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Published in: Current Nutrition Reports 3/2017

01-09-2017 | Gastroenterology, Critical Care, and Lifestyle Medicine (SA McClave, Section Editor)

Will Availability of SMOF Lipid Emulsions for Parenteral Nutrition Change Surgical Nutrition Practice?

Authors: Elizabeth H. Cameron, Neal Bhutiani, Matthew C. Bozeman

Published in: Current Nutrition Reports | Issue 3/2017

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Abstract

Purpose of Review

Parenteral nutrition (PN) is a widely accepted form of nutrition administration in patients in whom enteral feeding is contraindicated or insufficient. This is true in surgical patient populations, as well. As a component of PN, intravenous fat emulsions (IVFEs) are essential for the administration of essential fatty acids (EFAs) and adequate energy intake. The oils that make up standard IVFE formulations have evolved over time.

Recent Findings

A newer formulation, known as SMOF, contains a combination of soybean oil, medium chain triglycerides, olive oil, and fish oil and is gaining popularity for its purported beneficial effects on liver function, inflammation, and anti-oxidant status.

Summary

This literature review examines the current data regarding the effects of SMOF in the patient receiving PN and examines the role SMOF may play in the future management of nutrition in the surgical population.
Literature
1.
go back to reference Vassilyadi F, Panteliadou AK, Panteliadis C. Hallmarks in the history of enteral and parenteral nutrition: from antiquity to the 20th century. Nutr Clin Pract. 2013;28(2):209–17.CrossRefPubMed Vassilyadi F, Panteliadou AK, Panteliadis C. Hallmarks in the history of enteral and parenteral nutrition: from antiquity to the 20th century. Nutr Clin Pract. 2013;28(2):209–17.CrossRefPubMed
2.
go back to reference • Anez-Bustillos L, Dao DT, Baker MA, Fell GL, Puder M, Gura KM. Intravenous fat emulsion formulations for the adult and pediatric patient: understanding the differences. Nutr Clin Pract. 2016;31(5):596–609. Understanding the metabolic actions of the various lipid components available in PN solutions is foundational to PN administration. This article is an excellent review of the various mixtures and compounds available that make up the lipid component of PN. CrossRefPubMedPubMedCentral • Anez-Bustillos L, Dao DT, Baker MA, Fell GL, Puder M, Gura KM. Intravenous fat emulsion formulations for the adult and pediatric patient: understanding the differences. Nutr Clin Pract. 2016;31(5):596–609. Understanding the metabolic actions of the various lipid components available in PN solutions is foundational to PN administration. This article is an excellent review of the various mixtures and compounds available that make up the lipid component of PN. CrossRefPubMedPubMedCentral
3.
go back to reference Quigley EM, Marsh MN, Shaffer JL, Markin RS. Hepatobiliary complications of total parenteral nutrition. Gastroenterology. 1993;104(1):286–301.CrossRefPubMed Quigley EM, Marsh MN, Shaffer JL, Markin RS. Hepatobiliary complications of total parenteral nutrition. Gastroenterology. 1993;104(1):286–301.CrossRefPubMed
4.
go back to reference Kelly DA. Liver complications of pediatric parenteral nutrition--epidemiology. Nutrition. 1998;14(1):153–7.CrossRefPubMed Kelly DA. Liver complications of pediatric parenteral nutrition--epidemiology. Nutrition. 1998;14(1):153–7.CrossRefPubMed
5.
go back to reference Kumpf VJ. Parenteral nutrition-associated liver disease in adult and pediatric patients. Nutr Clin Pract. 2006;21(3):279–90.CrossRefPubMed Kumpf VJ. Parenteral nutrition-associated liver disease in adult and pediatric patients. Nutr Clin Pract. 2006;21(3):279–90.CrossRefPubMed
6.
go back to reference Squires RH, Duggan C, Teitelbaum DH, et al. Natural history of pediatric intestinal failure: initial report from the pediatric intestinal failure consortium. J Pediatr. 2012;161(4):723–8. e722CrossRefPubMedPubMedCentral Squires RH, Duggan C, Teitelbaum DH, et al. Natural history of pediatric intestinal failure: initial report from the pediatric intestinal failure consortium. J Pediatr. 2012;161(4):723–8. e722CrossRefPubMedPubMedCentral
7.
go back to reference Nandivada P, Fell GL, Gura KM, Puder M. Lipid emulsions in the treatment and prevention of parenteral nutrition-associated liver disease in infants and children. Am J Clin Nutr. 2016;103(2):629S–34S.CrossRefPubMedCentral Nandivada P, Fell GL, Gura KM, Puder M. Lipid emulsions in the treatment and prevention of parenteral nutrition-associated liver disease in infants and children. Am J Clin Nutr. 2016;103(2):629S–34S.CrossRefPubMedCentral
8.
go back to reference Messing B, Bories C, Kunstlinger F, Bernier JJ. Does total parenteral nutrition induce gallbladder sludge formation and lithiasis? Gastroenterology. 1983;84(5 Pt 1):1012–9.PubMed Messing B, Bories C, Kunstlinger F, Bernier JJ. Does total parenteral nutrition induce gallbladder sludge formation and lithiasis? Gastroenterology. 1983;84(5 Pt 1):1012–9.PubMed
9.
go back to reference Calder PC. Functional roles of fatty acids and their effects on human health. JPEN. J Parenter Enter Nutr. 2015;39(1 Suppl):18S–32S.CrossRef Calder PC. Functional roles of fatty acids and their effects on human health. JPEN. J Parenter Enter Nutr. 2015;39(1 Suppl):18S–32S.CrossRef
11.
go back to reference Serhan CN, Dalli J, Colas RA, Winkler JW, Chiang N. Protectins and maresins: new pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. Biochim Biophys Acta. 2015;1851(4):397–413.CrossRefPubMed Serhan CN, Dalli J, Colas RA, Winkler JW, Chiang N. Protectins and maresins: new pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. Biochim Biophys Acta. 2015;1851(4):397–413.CrossRefPubMed
13.
go back to reference Klein S, Kinney J, Jeejeebhoy K, et al. Nutrition support in clinical practice: review of published data and recommendations for future research directions. Summary of a conference sponsored by the National Institutes of Health, American Society for Parenteral and Enteral Nutrition, and American Society for Clinical Nutrition. Am J Clin Nutr. 1997;66(3):683–706. Klein S, Kinney J, Jeejeebhoy K, et al. Nutrition support in clinical practice: review of published data and recommendations for future research directions. Summary of a conference sponsored by the National Institutes of Health, American Society for Parenteral and Enteral Nutrition, and American Society for Clinical Nutrition. Am J Clin Nutr. 1997;66(3):683–706.
14.
go back to reference Villet S, Chiolero RL, Bollmann MD, et al. Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients. Clin Nutr. 2005;24(4):502–9.CrossRefPubMed Villet S, Chiolero RL, Bollmann MD, et al. Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients. Clin Nutr. 2005;24(4):502–9.CrossRefPubMed
15.
go back to reference Casaer MP, Mesotten D, Hermans G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011;365(6):506–17.CrossRefPubMed Casaer MP, Mesotten D, Hermans G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011;365(6):506–17.CrossRefPubMed
16.
go back to reference de Aguilar-Nascimento JE, Bicudo-Salomao A, Portari-Filho PE. Optimal timing for the initiation of enteral and parenteral nutrition in critical medical and surgical conditions. Nutrition. 2012;28(9):840–3.CrossRefPubMed de Aguilar-Nascimento JE, Bicudo-Salomao A, Portari-Filho PE. Optimal timing for the initiation of enteral and parenteral nutrition in critical medical and surgical conditions. Nutrition. 2012;28(9):840–3.CrossRefPubMed
18.
go back to reference Sandstrom R, Drott C, Hyltander A, et al. The effect of postoperative intravenous feeding (TPN) on outcome following major surgery evaluated in a randomized study. Ann Surg. 1993;217(2):185–95.CrossRefPubMedPubMedCentral Sandstrom R, Drott C, Hyltander A, et al. The effect of postoperative intravenous feeding (TPN) on outcome following major surgery evaluated in a randomized study. Ann Surg. 1993;217(2):185–95.CrossRefPubMedPubMedCentral
19.
go back to reference Grimble RF. Dietary lipids and the inflammatory response. Proc Nutr Soc. 1998;57(4):535–42.CrossRef Grimble RF. Dietary lipids and the inflammatory response. Proc Nutr Soc. 1998;57(4):535–42.CrossRef
20.
go back to reference Jolliet P, Pichard C. Immunonutrition in the critically ill. Intensive Care Med. 1999;25(6):631–3.CrossRefPubMed Jolliet P, Pichard C. Immunonutrition in the critically ill. Intensive Care Med. 1999;25(6):631–3.CrossRefPubMed
21.
go back to reference Santos JI. Nutrition, infection, and immunocompetence. Infect Dis Clin N Am. 1994;8(1):243–67. Santos JI. Nutrition, infection, and immunocompetence. Infect Dis Clin N Am. 1994;8(1):243–67.
22.
go back to reference Clayton PT, Bowron A, Mills KA, Massoud A, Casteels M, Milla PJ. Phytosterolemia in children with parenteral nutrition-associated cholestatic liver disease. Gastroenterology. 1993;105(6):1806–13.CrossRef Clayton PT, Bowron A, Mills KA, Massoud A, Casteels M, Milla PJ. Phytosterolemia in children with parenteral nutrition-associated cholestatic liver disease. Gastroenterology. 1993;105(6):1806–13.CrossRef
23.
go back to reference Iyer KR, Spitz L, Clayton P. BAPS prize lecture: new insight into mechanisms of parenteral nutrition-associated cholestasis: role of plant sterols. British Association of Paediatric Surgeons. J Pediatr Surg. 1998;33(1):1–6.CrossRefPubMed Iyer KR, Spitz L, Clayton P. BAPS prize lecture: new insight into mechanisms of parenteral nutrition-associated cholestasis: role of plant sterols. British Association of Paediatric Surgeons. J Pediatr Surg. 1998;33(1):1–6.CrossRefPubMed
24.
go back to reference Ulrich H, Pastores SM, Katz DP, Kvetan V. Parenteral use of medium-chain triglycerides: a reappraisal. Nutrition. 1996;12(4):231–8.CrossRefPubMed Ulrich H, Pastores SM, Katz DP, Kvetan V. Parenteral use of medium-chain triglycerides: a reappraisal. Nutrition. 1996;12(4):231–8.CrossRefPubMed
25.
go back to reference Mok KT, Maiz A, Yamazaki K, et al. Structured medium-chain and long-chain triglyceride emulsions are superior to physical mixtures in sparing body protein in the burned rat. Metab Clin Exp. 1984;33(10):910–5.CrossRefPubMed Mok KT, Maiz A, Yamazaki K, et al. Structured medium-chain and long-chain triglyceride emulsions are superior to physical mixtures in sparing body protein in the burned rat. Metab Clin Exp. 1984;33(10):910–5.CrossRefPubMed
26.
go back to reference Baldermann H, Wicklmayr M, Rett K, Banholzer P, Dietze G, Mehnert H. Changes of hepatic morphology during parenteral nutrition with lipid emulsions containing LCT or MCT/LCT quantified by ultrasound. JPEN. J Parenter Enter Nutr. 1991;15(6):601–3.CrossRef Baldermann H, Wicklmayr M, Rett K, Banholzer P, Dietze G, Mehnert H. Changes of hepatic morphology during parenteral nutrition with lipid emulsions containing LCT or MCT/LCT quantified by ultrasound. JPEN. J Parenter Enter Nutr. 1991;15(6):601–3.CrossRef
27.
go back to reference Clayton PT, Whitfield P, Iyer K. The role of phytosterols in the pathogenesis of liver complications of pediatric parenteral nutrition. Nutrition. 1998;14(1):158–64.CrossRefPubMed Clayton PT, Whitfield P, Iyer K. The role of phytosterols in the pathogenesis of liver complications of pediatric parenteral nutrition. Nutrition. 1998;14(1):158–64.CrossRefPubMed
28.
go back to reference Savini S, D'Ascenzo R, Biagetti C, et al. The effect of 5 intravenous lipid emulsions on plasma phytosterols in preterm infants receiving parenteral nutrition: a randomized clinical trial. Am J Clin Nutr. 2013;98(2):312–8.CrossRefPubMed Savini S, D'Ascenzo R, Biagetti C, et al. The effect of 5 intravenous lipid emulsions on plasma phytosterols in preterm infants receiving parenteral nutrition: a randomized clinical trial. Am J Clin Nutr. 2013;98(2):312–8.CrossRefPubMed
29.
go back to reference Vlaardingerbroek H, Vermeulen MJ, Carnielli VP, Vaz FM, van den Akker CH, van Goudoever JB. Growth and fatty acid profiles of VLBW infants receiving a multicomponent lipid emulsion from birth. J Pediatr Gastroenterol Nutr. 2014;58(4):417–27.CrossRefPubMed Vlaardingerbroek H, Vermeulen MJ, Carnielli VP, Vaz FM, van den Akker CH, van Goudoever JB. Growth and fatty acid profiles of VLBW infants receiving a multicomponent lipid emulsion from birth. J Pediatr Gastroenterol Nutr. 2014;58(4):417–27.CrossRefPubMed
30.
go back to reference Antebi H, Mansoor O, Ferrier C, et al. Liver function and plasma antioxidant status in intensive care unit patients requiring total parenteral nutrition: comparison of 2 fat emulsions. JPEN. J Parenter Enter Nutr. 2004;28(3):142–8.CrossRef Antebi H, Mansoor O, Ferrier C, et al. Liver function and plasma antioxidant status in intensive care unit patients requiring total parenteral nutrition: comparison of 2 fat emulsions. JPEN. J Parenter Enter Nutr. 2004;28(3):142–8.CrossRef
31.
go back to reference •• Klek S, Chambrier C, Singer P, et al. Four-week parenteral nutrition using a third generation lipid emulsion (SMOFlipid)--a double-blind, randomised, multicentre study in adults. Clin Nutr. 2013;32(2):224–31. PRCT of 73 patients comparing a SMOF mixture versus standard intralipid, patients were given 4 weeks of each. SMOF group demonstrated improvement in liver function tests, as well as improved lipid profiles when compared with control group. Study demonstrated longer term safety in use of the SMOF formulas. CrossRefPubMed •• Klek S, Chambrier C, Singer P, et al. Four-week parenteral nutrition using a third generation lipid emulsion (SMOFlipid)--a double-blind, randomised, multicentre study in adults. Clin Nutr. 2013;32(2):224–31. PRCT of 73 patients comparing a SMOF mixture versus standard intralipid, patients were given 4 weeks of each. SMOF group demonstrated improvement in liver function tests, as well as improved lipid profiles when compared with control group. Study demonstrated longer term safety in use of the SMOF formulas. CrossRefPubMed
32.
go back to reference •• Rayyan M, Devlieger H, Jochum F, Allegaert K. Short-term use of parenteral nutrition with a lipid emulsion containing a mixture of soybean oil, olive oil, medium-chain triglycerides, and fish oil: a randomized double-blind study in preterm infants. JPEN J Parenter Enteral Nutr. 2012;36(1 Suppl):81S–94S. Double blinded RCT comparing greater than 7 days of PN with soybean oil versus SMOF in preterm infants requiring PN. Statisitically significant reduction was seen in the SMOF group in total and direct bilirubin, as well as significant improvement overall fatty acid profiles, when compared with the soybean group. CrossRefPubMedPubMedCentral •• Rayyan M, Devlieger H, Jochum F, Allegaert K. Short-term use of parenteral nutrition with a lipid emulsion containing a mixture of soybean oil, olive oil, medium-chain triglycerides, and fish oil: a randomized double-blind study in preterm infants. JPEN J Parenter Enteral Nutr. 2012;36(1 Suppl):81S–94S. Double blinded RCT comparing greater than 7 days of PN with soybean oil versus SMOF in preterm infants requiring PN. Statisitically significant reduction was seen in the SMOF group in total and direct bilirubin, as well as significant improvement overall fatty acid profiles, when compared with the soybean group. CrossRefPubMedPubMedCentral
33.
go back to reference Tomsits E, Pataki M, Tolgyesi A, Fekete G, Rischak K, Szollar L. Safety and efficacy of a lipid emulsion containing a mixture of soybean oil, medium-chain triglycerides, olive oil, and fish oil: a randomised, double-blind clinical trial in premature infants requiring parenteral nutrition. J Pediatr Gastroenterol Nutr. 2010;51(4):514–21.CrossRefPubMed Tomsits E, Pataki M, Tolgyesi A, Fekete G, Rischak K, Szollar L. Safety and efficacy of a lipid emulsion containing a mixture of soybean oil, medium-chain triglycerides, olive oil, and fish oil: a randomised, double-blind clinical trial in premature infants requiring parenteral nutrition. J Pediatr Gastroenterol Nutr. 2010;51(4):514–21.CrossRefPubMed
34.
go back to reference Goulet O, Antebi H, Wolf C, et al. A new intravenous fat emulsion containing soybean oil, medium-chain triglycerides, olive oil, and fish oil: a single-center, double-blind randomized study on efficacy and safety in pediatric patients receiving home parenteral nutrition. JPEN. J Parenter Enter Nutr. 2010;34(5):485–95.CrossRef Goulet O, Antebi H, Wolf C, et al. A new intravenous fat emulsion containing soybean oil, medium-chain triglycerides, olive oil, and fish oil: a single-center, double-blind randomized study on efficacy and safety in pediatric patients receiving home parenteral nutrition. JPEN. J Parenter Enter Nutr. 2010;34(5):485–95.CrossRef
35.
go back to reference Grimm H, Tibell A, Norrlind B, Blecher C, Wilker S, Schwemmle K. Immunoregulation by parenteral lipids: impact of the n-3 to n-6 fatty acid ratio. JPEN J Parenter Enter Nutr. 1994;18(5):417–21.CrossRef Grimm H, Tibell A, Norrlind B, Blecher C, Wilker S, Schwemmle K. Immunoregulation by parenteral lipids: impact of the n-3 to n-6 fatty acid ratio. JPEN J Parenter Enter Nutr. 1994;18(5):417–21.CrossRef
36.
go back to reference Simopoulos AP, Leaf A, Salem N Jr. Essentiality of and recommended dietary intakes for omega-6 and omega-3 fatty acids. Ann Nutr Metab. 1999;43(2):127–30.CrossRefPubMed Simopoulos AP, Leaf A, Salem N Jr. Essentiality of and recommended dietary intakes for omega-6 and omega-3 fatty acids. Ann Nutr Metab. 1999;43(2):127–30.CrossRefPubMed
37.
go back to reference Kinsella JE, Broughton KS, Whelan JW. Dietary unsaturated fatty acids: interactions and possible needs in relation to eicosanoid synthesis. J Nutr Biochem. 1990;1(3):123–41.CrossRefPubMed Kinsella JE, Broughton KS, Whelan JW. Dietary unsaturated fatty acids: interactions and possible needs in relation to eicosanoid synthesis. J Nutr Biochem. 1990;1(3):123–41.CrossRefPubMed
38.
go back to reference Grimm H, Mertes N, Goeters C, et al. Improved fatty acid and leukotriene pattern with a novel lipid emulsion in surgical patients. Eur J Nutr. 2006;45(1):55–60.CrossRefPubMed Grimm H, Mertes N, Goeters C, et al. Improved fatty acid and leukotriene pattern with a novel lipid emulsion in surgical patients. Eur J Nutr. 2006;45(1):55–60.CrossRefPubMed
39.
go back to reference Ma CJ, Sun LC, Chen FM, et al. A double-blind randomized study comparing the efficacy and safety of a composite vs a conventional intravenous fat emulsion in postsurgical gastrointestinal tumor patients. Nutr Clin Pract. 2012;27(3):410–5.CrossRefPubMed Ma CJ, Sun LC, Chen FM, et al. A double-blind randomized study comparing the efficacy and safety of a composite vs a conventional intravenous fat emulsion in postsurgical gastrointestinal tumor patients. Nutr Clin Pract. 2012;27(3):410–5.CrossRefPubMed
40.
go back to reference Wu MH, Wang MY, Yang CY, Kuo ML, Lin MT. Randomized clinical trial of new intravenous lipid (SMOFlipid 20%) versus medium-chain triglycerides/long-chain triglycerides in adult patients undergoing gastrointestinal surgery. JPEN. J Parenter Enter Nutr. 2014;38(7):800–8.CrossRef Wu MH, Wang MY, Yang CY, Kuo ML, Lin MT. Randomized clinical trial of new intravenous lipid (SMOFlipid 20%) versus medium-chain triglycerides/long-chain triglycerides in adult patients undergoing gastrointestinal surgery. JPEN. J Parenter Enter Nutr. 2014;38(7):800–8.CrossRef
41.
go back to reference Linseisen J, Hoffmann J, Lienhard S, Jauch KW, Wolfram G. Antioxidant status of surgical patients receiving TPN with an omega-3-fatty acid-containing lipid emulsion supplemented with alpha-tocopherol. Clin Nutr. 2000;19(3):177–84.CrossRefPubMed Linseisen J, Hoffmann J, Lienhard S, Jauch KW, Wolfram G. Antioxidant status of surgical patients receiving TPN with an omega-3-fatty acid-containing lipid emulsion supplemented with alpha-tocopherol. Clin Nutr. 2000;19(3):177–84.CrossRefPubMed
42.
go back to reference Skouroliakou M, Konstantinou D, Koutri K, et al. A double-blind, randomized clinical trial of the effect of omega-3 fatty acids on the oxidative stress of preterm neonates fed through parenteral nutrition. Eur J Clin Nutr. 2010;64(9):940–7.CrossRef Skouroliakou M, Konstantinou D, Koutri K, et al. A double-blind, randomized clinical trial of the effect of omega-3 fatty acids on the oxidative stress of preterm neonates fed through parenteral nutrition. Eur J Clin Nutr. 2010;64(9):940–7.CrossRef
43.
go back to reference Jones CJ, Calder PC. Influence of different intravenous lipid emulsions on fatty acid status and laboratory and clinical outcomes in adult patients receiving home parenteral nutrition: a systematic review. Clin Nutr. 2016. Jones CJ, Calder PC. Influence of different intravenous lipid emulsions on fatty acid status and laboratory and clinical outcomes in adult patients receiving home parenteral nutrition: a systematic review. Clin Nutr. 2016.
44.
go back to reference Wanten GJ, Calder PC. Immune modulation by parenteral lipid emulsions. Am J Clin Nutr. 2007;85(5):1171–84.PubMed Wanten GJ, Calder PC. Immune modulation by parenteral lipid emulsions. Am J Clin Nutr. 2007;85(5):1171–84.PubMed
Metadata
Title
Will Availability of SMOF Lipid Emulsions for Parenteral Nutrition Change Surgical Nutrition Practice?
Authors
Elizabeth H. Cameron
Neal Bhutiani
Matthew C. Bozeman
Publication date
01-09-2017
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 3/2017
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-017-0215-9

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