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Published in: Current Geriatrics Reports 3/2019

01-09-2019 | Surgical Care (F Luchette and R Gonzalez, Section Editors)

Delirium in the Elderly Surgical Patient

Authors: Anna Liveris, Deborah M. Stein

Published in: Current Geriatrics Reports | Issue 3/2019

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Abstract

Purpose of Review

Delirium is an unfortunately frequent complication in the postoperative course of elderly patients, affecting as much as half of all patients with even higher rates in the intensive care unit. Early recognition and diagnosis are tantamount to prevention of the associated increased morbidity and mortality. In this review, we will summarize the current literature pertaining to the diagnosis, prevention, and treatment of delirium in the elderly surgical patient population.

Recent Findings

Several large randomized control trials looking at the treatment of delirium with neuroleptic medications have been published in the last decade. None has proven that these medications have any benefit in terms of incidence, duration, or severity. In the surgical population, there has been particular interest in contributory intraoperative factors. Fluctuations in blood pressure, Bispectral index monitoring, and regional anesthesia have been shown to play a role.

Summary

Well-validated screening tools are available for use in the hospital setting. Prevention and subsequent treatment with environmental and supportive methods is considered first-line therapy. Precipitating causes, such as sepsis, electrolyte imbalances, and hypoxia, should be identified and treated. Subsequent use of antipsychotic medications is described for patients with severe agitation only, despite a lack of definitive evidence to suggest benefit.
Literature
1.
go back to reference Association AP. Diagnostic and statistical manual of mental disorders (DSM-5®): American Psychiatric Pub; 2013.CrossRef Association AP. Diagnostic and statistical manual of mental disorders (DSM-5®): American Psychiatric Pub; 2013.CrossRef
2.
go back to reference Association ED. The DSM-5 criteria, level of arousal and delirium diagnosis: inclusiveness is safer. BMC Med. 2014;12(1):141.CrossRef Association ED. The DSM-5 criteria, level of arousal and delirium diagnosis: inclusiveness is safer. BMC Med. 2014;12(1):141.CrossRef
3.
go back to reference Inouye SK, Westendorp RG, Saczynski JS. Delirium in elderly people. Lancet. 2014;383(9920):911–22.CrossRefPubMed Inouye SK, Westendorp RG, Saczynski JS. Delirium in elderly people. Lancet. 2014;383(9920):911–22.CrossRefPubMed
4.
go back to reference Dasgupta M, Dumbrell AC. Preoperative risk assessment for delirium after noncardiac surgery: a systematic review. J Am Geriatr Soc. 2006;54(10):1578–89.CrossRefPubMed Dasgupta M, Dumbrell AC. Preoperative risk assessment for delirium after noncardiac surgery: a systematic review. J Am Geriatr Soc. 2006;54(10):1578–89.CrossRefPubMed
5.
go back to reference Robinson TN, Raeburn CD, Tran ZV, Angles EM, Brenner LA, Moss M. Postoperative delirium in the elderly: risk factors and outcomes. Ann Surg. 2009;249(1):173–8.CrossRefPubMed Robinson TN, Raeburn CD, Tran ZV, Angles EM, Brenner LA, Moss M. Postoperative delirium in the elderly: risk factors and outcomes. Ann Surg. 2009;249(1):173–8.CrossRefPubMed
6.
go back to reference Pandharipande P, Cotton BA, Shintani A, Thompson J, Pun BT, Morris JA Jr, et al. Prevalence and risk factors for development of delirium in surgical and trauma ICU patients. J Trauma. 2008;65(1):34–41.CrossRefPubMedPubMedCentral Pandharipande P, Cotton BA, Shintani A, Thompson J, Pun BT, Morris JA Jr, et al. Prevalence and risk factors for development of delirium in surgical and trauma ICU patients. J Trauma. 2008;65(1):34–41.CrossRefPubMedPubMedCentral
8.
9.
go back to reference Potter JF, Burton JR, Drach GW, Eisner J, Lundebjerg NE, Solomon DH. Geriatrics for residents in the surgical and medical specialties: implementation of curricula and training experiences. J Am Geriatr Soc. 2005;53(3):511–5.CrossRefPubMed Potter JF, Burton JR, Drach GW, Eisner J, Lundebjerg NE, Solomon DH. Geriatrics for residents in the surgical and medical specialties: implementation of curricula and training experiences. J Am Geriatr Soc. 2005;53(3):511–5.CrossRefPubMed
10.
go back to reference Webb TP, Duthie E Jr. Geriatrics for surgeons: infusing life into an aging subject. J Surg Educ. 2008;65(2):91–4.CrossRefPubMed Webb TP, Duthie E Jr. Geriatrics for surgeons: infusing life into an aging subject. J Surg Educ. 2008;65(2):91–4.CrossRefPubMed
11.
go back to reference Krain LP, Fitzgerald JT, Halter JB, Williams BC. Geriatrics attitudes and knowledge among surgical and medical subspecialty house officers. J Am Geriatr Soc. 2007;55(12):2056–60.CrossRefPubMed Krain LP, Fitzgerald JT, Halter JB, Williams BC. Geriatrics attitudes and knowledge among surgical and medical subspecialty house officers. J Am Geriatr Soc. 2007;55(12):2056–60.CrossRefPubMed
12.
go back to reference Detsky AS, Abrams HB, McLaughlin JR, Drucker DJ, Sasson Z, Johnston N, et al. Predicting cardiac complications in patients undergoing non-cardiac surgery. J Gen Intern Med. 1986;1(4):211–9.CrossRefPubMed Detsky AS, Abrams HB, McLaughlin JR, Drucker DJ, Sasson Z, Johnston N, et al. Predicting cardiac complications in patients undergoing non-cardiac surgery. J Gen Intern Med. 1986;1(4):211–9.CrossRefPubMed
13.
go back to reference Edelstein DM, Aharonoff GB, Karp A, Capla EL, Zuckerman JD, Koval KJ. Effect of postoperative delirium on outcome after hip fracture. Clin Orthop Relat Res. 2004;422:195–200.CrossRef Edelstein DM, Aharonoff GB, Karp A, Capla EL, Zuckerman JD, Koval KJ. Effect of postoperative delirium on outcome after hip fracture. Clin Orthop Relat Res. 2004;422:195–200.CrossRef
14.
go back to reference Bellelli G, Mazzola P, Morandi A, Bruni A, Carnevali L, Corsi M, et al. Duration of postoperative delirium is an independent predictor of 6-month mortality in older adults after hip fracture. J Am Geriatr Soc. 2014;62(7):1335–40.CrossRefPubMed Bellelli G, Mazzola P, Morandi A, Bruni A, Carnevali L, Corsi M, et al. Duration of postoperative delirium is an independent predictor of 6-month mortality in older adults after hip fracture. J Am Geriatr Soc. 2014;62(7):1335–40.CrossRefPubMed
15.
go back to reference Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, et al. Long-term cognitive impairment after critical illness. N Engl J Med. 2013;369(14):1306–16.CrossRefPubMedPubMedCentral Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, et al. Long-term cognitive impairment after critical illness. N Engl J Med. 2013;369(14):1306–16.CrossRefPubMedPubMedCentral
16.
go back to reference Saczynski JS, Marcantonio ER, Quach L, Fong TG, Gross A, Inouye SK, et al. Cognitive trajectories after postoperative delirium. N Engl J Med. 2012;367(1):30–9.CrossRefPubMedPubMedCentral Saczynski JS, Marcantonio ER, Quach L, Fong TG, Gross A, Inouye SK, et al. Cognitive trajectories after postoperative delirium. N Engl J Med. 2012;367(1):30–9.CrossRefPubMedPubMedCentral
17.
go back to reference Koster S, Hensens AG, van der Palen J. The long-term cognitive and functional outcomes of postoperative delirium after cardiac surgery. Ann Thorac Surg. 2009;87(5):1469–74.CrossRefPubMed Koster S, Hensens AG, van der Palen J. The long-term cognitive and functional outcomes of postoperative delirium after cardiac surgery. Ann Thorac Surg. 2009;87(5):1469–74.CrossRefPubMed
19.
go back to reference Girard TD, Thompson JL, Pandharipande PP, Brummel NE, Jackson JC, Patel MB, et al. Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study. Lancet Respir Med. 2018;6(3):213–22.CrossRefPubMedPubMedCentral Girard TD, Thompson JL, Pandharipande PP, Brummel NE, Jackson JC, Patel MB, et al. Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study. Lancet Respir Med. 2018;6(3):213–22.CrossRefPubMedPubMedCentral
20.
go back to reference Pandharipande P, Cotton BA, Shintani A, Thompson J, Costabile S, Pun BT, et al. Motoric subtypes of delirium in mechanically ventilated surgical and trauma intensive care unit patients. Intensive Care Med. 2007;33(10):1726–31.CrossRefPubMed Pandharipande P, Cotton BA, Shintani A, Thompson J, Costabile S, Pun BT, et al. Motoric subtypes of delirium in mechanically ventilated surgical and trauma intensive care unit patients. Intensive Care Med. 2007;33(10):1726–31.CrossRefPubMed
21.
go back to reference Stransky M, Schmidt C, Ganslmeier P, Grossmann E, Haneya A, Moritz S, et al. Hypoactive delirium after cardiac surgery as an independent risk factor for prolonged mechanical ventilation. J Cardiothorac Vasc Anesth. 2011;25(6):968–74.CrossRefPubMed Stransky M, Schmidt C, Ganslmeier P, Grossmann E, Haneya A, Moritz S, et al. Hypoactive delirium after cardiac surgery as an independent risk factor for prolonged mechanical ventilation. J Cardiothorac Vasc Anesth. 2011;25(6):968–74.CrossRefPubMed
22.
go back to reference Yang FM, Marcantonio ER, Inouye SK, Kiely DK, Rudolph JL, Fearing MA, et al. Phenomenological subtypes of delirium in older persons: patterns, prevalence, and prognosis. Psychosomatics. 2009;50(3):248–54.CrossRefPubMedPubMedCentral Yang FM, Marcantonio ER, Inouye SK, Kiely DK, Rudolph JL, Fearing MA, et al. Phenomenological subtypes of delirium in older persons: patterns, prevalence, and prognosis. Psychosomatics. 2009;50(3):248–54.CrossRefPubMedPubMedCentral
23.
go back to reference O’Keeffe ST. Clinical subtypes of delirium in the elderly. Dement Geriatr Cogn Disord. 1999;10(5):380–5.CrossRefPubMed O’Keeffe ST. Clinical subtypes of delirium in the elderly. Dement Geriatr Cogn Disord. 1999;10(5):380–5.CrossRefPubMed
24.
go back to reference Albrecht JS, Marcantonio ER, Roffey DM, Orwig D, Magaziner J, Terrin M, et al. Stability of postoperative delirium psychomotor subtypes in individuals with hip fracture. J Am Geriatr Soc. 2015;63(5):970–6.CrossRefPubMedPubMedCentral Albrecht JS, Marcantonio ER, Roffey DM, Orwig D, Magaziner J, Terrin M, et al. Stability of postoperative delirium psychomotor subtypes in individuals with hip fracture. J Am Geriatr Soc. 2015;63(5):970–6.CrossRefPubMedPubMedCentral
25.
go back to reference MacLullich AM, Ferguson KJ, Miller T, de Rooij SE, Cunningham C. Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. J Psychosom Res. 2008;65(3):229–38.CrossRefPubMedPubMedCentral MacLullich AM, Ferguson KJ, Miller T, de Rooij SE, Cunningham C. Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. J Psychosom Res. 2008;65(3):229–38.CrossRefPubMedPubMedCentral
26.
go back to reference Inouye S, Charpentier P. Precipitating factors for delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability. JAMA. 1996;275(11):852–7.CrossRefPubMed Inouye S, Charpentier P. Precipitating factors for delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability. JAMA. 1996;275(11):852–7.CrossRefPubMed
27.
go back to reference Girard TD, Ware LB, Bernard GR, Pandharipande PP, Thompson JL, Shintani AK, et al. Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med. 2012;38(12):1965–73.CrossRefPubMedPubMedCentral Girard TD, Ware LB, Bernard GR, Pandharipande PP, Thompson JL, Shintani AK, et al. Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med. 2012;38(12):1965–73.CrossRefPubMedPubMedCentral
28.
go back to reference Ansaloni L, Catena F, Chattat R, Fortuna D, Franceschi C, Mascitti P, et al. Risk factors and incidence of postoperative delirium in elderly patients after elective and emergency surgery. Br J Surg. 2010;97(2):273–80.CrossRefPubMed Ansaloni L, Catena F, Chattat R, Fortuna D, Franceschi C, Mascitti P, et al. Risk factors and incidence of postoperative delirium in elderly patients after elective and emergency surgery. Br J Surg. 2010;97(2):273–80.CrossRefPubMed
29.
go back to reference Kalisvaart KJ, Vreeswijk R, De Jonghe JF, Van Der Ploeg T, Van Gool WA, Eikelenboom P. Risk factors and prediction of postoperative delirium in elderly hip-surgery patients: implementation and validation of a medical risk factor model. J Am Geriatr Soc. 2006;54(5):817–22.CrossRefPubMed Kalisvaart KJ, Vreeswijk R, De Jonghe JF, Van Der Ploeg T, Van Gool WA, Eikelenboom P. Risk factors and prediction of postoperative delirium in elderly hip-surgery patients: implementation and validation of a medical risk factor model. J Am Geriatr Soc. 2006;54(5):817–22.CrossRefPubMed
30.
go back to reference Clegg A, Young JB. Which medications to avoid in people at risk of delirium: a systematic review. Age Ageing. 2010;40(1):23–9.CrossRefPubMed Clegg A, Young JB. Which medications to avoid in people at risk of delirium: a systematic review. Age Ageing. 2010;40(1):23–9.CrossRefPubMed
31.
go back to reference Tune LE, Bylsma FW. Benzodiazepine-induced and anticholinergic-induced delirium in the elderly. Int Psychogeriatr. 1991;3(2):397–408.CrossRefPubMed Tune LE, Bylsma FW. Benzodiazepine-induced and anticholinergic-induced delirium in the elderly. Int Psychogeriatr. 1991;3(2):397–408.CrossRefPubMed
32.
go back to reference Panel AGSBCUE, Fick DM, Semla TP, Beizer J, Brandt N, Dombrowski R, et al. American Geriatrics Society 2015 updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;63(11):2227–46.CrossRef Panel AGSBCUE, Fick DM, Semla TP, Beizer J, Brandt N, Dombrowski R, et al. American Geriatrics Society 2015 updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;63(11):2227–46.CrossRef
33.
go back to reference •• Aldecoa C, Bettelli G, Bilotta F, Sanders RD, Audisio R, Borozdina A, et al. European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium. Eur J Anaesth. 2017;34(4):192–214 In these most recently published practice guidelines, the European Society of Anesthesiologists reviews the current literature and develops evidence-based guidelines for the prevention and treatment of postoperative delirium.CrossRef •• Aldecoa C, Bettelli G, Bilotta F, Sanders RD, Audisio R, Borozdina A, et al. European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium. Eur J Anaesth. 2017;34(4):192–214 In these most recently published practice guidelines, the European Society of Anesthesiologists reviews the current literature and develops evidence-based guidelines for the prevention and treatment of postoperative delirium.CrossRef
34.
go back to reference Fick DM, Agostini JV, Inouye SK. Delirium superimposed on dementia: a systematic review. J Am Geriatr Soc. 2002;50(10):1723–32.CrossRefPubMed Fick DM, Agostini JV, Inouye SK. Delirium superimposed on dementia: a systematic review. J Am Geriatr Soc. 2002;50(10):1723–32.CrossRefPubMed
35.
go back to reference •• Inouye SK, Robinson T, Blaum C, Busby-Whitehead J, Boustani M, Chalian A, et al. Postoperative delirium in older adults: best practice statement from the American Geriatrics Society. J Am Coll Surg. 2015;220(2):136–48. e1 These guidelines published in 2015 by the American Geriatrics Society has several important evidence-based guidelines for the screening, diagnosis, prevention, and treatment of postoperative delirium in the elderly. The committee consisted of many of the authors who pioneered the field and shaped our understanding of geriatric patients with delirium. CrossRef •• Inouye SK, Robinson T, Blaum C, Busby-Whitehead J, Boustani M, Chalian A, et al. Postoperative delirium in older adults: best practice statement from the American Geriatrics Society. J Am Coll Surg. 2015;220(2):136–48. e1 These guidelines published in 2015 by the American Geriatrics Society has several important evidence-based guidelines for the screening, diagnosis, prevention, and treatment of postoperative delirium in the elderly. The committee consisted of many of the authors who pioneered the field and shaped our understanding of geriatric patients with delirium. CrossRef
36.
go back to reference Greer N, Rossom R, Anderson P. Delirium: screening, prevention, and diagnosis—a systematic review of the evidence. Washington, DC: Department of Veterans Affairs (US); 2011. 2012. Greer N, Rossom R, Anderson P. Delirium: screening, prevention, and diagnosis—a systematic review of the evidence. Washington, DC: Department of Veterans Affairs (US); 2011. 2012.
37.
go back to reference •• Devlin JW, Skrobik Y, Gélinas C, Needham DM, Slooter AJ, Pandharipande PP, et al. Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med 2018;46(9):e825-ee73. These are the most recently published guidelines on the topic of delirium in the elderly. It reviews not only delirium but other topics pertinent to the matter such as pain management and sleep-wake cycles. •• Devlin JW, Skrobik Y, Gélinas C, Needham DM, Slooter AJ, Pandharipande PP, et al. Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med 2018;46(9):e825-ee73. These are the most recently published guidelines on the topic of delirium in the elderly. It reviews not only delirium but other topics pertinent to the matter such as pain management and sleep-wake cycles.
38.
go back to reference Lai M, Wong Tin Niam D. Intracranial cause of delirium: computed tomography yield and predictive factors. Intern Med J. 2012;42(4):422–7.CrossRefPubMed Lai M, Wong Tin Niam D. Intracranial cause of delirium: computed tomography yield and predictive factors. Intern Med J. 2012;42(4):422–7.CrossRefPubMed
39.
go back to reference Nitchingham A, Kumar V, Shenkin S, Ferguson KJ, Caplan GA. A systematic review of neuroimaging in delirium: predictors, correlates and consequences. Int J Geriatr Psychiatry. 2018;33(11):1458–78.CrossRefPubMed Nitchingham A, Kumar V, Shenkin S, Ferguson KJ, Caplan GA. A systematic review of neuroimaging in delirium: predictors, correlates and consequences. Int J Geriatr Psychiatry. 2018;33(11):1458–78.CrossRefPubMed
40.
go back to reference Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI. Clarifying confusion: the confusion assessment method: a new method for detection of delirium. Ann Intern Med. 1990;113(12):941–8.CrossRefPubMed Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI. Clarifying confusion: the confusion assessment method: a new method for detection of delirium. Ann Intern Med. 1990;113(12):941–8.CrossRefPubMed
41.
go back to reference Ely EW, Margolin R, Francis J, May L, Truman B, Dittus R, et al. Evaluation of delirium in critically ill patients: validation of the confusion assessment method for the intensive care unit (CAM-ICU). Crit Care Med. 2001;29(7):1370–9.CrossRefPubMed Ely EW, Margolin R, Francis J, May L, Truman B, Dittus R, et al. Evaluation of delirium in critically ill patients: validation of the confusion assessment method for the intensive care unit (CAM-ICU). Crit Care Med. 2001;29(7):1370–9.CrossRefPubMed
42.
go back to reference Larsson C, Axell AG, Ersson A. Confusion assessment method for the intensive care unit (CAM-ICU): translation, retranslation and validation into Swedish intensive care settings. Acta Anaesthesiol Scand. 2007;51(7):888–92.CrossRefPubMed Larsson C, Axell AG, Ersson A. Confusion assessment method for the intensive care unit (CAM-ICU): translation, retranslation and validation into Swedish intensive care settings. Acta Anaesthesiol Scand. 2007;51(7):888–92.CrossRefPubMed
43.
go back to reference Adamis D, Dimitriou C, Anifantaki S, Zachariadis A, Astrinaki I, Alegakis A, et al. Validation of the Greek version of confusion assessment method for the intensive care unit (CAM-ICU). Intensive Critical Care Nursing. 2012;28(6):337–43.CrossRefPubMed Adamis D, Dimitriou C, Anifantaki S, Zachariadis A, Astrinaki I, Alegakis A, et al. Validation of the Greek version of confusion assessment method for the intensive care unit (CAM-ICU). Intensive Critical Care Nursing. 2012;28(6):337–43.CrossRefPubMed
44.
go back to reference Tobar E, Romero C, Galleguillos T, Fuentes P, Cornejo R, Lira M, et al. Confusion assessment method for diagnosing delirium in ICU patients (CAM-ICU): cultural adaptation and validation of the Spanish version. Med Int. 2010;34(1):4–13. Tobar E, Romero C, Galleguillos T, Fuentes P, Cornejo R, Lira M, et al. Confusion assessment method for diagnosing delirium in ICU patients (CAM-ICU): cultural adaptation and validation of the Spanish version. Med Int. 2010;34(1):4–13.
45.
go back to reference Ryan K, Leonard M, Guerin S, Donnelly S, Conroy M, Meagher D. Validation of the confusion assessment method in the palliative care setting. Palliat Med. 2009;23(1):40–5.CrossRefPubMed Ryan K, Leonard M, Guerin S, Donnelly S, Conroy M, Meagher D. Validation of the confusion assessment method in the palliative care setting. Palliat Med. 2009;23(1):40–5.CrossRefPubMed
46.
go back to reference Han JH, Wilson A, Graves AJ, Shintani A, Schnelle JF, Dittus RS, et al. Validation of the confusion assessment method for the intensive care unit in older emergency department patients. Acad Emerg Med. 2014;21(2):180–7.CrossRefPubMedPubMedCentral Han JH, Wilson A, Graves AJ, Shintani A, Schnelle JF, Dittus RS, et al. Validation of the confusion assessment method for the intensive care unit in older emergency department patients. Acad Emerg Med. 2014;21(2):180–7.CrossRefPubMedPubMedCentral
47.
go back to reference Wei LA, Fearing MA, Sternberg EJ, Inouye SK. The confusion assessment method: a systematic review of current usage. J Am Geriatr Soc. 2008;56(5):823–30.CrossRefPubMedPubMedCentral Wei LA, Fearing MA, Sternberg EJ, Inouye SK. The confusion assessment method: a systematic review of current usage. J Am Geriatr Soc. 2008;56(5):823–30.CrossRefPubMedPubMedCentral
48.
go back to reference Inouye SK, Kosar CM, Tommet D, Schmitt EM, Puelle MR, Saczynski JS, et al. The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts. Ann Intern Med. 2014;160(8):526–33.CrossRefPubMedPubMedCentral Inouye SK, Kosar CM, Tommet D, Schmitt EM, Puelle MR, Saczynski JS, et al. The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts. Ann Intern Med. 2014;160(8):526–33.CrossRefPubMedPubMedCentral
49.
go back to reference Heng M, Eagen CE, Javedan H, Kodela J, Weaver MJ, Harris MB. Abnormal mini-cog is associated with higher risk of complications and delirium in geriatric patients with fracture. J Bone Joint Surg. 2016;98(9):742–50.CrossRefPubMed Heng M, Eagen CE, Javedan H, Kodela J, Weaver MJ, Harris MB. Abnormal mini-cog is associated with higher risk of complications and delirium in geriatric patients with fracture. J Bone Joint Surg. 2016;98(9):742–50.CrossRefPubMed
50.
go back to reference Borson S, Scanlan J, Brush M, Vitaliano P, Dokmak A. The mini-cog: a cognitive ‘vital signs’ measure for dementia screening in multi-lingual elderly. Int J Geriatr Psychiatry. 2000;15(11):1021–7.CrossRefPubMed Borson S, Scanlan J, Brush M, Vitaliano P, Dokmak A. The mini-cog: a cognitive ‘vital signs’ measure for dementia screening in multi-lingual elderly. Int J Geriatr Psychiatry. 2000;15(11):1021–7.CrossRefPubMed
51.
go back to reference Bergeron N, Dubois M-J, Dumont M, Dial S, Skrobik Y. Intensive care delirium screening checklist: evaluation of a new screening tool. Intensive Care Med. 2001;27(5):859–64.CrossRefPubMed Bergeron N, Dubois M-J, Dumont M, Dial S, Skrobik Y. Intensive care delirium screening checklist: evaluation of a new screening tool. Intensive Care Med. 2001;27(5):859–64.CrossRefPubMed
52.
go back to reference Plaschke K, Von Haken R, Scholz M, Engelhardt R, Brobeil A, Martin E, et al. Comparison of the confusion assessment method for the intensive care unit (CAM-ICU) with the intensive care delirium screening checklist (ICDSC) for delirium in critical care patients gives high agreement rate (s). Intensive Care Med. 2008;34(3):431–6.CrossRefPubMed Plaschke K, Von Haken R, Scholz M, Engelhardt R, Brobeil A, Martin E, et al. Comparison of the confusion assessment method for the intensive care unit (CAM-ICU) with the intensive care delirium screening checklist (ICDSC) for delirium in critical care patients gives high agreement rate (s). Intensive Care Med. 2008;34(3):431–6.CrossRefPubMed
53.
go back to reference Adamis D, Meagher D, Murray O, O'neill D, O'mahony E, Mulligan O, et al. Evaluating attention in delirium: a comparison of bedside tests of attention. Geriatr Gerontol Int. 2016;16(9):1028–35.CrossRefPubMed Adamis D, Meagher D, Murray O, O'neill D, O'mahony E, Mulligan O, et al. Evaluating attention in delirium: a comparison of bedside tests of attention. Geriatr Gerontol Int. 2016;16(9):1028–35.CrossRefPubMed
54.
go back to reference Han JH, Wilson A, Vasilevskis EE, Shintani A, Schnelle JF, Dittus RS, et al. Diagnosing delirium in older emergency department patients: validity and reliability of the delirium triage screen and the brief confusion assessment method. Ann Emerg Med. 2013;62(5):457–65.CrossRefPubMedPubMedCentral Han JH, Wilson A, Vasilevskis EE, Shintani A, Schnelle JF, Dittus RS, et al. Diagnosing delirium in older emergency department patients: validity and reliability of the delirium triage screen and the brief confusion assessment method. Ann Emerg Med. 2013;62(5):457–65.CrossRefPubMedPubMedCentral
55.
go back to reference Bellelli G, Morandi A, Davis DH, Mazzola P, Turco R, Gentile S, et al. Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people. Age Ageing. 2014;43(4):496–502.CrossRefPubMedPubMedCentral Bellelli G, Morandi A, Davis DH, Mazzola P, Turco R, Gentile S, et al. Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people. Age Ageing. 2014;43(4):496–502.CrossRefPubMedPubMedCentral
56.
go back to reference Inouye SK, Bogardus ST Jr, Charpentier PA, Leo-Summers L, Acampora D, Holford TR, et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med. 1999;340(9):669–76.CrossRefPubMed Inouye SK, Bogardus ST Jr, Charpentier PA, Leo-Summers L, Acampora D, Holford TR, et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med. 1999;340(9):669–76.CrossRefPubMed
57.
go back to reference • Siddiqi N, Harrison JK, Clegg A, Teale EA, Young J, Taylor J, et al. Interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev. (2016, 3) This Cochrane review from 2016 details the available evidence regarding nonpharmacologic and pharmacologic strategies for prevention of delirium in the non-critically ill patient. • Siddiqi N, Harrison JK, Clegg A, Teale EA, Young J, Taylor J, et al. Interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev. (2016, 3) This Cochrane review from 2016 details the available evidence regarding nonpharmacologic and pharmacologic strategies for prevention of delirium in the non-critically ill patient.
58.
go back to reference Lundström M, Olofsson B, Stenvall M, Karlsson S, Nyberg L, Englund U, et al. Postoperative delirium in old patients with femoral neck fracture: a randomized intervention study. Aging Clin Exp Res. 2007;19(3):178–86.CrossRefPubMed Lundström M, Olofsson B, Stenvall M, Karlsson S, Nyberg L, Englund U, et al. Postoperative delirium in old patients with femoral neck fracture: a randomized intervention study. Aging Clin Exp Res. 2007;19(3):178–86.CrossRefPubMed
59.
go back to reference Björkelund K, Hommel A, Thorngren KG, Gustafson L, Larsson S, Lundberg D. Reducing delirium in elderly patients with hip fracture: a multi-factorial intervention study. Acta Anaesthesiol Scand. 2010;54(6):678–88.CrossRefPubMed Björkelund K, Hommel A, Thorngren KG, Gustafson L, Larsson S, Lundberg D. Reducing delirium in elderly patients with hip fracture: a multi-factorial intervention study. Acta Anaesthesiol Scand. 2010;54(6):678–88.CrossRefPubMed
60.
go back to reference Holt R, Young J, Heseltine D. Effectiveness of a multi-component intervention to reduce delirium incidence in elderly care wards. Age Ageing. 2013;42(6):721–7.CrossRefPubMed Holt R, Young J, Heseltine D. Effectiveness of a multi-component intervention to reduce delirium incidence in elderly care wards. Age Ageing. 2013;42(6):721–7.CrossRefPubMed
61.
go back to reference Hshieh TT, Yue J, Oh E, Puelle M, Dowal S, Travison T, et al. Effectiveness of multicomponent nonpharmacological delirium interventions: a meta-analysis. JAMA Intern Med. 2015;175(4):512–20.CrossRefPubMedPubMedCentral Hshieh TT, Yue J, Oh E, Puelle M, Dowal S, Travison T, et al. Effectiveness of multicomponent nonpharmacological delirium interventions: a meta-analysis. JAMA Intern Med. 2015;175(4):512–20.CrossRefPubMedPubMedCentral
62.
go back to reference Chen CC-H, Lin M-T, Tien Y-W, Yen C-J, Huang G-H, Inouye SK. Modified hospital elder life program: effects on abdominal surgery patients. J Am Coll Surg. 2011;213(2):245–52.CrossRefPubMed Chen CC-H, Lin M-T, Tien Y-W, Yen C-J, Huang G-H, Inouye SK. Modified hospital elder life program: effects on abdominal surgery patients. J Am Coll Surg. 2011;213(2):245–52.CrossRefPubMed
63.
go back to reference Milisen K, Foreman MD, Abraham IL, De Geest S, Godderis J, Vandermeulen E, et al. A nurse-led interdisciplinary intervention program for delirium in elderly hip-fracture patients. J Am Geriatr Soc. 2001;49(5):523–32.CrossRefPubMed Milisen K, Foreman MD, Abraham IL, De Geest S, Godderis J, Vandermeulen E, et al. A nurse-led interdisciplinary intervention program for delirium in elderly hip-fracture patients. J Am Geriatr Soc. 2001;49(5):523–32.CrossRefPubMed
64.
go back to reference Abraha I, Trotta F, Rimland JM, Cruz-Jentoft A, Lozano-Montoya I, Soiza RL, et al. Efficacy of non-pharmacological interventions to prevent and treat delirium in older patients: a systematic overview. The SENATOR project ONTOP series. PLoS One. 2015;10(6):e0123090.CrossRefPubMedPubMedCentral Abraha I, Trotta F, Rimland JM, Cruz-Jentoft A, Lozano-Montoya I, Soiza RL, et al. Efficacy of non-pharmacological interventions to prevent and treat delirium in older patients: a systematic overview. The SENATOR project ONTOP series. PLoS One. 2015;10(6):e0123090.CrossRefPubMedPubMedCentral
65.
go back to reference Hirsch J, DePalma G, Tsai T, Sands L, Leung J. Impact of intraoperative hypotension and blood pressure fluctuations on early postoperative delirium after non-cardiac surgery. Surv Anesthesiol. 2016;60(3):119–20.CrossRef Hirsch J, DePalma G, Tsai T, Sands L, Leung J. Impact of intraoperative hypotension and blood pressure fluctuations on early postoperative delirium after non-cardiac surgery. Surv Anesthesiol. 2016;60(3):119–20.CrossRef
66.
go back to reference Marcantonio ER, Goldman L, Orav EJ, Cook EF, Lee TH. The association of intraoperative factors with the development of postoperative delirium. Am J Med. 1998;105(5):380–4.CrossRefPubMed Marcantonio ER, Goldman L, Orav EJ, Cook EF, Lee TH. The association of intraoperative factors with the development of postoperative delirium. Am J Med. 1998;105(5):380–4.CrossRefPubMed
67.
go back to reference Sieber FE, Zakriya KJ, Gottschalk A, Blute M-R, Lee HB, Rosenberg PB, et al., editors. Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair. Mayo Clinic Proceedings; 2010: Elsevier. Sieber FE, Zakriya KJ, Gottschalk A, Blute M-R, Lee HB, Rosenberg PB, et al., editors. Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair. Mayo Clinic Proceedings; 2010: Elsevier.
68.
go back to reference Santarpino G, Fasol R, Sirch J, Ackermann B, Pfeiffer S, Fischlein T. Impact of bispectral index monitoring on postoperative delirium in patients undergoing aortic surgery. HSR proceedings in intensive care & cardiovascular anesthesia. 2011;3(1):47–58. Santarpino G, Fasol R, Sirch J, Ackermann B, Pfeiffer S, Fischlein T. Impact of bispectral index monitoring on postoperative delirium in patients undergoing aortic surgery. HSR proceedings in intensive care & cardiovascular anesthesia. 2011;3(1):47–58.
69.
go back to reference Wildes TS, Mickle AM, Abdallah AB, Maybrier HR, Oberhaus J, Budelier TP, et al. Effect of electroencephalography-guided anesthetic administration on postoperative delirium among older adults undergoing major surgery: the ENGAGES randomized clinical trial. Jama. 2019;321(5):473–83.CrossRefPubMedPubMedCentral Wildes TS, Mickle AM, Abdallah AB, Maybrier HR, Oberhaus J, Budelier TP, et al. Effect of electroencephalography-guided anesthetic administration on postoperative delirium among older adults undergoing major surgery: the ENGAGES randomized clinical trial. Jama. 2019;321(5):473–83.CrossRefPubMedPubMedCentral
70.
go back to reference Radtke F, Franck M, Lendner J, Krüger S, Wernecke K, Spies C. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction. Br J Anaesth. 2013;110(suppl_1):i98–i105.CrossRefPubMed Radtke F, Franck M, Lendner J, Krüger S, Wernecke K, Spies C. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction. Br J Anaesth. 2013;110(suppl_1):i98–i105.CrossRefPubMed
71.
go back to reference Chan MT, Cheng BC, Lee TM, Gin T, Group CT. BIS-guided anesthesia decreases postoperative delirium and cognitive decline. J Neurosurg Anesthesiol. 2013;25(1):33–42.CrossRefPubMed Chan MT, Cheng BC, Lee TM, Gin T, Group CT. BIS-guided anesthesia decreases postoperative delirium and cognitive decline. J Neurosurg Anesthesiol. 2013;25(1):33–42.CrossRefPubMed
72.
go back to reference Lynch EP, Lazor MA, Gellis JE, Orav J, Goldman L, Marcantonio ER. The impact of postoperative pain on the development of postoperative delirium. Anesth Analg. 1998;86(4):781–5.CrossRefPubMed Lynch EP, Lazor MA, Gellis JE, Orav J, Goldman L, Marcantonio ER. The impact of postoperative pain on the development of postoperative delirium. Anesth Analg. 1998;86(4):781–5.CrossRefPubMed
73.
go back to reference Vaurio LE, Sands LP, Wang Y, Mullen EA, Leung JM. Postoperative delirium: the importance of pain and pain management. Anesth Analg. 2006;102(4):1267–73.CrossRefPubMed Vaurio LE, Sands LP, Wang Y, Mullen EA, Leung JM. Postoperative delirium: the importance of pain and pain management. Anesth Analg. 2006;102(4):1267–73.CrossRefPubMed
74.
go back to reference Morrison RS, Magaziner J, Gilbert M, Koval KJ, McLaughlin MA, Orosz G, et al. Relationship between pain and opioid analgesics on the development of delirium following hip fracture. J Gerontol Ser A Biol Med Sci. 2003;58(1):M76–81.CrossRef Morrison RS, Magaziner J, Gilbert M, Koval KJ, McLaughlin MA, Orosz G, et al. Relationship between pain and opioid analgesics on the development of delirium following hip fracture. J Gerontol Ser A Biol Med Sci. 2003;58(1):M76–81.CrossRef
75.
go back to reference Leung J, Sands L, Rico M, Petersen K, Rowbotham M, Dahl J, et al. Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients. Neurology. 2006;67(7):1251–3.CrossRefPubMed Leung J, Sands L, Rico M, Petersen K, Rowbotham M, Dahl J, et al. Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients. Neurology. 2006;67(7):1251–3.CrossRefPubMed
76.
go back to reference Kinjo S, Lim E, Sands LP, Bozic KJ, Leung JM. Does using a femoral nerve block for total knee replacement decrease postoperative delirium? BMC Anesthesiol. 2012;12(1):4.CrossRefPubMedPubMedCentral Kinjo S, Lim E, Sands LP, Bozic KJ, Leung JM. Does using a femoral nerve block for total knee replacement decrease postoperative delirium? BMC Anesthesiol. 2012;12(1):4.CrossRefPubMedPubMedCentral
77.
go back to reference Mouzopoulos G, Vasiliadis G, Lasanianos N, Nikolaras G, Morakis E, Kaminaris M. Fascia iliaca block prophylaxis for hip fracture patients at risk for delirium: a randomized placebo-controlled study. J Orthop Traumatol. 2009;10(3):127–33.CrossRefPubMedPubMedCentral Mouzopoulos G, Vasiliadis G, Lasanianos N, Nikolaras G, Morakis E, Kaminaris M. Fascia iliaca block prophylaxis for hip fracture patients at risk for delirium: a randomized placebo-controlled study. J Orthop Traumatol. 2009;10(3):127–33.CrossRefPubMedPubMedCentral
78.
go back to reference O’Connell KM, Quistberg DA, Tessler R, Robinson BR, Cuschieri J, Maier RV, et al. Decreased risk of delirium with use of regional analgesia in geriatric trauma patients with multiple rib fractures. Ann Surg. 2018;268(3):534–40.CrossRefPubMed O’Connell KM, Quistberg DA, Tessler R, Robinson BR, Cuschieri J, Maier RV, et al. Decreased risk of delirium with use of regional analgesia in geriatric trauma patients with multiple rib fractures. Ann Surg. 2018;268(3):534–40.CrossRefPubMed
79.
go back to reference Carvalho J, Alvim R, Martins J, Bouza C, Zenaide P, Zantieff R, et al. Pharmacological treatment of hypoactive delirium in critically ill patients: a systematic review. Crit Care. 2013;17(3):P36.CrossRefPubMedCentral Carvalho J, Alvim R, Martins J, Bouza C, Zenaide P, Zantieff R, et al. Pharmacological treatment of hypoactive delirium in critically ill patients: a systematic review. Crit Care. 2013;17(3):P36.CrossRefPubMedCentral
80.
go back to reference Campbell N, Boustani MA, Ayub A, Fox GC, Munger SL, Ott C, et al. Pharmacological management of delirium in hospitalized adults–a systematic evidence review. J Gen Intern Med. 2009;24(7):848–53.CrossRefPubMedPubMedCentral Campbell N, Boustani MA, Ayub A, Fox GC, Munger SL, Ott C, et al. Pharmacological management of delirium in hospitalized adults–a systematic evidence review. J Gen Intern Med. 2009;24(7):848–53.CrossRefPubMedPubMedCentral
81.
go back to reference Neufeld KJ, Yue J, Robinson TN, Inouye SK, Needham DM. Antipsychotic medication for prevention and treatment of delirium in hospitalized adults: a systematic review and meta-analysis. J Am Geriatr Soc. 2016;64(4):705–14.CrossRefPubMedPubMedCentral Neufeld KJ, Yue J, Robinson TN, Inouye SK, Needham DM. Antipsychotic medication for prevention and treatment of delirium in hospitalized adults: a systematic review and meta-analysis. J Am Geriatr Soc. 2016;64(4):705–14.CrossRefPubMedPubMedCentral
82.
go back to reference Girard TD, Pandharipande PP, Carson SS, Schmidt GA, Wright PE, Canonico AE, et al. Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med. 2010;38(2):428–37.CrossRefPubMedPubMedCentral Girard TD, Pandharipande PP, Carson SS, Schmidt GA, Wright PE, Canonico AE, et al. Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med. 2010;38(2):428–37.CrossRefPubMedPubMedCentral
83.
go back to reference Breitbart W, Marotta R, Platt MM, Weisman H, Derevenco M, Grau C, et al. A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Focus. 2005;153(2):231–340. Breitbart W, Marotta R, Platt MM, Weisman H, Derevenco M, Grau C, et al. A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Focus. 2005;153(2):231–340.
84.
go back to reference • Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, et al. Haloperidol and ziprasidone for treatment of delirium in critical illness. N Engl J Med. 2018;379(26):2506–16 This large randomized control trial published in the New England journal is the most recent of many showing no substantial difference in the use of antipsychotic medications in the management of delirium. CrossRefPubMedPubMedCentral • Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, et al. Haloperidol and ziprasidone for treatment of delirium in critical illness. N Engl J Med. 2018;379(26):2506–16 This large randomized control trial published in the New England journal is the most recent of many showing no substantial difference in the use of antipsychotic medications in the management of delirium. CrossRefPubMedPubMedCentral
85.
go back to reference Page VJ, Ely EW, Gates S, Zhao XB, Alce T, Shintani A, et al. Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. Lancet Respir Med. 2013;1(7):515–23.CrossRefPubMedPubMedCentral Page VJ, Ely EW, Gates S, Zhao XB, Alce T, Shintani A, et al. Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. Lancet Respir Med. 2013;1(7):515–23.CrossRefPubMedPubMedCentral
86.
go back to reference • Burry L, Mehta S, Perreault MM, Luxenberg JS, Siddiqi N, Hutton B, et al. Antipsychotics for treatment of delirium in hospitalised non-ICU patients. Cochrane Database of Systematic Reviews. 2018(6). This recent Cochrane review does a thorough analysis of the data for and against the use of antipsychotics in the delirious patient. • Burry L, Mehta S, Perreault MM, Luxenberg JS, Siddiqi N, Hutton B, et al. Antipsychotics for treatment of delirium in hospitalised non-ICU patients. Cochrane Database of Systematic Reviews. 2018(6). This recent Cochrane review does a thorough analysis of the data for and against the use of antipsychotics in the delirious patient.
87.
go back to reference Van Den Boogaard M, Slooter AJ, Brüggemann RJ, Schoonhoven L, Beishuizen A, Vermeijden JW, et al. Effect of haloperidol on survival among critically ill adults with a high risk of delirium: the REDUCE randomized clinical trial. Jama. 2018;319(7):680–90.CrossRefPubMedPubMedCentral Van Den Boogaard M, Slooter AJ, Brüggemann RJ, Schoonhoven L, Beishuizen A, Vermeijden JW, et al. Effect of haloperidol on survival among critically ill adults with a high risk of delirium: the REDUCE randomized clinical trial. Jama. 2018;319(7):680–90.CrossRefPubMedPubMedCentral
88.
go back to reference Larsen KA, Kelly SE, Stern TA, Bode RH, Price LL, Hunter DJ, et al. Administration of olanzapine to prevent postoperative delirium in elderly joint-replacement patients: a randomized, controlled trial. Psychosomatics. 2010;51(5):409–18.CrossRefPubMed Larsen KA, Kelly SE, Stern TA, Bode RH, Price LL, Hunter DJ, et al. Administration of olanzapine to prevent postoperative delirium in elderly joint-replacement patients: a randomized, controlled trial. Psychosomatics. 2010;51(5):409–18.CrossRefPubMed
89.
go back to reference Wang W, Li H-L, Wang D-X, Zhu X, Li S-L, Yao G-Q, et al. Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial. Crit Care Med. 2012;40(3):731–9.CrossRefPubMed Wang W, Li H-L, Wang D-X, Zhu X, Li S-L, Yao G-Q, et al. Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial. Crit Care Med. 2012;40(3):731–9.CrossRefPubMed
90.
go back to reference ELDesoky ES. Pharmacokinetic-pharmacodynamic crisis in the elderly. Am J Ther. 2007;14(5):488–98.CrossRefPubMed ELDesoky ES. Pharmacokinetic-pharmacodynamic crisis in the elderly. Am J Ther. 2007;14(5):488–98.CrossRefPubMed
91.
go back to reference Gagnon B, Low G, Schreier G. Methylphenidate hydrochloride improves cognitive function in patients with advanced cancer and hypoactive delirium: a prospective clinical study. J Psychiatry Neurosci. 2005;30(2):100.PubMedPubMedCentral Gagnon B, Low G, Schreier G. Methylphenidate hydrochloride improves cognitive function in patients with advanced cancer and hypoactive delirium: a prospective clinical study. J Psychiatry Neurosci. 2005;30(2):100.PubMedPubMedCentral
92.
go back to reference Morita T, Otani H, Tsunoda J, Inoue S, Chihara S. Successful palliation of hypoactive delirium due to multi-organ failure by oral methylphenidate. Support Care Cancer. 2000;8(2):134–7.CrossRefPubMed Morita T, Otani H, Tsunoda J, Inoue S, Chihara S. Successful palliation of hypoactive delirium due to multi-organ failure by oral methylphenidate. Support Care Cancer. 2000;8(2):134–7.CrossRefPubMed
93.
go back to reference Keen J, Brown D. Psychostimulants and delirium in patients receiving palliative care. Palliat Support Care. 2004;2(2):199–202.CrossRefPubMed Keen J, Brown D. Psychostimulants and delirium in patients receiving palliative care. Palliat Support Care. 2004;2(2):199–202.CrossRefPubMed
94.
go back to reference Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, et al. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology. 2006;104(1):21–6.CrossRefPubMed Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, et al. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology. 2006;104(1):21–6.CrossRefPubMed
Metadata
Title
Delirium in the Elderly Surgical Patient
Authors
Anna Liveris
Deborah M. Stein
Publication date
01-09-2019
Publisher
Springer US
Published in
Current Geriatrics Reports / Issue 3/2019
Electronic ISSN: 2196-7865
DOI
https://doi.org/10.1007/s13670-019-00288-4

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