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Current Pulmonology Reports

Published in:

01-12-2018 | Interstitial Lung Disease (A. Hajari Case, Section Editor)

Approved and Experimental Therapies for Idiopathic Pulmonary Fibrosis

Authors: Giuliana Pasciuto, Riccardo Inchingolo, Carola Condoluci, Daniele Magnini, Bruno Iovene, Luca Richeldi

Published in: Current Pulmonology Reports | Issue 4/2018

Abstract

Purpose of Review

Treatment of idiopathic pulmonary fibrosis (IPF) shifted significantly in the past few years, in the light of advances in understanding pathological pathways. The promising results coming from recent trials led to a growing number of studies dealing with IPF. The purpose of this article is to review scientific evidences supporting approved therapies and to provide an overview of experimental treatments that are currently under investigation.

Recent Findings

Approved anti-fibrotic treatments are based on large randomized trials showing the efficacy of pirfenidone and nintedanib in slowing IPF progression with an acceptable tolerability. However, we are still far from a definite cure and research efforts are focused on exploring new therapeutic targets and alternative treatment strategies.

Summary

Although pirfenidone and nintedanib remain the mainstay of IPF treatment, novel therapies are under investigation in clinical trials. Combination therapy will probably be a successful key for the future, targeting multiple pathways simultaneously.

Clinical Registration

NCT01619085

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Title: Approved and Experimental Therapies for Idiopathic Pulmonary Fibrosis
Authors: Giuliana Pasciuto
Riccardo Inchingolo
Carola Condoluci
Daniele Magnini
Bruno Iovene
Luca Richeldi
Publication date: 01-12-2018
Publisher: Springer US
Published in: Current Pulmonology Reports / Issue 4/2018
Electronic ISSN: 2199-2428
DOI: https://doi.org/10.1007/s13665-018-0209-0

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Approved and Experimental Therapies for Idiopathic Pulmonary Fibrosis

Abstract

Purpose of Review

Recent Findings

Summary

Clinical Registration

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Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

Clinical Registration

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