Top

Published in:

Open Access 01-09-2016 | Original Article

Detection superiority of 7 T MRI protocol in patients with epilepsy and suspected focal cortical dysplasia

Authors: A. J. Colon, M. J. P. van Osch, M. Buijs, J. v. d. Grond, P. Boon, M. A. van Buchem, P. A. M. Hofman

Published in: Acta Neurologica Belgica | Issue 3/2016

Abstract

In 11 adult patients with suspicion of Focal cortical dysplasia (FCD) on 1.5 T (n = 1) or 3 T (n = 10) magnetic resonance imaging (MRI), 7 T MRI was performed. Visibility, extent, morphological features and delineation were independently rated and subsequently discussed by three observers. Additionally, head-to-head comparisons with corresponding 3 T images were made in the eight patients with a previous 3 T MRI and sustained suspicion of FCD. Comparison with histopathology was done in the five patients that underwent surgery. All lesions, seen at 1.5 and 3 T, were also recognized on 7 T. At 7 T FLAIR highlighted the FCD-like lesions best, whereas T2 and T2* were deemed better suited to review structure and extent of the lesion. Image quality with the used 7 T MRI setup was higher than the quality with the used 3 T MRI setup. In 2 out of 11 patients diagnosis changed, in one after re-evaluation of the images, and in the other based on histopathology. With the used 7 T MRI setup, FCD-like lesions can be detected with more confidence and detail as compared to lower field strength. However, concordance between radiologic diagnosis and final diagnosis seems to be lower than expected.

Available only for authorised users

Cockerell OC, Johnson AL, Sander JW, Hart YM, Shorvon SD (1995) Remission of epilepsy: results from the national general practice study of epilepsy. Lancet 346:1228CrossRefPubMed

Kwan P, Brodie MJ (2000) Early identification of refractory epilepsy. N Engl J Med 342(5):314–319CrossRefPubMed

Kim YH, Kang HC, Kim DS, Kim SH, Shim KW, Kim HD, Lee JS (2011) Neuroimaging in identifying focal cortical dysplasia and prognostic factors in pediatric and adolescent epilepsy surgery. Epilepsia 52(4):722–727CrossRefPubMed

Bien CG, Szinay M, Wagner J, Clusmann H, Becker AJ, Urbach H (2009) Characteristics and surgical outcomes of patients with refractory magnetic resonance imaging-negative epilepsies. Arch Neurol 66:1491–1499CrossRefPubMed

Oster JM, Igbokwe E, Cosgrove R, Cole AJ (2012) Identifying subtle cortical gyral abnormalities as a predictor of focal cortical dysplasia and a cure for epilepsy. Arch Neurol 69(2):257–261CrossRefPubMed

Rowland NC, Englot DJ, Cage TA, Sughrue ME, Barbaro NM, Chang EF (2012) A meta-analysis of predictors of seizure freedom in the surgical management of focal cortical dysplasia. J Neurosurg 116(5):1035–1041CrossRefPubMed

Von Oertzen J, Urbach H, Jungbluth S, Kurthen M, Reuber M, Fernández G, Elger CE (2002) Standard magnetic resonance imaging is inadequate for patients with refractory focal epilepsy. J Neurol Neurosurg Psychiatry 73(6):643–647CrossRef

Knake S, Triantafyllou C, Wald LL, Wiggins G, Kirk GP, Larsson PG et al (2005) 3 T phased array MRI improves the presurgical evaluation in focal epilepsies: a prospective study. Neurology 65:1026–1031CrossRefPubMed

Phal PM, Usmanov A, Nesbit GM, Anderson JC, Spencer D, Wang P, Helwig JA, Roberts C, Hamilton BE (2008) Qualitative comparison of 3-T and 1.5-T MRI in the evaluation of epilepsy. AJR Am J Roentgenol 191(3):890–895CrossRefPubMed

10.

Strandberg M, Larsson EM, Backman S, Kallen K (2008) Pre-surgical epilepsy evaluation using 3 T MRI. Do surface coils provide additional information? Epileptic Disord 10:83–92PubMed

11.

Mellerio C, Labeyrie MA, Chassoux F, Roca P, Alami O, Plat M, Naggara O, Devaux B, Meder JF, Oppenheim C (2014) 3 T MRI improves the detection of transmantle sign in type 2 focal cortical dysplasia. Epilepsia 55(1):117–122CrossRefPubMed

12.

Tselikas L, Souillard-Scemama R, Naggara O, Mellerio C, Varlet P, Dezamis E, Domont J, Dhermain F, Devaux B, Chrétien F, Meder JF, Pallud J, Oppenheim C (2015) Imaging of gliomas at 1.5 and 3 Tesla—a comparative study. Neuro Oncol 17(6):895–900CrossRefPubMed

13.

Li TQ, van Gelderen P, Merkle H, Talagala L, Koretsky AP, Duyn J (2006) Extensive heterogeneity in white matter intensity in high-resolution T2*-weighted MRI of the human brain at 7.0 T. Neuroimage 32(3):1032–1040CrossRefPubMed

14.

Kwan JY, Jeong SY, Van Gelderen P, Deng HX, Quezado MM, Danielian LE, Butman JA, Chen L, Bayat E, Russell J, Siddique T, Duyn JH, Rouault TA, Floeter MK (2012) Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 Tesla MRI and pathology. PLoS One 7(4):e35241. doi:10.1371/journal.pone.0035241 CrossRefPubMedPubMedCentral

15.

Fukunaga M, Li TQ, van Gelderen P, de Zwart JA, Shmueli K, Yao B, Lee J, Maric D, Aronova MA, Zhang G, Leapman RD, Schenck JF, Merkle H, Duyn JH (2010) Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast. Proc Natl Acad Sci USA 107(8):3834–3839CrossRefPubMedPubMedCentral

16.

Conijn MM, Geerlings MI, Biessels GJ, Takahara T, Witkamp TD, Zwanenburg JJ, Luijten PR, Hendrikse J (2011) Cerebral microbleeds on MR imaging: comparison between 1.5 and 7 T. AJNR Am J Neuroradiol 32(6):1043–1049CrossRefPubMed

17.

Yao B, Bagnato F, Matsuura E, Merkle H, van Gelderen P, Cantor FK, Duyn JH (2012) Chronic multiple sclerosis lesions: characterization with high-field-strength MR imaging. Radiology 262(1):206–215CrossRefPubMedPubMedCentral

18.

Van Veluw SJ, Zwanenburg JJ, Engelen-Lee J, Spliet WG, Hendrikse J, Luijten PR, Biessels GJ (2013) In vivo detection of cerebral cortical microinfarcts with high-resolution 7 T MRI. J Cereb Blood Flow Metab 33(3):322–329CrossRefPubMed

19.

Breyer T, Wanke I, Maderwald S, Woermann FG, Kraff O, Theysohn JM, Ebner A, Forsting M, Ladd ME, Schlamann M (2010) Imaging of patients with hippocampal sclerosis at 7 Tesla: initial results. Acad Radiol 17(4):421–426CrossRefPubMed

20.

Alexiou GA, Varely M, Sfakianos G, Prodromou N (2009) Benign lesions accompanied by intractable epilepsy in children. J Child Neurol 24(6):697–700CrossRefPubMed

21.

Piao YS, Lu DH, Chen L, Liu J, Wang W, Liu L, Yu T, Wang YP, Li YJ (2010) Neuropathological findings in intractable epilepsy: 435 Chinese cases. Brain Pathol 20(5):902–908PubMed

22.

Tassi L, Colombo N, Garbelli R, Francione S, Lo RG, Mai R et al (2002) Focal cortical dysplasia: neuropathological subtypes, EEG, neuroimaging and surgical outcome. Brain 125:1719–1732CrossRefPubMed

23.

Krsek P, Maton B, Korman B, Pacheco-Jacome E, Jayakar P, Dunoyer C, Rey G, Morrison G, Ragheb J, Vinters HV, Resnick T, Duchowny M (2008) Different features of histopathological subtypes of pediatric focal cortical dysplasia. Ann Neurol 63(6):758–769CrossRefPubMed

24.

Abdel Razek AA, Kandell AY, Elsorogy LG, Elmongy A, Basett AA (2009) Disorders of cortical formation: MR imaging features. AJNR Am J Neuroradiol 30(1):4–11CrossRefPubMed

25.

Colombo N, Tassi L, Deleo F, Citterio A, Bramerio M, Mai R, Sartori I, Cardinale F, Lo Russo G, Spreafico R (2012) Focal cortical dysplasia type IIa and IIb: MRI aspects in 118 cases proven by histopathology. Neuroradiology 54(10):1065–1077CrossRefPubMed

26.

Blümcke I, Thom M, Aronica E, Armstrong DD, Vinters HV, Palmini A et al (2011) The clinicopathologic spectrum of focal cortical dysplasia’s: a consensus classification proposed by an ad hoc task force of the ILAE diagnostic methods commission(1). Epilepsia 52:158–174CrossRefPubMed

27.

Wezel J, Kooij BJ, Webb AG (2014) Assessing the MR compatibility of dental retainer wires at 7 Tesla. Magn Reson Med 72(4):1191–1198CrossRefPubMed

28.

Likert R (1932) A technique for the measurement of attitudes. Arch Psychol 140:1–55

29.

Krsek P, Maton B, Jayakar P, Dean P, Korman B, Rey G, Dunoyer C, Pacheco-Jacome E, Morrison G, Ragheb J, Vinters HV, Resnick T, Duchowny M (2009) Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome. Neurology 72:217–223CrossRefPubMed

30.

Lerner JT, Salamon N, Hauptman JS et al (2009) Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience. Epilepsia 50:1310–1335CrossRefPubMed

31.

Urbach H, Scheffler B, Heinrichsmeier T et al (2002) Focal cortical dysplasia of Taylor’s balloon cell type: a clinicopathological entity with characteristic neuroimaging and histopathological features, and favorable postsurgical outcome. Epilepsia 43:33–40CrossRefPubMed

32.

Colombo N, Tassi L, Galli C et al (2003) Focal cortical dysplasias: MR imaging, histopathologic, and clinical correlations in surgically treated patients with epilepsy. AJNR Am J Neuroradiol 24:724–733PubMed

33.

Besson P, Andermann F, Dubeau F et al (2008) Small focal cortical dysplasia lesions are located at the bottom of a deep sulcus. Brain 131:3246–3255CrossRefPubMed

34.

Van der Kolk AG, Hendrikse J, Luijten PR (2012) Ultrahigh-field magnetic resonance imaging: the clinical potential for anatomy, pathogenesis, diagnosis, and treatment planning in brain disease. Neuroimaging Clin N Am 22(2):343–362CrossRefPubMed

35.

Versluis MJ, van der Grond J, van Buchem MA, van Zijl P, Webb AG (2012) High-field imaging of neurodegenerative diseases. Neuroimaging Clin N Am 22(2):159–171CrossRefPubMedPubMedCentral

36.

Zwanenburg JJ, Hendrikse J, Visser F, Takahara T, Luijten PR (2010) Fluid attenuated inversion recovery (FLAIR) MRI at 7.0 Tesla: comparison with 1.5 and 3.0 Tesla. Eur Radiol 20(4):915–922CrossRefPubMed

37.

Zwanenburg JJM, Hendrikse J, Luijten PR (2012) Generalized multiple-layer appearance of the cerebral cortex with 3D FLAIR 7.0-T MR imaging. Radiology 263(3):995–1001CrossRef

38.

Gennari F (1782) Francisci Gennari parmensis medicinae doctoris collegiati de peculiari structura cerebri nonnullisque eius morbis–paucae aliae anatom. Observat Accedunt, Regio Typographeo, Parma

39.

Hagemeier J, Geurts JJ, Zivadinov R (2012) Brain iron accumulation in aging and neurodegenerative disorders. Expert Rev Neurother 12(12):1467–1480CrossRefPubMed

40.

Salmenpera TM, Symms MR, Rugg-Gunn FJ, Boulby PA, Free SL, Barker GJ, Yousry TA, Duncan JS (2007) Evaluation of quantitative magnetic resonance imaging contrasts in MRI-negative refractory focal epilepsy. Epilepsia 48(2):229–237CrossRefPubMed

41.

De Ciantis A, Barba C, Tassi L, Cosottini M, Tosetti M, Costagli M, Bramerio M, Bartolini E, Biagi L, Cossu M, Pelliccia V, Symms MR, Guerrini R (2016) 7T MRI in focal epilepsy with unrevealing conventional field strength imaging. Epilepsia. doi:10.1111/epi.13313 PubMed

42.

Colon AJ, Osch MJPv, Buijs M, Grond Jvd, Hillebrandt A, Schijns O, Ossenblok P, Hofman P, Buchem Mv, Boon P (2016) MEG-guided analysis of 7 T-MRI in patients with epilepsy. (submitted)

Title: Detection superiority of 7 T MRI protocol in patients with epilepsy and suspected focal cortical dysplasia
Authors: A. J. Colon
M. J. P. van Osch
M. Buijs
J. v. d. Grond
P. Boon
M. A. van Buchem
P. A. M. Hofman
Publication date: 01-09-2016
Publisher: Springer International Publishing
Published in: Acta Neurologica Belgica / Issue 3/2016
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-016-0662-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Detection superiority of 7 T MRI protocol in patients with epilepsy and suspected focal cortical dysplasia

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2016

Brait–Fahn–Schwarz disease: Parkinson’s disease and amyotrophic lateral sclerosis complex

Solitary Langerhans cell histiocytosis of the cavernous sinus with orbital extension in an adult

Transient global amnesia like syndrome associated with acute infarction of the corpus callosum: a case report

A sudden cardiac asystole and cardiopulmonary resuscitation of trigeminocardiac reflex during retrosigmoid approach surgery

Vagus nerve stimulation therapy in partial epilepsy: a review

Hereditary multiple exostoses: an unusual cause of spinal cord compression