Targeting inflammation using celecoxib with glimepiride in the treatment of obese type 2 diabetic Egyptian patients

Obesity, insulin resistance (IR), inflammation, and progressive decline in pancreatic β cell function are major features of type 2 diabetes mellitus (T2DM). We aimed to investigate the effect of co-administration of celecoxib (CE) with glimepiride (GL) in the treatment of obese T2DM patients. Body Mass Index (BMI), serum glucose, C-peptide, lipid profile, adiponectin, tumor necrosis factor-α (TNF-α), visfatin, and leptin levels were determined in 40 obese T2DM patients before and after treatment with GL alone or in combination with a selective cyclooxygenase-2 (COX-2) inhibitor CE for 3 months. Homeostasis model assessment of insulin resistance (HOMA2-IR) and atherogenic index (AI) was calculated. Increased levels of serum glucose, C-peptide, total cholesterol (TCH), low-density lipoprotein (LDL-C), triglycerides (TGs), visfatin, TNF-α, leptin, AI, and HOMA2-IR shown in obese diabetic patients were significantly decreased after co-treatment with GL plus CE compared to patients who received GL alone. On the other hand, adiponectin levels showed a significant increase after treatment. The obtained results demonstrate that targeting inflammation using celecoxib with glimepiride improves insulin resistance, glycemia, and inflammatory process in obese type 2 diabetics.