Published in:
Open Access
01-08-2020 | Melanoma | Case Report
Toripalimab-Induced Dermatomyositis in a Patient with Metastatic Melanoma
Authors:
Jingrong Lin, Minmin Xue, Mingyang Gao, Pu Yu, Shixin Han
Published in:
Dermatology and Therapy
|
Issue 4/2020
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Abstract
Toripalimab is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). It has recently been approved as an immune checkpoint inhibitor in second-line therapies in patients with unresectable or metastatic melanoma; however, it may be associated with various immune-related adverse events (irAEs). Here we report a case of toripalimab-induced dermatomyositis in a patient receiving treatment for metastatic melanoma. The symptoms were relieved by discontinuing toripalimab and administering once-daily intravenous methylprednisolone 1 mg/kg. We suggest that this case serves a warning to clinicians of the need to be aware of the possiblilty of toripalimab-induced dermatomyositis. Early recognition and treatment may prevent progression and improve prognosis of this irAE.