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Current Obesity Reports
Published in: Current Obesity Reports 4/2014

01-12-2014 | Metabolism (R Pasquali, Section Editor)

Predictors of Ectopic Fat in Humans

Authors: Mauro Zamboni, Andrea P Rossi, Francesco Fantin, Simona L Budui, Elena Zoico, Giulia A Zamboni, Gloria Mazzali

Published in: Current Obesity Reports | Issue 4/2014

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Abstract

In the last decade there has been increasing focus on body fat distribution, rather than on the degree of obesity. More recently, great interest has also been dedicated to ectopic fat deposition in overnourished individuals that reflects a failure of the system of intracellular lipid homeostasis, which, in normal conditions, prevents lipotoxicity in the organs, by confining lipid overload to cells specifically designed to store large quantities of surplus calories, the white adipocytes. Consequently, excess body weight leads to fat infiltration of multiple organs including liver, pancreas, skeletal muscle, and heart thus forming “ectopic fat”. Although overfeeding is considered the main predictor of ectopic fat deposition, other factors may be also involved. The purpose of this review is to evaluate the current available data on the predictors of ectopic fat deposition in humans.
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Metadata
Title
Predictors of Ectopic Fat in Humans
Authors
Mauro Zamboni
Andrea P Rossi
Francesco Fantin
Simona L Budui
Elena Zoico
Giulia A Zamboni
Gloria Mazzali
Publication date
01-12-2014
Publisher
Springer US
Published in
Current Obesity Reports / Issue 4/2014
Electronic ISSN: 2162-4968
DOI
https://doi.org/10.1007/s13679-014-0126-7

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