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Dermatology and Therapy
Published in: Dermatology and Therapy 1/2017

Open Access 01-03-2017 | Review

Vegas (Verruciform Genital-Associated) Xanthoma: A Comprehensive Literature Review

Authors: Katherine M. Stiff, Philip R. Cohen

Published in: Dermatology and Therapy | Issue 1/2017

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Abstract

Introduction

Verruciform xanthoma is a wart-like benign lesion. The classic histologic appearance consists of foamy histiocytes within elongated dermal papillae and epithelial acanthosis. The lesion most commonly occurs in the oral cavity, but has been reported in extra-oral sites such as the penis, scrotum, and vulva. The clinical and histologic characteristics of verruciform genital-associated (Vegas) xanthomas of the penis, scrotum, and vulva are reviewed.

Methods

PubMed was used to search the following term: verruciform xanthoma. The relevant papers were obtained and reviewed.

Results

There have been 193 cases of genital-associated verruciform xanthomas. There were 164 in men and 29 in women. Similar to verruciform xanthomas of the oral mucosa, they presented as asymptomatic lesions, demonstrated foam cells in the dermal papillae, and were typically managed successfully with surgical excision.

Conclusion

Verruciform xanthoma is a benign lesion characterized by a wart-like growth that is most commonly seen in the oral mucosa. Verruciform xanthomas of the genital region have been coined Vegas xanthomas. Vegas xanthomas have been reported in association with a variety of diseases, as well as in healthy individuals. Biopsy is required for diagnosis, and complete surgical excision is typically curative.
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Metadata
Title
Vegas (Verruciform Genital-Associated) Xanthoma: A Comprehensive Literature Review
Authors
Katherine M. Stiff
Philip R. Cohen
Publication date
01-03-2017
Publisher
Springer Healthcare
Published in
Dermatology and Therapy / Issue 1/2017
Print ISSN: 2193-8210
Electronic ISSN: 2190-9172
DOI
https://doi.org/10.1007/s13555-016-0155-0

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