson J, Gerdle B (2003) Cognitive impairment in patients with chronic whiplash-associated disorder—a matched control study. NeuroRehabilitation 18:307–315PubMed Antepohl W, Kiviloog L, Andersson J, Gerdle B (2003) Cognitive impairment in patients with chronic whiplash-associated disorder—a matched control study. NeuroRehabilitation 18:307–315PubMed
7.
go back to reference Guez M (2006) Chronic neck pain. An epidemiological, psychological and SPECT study with emphasis on whiplash-associated disorders. Acta Orthop Suppl 77:3–33 Guez M (2006) Chronic neck pain. An epidemiological, psychological and SPECT study with emphasis on whiplash-associated disorders. Acta Orthop Suppl 77:3–33
8.
go back to reference Robinson JP, Burwinkle T, Turk DC (2007) Perceived and actual memory, concentration and attention problems after whiplash-associated disorders (grades I and II): prevalence and predictors. Arch Phys Med Rehabil 88:774–779CrossRefPubMed Robinson JP, Burwinkle T, Turk DC (2007) Perceived and actual memory, concentration and attention problems after whiplash-associated disorders (grades I and II): prevalence and predictors. Arch Phys Med Rehabil 88:774–779CrossRefPubMed
9.
go back to reference Lee H, Wintermark M, Gean AD, Ghajar J, Manley GT, Mukherjee P (2008) Focal lesions in acute mild traumatic brain injury and neurocognitive outcome: CT versus 3T MRI. J Neurotrauma 25:1049–1056CrossRefPubMed Lee H, Wintermark M, Gean AD, Ghajar J, Manley GT, Mukherjee P (2008) Focal lesions in acute mild traumatic brain injury and neurocognitive outcome: CT versus 3T MRI. J Neurotrauma 25:1049–1056CrossRefPubMed
10.
go back to reference Sturzenegger M, Radanov BP, Winter P, Simko M, Farra AD, Di Stefano G (2008) MRI-based brain volumetry in chronic whiplash patients: no evidence for traumatic brain injury. Acta Neurol Scand 117:49–54PubMed Sturzenegger M, Radanov BP, Winter P, Simko M, Farra AD, Di Stefano G (2008) MRI-based brain volumetry in chronic whiplash patients: no evidence for traumatic brain injury. Acta Neurol Scand 117:49–54PubMed
11.
go back to reference Meeus M, Van Oosterwijck J, Ickmans K, Baert I, Coppieters I, Roussel N, Nijs J (2015) Interrelationships between pain processing, cortisol and cognitive performance in chronic whiplash-associated disorders. Clin Rheumatol 34:545–553CrossRefPubMed Meeus M, Van Oosterwijck J, Ickmans K, Baert I, Coppieters I, Roussel N, Nijs J (2015) Interrelationships between pain processing, cortisol and cognitive performance in chronic whiplash-associated disorders. Clin Rheumatol 34:545–553CrossRefPubMed
12.
go back to reference Miotto EC, Cinalli FZ, Serrao VT, Benute GG, Lucia MC, Scaff M (2010) Cognitive deficits in patients with mild to moderate traumatic brain injury. Arq Neuropsiquiatr 68:862–868CrossRefPubMed Miotto EC, Cinalli FZ, Serrao VT, Benute GG, Lucia MC, Scaff M (2010) Cognitive deficits in patients with mild to moderate traumatic brain injury. Arq Neuropsiquiatr 68:862–868CrossRefPubMed
13.
go back to reference Konrad C, Geburek AJ, Rist F, Blumenroth H, Fischer B, Husstedt I, Lohmann H (2011) Long-term cognitive and emotional consequences of mild traumatic brain injury. Psychol Med 41:1197–1211CrossRefPubMed Konrad C, Geburek AJ, Rist F, Blumenroth H, Fischer B, Husstedt I, Lohmann H (2011) Long-term cognitive and emotional consequences of mild traumatic brain injury. Psychol Med 41:1197–1211CrossRefPubMed
14.
go back to reference Schiehser DM, Delis DC, Filoteo JV, Delano-Wood L, Han SD, Jak AJ et al (2011) Are self-reported symptoms of executive dysfunction associated with objective executive function performance following mild to moderate traumatic brain injury? J Clin Exp Neuropsychol 33:704–714CrossRefPubMedPubMedCentral Schiehser DM, Delis DC, Filoteo JV, Delano-Wood L, Han SD, Jak AJ et al (2011) Are self-reported symptoms of executive dysfunction associated with objective executive function performance following mild to moderate traumatic brain injury? J Clin Exp Neuropsychol 33:704–714CrossRefPubMedPubMedCentral
15.
go back to reference Jamora CW, Young A, Ruff RM (2012) Comparison of subjective cognitive complaints with neuropsychological tests in individuals with mild vs more severe traumatic brain injuries. Brain Inj 26:36–47CrossRefPubMed Jamora CW, Young A, Ruff RM (2012) Comparison of subjective cognitive complaints with neuropsychological tests in individuals with mild vs more severe traumatic brain injuries. Brain Inj 26:36–47CrossRefPubMed
16.
go back to reference Dean PJ, Stern A (2013) Long-term effects of mild traumatic brain injury on cognitive performance. Front Human Neurosci 7:1–11CrossRef Dean PJ, Stern A (2013) Long-term effects of mild traumatic brain injury on cognitive performance. Front Human Neurosci 7:1–11CrossRef
17.
go back to reference Grossman EJ, Jensen JH, Babb JS, Chen Q, Tabesh A, Fieremans E et al (2013) Cognitive impairment in mild traumatic brain injury: a longitudinal diffusional kurtosis and perfusion imaging study. Am J Neuroradiol 34:951–957CrossRefPubMed Grossman EJ, Jensen JH, Babb JS, Chen Q, Tabesh A, Fieremans E et al (2013) Cognitive impairment in mild traumatic brain injury: a longitudinal diffusional kurtosis and perfusion imaging study. Am J Neuroradiol 34:951–957CrossRefPubMed
18.
go back to reference Hanten G, Li X, Ibarra A, Wilde EA, Barnes A, McCauley SR et al (2013) Updating memory after mild traumatic brain injury and orthopedic injuries. J Neurotrauma 30:618–624CrossRefPubMedPubMedCentral Hanten G, Li X, Ibarra A, Wilde EA, Barnes A, McCauley SR et al (2013) Updating memory after mild traumatic brain injury and orthopedic injuries. J Neurotrauma 30:618–624CrossRefPubMedPubMedCentral
19.
go back to reference Monti JM, Voss MW, Pence A, McAuley E, Kramer AF, Cohen NJ (2013) History of mild traumatic brain injury is associated with deficits in relational memory, reduced hippocampal volume, and less neural activity later in life. Front Aging Neurosci 5:41–43CrossRefPubMedPubMedCentral Monti JM, Voss MW, Pence A, McAuley E, Kramer AF, Cohen NJ (2013) History of mild traumatic brain injury is associated with deficits in relational memory, reduced hippocampal volume, and less neural activity later in life. Front Aging Neurosci 5:41–43CrossRefPubMedPubMedCentral
20.
go back to reference Smed A (1997) Cognitive function and distress after common whiplash injury. Acta Neurol Scand 95:73–80CrossRefPubMed Smed A (1997) Cognitive function and distress after common whiplash injury. Acta Neurol Scand 95:73–80CrossRefPubMed
21.
go back to reference Gimse R, Björgen IA, Tjell C, Solve-Tyssedal J, Bo K (1997) Reduced cognitive functions in a group of whiplash patients with demonstrated disturbances in the posture control system. J Clin Exp Neuropsychol 19:838–849CrossRefPubMed Gimse R, Björgen IA, Tjell C, Solve-Tyssedal J, Bo K (1997) Reduced cognitive functions in a group of whiplash patients with demonstrated disturbances in the posture control system. J Clin Exp Neuropsychol 19:838–849CrossRefPubMed
22.
go back to reference Lewine JD, Davis JT, Bigler ED, Thoma R, Hill D, Funke M et al (2007) Objective documentation of traumatic brain injury subsequent to mild head trauma: multimodal brain imaging with MEG, SPECT, and MRI. J Head Trauma Rehabil 22:141–155CrossRefPubMed Lewine JD, Davis JT, Bigler ED, Thoma R, Hill D, Funke M et al (2007) Objective documentation of traumatic brain injury subsequent to mild head trauma: multimodal brain imaging with MEG, SPECT, and MRI. J Head Trauma Rehabil 22:141–155CrossRefPubMed
23.
go back to reference Bigler ED (2008) Neuropsychology and clinical neuroscience of persistent post-concussive syndrome. J Int Neuropsychol Soc 14:1–22CrossRefPubMed Bigler ED (2008) Neuropsychology and clinical neuroscience of persistent post-concussive syndrome. J Int Neuropsychol Soc 14:1–22CrossRefPubMed
24.
go back to reference Belanger HG, Curtiss G, Demery JA, Lebowitz BK, Vanderploeg RD (2005) Factors moderating neuropsychological outcomes following mild traumatic brain injury: a meta-analysis. J Int Neuropsychol Soc 11:2015–2227 Belanger HG, Curtiss G, Demery JA, Lebowitz BK, Vanderploeg RD (2005) Factors moderating neuropsychological outcomes following mild traumatic brain injury: a meta-analysis. J Int Neuropsychol Soc 11:2015–2227
25.
go back to reference Frencham KAR, Fox AM, Maybery MT (2005) Neuropsychological studies of mild traumatic brain injury: a meta-analytic review of research since 1995. J Clin Exp Neuropsychol 27:334–351CrossRefPubMed Frencham KAR, Fox AM, Maybery MT (2005) Neuropsychological studies of mild traumatic brain injury: a meta-analytic review of research since 1995. J Clin Exp Neuropsychol 27:334–351CrossRefPubMed
26.
go back to reference Datta SG, Pillai SV, Rao SL, Kovoor JM, Chandramouli BA (2009) Post-concussion syndrome: correlation of neuropsychological deficits, structural lesions on magnetic resonance imaging and symptoms. Neurology 57:594–598 Datta SG, Pillai SV, Rao SL, Kovoor JM, Chandramouli BA (2009) Post-concussion syndrome: correlation of neuropsychological deficits, structural lesions on magnetic resonance imaging and symptoms. Neurology 57:594–598
27.
go back to reference Holli KK, Wäljas M, Harrison L, Liimatainen S, Luukkaala T, Ryymin P et al (2010) Mild traumatic brain injury: tissue texture analysis correlated to neuropsychological and DTI findings. Acad Radiol 17:1096–1102CrossRefPubMed Holli KK, Wäljas M, Harrison L, Liimatainen S, Luukkaala T, Ryymin P et al (2010) Mild traumatic brain injury: tissue texture analysis correlated to neuropsychological and DTI findings. Acad Radiol 17:1096–1102CrossRefPubMed
28.
go back to reference Alexander MP (1998) In the pursuit of proof of brain damage after whiplash injury. Neurology 51:336–340CrossRefPubMed Alexander MP (1998) In the pursuit of proof of brain damage after whiplash injury. Neurology 51:336–340CrossRefPubMed
29.
go back to reference Radanov BP, Bicik I, Dvorak J, Antinnes J, von Schulthess GK, Buck A (1999) Relation between neuropsychological and neuroimaging findings in patients with late whiplash syndrome. J Neurol Neurosurg Psychiatry 66:485–489CrossRefPubMedPubMedCentral Radanov BP, Bicik I, Dvorak J, Antinnes J, von Schulthess GK, Buck A (1999) Relation between neuropsychological and neuroimaging findings in patients with late whiplash syndrome. J Neurol Neurosurg Psychiatry 66:485–489CrossRefPubMedPubMedCentral
30.
go back to reference Schmand B, Lindeboom J, Schagen S, Heijt R, Koene T, Hamburger HL (1998) Cognitive complaints in patients with whiplash injury: the impact of malingering. J Neurolol Neurosurg Psychiatry 64:339–343CrossRef Schmand B, Lindeboom J, Schagen S, Heijt R, Koene T, Hamburger HL (1998) Cognitive complaints in patients with whiplash injury: the impact of malingering. J Neurolol Neurosurg Psychiatry 64:339–343CrossRef
31.
go back to reference Radanov BP, Di Stefano G, Schnidrig A, Ballinari P (1991) Role of psychosocial stress in recovery from common whiplash. Lancet 21:712–715CrossRef Radanov BP, Di Stefano G, Schnidrig A, Ballinari P (1991) Role of psychosocial stress in recovery from common whiplash. Lancet 21:712–715CrossRef
32.
go back to reference Jennett B, Teasdale G (1981) Management of head injuries. Contemporary neurology series. FA Davis Company, Philadelphia Jennett B, Teasdale G (1981) Management of head injuries. Contemporary neurology series. FA Davis Company, Philadelphia
33.
go back to reference Nas J (1961) Enkele aspecten van de Bourdon-Wiersma. Nederlands Tijdschrift voor Psychologie 16:360–380 Nas J (1961) Enkele aspecten van de Bourdon-Wiersma. Nederlands Tijdschrift voor Psychologie 16:360–380
34.
go back to reference Brickenkamp R, Oosterveld P (2011) D-2: aandachts- en concentratietest voor kinderen en volwassenen. Hogrefe, Amsterdam Brickenkamp R, Oosterveld P (2011) D-2: aandachts- en concentratietest voor kinderen en volwassenen. Hogrefe, Amsterdam
35.
go back to reference Hammes JW (1978) De Stroop Kleur-woord Test. Swets & Zeitlinger, Lisse Hammes JW (1978) De Stroop Kleur-woord Test. Swets & Zeitlinger, Lisse
36.
go back to reference Reitan RM (1958) Validity of the trail making test as an indicator of organic brain damage. Percept Mot Skills 8:271–276CrossRef Reitan RM (1958) Validity of the trail making test as an indicator of organic brain damage. Percept Mot Skills 8:271–276CrossRef
37.
go back to reference Gronwall DM (1977) Paced auditory serial addition task: a measure of recovery from concussion. Percept Mot Skills 44:367–373CrossRefPubMed Gronwall DM (1977) Paced auditory serial addition task: a measure of recovery from concussion. Percept Mot Skills 44:367–373CrossRefPubMed
38.
go back to reference Rey A (1964) L’examen clinique en psychologie. Presses Universitaires de France, Paris Rey A (1964) L’examen clinique en psychologie. Presses Universitaires de France, Paris
39.
go back to reference Miatton M, Wolters M, Lannoo E, Vingerhoets G (2004) Updated and extended Flemish normative data of commonly used neuropsychological tests. Psychol Belg 44:189–216 Miatton M, Wolters M, Lannoo E, Vingerhoets G (2004) Updated and extended Flemish normative data of commonly used neuropsychological tests. Psychol Belg 44:189–216
40.
go back to reference Meyers J, Meyers K (1995) Rey complex figure test and recognition trial. Psychological Assessment Resources (PAR), Lutz Meyers J, Meyers K (1995) Rey complex figure test and recognition trial. Psychological Assessment Resources (PAR), Lutz
41.
go back to reference Hooper HE (1983) Hooper visual organisation test. Western Psychological Services, Los Angeles Hooper HE (1983) Hooper visual organisation test. Western Psychological Services, Los Angeles
42.
go back to reference Benton A, Hamsher K, Varney NR, Spreen O (1983) Contributions to neuropsychological assessment: a clinical manual. Oxford University Press, New York Benton A, Hamsher K, Varney NR, Spreen O (1983) Contributions to neuropsychological assessment: a clinical manual. Oxford University Press, New York
43.
go back to reference Luteijn F, Barelds D (2004) Groninger Intelligentie Test (GIT-2). Pearson Assessment and Information, Amsterdam Luteijn F, Barelds D (2004) Groninger Intelligentie Test (GIT-2). Pearson Assessment and Information, Amsterdam
44.
go back to reference Wetzel L, Boll T (1987) Short category test, booklet format. Western Psychological Services, Los Angeles Wetzel L, Boll T (1987) Short category test, booklet format. Western Psychological Services, Los Angeles
45.
go back to reference Chapuis F (1992) Labyrinthtest. Hogreve, Göttingen Chapuis F (1992) Labyrinthtest. Hogreve, Göttingen
Metadata
Title
Persistent cognitive deficits after whiplash injury: a comparative study with mild traumatic brain injury patients and healthy volunteers
Authors
Kurt Beeckmans
Cleo Crunelle
Silke Van Ingelgom
Karla Michiels
Eva Dierckx
Patrick Vancoillie
Henri Hauman
Bernard Sabbe
Publication date
01-06-2017
Publisher
Springer International Publishing
Published in
Acta Neurologica Belgica / Issue 2/2017
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-017-0745-3

Other articles of this Issue 2/2017

Acta Neurologica Belgica 2/2017 Go to the issue